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Phenytoin is a first-line antiepileptic drug with narrow therapeutic range and follows non-linear pharmacokinetics. Pharmacokinetics of phenytoin have been studied in plasma matrix before, however, there were several disadvantages. This study aimed to obtain partial validation data of the analytical method and the pharmacokinetic profile of phenytoin in Dried Blood Spot (DBS) of six healthy subjects. DBS has the advantage of only requiring small sample volumes and could be transported more efficiently. Phenytoin along with carbamazepine as the chosen internal standard was analyzed with a reversed-phase high performance-liquid chromatography system and a photodiode array detector at 205 nm. The results of partial validation, which evaluated the linearity, within-run accuracy, and precision, were within the criteria acceptance range. The pharmacokinetic profile showed that average AUC0-t was 83.81 ± 37.32 μg.h/mL and AUC0-∞ was 83.65 ± 38.89 μg.h/mL with an average ratio of 93%. Previous study quantifying phenytoin in the plasma matrix found the average AUC0-t was 39.41 ± 8.57 µg.h/mL and AUC0-∞ was 42.94 ± 9.55 µg.h/mL. Despite the difference between parameters of phenytoin analyzed in DBS and plasma matrices, the pharmacokinetic profiles obtained from both matrices were similar indicated by comparable concentration-time curves, thus, proving that DBS matrix can be used interchangeably with the plasma matrix as a more comfortable and effective alternative to phenytoin quantification in blood.

Preliminary studies showed that almost 50% of the people around the Morosi nickel mining industry had very high creatinine levels (26 mmol/l). High creatinine levels indicate impaired kidney function. This study aims to analyze the determinants of high creatinine levels in the urine of people around the Morosi nickel mines. There were 61 participants who were interviewed and urine samples were taken to test their creatinine levels. High levels of creatinine indicate kidney disorders. Measurement of creatinine levels used urine reagent strips 13G. Then it was connected between the condition of water sources, houses, solid and liquid waste management with the participants' creatinine levels with the multinomial regression statistical test. The house condition and liquid waste management had significant association with creatinine levels (P=0.005 and P=0.026, respectively). More than 80% of people lived in houses with good condition and had very low creatinine levels (≤0.9 mmol/l). Most of them had done appropriate liquid waste management (63.9%). However, water sources and solid waste management had no association with creatinine levels (P=0.195 and P=0.130, respectively). The majority of them had used good water sources such as piped and gallon water (80.3%). There were only 19.7% of them who used dug wells and 60.7% who throw their solid waste into the river or burn it. This study concludes that house condition and liquid waste management determine of the high urine‑creatinine levels of people leaving around the Morosi Nickel Mining Industries.

Sedayu Village, Tulung District, Klaten Regency is a rural area, where there is still a lot of vacant land that is not used. In fact, almost every resident in Sedayu has a large and productive yard or vacant land to use. In order to optimize the vacant land, it is necessary to carry out an aquaponics program, namely for the cultivation of catfish and kale. This program is expected to strengthen food and open up business opportunities for the community, so that the level of welfare in Sedayu can increase. This research contains how to optimize land and create new business opportunities by cultivating catfish and water spinach plants using the aquaponics method

This paper analyzes the effect of liquidity risk and credit risk on Islamic bank stability and whether the risk-stability nexus changes during the Covid-19 pandemic. Using a panel quarterly dataset of 14 Islamic banks from 2017 to 2020, a total of 224 quarterly-bank observations in total and the system generalized method of moment, we find that credit risk and liquidity risk are negatively associated with bank stability. Moreover, the COVID-19 does not alter the negative relationship between liquidity risk and stability. To validate the results, we also estimate the model using the LSDVC. The LSDVC results remain consistent. These results provide new insight into understanding risk management implementation for minimizing these risks.

