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1. How Are the Prospects for Refugees to Become Active Members of Society? – The Vision and Practices in Turkish Adult Education

Author

Erdoğan, Armağan, Unutulmaz, K. Onur, Aydemir, Suna G., Erdoğan, M. Murat, Evans, Karen, Series Editor, Biasin, Chiara, Editorial Board Member, Brown, Andrew, Series Editor, Desjardins, Richard, Editorial Board Member, te Riele, Kitty, Editorial Board Member, Sawano, Yukiko, Editorial Board Member, Slowey, Maria, Editorial Board Member, Taylor, Maurice, Editorial Board Member, Teglborg, Ann-Charlotte, Editorial Board Member, Ye Rongling, Rebecca, Editorial Board Member, Yuan, Dayong, Editorial Board Member, Kersh, Natasha, editor, Toiviainen, Hanna, editor, Pitkänen, Pirkko, editor, and Zarifis, George K., editor

Published
2021
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15. Turkish nationalism after the 15 July coup attempt: the making of a new political myth.

Author

Aydemir, Suna G. and Decker, Philipp

Abstract

The ruling Justice and Development Party (AKP) responded to the violent coup attempt of 15 July 2016 with calls for a second ‘national war of liberation’ and declared a state of emergency that was upheld for 2 years. Drawing on the methodology of the Essex School, Barthes semiology and recent applications of securitization theory, this study investigates the construction of the myth of ‘15 July’. Through an analysis of educational media, we show how the official narration of ‘15 July’ moved religious signifiers into the center of a distinctively religious-populist version of Turkish nationalism. The findings demonstrate that the political myth of ‘15 July’ is essentially based on a cyclical conception of history and two sub-myths that reflect heroization and demonization: First, the myth of the heroic citizens, who sacrifice their lives for defending freedom of nation and homeland. Second, the myth of the always returning enemy that seeks to enslave and occupy the homeland by using collaborators. Woven together, these narratives produce ‘15 July’ as a cohesive political myth. [ABSTRACT FROM AUTHOR]

Published
2024
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19. How Are the Prospects for Refugees to Become Active Members of Society? – The Vision and Practices in Turkish Adult Education

Author

K. Onur Unutulmaz, Armağan Erdoğan, M. Murat Erdoğan, and Suna G. Aydemir

Subjects
Economic growth, Turkish, media_common.quotation_subject, Refugee, 05 social sciences, Lifelong learning, 0507 social and economic geography, Context (language use), Citizen journalism, language.human_language, 0506 political science, Adult education, Social integration, Political science, 050602 political science & public administration, language, 050703 geography, Citizenship, media_common
Abstract

Social integration of refugees is a major challenge for any country that hosts sizable refugee communities. Recently, Turkey has joined the ranks of such countries as it was transformed to become the country with the highest number of refugees in the world through an inflow of over 3.6 million mostly young and uneducated asylum-seekers from Syria in a matter of a few years. This chapter presents a critical analysis of the Turkish adult education (AE) sector by applying the concept of active participatory citizenship in the context of the current refugee crisis with a focus on its role in helping this vulnerable community to become active members of the society. This chapter argues that AE and Lifelong Learning (LLL) programs have the potential to empower Syrian refugees in such a way to make them into active members, contributing social, economic and cultural ways in Turkish society. To make its arguments, the chapter firstly provides a brief analysis of Turkey’s reform agenda in the field of AE since 1990s. By drawing on selected statistics it highlights the shortcomings in Turkey with respect to developing sustainable and gender sensitive AE programs, especially for young adults. Secondly, it investigates the major legal and institutional developments in Turkey since the first wave of the refugees entering to Turkey after beginning of the Syrian Civil War in 2011. Lastly, it will provide an analysis of how new AE programs for refugees are designed, which are characterised by a holistic view of social inclusion and target specific groups of refugees under the pressure of multiple vulnerabilities.

Published
2021

20. Anti-desmoglein2 autoantibodies are present in patients with cardiac sarcoidosis and correlate with cardiac inflammation

Author

Suna, G, primary, Kolios, A, additional, Chatterjee, D, additional, Fatah, M, additional, Gasperetti, A, additional, Casella, M, additional, Sommariva, E, additional, Franzen, D, additional, Manka, R, additional, Pazhenkottil, A, additional, Ruschitzka, F, additional, Boyman, O, additional, Duru, F, additional, Hamilton, RM, additional, and Saguner, AM, additional

Published
2021
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23. Auftritt der Massen als Folge und Herausforderung der Moderne

Author

Suna G. Aydemir

Abstract

Die Arbeit hat im vorausgegangenen Kapitel mit Bezug auf die „Offnung“ der modernen Politik expliziert, warum die Artikulation der Volkssouveranitat als das uberlegene Prinzip der Politik einem Umbruchmoment entspricht. Durch die Artikulation der Volkssouveranitat wurde zum einen die gottliche/transzendentale Vermittlung der politischen Legitimitat abgeschafft; zum anderen wurde die Moglichkeit der Artikulation der Umma als Signifikant der modernen Kollektivitat eliminiert. Diese zwei Fakten sind bedeutsam hinsichtlich des Ruckzugs des Religiosen bzw. des Islamischen.

Published
2019

24. Die Türkisch-Islamische Synthese I – 1945–1960

Author

Suna G. Aydemir

Abstract

Im „Politischen Panorama“ (Kapitel 4.1.) wurde die funfjahrige Zeitspanne zwischen der Etablierung des Mehrparteiensystems und der Machtubernahme der DP (1945–1950) als Ubergangsara von der ersten zur zweiten Modernisierungswelle dargestellt. In diesem kurzen Zeitraum kamen hinsichtlich der Subjektivierung Ziel- und methodische Anderungen zustande, welche die wirtschaftlichen, politischen und sozialen Komponenten des Modernisierungsprojekts – alle drei Hauptaspekte – beeinflusten. In der Ubergangsara (1945–1950) war die CHP noch an der Macht.

