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Generating output characteristics of a EYE-type piezoelectric generator depending on ceramic size and materials of the elastic body were studied. EYE-type piezoelectric-generating device consist of the ceramic was attached between the both elastic body. piezoelectric-generating is that if the tension occurred at both ends of an elastic body, the piezoelectric effect occurs at ceramics through the form change of the elastic body. The structure of this EYE-type generator use various area. than a existing type generator, because the ceramic position of the directly force at does not apply. Resonance and output characteristics of the generator were analyzed by using FEM program. Generators were fabricated on the basis of analyzed results and attached on a frequency controllable vibrator to measure output characteristics. Also, the experimental results were compared with the simulated results. As a result, output characteristics of the generator increased depending on the increase in ceramic thickness. In case of increase in ceramic width, resonance frequency of the generator also decreased.

Background : Unresectable non-small cell lung cancer has a poor response to chemotherapy and has an unfortunate prognosis. More effective and less toxic cytotoxic agents are needed to improve the outcome of these patients. The efficacy and safety of vinorelbine monotherapy in these advanced lung cancer patients was evaluanted. Materials and Methods : Sixteen patients with non-small cell lung cancer in stage III or IV, who received vinorelbine alone as an initial anticancer chemotherapy from June 1996 to December 2000 were enrolled in this study. Vinorelbine was given intravenously at a dose 30mg/ every week. Results : A mong the sixteen patients, six had a partial response(38%) and the median survival was 16 weeks. The median response duration was 27 weeks (95% CI 6-47), and the time to progression was 16 weeks(95% CI 6-26). Among a total of 112 cycles, neutropenia(WHO grade 3 or 4) and anemia(grade 3) occurred in 9% and 3%, respectively. Only 1 patient required hospitalization for neutropenic fever. Non-hematologic toxicity was minor and was easily controlled. Conclusion : Vinorelbine monotherapy was well tolerated, and moderately effective in patients with advanced non-small cell lung cancer.