Abstract N7-(2-carbamoyl-2-hydroxyethyl)guanine (N7-CAG) is a DNA adduct formed by glycidamide, which is the metabolite of acrylamide. Acrylamide can be found in foods containing reducing sugars and asparagine that are heated at high temperatures. Analysis of N7-CAG was performed in Dried Blood Spot (DBS) samples from 25 subjects of group test who consumed a lot of acrylamide-containing foods and 25 subjects of negative control group. This study aimed to determine whether there is a significant difference in the levels of N7-CAG between the two groups. DBS samples were extracted using the QIAamp DNA Mini Blood Kit and analyzed using Ultra High Performance Liquid Chromatography–Tandem Mass Spectrometry (UHPLC-MS/MS). Separation was performed using an Acquity UPLC BEH C18 column (2.1 mm × 100 mm; 1.7 μm), eluted a flow rate of 0.1 ml/min under an isocratic of mobile phase of 0.1% formic acid and acetonitrile. The bioanalytical method of N7-CAG in DBS with allopurinol as the internal standard by using UHPLC-MS/MS has been validated. The calibration curve range of N7-CAG obtained was 10–300 ng/ml with a coefficient of correlation of 0.997. The results of the analysis on 25 test group subjects showed that the concentration of N7-CAG ranged from 1.87 to 23.71 ng/ml, while the 25 subjects in the negative group ranged from 1.18 to 8.47 ng/ml. The results of the Mann Whitney test showed that there was a significant difference in the levels of N7-CAG between the test group and the negative control group with p value less than 0.001.

Abstrak Latar Belakang : Kelas Ibu Hamil (KIH) adalah kelompok belajar ibu-ibu hamil dengan anggota maksimal 10 orang yang merupakan sarana untuk belajar bersama. Puskesmas Menur merupakan puskesmas yang terendah cakupan K4 66,93% dari target 90%. Jumlah peserta dari kelas ibu hamil sendiri 3,4%. Tujuan dari penelitian ini adalah menganalisis pengaruh partisipasi ibu dalam kelas ibu terhadap cakupan K4. Metode dan Bahan Penelitian : Jenis penelitian ini observasional analitik dengan pendekatan cross sectional. Besar sampel sebanyak 44 orang, dengan teknik pengambilan sampel accidental sampling. Variabel Independent yang diukur adalah partisipasi ibu dalam kelas ibu hamil sedangkan variabel dependent adalah cakupan K4. Pengambilan data dengan menggunakan kuisioner untuk mengukur partisipasi ibu dalam kelas ibu hamil dan cakupan K4 dengan mengobservasi dari buku KIA dan kohort. Analisis data menggunakan uji statistik Spearman Rho’ dengan α= 0,05. Hasil : Sebagian besar ibu hamil (65,9%) memiliki partisipasi baik, ibu hamil yang berpartisipasi baik sebagian besar (61,4%) cakupan K4 lengkap, dan ibu hamil yang berpartisipasi kurang sebagian kecil (13,6%) cakupan K4 tidak lengkap. Pada analisis data didapatkan p value = 0,004 (p

The aim of this development was to produce a rough motoric module for early childhood Education (PAUD). This research was included as research and development (R&D) with Brog and Gall model which consists of seven stages. The result of validation from material experts obtained that the average percentage of the feasibility of the modules was 93% (very feasible). Then, the result of validation from design experts obtained a percentage of 90% (very feasible); the result of small group assessments by subject teachers was 97% (very feasible;) and the result of large group test by all teachers in group III was 96% (very feasible). The module provided an open opportunity for PAUD teachers to develop children's rough motoric skills. Moreover, rough motoric development materials provided a variety of new learning styles so they enriched insights to PAUD teachers. It could be concluded that the module was suitable to be used by kindergarten teachers. This module could also be used as a reference for teachers in PAUD educational institutions.

