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This paper presents a simplified joint synchronization scheme for the integer carrier frequency offset and physical cell identity using a primary synchronization signal (PSS) in 5G new radio (NR) communication systems. We demonstrate the efficiency of our proposed NR-PSS synchronization scheme by deriving its simplified implementation, which exploits the near-zero autocorrelation feature between cyclically shifted NR-PSS symbols. As a figure of merit, we compute the probability of detection failure of the proposed NR-PSS synchronization scheme and validate its accuracy via simulations. To illustrate the benefits and limitations of the proposed NR-PSS synchronization scheme, we compare it with the conventional NR-PSS synchronization scheme, considering factors such as detection performance and computation complexity. Numerical results indicate that, regardless of the channel environment, the proposed NR-PSS synchronization scheme achieves a significant reduction in arithmetic complexity while maintaining the same detection capability as existing NR-PSS synchronization schemes.

This paper presents a novel formulation for detecting the secondary synchronization signal in a narrowband Internet of Things communication system. The proposed approach is supported by a noncoherent algorithm that eliminates the need for channel information. A robust joint synchronization scheme is developed by decoupling the estimations of the physical cell identity and the carrier frequency offset. We derive the detection probability of the proposed physical cell identity detector and the mean squared error of the carrier frequency offset estimator, demonstrating their accuracy through simulation results. The performance of the proposed detection scheme is compared with that of existing detection schemes in terms of both estimation accuracy and computational complexity. Experimental results confirm that the proposed synchronization method exhibits superior performance while maintaining relatively lower complexity compared with benchmark methods.

Abstract Background Early diagnosis and continuous monitoring are necessary for an efficient management of cervical cancers (CC). Liquid biopsy, such as detecting circulating tumor DNA (ctDNA) from blood, is a simple, non-invasive method for testing and monitoring cancer markers. However, tumor-specific alterations in ctDNA have not been extensively investigated or compared to other circulating biomarkers in the diagnosis and monitoring of the CC. Therfore, Next-generation sequencing (NGS) analysis with blood samples can be a new approach for highly accurate diagnosis and monitoring of the CC. Method Using a bioinformatics approach, we designed a panel of 24 genes associated with CC to detect and characterize patterns of somatic single-nucleotide variations, indels, and copy number variations. Our NGS CC panel covers most of the genes in The Cancer Genome Atlas (TCGA) as well as additional cancer driver and tumor suppressor genes. We profiled the variants in ctDNA from 24 CC patients who were being treated with systemic chemotherapy and local radiotherapy at the Jeonbuk National University Hospital, Korea. Result Eighteen out of 24 genes in our NGS CC panel had mutations across the 24 CC patients, including somatic alterations of mutated genes (ZFHX3–83%, KMT2C-79%, KMT2D-79%, NSD1–67%, ATM-38% and RNF213–27%). We demonstrated that the RNF213 mutation could be used potentially used as a monitoring marker for response to chemo- and radiotherapy. Conclusion We developed our NGS CC panel and demostrated that our NGS panel can be useful for the diagnosis and monitoring of the CC, since the panel detected the common somatic variations in CC patients and we observed how these genetic variations change according to the treatment pattern of the patient.