Published
2019

25. Resümee

Author

Suna G. Aydemir

Published
2019

26. Einführung

Author

Suna G. Aydemir

Published
2019

27. Türkisch-Islamische Synthese II – 1960–1980

Author

Suna G. Aydemir

Abstract

Die zwei Jahrzehnte zwischen den „gelungenen Militarputschen“ vom 27. Mai 1960 und 12. September 1980 bilden eine Periode, die von mehreren politischen Akteuren und von insgesamt 19 Regierungen gepragt wurde (Aksin, 2007: 605): Der Putsch vom 27. Mai 1960 und die Macht-Ara des Komitees der Nationalen Einheit (Milli Birlik Komitesi, MBK), die von der CHP dominierte Regierungsara, das zunehmende politische Gewicht der Gerechtigkeitspartei (AP) nach 1965 unter der Fuhrung Suleyman Demirels, das Memorandum vom 12. Marz 1971 und die zunehmende Instabilitat und Sichtbarkeit der radikalen politischen Bewegungen in den spaten 70er Jahren und der Erhalt der wichtigen staatlichen Posten bzw. Entscheidungsrechte seitens radikal nationalistischer und islamistischer Kader als eine Reaktion „von oben“ auf den Aufstieg der linken Bewegung.

Published
2019

28. Der Rückzug des Religiösen in der frühen Republik (1923–1950)

Author

Suna G. Aydemir

Abstract

Die Proklamation der Republik am 29. Oktober 1923 markierte sowohl die Auflosung des osmanischen Imperiums als auch die Geburt des turkischen Nationalstaates. Der turkische Befreiungskrieg von 1919 bis 1922 ist hier als Vorbereitungsphase dieser sozio-politischen Umwalzung auf drei Stichpunkte bezugnehmend zu erwahnen: Erstens, die politischen Grenzen der heutigen Turkei wurden durch die im Laufe des Befreiungskriegs und die danach unterschriebenen Friedensvertrage gezogen. In diesem Sinne war der Befreiungskrieg ein um die wirtschaftliche und politische Souveranitat bzw. um das Vollverfugungsrecht uber das Land durchgefuhrter Krieg.

Published
2019

30. Die spätosmanische Ära (1839–1918)

Author

Suna G. Aydemir

Abstract

Die osmanisch-turkische Modernisierungsgeschichte geht bis ins 18. Jahrhundert, zur sog. Tulpenzeit (1703–1730) zuruck (Caner, 1999: 176). Durch die Landverluste ab 1683, insbesondere auf dem Balkan, nahmen die Osmanen sukzessive die Reversion des Uberlegenheitsverhaltnisses zwischen sich und dem „Westen“ (zugunsten des Westens) wahr (Aksin, 1997: 217). Die ersten Reformen bezweckten vor diesem Hintergrund grundsatzlich die Verbesserung der Streitkrafte.

Published
2019

31. Die Transformation(en) der politischen Struktur in der zweiten Modernisierungswelle (1950–2002)

Author

Suna G. Aydemir

Abstract

Die betreffende 50-jahrige Zeitspanne wurde von einer Inflation der politischen Ereignisse gepragt. Der vorliegende Abschnitt entspricht einer Zusammenfassung und wird die Ereignisse in ihrer Gesamtheit nicht ganz umfassen konnen. Der Fokus liegt auf paradigmatischen Umbruchen und jenen Ereignissen, welche die hegemonialen Transformationen des turkischen Gesellschaftsprojektes begreiflich und anschaulich machen.

Published
2019

32. Zur Beziehung zwischen Religion und Politik in der zweiten Modernisierungsära (1950–2002) – ein Ansatz

Author

Suna G. Aydemir

Abstract

Die vorliegende Arbeit befasste sich im ersten Teil mit den Reformen in der spat-osmanischen und fruh-republikanischen Ara (1839–1945), um das Artikulationsregime des Religiosen (der religiosen Zugehorigkeiten, Agenten und Symbole) beim Aufbau des modernen Subjektes (der Nation und des Burgers) in der ersten Welle zu untersuchen. Die betreffenden Kapitel zeigten uns, dass die Artikulation des Religiosen in der ersten Modernisierungswelle, in Form eines „Ruckzugs aus den Subjektivierungen“ stattfand.

Published
2019

33. Türkisch-Islamische Synthese III – nach 1980

Author

Suna G. Aydemir

Abstract

Der Putsch vom 12. September 1980 stellt den letzten und scharfsten Wendepunkt in der zweiten Modernisierungsara zwischen 1950 und 2002 dar. Er verkorperte vor allem eine Reaktion auf die historische Krise der „organisierten Moderne“ ab Ende der 70er Jahre. Ihre Auflosung war wie fur viele andere auch fur die turkische Gesellschaft herausfordernd.

Published
2019

34. Rückzug und Rückkehr des Religiösen : Religionspolitik(en) der modernen Türkei (1839-2002)

Author

Suna G. Aydemir and Suna G. Aydemir

Subjects
History, Islam and politics--History--19th century.--, Islam and politics--History--20th century.--, Islam and politics
Abstract

Suna G. Aydemir setzt sich in dieser Studie mit der modernen und postmodernen Religionspolitik der Türkei innovativ auseinander, indem sie im Gegensatz zur traditionellen Historiographie eine Genealogie bzw. eine Geschichte des gegenwärtigen Islams und dessen Akteure anbietet. Die Modernisierungsgeschichte des Landes als die Transformation des letzten islamischen Imperiums zu einem säkularen Nationalstaat hat von jeher politisch Interessierte in ihren Bann gezogen. In diesem Zusammenhang stellt der Aufstieg des politischen Islams seit den 1980er Jahren ein brennendes Diskussionsthema dar.