Status gizi merupakan indikator kesehatan yang penting bagi balita karena anak usia di bawah lima tahun merupakan kelompok yang rentan terhadap kesehatan dan gizi yang dampak fisiknya diukur secara antropometri dan dikategorikan berdasarkan standar baku WHO dengan indeks BB/U (Berat Badan menurut Umur) , TB/U (Tinggi Badan menurut Umur) dan BB/TB (Berat Badan menurut Tinggi Badan). Salah satu indikator status gizi adalah balita dengan keadaan TB/U atau PB/U (Panjang Badan menurut Umur) sangat pendek atau pendek hingga melampaui defisit dua Standar Deviasi (SD) berdasarkan pengukuran antropometri (Khoeroh and Indriyanti, 2017). Penelitian ini bertujuan untuk mengetahui hubungan Pengeluaran Pangan, Sumber Air Minum dan Tingkat Pendidikan Ibu dengan Status Stunting Pada Balita Usia 6-59 bulan di Kabupaten Buton. Penelitian ini merupakan studi cross sectional. Populasi adalah Balita Stunting di Desa Manuru Kabupaten Buton yang merupakan salah satu Desa Lokus Stunting yaitu sebanyak 89 Balita dan sampel sebanyak 73 Balita yang diperoleh secara Simple Random Sampling. Hasil uji statistik dengan menggunakan uji Fisher Exact, didapatkan untuk variabel Pengeluaran Pangan bahwa nilai P=0,089>α= 1,000, Sumber Air Minum berdasarkan hasil uji statistik dengan menggunakan uji Fisher Exact didapatkan bahwa nilai p sebesar 0.000 lebih kecil dari alpha (pα= 1,000. Kesimpulan hasil penelitian ini ada hubungan sumber air minum dengan status Stunting pada Balita. Sedangkan Pengeluaran Pangan dan Tingkat Pendidikan Ibu tidak berhubungan secara signifikan dengan Status Stunting pada Balita. Nutritional status is an important health indicator for toddlers because children under five years are a group that is vulnerable to health and nutrition whose physical impact is measured anthropometrically and is categorized based on WHO standard with BB / U index (Weight by Age), TB / U (Height by Age) and BB / TB (Weight by Height). One indicator of nutritional status is a toddler whose TB / U or PB / U (Body Length by Age) is very short or short to exceed the deficit of two Standard Deviations (SD) based on anthropometric measurements (Khoeroh and Indriyanti, 2017). This study aims to determine the relationship of Food Expenditure, Source of Drinking Water and Mother's Education Level with Stunting Status in Toddlers Age 6-59 months in Buton Regency. This research is a cross sectional study. The population is Stunting Toddler in Manuru Village, Buton Regency, which is one of the Locus Stunting Villages, which is 89 Toddlers and as many as 73 Toddlers obtained by Simple Random Sampling. Statistical test results using the Fisher Exact test, obtained for the variable Food Expenditure that the value of P = 0.089> α = 1,000, Source of Drinking Water based on the results of statistical tests using the Fisher Exact test found that the p value of 0,000 is smaller than alpha (p α = 1,000. The conclusion of this research is that there is a relationship between drinking water sources and Stunting status in under-fives. Whereas Food Expenditures and Education Level of Mothers did not significantly correlate with Stunting Status in Toddlers.

Phenytoin is a first-line antiepileptic drug with narrow therapeutic range and follows non-linear pharmacokinetics. Pharmacokinetics of phenytoin have been studied in plasma matrix before, however, there were several disadvantages. This study aimed to obtain partial validation data of the analytical method and the pharmacokinetic profile of phenytoin in Dried Blood Spot (DBS) of six healthy subjects. DBS has the advantage of only requiring small sample volumes and could be transported more efficiently. Phenytoin along with carbamazepine as the chosen internal standard was analyzed with a reversed-phase high performance-liquid chromatography system and a photodiode array detector at 205 nm. The results of partial validation, which evaluated the linearity, within-run accuracy, and precision, were within the criteria acceptance range. The pharmacokinetic profile showed that average AUC0-t was 83.81 ± 37.32 μg.h/mL and AUC0-∞ was 83.65 ± 38.89 μg.h/mL with an average ratio of 93%. Previous study quantifying phenytoin in the plasma matrix found the average AUC0-t was 39.41 ± 8.57 µg.h/mL and AUC0-∞ was 42.94 ± 9.55 µg.h/mL. Despite the difference between parameters of phenytoin analyzed in DBS and plasma matrices, the pharmacokinetic profiles obtained from both matrices were similar indicated by comparable concentration-time curves, thus, proving that DBS matrix can be used interchangeably with the plasma matrix as a more comfortable and effective alternative to phenytoin quantification in blood. [ABSTRACT FROM AUTHOR]