This study aimed to identify the expression profile of circulating microRNAs in dogs with eccentric or concentric cardiac hypertrophy. A total of 291 microRNAs in serum samples of five dogs with myxomatous mitral valve degeneration (MMVD) and five dogs with pulmonic stenosis (PS) were compared with those of five healthy dogs using microarray analysis. Results of microarray analysis revealed up-regulation of cfa-miR-130b [fold change (FC) = 2.13, p = 0.014), down-regulation of cfa-miR-375 (FC = 1.51, p = 0.014), cfa-miR-425 (FC = 2.56, p = 0.045), cfa-miR-30d (FC = 3.02, p = 0.047), cfa-miR-151 (FC = 1.89, p = 0.023), cfa-miR-19b (FC = 3.01, p = 0.008), and cfa-let-7g (FC = 2.53, p = 0.015) in MMVD group which showed eccentric cardiac hypertrophy, up-regulation of cfa-miR-346 (FC = 2.74, p = 0.032), down-regulation of cfa-miR-505 (FC = 1.56, p = 0.016) in PS group which showed concentric cardiac hypertrophy, and down-regulation of cfa-miR-30c (FC = 3.45, p = 0.013 in MMVD group; FC = 3.31, p = 0.014 in PS group) and cfa-let-7b (FC = 11.42, p = 0.049 in MMVD group; FC = 5.88, p = 0.01 in PS group) in both MMVD and PS groups. In addition, the unsupervised hierarchical clustering of differentially expressed microRNAs in each group resulted in complete separation of healthy dogs from dogs with heart diseases. Therefore, eleven microRNAs among 291 microRNAs were identified as differentially expressed circulating microRNAs related to MMVD or PS in dogs. This pilot study demonstrates that the microRNAs identified in this study could be possible candidates for novel biomarker or therapeutic target related to cardiac hypertrophy in dogs.

Narrowband Internet of Things (NB-IoT) is one of the low-power wide-area network technologies that aim to support enormous connection, deep coverage, low power consumption, and low cost. Therefore, low cost of implementation and maintenance is one of the key challenges of NB-IoT terminals. This paper presents a low-complexity formulation for narrowband secondary synchronization signal (NSSS) detection in the NB-IoT system, supported by a coherent algorithm that requires a priori knowledge of the channel. By exploiting a symmetric conjugate feature of the NSSS sequence, a joint physical cell ID and radio frame number detection method with low complexity is proposed for coherent detection. The probability of erroneous detection of the presented NSSS detection method is computed, and the analytical model is verified by means of simulation. Numerical experiments will demonstrate that the proposed detection scheme remarkably reduces the computational complexity with almost the same detection ability compared to the existing detection scheme.

Various technologies and standards for the Internet of Things (IoT) have defined the way devices should interact with each other to provide an intelligent IoT service to users in an efficient manner. Although the usability of system interface between the platform and users is one of the key factors for the success of IoT ecosystems, the manner in which IoT platforms should interact with users has not been well studied. Current IoT platforms provide a simple list-based interface to manage devices, which result in the degradation of their usability as the number of devices increases. In this paper, we propose an interactive web-based IoT management system where deep object detection techniques are adopted to facilitate user’s device selection and management. The proposed system automatically recognizes the device type from video streams and accordingly generates smart controllers. The users can choose a device by touching an object in the video stream and use a smart controller to control the selected device. Finally, we show the feasibility of the proposed system through the implementation of a prototype which demonstrates a set of user scenarios.

The cardioprotective effects of KR-31761, a newly synthesized K+ATP opener, were evaluated in rat models of ischemia/reperfusion (I/R) heart injury. In isolated rat hearts subjected to 30-min global ischemia/30-min reperfusion, KR-31761 perfused prior to ischemia significantly increased both the left ventricular developed pressure (% of predrug LVDP: 17.8, 45.1, 54.2, and 62.6 for the control, 1 μM, 3 μM, and 10 μM, respectively) and double product (DP: heart rate × LVDP; % of predrug DP: 17.5, 44.9, 56.2, and 64.5 for the control, 1 μM, 3 μM, and 10 μM, respectively) at 30-min reperfusion while decreasing the left ventricular end-diastolic pressure (LVEDP). KR-31761 (10 μM) significantly increased the time to contracture during the ischemic period, whereas it concentration-dependently decreased the lactate dehydrogenase release during reperfusion. All these parameters were significantly reversed by 5-hydroxydecanoate (5-HD, 100 μM) and glyburide (1 μM), selective and nonselective blockers of the mitochondrial K+ATP (mitoK+ATP) channel and K+ATP channel, respectively. In anesthetized rats subjected to 30-min occlusion of left anterior descending coronary artery/2.5-h reperfusion, KR-31761 administered 15 min before the onset of ischemia significantly decreased the infarct size (72.2%, 55.1%, and 47.1% for the control, 0.3 mg/kg, i.v., and 1.0 mg/kg, i.v., respectively); and these effects were completely and almost completely abolished by 5-HD (10 mg/kg, i.v.) and HMR-1098, a selective blocker of sarcolemmal K+ATP (sarcK+ATP) channel (6 mg/kg, i.v.) administered 5 min prior to KR-31761 (72.3% and 67.9%, respectively). KR-31761 only slightly relaxed methoxamine-precontracted rat aorta (IC50: >30.0 μM). These results suggest that KR-31761 exerts potent cardioprotective effects through the opening of both mitoK+ATP and sarcK+ATP channels in rat hearts with a minimal vasorelaxant effect. Keywords:: KR-31761, cardioprotection, KATP, ischemia/reperfusion, rat heart