Published
2019

35. White Light Emitting Polymers Possessing Thienothiophene And Boron Units

Author

Sahin, O., Cinar, M. E., Tekin, E., Mucur, S. P., Topal, S., Suna, G., Eroglu, M. S., and Ozturk, T.

Abstract

In this work, seven copolymers possessing thienothiophene and mesitylboron units were prepared. Incorporation of triphenylamine (TPA) and tetraphenylethene (TPE) into TT unit was probed to enhance their light-emitting efficiencies. Density functional theory investigations of the model compounds revealed the presence of an intramolecular charge transfer transition between the donor TT units and the boron acceptor atom. Among the seven TT-boron copolymers, four of them were used for the fabrication of polymer light emitting diodes 9PLEDs) and two of the devices exhibited pure white color according to the CIE. Although the efficiencies of the devices are low, as this study is the first example of thienothiophene inverted perpendicular inverted perpendicular-boron copolymers emitting white color, they are promising examples for future studies.

Published
2017

40. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries.

Author

Suna, G, Wojakowski, W, Lynch, M, Barallobre-Barreiro, J, Yin, X, Mayr, U, Baig, F, Lu, R, Fava, M, Hayward, R, Molenaar, C, White, Stephen, Roleder, T, Milewski, K, Gasior, P, Buszman, PP, Buszman, PE, Jahangiri, M, Shanahan, C, Hill, JM, Mayr, M, Suna, G, Wojakowski, W, Lynch, M, Barallobre-Barreiro, J, Yin, X, Mayr, U, Baig, F, Lu, R, Fava, M, Hayward, R, Molenaar, C, White, Stephen, Roleder, T, Milewski, K, Gasior, P, Buszman, PP, Buszman, PE, Jahangiri, M, Shanahan, C, Hill, JM, and Mayr, M

Abstract

Background -Extracellular matrix (ECM) remodeling contributes to in-stent restenosis and thrombosis. Despite its important clinical implications little is known about ECM changes post-stent implantation. Methods -Bare-metal (BMS) and drug-eluting stents (DES) were implanted in pig coronary arteries with an overstretch under optical coherence tomography guidance. Stented segments were harvested 1, 3, 7, 14 and 28 days post-stenting for proteomics analysis of the media and neointima. Results -A total of 151 ECM and ECM-associated proteins were identified by mass spectrometry. After stent implantation, proteins involved in regulating calcification were upregulated in the neointima of DES. The earliest changes in the media were proteins involved in inflammation and thrombosis, followed by changes in regulatory ECM proteins. By day 28, basement membrane proteins were reduced in DES compared with BMS. In contrast, the large aggregating proteoglycan aggrecan was increased. Aggrecanases of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family contribute to the catabolism of vascular proteoglycans. An increase in ADAMTS-specific aggrecan fragments was accompanied by a notable shift from ADAMTS1 and ADAMTS5 to ADAMTS4 gene expression after stent implantation. Immunostaining in human stented coronary arteries confirmed the presence of aggrecan and aggrecan fragments, in particular at the contacts of the stent struts with the artery. Further investigation of aggrecan presence in the human vasculature revealed that aggrecan and aggrecan cleavage were more abundant in human arteries compared to veins. Also, aggrecan synthesis was induced upon grafting a vein into the arterial circulation, suggesting an important role for aggrecan in vascular plasticity. Finally, lack of ADAMTS-5 activity in mice resulted in an accumulation of aggrecan and a dilation of the thoracic aorta, confirming that aggrecanase activity regulates aggrecan abundance in the arteria