Climate change causes erratic rainfall and often results in flooding of urban areas. Floods are hydrometeorological disasters that occur in various regions of Indonesia. Flood vulnerability in urban areas has increased over the past 30 years. Kauman Village is included in the Asri water catchment area, which has an Asri primary channel downstream of the urban area of Nganjuk District. However, from 2019 to 2022, the urban area of Nganjuk District, including Kauman Village, was affected by flooding. Urban floods inundated office areas, schools, housing, and public facilities such as the Nganjuk District General Hospital. The factor indicated as the cause of flooding is the clogging of the drainage channel with rubbish. Therefore, field research and mathematical calculations were conducted to evaluate the discharge capacity of drainage channels in the village. Based on the research, it was found that the existing drainage channel discharge in the research area could not accommodate the planned discharge for the 10-year return period. In addition, there are 33 channels that are unable to accommodate the planned discharge because the channel dimensions are too small, some channels are slightly damaged, sedimentation occurs, and they are blocked by rubbish. Drainage channels that do not function optimally affect urban flooding. Therefore, several efforts have been made to reduce the risk of flooding by changing the dimensions of drainage channels, normalizing drainage channels, and getting used to maintain drainage channels and not throwing rubbish in drainage channels. [ABSTRACT FROM AUTHOR]

In the past years, Esomeprazole (EMP) was analyzed in human plasma samples, which still has stability issues; thus, the new biosampling technique known as Dried Blood Spot (DBS) might solve the issue. This research aims to evaluate the incurred sample stability of esomeprazole in dried blood spot using high performance liquid chromatography-photodiode array with lansoprazole as an internal standard. The analytical separation was performed on a C-18 column (Waters, Sunfire™ 5 μm; 250 × 4.6 mm) at 40 °C. The mobile phase used was acetonitrile–phosphate buffer pH 7.6 (40:60% v/v) with a flow rate of 1.00 mL/min; and was detected at 300 nm. The analyte was extracted from dried blood spot by methanol. Incurred sample stability was evaluated from 6 healthy subjects on day 0, 7, 14, and 28, respectively. This method was linear in the range concentration of 70–1400 ng/mL with r > 0.98. Pharmacokinetic study shows that the average of AUC0–t of EMP in the DBS sample was 1765.41 ngh/mL. The highest percent difference value of esomeprazole’s incurred samples stability on day 7, 14, and 28 from 6 healthy subjects were 9.81%. This result fulfilled the acceptance criteria, which is the percent difference should not be greater than 20%, and 67% of total samples have to fulfill the criteria. The incurred sample stability result showed that esomeprazole was stable in the DBS sample at least until 28 days with the highest value of percent difference is 9.81%.

Floods are hydrometeorological disasters that often occur in various regions, including in Nganjuk Regency. From 2019 to 2022, there were urban floods that inundated highways, markets and hospitals and disrupted community and government activities. Heavy rain is one of the causes of flooding. Rain intensity, duration and frequency (IDF) curves were constructed using rainfall data from six rain gauge stations. This curve is used to determine the 10-year and 25-year probabilities of PUH intensity and the probability of causing flooding in Nganjuk District. Rain intensity in Nganjuk Regency is PUH 10 and 25 with an average rain duration of 15-60 minutes which is included in the moderate rain category, namely 20-50 mm/day. The results of this analysis will become the basis for consideration in formulating policies and strategies for urban flood disaster prevention and management in Nganjuk Regency. Therefore, coordination between the city government and the government is needed to reduce the risk of urban flooding in Nganjuk Regency.