Korea Multi-Purpose Satellite I(KOMPSAT-I, the first multi-purpose Korean satellite) will be launched in the third quarter of 1999, which is operated on the sun-synchronous orbit for cartography, ocean color monitoring, and space environment monitoring. The main mission of Electro-Optical Camera(EOC) which is one of KOMSAT-I sensors is to provide images for the production of scale maps of Korea. EOC collects panchromatic imagery with the ground sample distance of 6.6m at nadir through visible spectral band of 510-730nm. For determining KOMSAT-I crossing time over Korea, this study examines the diurnal variation of solar and atmospheric variables that can exert a great influence on the EOC imagery. The results are as follows: 1)After 10:30 a.m. at the winter solstice, solar zenith angle is less than 70 and expected flux of EOC spectral band over land for clear sky is greater than about 2.4mW/cm2. 2)For daytime the distribution of cloud cover(clear sky) shows minimum(maximum) at about 11:00 a.m. Although the occurrence frequency of poor visibility by fog decreases from early morning toward noon, its effect on the distribution of clear sky is negligible. From the above examination it is concluded that determining KOMSAT-I crossing time over Korea between 10:30 and 11:30 a.m. is adequate.

BACKGROUND: L1 retrotransposable elements are potent insertional mutagens responsible for the generation of genomic variation and diversification of mammalian genomes, but reliable estimates of the numbers of actively transposing L1 elements are mostly nonexistent. While the human and mouse genomes contain comparable numbers of L1 elements, several phylogenetic and L1Xplore analyses in the mouse genome suggest that 1,500-3,000 active L1 elements currently exist and that they are still expanding in the genome. Conversely, the human genome contains only 150 active L1 elements. In addition, there is a discrepancy among the nature and number of mouse L1 elements in L1Xplore and the mouse genome browser at the UCSC and in the literature. To date, the reason why a high copy number of active L1 elements exist in the mouse genome but not in the human genome is unknown, as are the potential mechanisms that are responsible for transcriptional activation of mouse L1 elements. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the promoter sequences of the 1,501 potentially active mouse L1 elements retrieved from the GenBank and L1Xplore databases and evaluated their transcription factors binding sites and CpG content. To this end, we found that a substantial number of mouse L1 elements contain altered transcription factor YY1 binding sites on their promoter sequences that are required for transcriptional initiation, suggesting that only a half of L1 elements are capable of being transcriptionally active. Furthermore, we present experimental evidence that previously unreported CpG islands exist in the promoters of the most active T(F) family of mouse L1 elements. The presence of sequence variations and polymorphisms in CpG islands of L1 promoters that arise from transition mutations indicates that CpG methylation could play a significant role in determining the activity of L1 elements in the mouse genome. CONCLUSIONS: A comprehensive analysis of mouse L1 promoters suggests that the number of transcriptionally active elements is significantly lower than the total number of full-length copies from the three active mouse L1 families. Like human L1 elements, the CpG islands and potentially the transcription factor YY1 binding sites are likely to be required for transcriptional initiation of mouse L1 elements.