Published
2017

42. Measurement of the D -> K- pi(+) strong phase difference in psi(3770) -> D-0(D)over-bar(0)

Author

Ablikima, M., Achasovh, M. N., 1, Aia, X. C., Albayrakd, O., Albrechtc, M., Ambrosear, D. J., Ana, F. F., Anas, Q., Baia, J. Z., Baldini Ferrolis, R., Banac, Y., Bennettr, D. W., Bennettr, J. V., Bertanis, M., Bianaq, J. M., Bogerv, E., 5, Bondarenkow, O., Boykov, I., Braunan, S., Briered, R. A., Caiaz, H., Caia, X., Cakirak, O., Calcaterras, A., Caoa, G. F., Cetinal, S. A., Changa, J. F., Chelkovv, G., 2, Chena, G., Chena, H. S., Chena, J. C., Chena, M. L., Chenaa, S. J., Chena, X., Chenx, X. R., Chena, Y. B., Chengp, H. P., Chuac, X. K., Chua, Y. P., Cronin Hennessyaq, D., Daia, H. L., Daia, J. P., Dedovichv, D., Denga, Z. Y., Denigu, A., Denysenkov, I., Destefanis, MARCO GIOVANNI, Dingae, W. M., Dingy, Y., Dongab, C., Donga, J., Donga, L. Y., Donga, M. Y., Dubb, S. X., Fanaj, J. Z., Fanga, J., Fanga, S. S., Fanga, Y., Favaaw, L., Fengas, C. Q., Fua, C. D., Fuksv, O., Gaoa, Q., Gaoaj, Y., Gengas, C., Goetzeni, K., Gonga, W. X., Gradlu, W., Greco, Michela, Gua, M. H., Guk, Y. T., Guana, Y. H., Guoz, L. B., Guoz, T., Guou, Y. P., Haddadiw, Z., Hana, Y. L., Harrisap, F. A., Hea, K. L., Hea, M., Heab, Z. Y., Heldc, T., Henga, Y. K., Houa, Z. L., Huz, C., Hua, H. M., Huan, J. F., Hua, T., Huange, G. M., Huangas, G. S., Huangaz, H. P., Huangn, J. S., Huanga, L., Huangae, X. T., Huangaa, Y., Hussainau, T., Jias, C. S., Jia, Q., Jiab, Q. P., Jia, X. B., Jia, X. L., Jianga, L. L., Jiangaz, L. W., Jianga, X. S., Jiaoae, J. B., Jiaop, Z., Jina, D. P., Jina, S., Johanssonay, T., Julinaq, A., Kalantar Nayestanakiw, N., Kanga, X. L., Kangab, X. S., Kavatsyukw, M., Klossu, B., Kopfc, B., Kornicerap, M., Kuehnan, W., Kupscay, A., Laia, W., Langean, J. S., Larar, M., Larinm, P., Leyhec, M., Lia, C. H., Cheng, Lias, Cui, Lias, Liq, D., Libb, D. M., Lia, F., Lia, G., Lia, H. B., Lia, J. C., Jin, Liad, Liae, K., Lil, K., Lei, Lia, Liao, P. R., Lia, Q. J., Liae, T., Lia, W. D., Lia, W. G., Liae, X. L., Lia, X. N., Liab, X. Q., Liai, Z. B., Liangas, H., Liangag, Y. F., Liangan, Y. T., Linm, D. X., Liua, B. J., Liud, C. L., Liua, C. X., Liuaf, F. H., Fang, Liua, Feng, Liue, Liuk, H. B., Liuo, H. H., Liua, H. M., Liua, J., Liuaz, J. P., Liuaj, K., Liuy, K. Y., Liuae, P. L., Liuao, Q., Liuas, S. B., Liux, X., Liuab, Y. B., Liua, Z. A., Zhiqiang, Liua, Zhiqing, Liuu, Loehnerw, H., Loua, X. C., 3, Lun, G. R., Lup, H. J., Lua, H. L., Lua, J. G., Lua, Y., Lua, Y. P., Luoz, C. L., Luoba, M. X., Luoap, T., Luoa, X. L., Lva, M., Lyuao, X. R., May, F. C., Maa, H. L., Maa, Q. M., Maa, S., Maa, T., Maa, X. Y., Maasm, F. E., Maggiora, Marco, Malikau, Q. A., Maoac, Y. J., Maoa, Z. P., Messchendorpw, J. G., Mina, J., Mina, T. J., Mitchellr, R. E., Moa, X. H., Moe, Y. J., Moeiniw, H., Morales