A fuzzy optimization model was implemented in this study as a decision-making approach to optimize pollutant degradation processes in facultative ponds of domestic wastewater treatment plants. The fuzzy parameters are due to uncertain situations, which eliminate the need for managers to collect data, particularly when the data are no longer represent the real situation. The managers formulate the fuzzy parameters in the problem based on their intuition and experience in using the provided decision-making tool. Also, the fuzzy optimization model proposed in this study was solved using the fuzzy-based programming approach with the generalized gradient algorithm performed in LINGO 19.0 optimization software. In addition, the numerical experiment was conducted with secondary and generated data for the certain and fuzzy parameters, respectively. The results showed that optimal decisions were achieved and the manager can then use the proposed model in managing domestic wastewater treatment plants.

Problems that often appear before surgery are anxiety. Playing is an effective coping method to reduce anxiety experienced by children. This study aims to identify the effect of playing puzzle therapy on preoperative anxiety levels in the Children's Surgery Room of Dr. H. Abdul Moeloek Lampung Province. The design of this study was Quasy Experiment with the design of one group pretest-posttest. This type of quantitative research uses the technique of accidental sampling. The population in this study were preoperative patients. The analysis used is a parametic test of the t test dependent test. When the research began from July 12 to August 12 in the pediatric surgery oroom of Dr. H. Abdul Moeloek Lampung Province. The results show the average anxiety score before therapy is playing puzzle is 64.30 and after giving therapy the role playing puzzle is 48.60. p-value obtained is 0,000 which indicates the difference in preoperative anxiety scores before and after getting puzzle play therapy.

Introduction: Prevention effort of progestogen-only prevalence rate injectable discontinuation has not got the national target and it always increases. The prevalence rate is one of causes Total Fertility Rate (TFR) increasing. The study analyzed the risk factors associated with the progestogen-only injectable discontinuation case. Methods: This study used analytic observational with cross sectional design which was carried out in Puskesmas Mojo Surabaya on March – April 2019. Population are 646 discontinuation acceptors and 5,751 non discontinuation acceptors of progestogen-only injectable. The inclusion criteria were acceptors of progestogen-only injectable discontinuation case, have a husband, not yet menopause. The exclusion criteria were acceptor of progestogen-only injectable discontinuation who used other contraception. Total samples are 44 samples obtained by with consecutive sampling. Independent variables were desire pregnancy, myths, weight change, spotting, amenorrhea, husband support. Dependent variable was the progestogen-only injectable discontinuation case. The data are collected by questionnaire, analyzed by chi-square test with α < 0.005 and multivariate analysis with independent variable p

Introduction: Contraception usage in Indonesia had not effective yet. The high usage of contraception not compensated by evenness on each type of contraception. Implant as a long acting reversible contraception with high effectiveness is rarely used because of negative perception in society. The existence of negative perception caused by lack of information and knowledge about implant contraception. The study analysed association between implant contraception usage with Education Information Communication (EIC) and knowledge. Methods: An observational analytic with a case control design. The population were 822 contraceptive acceptors. Study period on January-December 2018. Total samples were 70 with a sampling technique using purposive sampling. Divided into 2 groups, (35 non-implant acceptors as a case group and 35 implant acceptors as a control group). Data obtained through primary data and obtained from the results of guided interviews and questionnaires. Then analyzed through the chi square statistical test. Results: 60% of acceptors got a good EIC about implant contraception (p=0.001), 51.4% of acceptors had enough knowledge about implant contraception (p=0.94). Conclusion: There is an association between EIC with implant contraception usage, but there isn’t an association between knowledge of implant contraception usage.

Penelitian ini bertujuan untuk mengungkap hubungan antara self esteem dan pengalaman belajar yang bermakna dengan kemampuan adaptasi terhadap dunia kerja pada siswa Kompetensi Keahlian Teknik Komputer dan Jaringan (TKJ) SMKN Kota Malang. Metode penelitian yang digunakan adalah kuantitatif dengan rancangan korelasional. Populasi penelitian ini meliputi siswa kelas XI TKJ yang telah melaksanakan Praktik Kerja Lapangan (PKL) yang berjumlah 317 siswa. Sampel penelitian sebanyak 167 siswa yang ditentukan dengan berpedoman pada nomogram Harry-King dengan taraf kesalahan 5%. Penentuan anggota sampel secara random dan proporsional dari tiap sekolah. Hasil penelitian menunjukkan bahwa terdapat hubungan antara self esteem dan pengalaman belajar yang bermakna dengan kemampuan adaptasi siswa SMK terhadap dunia kerja. Hal ini dibuktikan dari hasil uji hipotesis yang menunjukkan bahwa Fhitung > Ftabel yaitu 44,999 > 3,05 dan nilai phitung ≤ pstandar yaitu 0,000 < 0,05 sehingga H0 ditolak, artinya terdapat hubungan positif dan signifikan secara simultan antara self esteem dan pengalaman belajar yang bermakna dengan kemampuan adaptasi terhadap dunia kerja pada siswa Kompetensi Keahlian TKJ SMKN Kota Malang.

