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Quercetin, rutin, silibinin three flavonoids are the major flavonols taken in diet. Among these, Quercetin has many benefit but it is poor soluble in water, unstable in gastric fluids which leads to lower therapeutic value and bio-availability. Hence to increase the therapeutic efficacy and bio-availability, quercetin loaded anionic polymeric nanoparticulate system have been developed using nanoprecipitation methods. Quercetin loaded Nanoparticulate systems were employed Characrization studies like size of particles, morphology, in–vitro drug releases and storage stability. This research result was revealed that a mean size of particle was 84.4 nanometer (nm) with Polydispersity Index was 0.268 and potential of 10.2 milli volt (mV), morphological studies shown formulated quercetin polymeric nanoparticles were sphere-shaped. The invitro drug releases studies shown >95% release of drugs within 45 mins. This novel approach of nanocomposite may promise a original system for the safeguard and release of a range of water hating chemicals to target specific tissues using specialized drug delivery.

Flavonoids belong to the comprehensive category of polyphenols and namely flavon-3-ols (flavonols, anthocyanins, isoflavones, flavanones and flavones) are found in plant sources. Quercetin, rutin and silibinin exhibit numerous pharmacological spectrum but it has hurdles like poor aqueous solubility, rapid clearance and poor penetration potential attribute to reduced clinical usage. Hence the aim of this research is to design and evaluate of antimicrobial and wound healing activities of dual loaded flavones nano formulations scaffold with chitosan-based film by nanopreception techniques. The prepared film was subjected characterization studies such as physical appearance, thickness, weight variation, folding endurance and water absorption capacity in addition was to evaluate anti-microbial activity of dual loaded flavones nano formulation film by well diffusion method and skin irritation study performed as per OECD 406 guide lines. The prepared duo loaded flavonol scaffold chitosan film employed with in-vivo wound healing activity in excision wound model. Results revealed that chitosan film scaffold with quercetin and rutin nano formulations and film scaffold with quercetin and silibinin nano formulations showed significant zone of inhibition when compared with control group. Acute skin irritation study revealed that the film scaffold with quercetin and rutin nano formulations and film scaffold with quercetin and silibinin nano formulations shows no adverse event such erythema and skin irritation. It was further found that all three groups showed decreasing of wound area from day to day. However, on 14th day, control group showed 75.91% wound healing, whereas the quercetin and silibinin group showed 84.75% wound healing. On the other hand, Quercetin and Rutin Group showed appreciable wound healing activity of 90.70%. Hence Chitosan scaffold film with quercetin and rutin nano formulations has enhanced wound healing and re-epitheliasation activity.

Aim: Inflammation shows an important character in illnesses such for example cardiovascular diseases, asthma, malignant and diabetes. Food can guidance different phases of inflammation and can have an important influence on numerous inflammatory illnesses. Increasing scientific suggestion has displayed that polyphenolic compounds, such as flavonoids, which are originate in vegetables, fruits, cocoa or legumes, can have antiinflammatory activity. Current researches prevent enzymes or transcription factors significant for regulatory intermediaries involved in inflammation. Flavonoids are also famous as effective antioxidants with the potential to weaken tissue injury or fibrosis. Subsequently, frequent studies in vivo and in vitro models shows that flavonoids have the prospective to prevent the beginning and development of inflammatory activity. Materials and Methods: In the present research work, a series of flavones merge with Non-steroidal Anti-Inflammatory Drugs were synthesized from resorcinol through Baker- Venkataraman Method, characterized and calculated there in vitro anti-inflammatory activity by protein denaturation technique. Results: The outcome is protein denaturation studies shown that the compound FS found to be most potent anti-inflammatory activity. The percentage inhibitions were 97.66%. Key words: Albumin Denaturation, Baker Venkataraman transformation, Cyclooxygenase, Flavone, NSAIDS.

A vast number of biological properties have been recognised to Thiohydantoin derivatives, have attracted continuing interest because of their various biological activities, namely anticonvulsant, hypolipidemic activity, anti-thyroidal activity, and anti-microbial actions. In this look upon, multiple numbers of Thiohydantoin derivatives are synthesised besides anti-epileptic mechanisms have been investigated. A series of 3-substituted 2-thiohydantoin Derivatives were synthesised from Benzil via Benzil-Benzilic Acid Rearrangement, characterised and evaluated for their anti-epileptic activity by Maximal Electroshock Seizure (MES) model for the anti-epileptic activity of synthesised compounds was less when compared to standard. Among the activity, synthesised compounds 1 indicated more anti-epileptic activity. With this confirmation, we revised integrated a series of innovative 3-substituted 2-thiohydantoin derivatives with a different substituent on the construction and studied the structural activity relationship. The outcomes indicated with the purpose of all the tested compounds have displayed evident anti-epileptic activity. Among the series compounds, 1 shows more anti-epileptic activity than other synthesised compounds.