Moralesm, C., Moriyar, K., Muchnoih, N. Y. u., Muramatsuaq, H., Nefedovv, Y., Nerlingm, F., Nikolaevh, I. B., Ninga, Z., Nisarg, S., Niua, X. Y., Olsenad, S. L., Ouyanga, Q., Pacettit, S., Pelizaeusc, M., Pengas, H. P., Petersi, K., Pingz, J. L., Pinga, R. G., Polingaq, R., Qiaa, M., Qiana, S., Qiaoao, C. F., Qinae, L. Q., Qinaz, N., Qina, X. S., Qinac, Y., Qina, Z. H., Qiua, J. F., Rashidau, K. H., Redmeru, C. F., Ripkau, M., Ronga, G., Ruank, X. D., Sarantsevv, A., 4, Schoenningay, K., Schumannu, S., Shanac, W., Shaoas, M., Shenb, C. P., Shena, X. Y., Shenga, H. Y., Shepherdr, M. R., Songa, W. M., Songa, X. Y., Spataro, STEFANO GIOVANNI, Spruckan, B., Suna, G. X., Sunn, J. F., Suna, S. S., Sunas, Y. J., Suna, Y. Z., Suna, Z. J., Sunas, Z. T., Tangag, C. J., Tanga, X., Tapanam, I., Thorndikear, E. H., Tiemensw, M., Tothaq, D., Ullrichan, M., Umanal, I., Varnerap, G. S., Wangab, B., Wangac, D., Wangac, D. Y., Wanga, K., Wanga, L. L., Wanga, L. S., Wangae, M., Wanga, P., Wanga, P. L., Wanga, Q. J., Wangac, S. G., Wanga, W., Wangaj, X. F., Wangs, Y. D., Wanga, Y. F., Wangu, Y. Q., Wanga, Z., Wanga, Z. G., Wangas, Z. H., Wanga, Z. Y., Weij, D. H., Weiac, J. B., Weidenkaffu, P., Wena, S. P., Werneran, M., Wiednerc, U., Wolkeay, M., Wua, L. H., Wua, N., Wua, Z., Xiaaj, L. G., Xiaq, Y., Xiaoa, D., Xiaoz, Z. J., Xiea, Y. G., Xiua, Q. L., Xua, G. F., Xua, L., Xul, Q. J., Xuao, Q. N., Xuah, X. P., Xuea, Z., Yanas, L., Yanas, W. B., Yanas, W. C., Yanq, Y. H., Yanga, H. X., Yangaz, L., Yange, Y., Yangj, Y. X., Yea, H., Yea, M., Yef, M. H., Yua, B. X., Yuab, C. X., Yuac, H. W., Yux, J. S., Yuae, S. P., Yuana, C. Z., Yuanaa, W. L., Yuana, Y., Yuncual, A., Zafarau, A. A., Zallos, A., Zangaa, S. L., Zengq, Y., Zhanga, B. X., Zhanga, B. Y., Zhangaa, C., Zhangq, C. B., Zhanga, C. C., Zhanga, D. H., Zhangai, H. H., Zhanga, H. Y., Zhanga, J. J., Zhanga, J. Q., Zhanga, J. W., Zhanga, J. Y., Zhanga, J. Z., Zhanga, S. H., Zhanga, X. J., Zhangae, X. Y., Zhanga, Y., Zhanga, Y. H., Zhange, Z. H., Zhangas, Z. P., Zhangaz, Z. Y., Zhaoa, G., Zhaoa, J. W., Lei, Zhaoas, Ling, Zhaoa, Zhaoab, M. G., Zhaoa, Q., Zhaoa, Q. W., Zhaobb, S. J., Zhaoa, T. C., Zhaoaa, X. H., Zhaoa, Y. B., Zhaoas, Z. G., Zhemchugovv, A., Zhengat, B., Zhenga, J. P., Zhengao, Y. H., Zhongz, B., Zhoua, L., Zhouab, Li, Zhouaz, X., Zhouao, X. K., Zhouas, X. R., Zhoua, X. Y., Zhua, K., Zhua, K. J., Zhuaj, X. L., Zhuas, Y. C., Zhua, Y. S., Zhua, Z. A., Zhuanga, J., Zoua, B. S., and Zoua, J. H.