Taxes are a major contribution on state revenues which will then be used for national financing and development. However, taxpayers’ compliance level is still low. There are deviations made by the taxpayer in reducing taxes, in order not to get a high tax. One of them by tax avoidance. Tax avoidance is the process of controlling actions to avoid the consequences of improper taxation and is legal. The purpose of this research is to explain the effect of profitability, leverage, corporate governance, and firm size to tax avoidance. The researcher take a case study on a company listed on the Jakarta Islamic Index (JII) in 2012 until 2016. The sample are 65 samples consisting of 13 companies. Regression used in this research is panel data regression, where selected Fixed Effect as the right regression model. In this regression, the result shows that profitability as measured by ROA and firm size as measured by total asset have significant negative effect to tax avoidance, and leverage as measured by DER has a significant positive effect on tax avoidance. While corporate governance as measured by independent commissioners and audit committee does not affect tax avoidance

This classroom action research aims firstly is to determine the feasibility of learning by using the physics experimental method, secondly is to improve the critical and creative thinking skills of students of class X MM1 at SMK Negeri 1 Bantul, to improve learning outcomes of class X MM1 students at SMK Negeri 1 Bantul. This research data collection technique using observation, evaluation, field notes, and documentation. This research is a Classroom Action Research (CAR) which has 2 (two) cycles through 4 (four) stages starting from planning, implementing, observing and reflecting. The subjects of this study was 31 students of class X MM1 SMK Negeri 1 Bantul in the academic year of 2018/2019. The results of the study showed that the application of the physics experimental method was able to improve students' critical and creative thinking skills in class X MM1 SMK Negeri 1 Bantul in the 2018/2019 academic year. This is evidenced by the increase in value in the research instrument. In the student observation sheet, the shown 57.18 it was obtained with the criteria lacking at the initial observation stage, in the first cycle the value increased to 60.16 and in the second cycle the value was 69.56. In addition, classical completeness in the evaluation of learning outcomes also increased, at the initial evaluation classical completeness was 35.48%, in cycle I increased to 51.61% and in cycle II classical completeness became 77.42%.

Purpose – The purpose of this study is to examine the effect of Fama-French five-factor and momentum factor on Islamic stock portfolio excess returns listed in the Indonesia Sharia Stock Index (ISSI). Methodology – This study used return data from ISSI group, starting from January 2013 to December 2017, which are then formed into time series data with excess monthly stock portfolio. This study adapted the Fama and French (2015) methodology using 2x3 and 2x2 to form the portfolio and applied Ordinary Least Square (OLS) with monthly data frequency to test the relevance of the model to the expected stock return of 183 companies. Findings – The results showed that the risk premium, the book-to-market ratio which is proxied by High Minus Low (HML), the investment that is proxied by Conservative Minus Aggressive (CMA), and the momentum which is proxied by Up Minus Down (UMD) has a positive effect on the excess return of the company's stock portfolio registered in Indonesia Sharia Stock Index (ISSI) during the period. While, the size and profitability variable do not affect the expected stock return. Research limitations – The results of this study provides relevant information about the relationship between risk and stock return using Fama and French five-factor model and momentum. However, future researchers can expand the scale of the research by adding research periods and using daily return research data. It is intended that the results are more representative of the actual market conditions at the moment. Originality – Researches on the factors that influence the selection of Islamic stock portfolios based on excess return using Fama-French five-factor including the momentum factor are still limited. This study contributes to the asset pricing development by investigating factors influencing performance of ISSI’s portfolio excess return using five-factor model and momentum factor.