Published
2014

43. Study of e(+)e(-) -> p(p)over-bar in the vicinity of psi(3770)

Author

Ablikima, M., Achasovh, M. N., 1, Aia, X. C., Albayrakd, O., Albrechtc, M., Ambrosear, D. J., Ana, F. F., Anas, Q., Baia, J. Z., Baldini Ferrolis, R., Banac, Y., Bennettr, J. V., Bertanis, M., Bianaq, J. M., Bogerv, E., 2, Bondarenkow, O., Boykov, I., Braunan, S., Briered, R. A., Caiaz, H., Caia, X., Cakirak, O., Calcaterras, A., Caoa, G. F., Cetinal, S. A., Changa, J. F., Chelkovv, G., 3, Chena, G., Chena, H. S., Chena, J. C., Chena, M. L., Chenaa, S. J., Chena, X., Chenx, X. R., Chena, Y. B., Chengp, H. P., Chuac, X. K., Chua, Y. P., Cronin Hennessyaq, D., Daia, H. L., Daia, J. P., Dedovichv, D., Denga, Z. Y., Denigu, A., Denysenkov, I., Destefanis, MARCO GIOVANNI, Dingae, W. M., Dingy, Y., Dongab, C., Donga, J., Donga, L. Y., Donga, M. Y., Dubb, S. X., Fanaj, J. Z., Fanga, J., Fanga, S. S., Fanga, Y., Favaaw, L., Fengas, C. Q., Fua, C. D., Fuksv, O., Gaoa, Q., Gaoaj, Y., Gengas, C., Goetzeni, K., Gonga, W. X., Gradlu, W., Greco, Michela, Gua, M. H., Guk, Y. T., Guana, Y. H., Guoz, L. B., Guoz, T., Guou, Y. P., Hana, Y. L., Harrisap, F. A., Hea, K. L., Hea, M., Heab, Z. Y., Heldc, T., Henga, Y. K., Houa, Z. L., Huz, C., Hua, H. M., Huan, J. F., Hua, T., Huange, G. M., Huangas, G. S., Huangaz, H. P., Huangn, J. S., Huanga, L., Huangae, X. T., Huangaa, Y., Hussainau, T., Jias, C. S., Jia, Q., Jiab, Q. P., Jia, X. B., Jia, X. L., Jianga, L. L., Jiangaz, L. W., Jianga, X. S., Jiaoae, J. B., Jiaop, Z., Jina, D. P., Jina, S., Johanssonay, T., Kalantar Nayestanakiw, N., Kanga, X. L., Kangab, X. S., Kavatsyukw, M., Klossu, B., Kopfc, B., Kornicerap, M., Kühnan, W., Kupscay, A., Laia, W., Langean, J. S., Larar, M., Larinm, P., Leyhec, M., Lia, C. H., Cheng, Lias, Cui, Lias, Liq, D., Libb, D. M., Lia, F., Lia, G., Lia, H. B., Lia, J. C., Lil, K., Liae, K., Lei, Lia, Liao, P. R., Lia, Q. J., Liae, T., Lia, W. D., Lia, W. G., Liae, X. L., Lia, X. N., Liab, X. Q., Liai, Z. B., Liangas, H., Liangag, Y. F., Liangan, Y. T., Linm, D. X., Liua, B. J., Liud, C. L., Liua, C. X., Liuaf, F. H., Fang, Liua, Feng, Liue, Liuk, H. B., Liuo, H. H., Liua, H. M., Liua, J., Liuaz, J. P., Liuaj, K., Liuy, K. Y., Liuae, P. L., Liuao, Q., Liuas, S. B., Liux, X., Liuab, Y. B., Liua, Z. A., Zhiqiang, Liua, Zhiqing, Liuu, Loehnerw, H., Loua, X. C., 4, Lun, G. R., Lup, H. J., Lua, H. L., Lua, J. G., Luao, X. R., Lua, Y., Lua, Y. P., Luoz, C. L., Luoba, M. X., Luoap, T., Luoa, X. L., Lva, M., May, F. C., Maa, H. L., Maa, Q. M., Maa, S., Maa, T., Maa, X. Y., Maasm, F. E., Maggiora, Marco, Malikau, Q. A., Maoac, Y. J., Maoa, Z. P., Messchendorpw, J. G., Mina, J., Mina, T. J., Mitchellr, R. E., Moa, X. H., Moe, Y. J., Moeiniw, H., Morales Moralesm, C., Moriyar, K., Muchnoih, N. Y. u., Muramatsuaq, H., Nefedovv, Y., Nerlingm, F., Nikolaevh, I. B., Ninga, Z., Nisarg, S., Niua, X. Y., Olsenad, S. L., Ouyanga, Q., Pacettit, S., Pelizaeusc, M., Pengas, H. P., Petersi, K., Pingz, J. L., Pinga, R. G., Polingaq, R., Qiaa, M., Qiana, S., Qiaoao, C. F., Qinae, L. Q., Qinaz, N., Qina, X. S., Qinac, Y., Qina, Z. H., Qiua, J. F., Rashidau, K. H., Redmeru, C. F., Ripkau, M., Ronga, G., Ruank, X. D., Sarantsevv, A., 5, Schoenningay, K., Schumannu, S., Shanac, W., Shaoas, M., Shenb, C. P., Shena, X. Y., Shenga, H. Y., Shepherdr, M. R., Songa, W. M., Songa, X. Y., Spataro, STEFANO GIOVANNI, Spruckan, B., Suna, G. X., Sunn, J. F., Suna, S. S., Sunas, Y. J., Suna, Y. Z., Suna, Z. J., Sunas, Z. T., Tangag, C. J., Tanga, X., Tapanam, I., Thorndikear, E. H., Tothaq, D., Ullrichan, M., Umanal, I., Varnerap, G. S., Wangab, B., Wangac, D., Wangac, D. Y., Wanga, K., Wanga, L. L., Wanga, L. S., Wangae, M., Wanga, P., Wanga, P. L., Wanga, Q. J., Wangac, S. G., Wanga, W., Wangaj, X. F., Wangs, Y. D., Wanga, Y. F., Wangu, Y. Q., Wanga, Z., Wanga, Z. G., Wangas, Z. H., Wanga, Z. Y., Weij, D. H., Weiac, J. B., Weidenkaffu, P., Wena, S. P., Werneran, M., Wiednerc, U., Wolkeay, M., Wua, L. H., Wua, N., Wua, Z., Xiaaj, L. G., Xiaq, Y., Xiaoa, D., Xiaoz, Z. J., Xiea, Y. G., Xiua, Q. L., Xua, G. F., Xua, L., Xul, Q. J., Xuao, Q. N., Xuah, X. P., Xuea, Z., Yanas, L., Yanas, W. B., Yanas, W. C., Yanq, Y. H., Yanga, H. X., Yangaz, L., Yange, Y., Yangj, Y. X., Yea, H., Yea, M., Yef, M. H., Yua, B. X., Yuab, C. X., Yuac, H. W., Yux, J. S., Yuae, S. P., Yuana, C. Z., Yuanaa, W. L., Yuana, Y., Yuncual, A., Zafarau, A. A., Zallos, A., Zangaa, S. L., Zengq, Y., Zhanga, B. X., Zhanga, B. Y., Zhangaa, C., Zhangq, C. B., Zhanga, C. C., Zhanga, D. H., Zhangai, H. H., Zhanga, H. Y., Zhanga, J. J., Zhanga, J. Q., Zhanga, J. W., Zhanga, J. Y., Zhanga, J. Z., Zhanga, S. H., Zhanga, X. J., Zhangae, X. Y., Zhanga, Y., Zhanga, Y. H., Zhange, Z. H., Zhangas, Z. P., Zhangaz, Z. Y., Zhaoa, G., Zhaoa, J. W., Lei, Zhaoas, Ling, Zhaoa, Zhaoab, M. G., Zhaoa, Q., Zhaoa, Q. W., Zhaobb, S. J., Zhaoa, T. C., Zhaoaa, X. H., Zhaoa, Y. B., Zhaoas, Z. G., Zhemchugovv, A., Zhengat, B., Zhenga, J. P., Zhengao, Y. H., Zhongz, B., Zhoua, L., Zhouab, Li, Zhouaz, X., Zhouao, X. K., Zhouas, X. R., Zhoua, X. Y., Zhua, K., Zhua, K. J., Zhuaj, X. L., Zhuas, Y. C., Zhua, Y. S., Zhua, Z. A., Zhuanga, J., Zoua, B. S., and Zoua, J. H.

Published
2014

44. Poster session 1Cell growth, differentiation and stem cells - Heart72Understanding the metabolism of cardiac progenitor cells: a first step towards controlling their proliferation and differentiation?73Expression of pw1/peg3 identifies a new cardiac adult stem cell population involved in post-myocardial infarction remodeling74Long-term stimulation of iPS-derived cardiomyocytes using optogenetic techniques to promote phenotypic changes in E-C coupling75Benefits of electrical stimulation on differentiation and maturation of cardiomyocytes from human induced pluripotent stem cells76Constitutive beta-adrenoceptor-mediated cAMP production controls spontaneous automaticity of human induced pluripotent stem cell-derived cardiomyocytes77Formation and stability of T-tubules in cardiomyocytes78Identification of miRNAs promoting human cardiomyocyte proliferation by regulating Hippo pathway79A direct comparison of foetal to adult epicardial cell activation reveals distinct differences relevant for the post-injury response80Role of neuropilins in zebrafish heart regeneration81Highly efficient immunomagnetic purification of cardiomyocytes derived from human pluripotent stem cells82Cardiac progenitor cells posses a molecular circadian clock and display large 24-hour oscillations in proliferation and stress tolerance83Influence of sirolimus and everolimus on bone marrow-derived mesenchymal stem cell biology84Endoglin is important for epicardial behaviour following cardiac injuryCell death and apoptosis - Heart87Ultrastructural alterations reflecting Ca2+ handling and cell-to-cell coupling disorders precede occurrence of severe arrhythmias in intact animal heart88Urocortin-1 promotes cardioprotection through ERK1/2 and EPAC pathways: role in apoptosis and necrosis89Expression p38 MAPK and Cas-3 in myocardium LV of rats with experimental heart failure at melatonin and enalapril introductionTranscriptional control and RNA species - Heart92Accumulation of beta-amyloid 1-40 in HF patients: the role of lncRNA BACE1-AS93Role of miR-182 in zebrafish and mouse models of Holt-Oram syndrome94Mir-27 distinctly regulates muscle-enriched transcription factors and growth factors in cardiac and skeletal muscle cells95AF risk factors impair PITX2 expression leading to Wnt-microRNA-ion channel remodelingCytokines and cellular inflammation - Heart98Post-infarct survival depends on the interplay of monocytes, neutrophils and interferon gamma in a mouse model of myocardial Infarction99Inflammatory cd11b/c cells play a protective role in compensated cardiac hypertrophy by promoting an orai3-related pro-survival signal100Anti-inflammatory effects of endothelin receptor blockade in the atrial tissue of spontaneously hypertensive rats101Mesenchymal stromal cells reduce NLRP3 inflammasome activity in Coxsackievirus B3-induced myocarditis102Mesenchymal stromal cells modulate monocytes trafficking in Coxsackievirus B3-induced myocarditis103The impact of regulatory T lymphocytes on long-term mortality in patients with chronic heart failure104Temporal dynamics of dendritic cells after ST-elevation myocardial infarction relate with improvement of myocardial functionGrowth factors and neurohormones - Heart107Preconditioning of hypertrophied heart: miR-1 and IGF-1 crosstalk108Modulation of catecholamine secretion from human adrenal chromaffin cells by manipulation of G protein-coupled receptor kinase-2 activity109Evaluation of cyclic adenosin-3,5- monophosphate and neurohormones in patients with chronic heart failureNitric oxide and reactive oxygen species - Heart112Hydrogen sulfide donor inhibits oxidative and nitrosative stress, cardiohemodynamics disturbances and restores cNOS coupling in old rats113Role and mechanisms of action of aldehydes produced by monoamine oxidase A in cardiomyocyte death and heart failure114Exercise training has contrasting effects in myocardial infarction and pressure-overload due to different endothelial nitric oxide synthase regulation115S-Nitroso Human Serum Albumin dose-dependently leads to vasodilation and alters reactive hyperaemia in coronary arteries of an isolated mouse heart model116Modulating endothelial nitric oxide synthase with folic acid attenuates doxorubicin-induced cardiomyopathy119Effects of long-term very high intensity exercise on aortic structure and function in an animal model120Electron paramagnetic resonance spectroscopy quantification of nitrosylated hemoglobin (HbNO) as an index of vascular nitric oxide bioavailability in vivo121Deletion of repressor activator protein 1 impairs acetylcholine-induced relaxation due to production of reactive oxygen speciesExtracellular matrix and fibrosis - Heart124MicroRNA-19b is associated with myocardial collagen cross-linking in patients with severe aortic stenosis. Potential usefulness as a circulating biomarker125A new ex vivo model to study cardiac fibrosis126Heterogeneity of fibrosis and fibroblast differentiation in the left ventricle after myocardial infarction127Effect of carbohydrate metabolism degree compensation to the level of galectin-3 changes in hypertensive patients with chronic heart failure and type 2 diabetes mellitus128Statin paradox in association with calcification of bicuspid aortic valve interstitial cells129Cardiac function remains impaired despite reversible cardiac fibrosis after healed experimental viral myocarditisIon channels, ion exchangers and cellular electrophysiology - Heart132Identifying a novel role for PMCA1 (Atp2b1) in heart rhythm instability133Mutations of the caveolin-3 gene as a predisposing factor for cardiac arrhythmias134The human sinoatrial node action potential: time for a computational model135iPSC-derived cardiomyocytes as a model to dissect ion current alterations of genetic atrial fibrillation136Postextrasystolic potentiation in healthy and diseased hearts: effects of the site of origin and coupling interval of the preceding extrasystole137Absence of Nav1.8-based (late) sodium current in rabbit cardiomyocytes and human iPSC-CMs138hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit cellular electrophysiological abnormalitiesMicrocirculation141Atherogenic indices, collagen type IV turnover and the development of microvascular complications- study in diabetics with arterial hypertension142Changes in the microvasculature and blood viscosity in women with rheumatoid arthritis, hypercholesterolemia and hypertensionAtherosclerosis145Shear stress regulates endothelial autophagy: consequences on endothelial senescence and atherogenesis146Obstructive sleep apnea causes aortic remodeling in a chronic murine model147Aortic perivascular adipose tissue displays an aged phenotype in early and late atherosclerosis in ApoE-/- mice148A systematic evaluation of the cellular innate immune response during the process of human atherosclerosis149Inhibition of Coagulation factor Xa increases plaque stability and attenuates the onset and progression of atherosclerotic