The majority of an immune system infected by HIV (Human Immunodeficiency Virus) is CD4+ T cells. The HIV-1 transmission through cell to cell of CD4+ T cells supports the productive infection. On the other hand, infected CD4+ T cells stimulate cytotoxic T-lymphocytes cells to control HIV-1 infection. We develop and analyze a mathematical model incorporating the infection process through cell to cell contact of CD4+ T cells, CTL compartment and the combination of RTI and PI treatments. By means of the alternative reproduction ratio, it is analyzed the stability criteria and the existence of endemic equilibrium. Numerical simulations are presented to study the implication of the combination of RTI and PI therapy. The results indicate that RTI drug shows more significant effect in reducing HIV-1 infection compared to PI drug.

The World Health Organization (WHO) sets the standard for the birth of a sexually assault operation in a country to be around 5-15 percent per 1000 births worldwide. Based on Basic Health Research (2013) the level of childbirth sectio caesarea in Indonesia has exceeded the maximum limit of 5-15% WHO standard. The rate of cesarean delivery in Indonesia 15.3% of the 20,591 mothers who gave birth within the last 5 years surveyed from 33 provinces. This cesarean delivery may allow for higher complications than normal delivery. The usual complication is a pain. One of the handling interventions of pain with minimal side effects is nonpharmacological management, such as slow-breathing exercises and lavender aromatherapy. This study aims to determine differences in the intensity of pain in postoperative patients sectio caesarea undertaken slow deep breathing exercise with aromatherapy lavender in RSUD Dr. H. Abdul Moeloek Lampung Province in 2018. This type of research uses a quantitative method using quasi-experimental design with Non-Equivalent Control Group design approach. A technique of sampling using purposive sampling technique as much as 60 respondents, 30 respondents group slow deep breathing and 30 respondents aromatherapy group lavender. The study period began on May 18, 2018, to June 30, 2018, in the Pomegranate Room RSUD Dr. H. Abdul Moeloek Lampung Province. Statistical test using t independent Mann Widney. The results showed that there was a difference of slow deep breathing exercise with lavender aromatherapy on the intensity of pain in patients in post sectio caesarea patients in the Pomegranate Room RSUD Dr. H. Abdul Moeloek Lampung Province Year 2018 (p-value=0.000). Researchers suggest that patients can use lavender aromatherapy to reduce the level of pain postoperative sectio caesarea.

The Data obtained at Panca Jaya of Mesuji Regency on January-June of 2016, out of 430 women of childbearing age who did pap smear and IVA, as many 2 people (0,46%) was detected of having cervical cancer stage 1b, 57 people (13,4%) experiencing pre-cervical cancer lesions which were marked by inflammation, vaginal discharge, redness in the cervix, there was a lump in the cervix and the rest with the normal condition. This study was to be known the influence of cervix cancer socialization toward the motivation of women’s participation in doing Visual Inspection with Acetic Acid (IVA). This research was quantitative research, with Quasi-Experiment research. The population in this research was the women who were at working area of Adi Luhur Community Health Centre, Pancajaya sub-District of Mesuji Regency, on January of 2017 as many 2361 people. Total samples were 96 respondents. Sample taking was proportional random sampling method. Data were collected using questionnaire. The research was done on the date of Mei 1st-20th July 2017. The data was analyzed by univariate (mean) and bivariate (t-test). The result showed that the average score of motivation before the socialization was 42,79 with deviation standard of 7,367. The average score of motivation after the socialization was 62,00 with deviation standard of 6,059. There was the influence of socialization about cervix cancer with the motivation of participating on examination of IVA on women to do Visual Inspection with Acetic Acid (IVA) (t-test t-table 21,1251.714, p-value0,05). It was suggested that Community Health Centre to improve the skill for the staff in the field about socialization technique, also give the facility for sufficient socialization so that they can improve the motivation for the women.