plaque in apolipoprotein e-deficient mice150Regulatory CD4+ T cells from patients with atherosclerosis display pro-inflammatory skewing and enhanced suppression function151Hypoxia-inducible factor (HIF)-1alpha regulates macrophage energy metabolism by mediating miRNAs152Extracellular S100A4 is a key player of smooth muscle cell phenotypic transition: implications in atherosclerosis153Microparticles of healthy origins improve atherosclerosis-associated endothelial progenitor cell dysfunction via microRNA transfer154Arterial remodeling and metabolism impairment in early atherosclerosis155Role of pannexin1 in atherosclerotic plaque formationCalcium fluxes and excitation-contraction coupling158Amphiphysin II induces tubule formation in cardiac cells159Interleukin 1 beta regulation of connexin 43 in cardiac fibroblasts and the effects of adult cardiac myocyte:fibroblast co-culture on myocyte contraction160T-tubular electrical defects contribute to blunted beta-adrenergic response in heart failure161Beat-to-beat variability of intracellular Ca2+ dynamics of Purkinje cells in the infarct border zone of the mouse heart revealed by rapid-scanning confocal microscopy162The efficacy of late sodium current blockers in hypertrophic cardiomyopathy is dependent on genotype: a study on transgenic mouse models with different mutations163Synthesis of cADPR and NAADP by intracellular CD38 in heart: role in inotropic and arrhythmogenic effects of beta-adrenoceptor signalingContractile apparatus166Towards an engineered heart tissue model of HCM using hiPSC expressing the ACTC E99K mutation167Diastolic mechanical load delays structural and functional deterioration of ultrathin adult heart slices in culture168Structural investigation of the cardiac troponin complex by molecular dynamics169Exercise training restores myocardial and oxidative skeletal muscle function from myocardial infarction heart failure ratsOxygen sensing, ischaemia and reperfusion172A novel antibody specific to full-length stromal derived factor-1 alpha reveals that remote conditioning induces its cleavage by endothelial dipeptidyl peptidase 4173Attenuation of myocardial and vascular arginase activity by vagal nerve stimulation via a mechanism involving alpha-7 nicotinic receptor during cardiac ischemia and reperfusion174Novel nanoparticle-mediated medicine for myocardial ischemia-reperfusion injury simultaneously targeting mitochondrial injury and myocardial inflammation175Acetylcholine plays a key role in myocardial ischaemic preconditioning via recruitment of intrinsic cardiac ganglia176The role of nitric oxide and VEGFR-2 signaling in post ischemic revascularization and muscle recovery in aged hypercholesterolemic mice177Efficacy of ischemic preconditioning to protect the human myocardium: the role of clinical conditions and treatmentsCardiomyopathies and fibrosis180Plakophilin-2 haploinsufficiency leads to impaired canonical Wnt signaling in ARVC patient181Improved technique for customized, easier, safer and more reliable transverse aortic arch banding and debanding in mice as a model of pressure overload hypertrophy182Late sodium current inhibitors for the treatment of inducible obstruction and diastolic dysfunction in hypertrophic cardiomyopathy: a study on human myocardium183Angiotensin II receptor antagonist fimasartan has protective role of left ventricular fibrosis and remodeling in the rat ischemic heart184Role of High-Mobility Group Box 1 (HMGB1) redox state on cardiac fibroblasts activities and heart function after myocardial infarction185Atrial remodeling in hypertrophic cardiomyopathy: insights from mouse models carrying different mutations in cTnT186Electrophysiological abnormalities in ventricular cardiomyocytes from a Maine Coon cat with hypertrophic cardiomyopathy: effects of ranolazine187ZBTB17 is a novel cardiomyopathy candidate gene and regulates autophagy in the heart188Inhibition of SRSF4 in cardiomyocytes induces left ventricular hypertrophy189Molecular characterization of a novel cardiomyopathy related desmin frame shift mutation190Autonomic characterisation of electro-mechanical remodeling in an in-vitro leporine model of heart failure191Modulation of Ca2+-regulatory function by three novel mutations in TNNI3 associated with severe infant restrictive cardiomyopathyAging194The aging impact on cardiac mesenchymal like stromal cells (S+P+)195Reversal of premature aging markers after bariatric surgery196Sex-associated differences in vascular remodeling during aging: role of renin-angiotensin system197Role of the receptor for advanced glycation end-products (RAGE) in age dependent left ventricle dysfunctionsGenetics and epigenetics200hsa-miR-21-5p as a key factor in aortic remodeling during aneurysm formation201Co-inheritance of mutations associated with arrhythmogenic and hypertrophic cardiomyopathy in two Italian families202Lamin a/c hot spot codon 190: form various amino acid substitutions to clinical effects203Treatment with aspirin and atorvastatin attenuate cardiac injury induced by rat chest irradiation: Implication of myocardial miR-1, miR-21, connexin-43 and PKCGenomics, proteomics, metabolomics, lipidomics and glycomics206Differential phosphorylation of desmin at serines 27 and 31 drives the accumulation of preamyloid oligomers in heart failure207Potential role of kinase Akt2 in the reduced recovery of type 2 diabetic hearts subjected to ischemia / reperfusion injury208A proteomics comparison of extracellular matrix remodelling in porcine coronary arteries upon stent implantationMetabolism, diabetes mellitus and obesity211Targeting grk2 as therapeutic strategy for cancer associated to diabetes212Effects of salbutamol on large arterial stiffness in patients with metabolic syndrome213Circulating microRNA-1 and microRNA-133a: potential biomarkers of myocardial steatosis in type 2 diabetes mellitus214Anti-inflammatory nutrigenomic effects of hydroxytyrosol in human adipocytes - protective mechanisms of mediterranean diets in obesity-related inflammation215Alterations in the metal content of different cardiac regions within a rat model of diabetic cardiomyopathyTissue engineering218A novel conductive patch for application in cardiac tissue engineering219Establishment of a simplified and improved workflow from neonatal heart dissociation to cardiomyocyte purification and characterization220Effects of flexible substrate on cardiomyocytes cell culture221Mechanical stretching on cardiac adipose progenitors upregulates sarcomere-related genes

Author

Andre, E, primary, Yaniz-Galende, E, primary, Hamilton, C, primary, Dusting, G J, primary, Hellen, N, primary, Poulet, CE, primary, Diez Cunado, M, primary, Smits, AM, primary, Lowe, V, primary, Eckardt, D, primary, Du Pre, B, primary, Sanz Ruiz, R, primary, Moerkamp, A T, primary, Tribulova, N, primary, Smani, T, primary, Liskova, Y V, primary, Greco, S, primary, Guzzolino, E, primary, Franco, D, primary, Lozano-Velasco, E, primary, Knorr, M, primary, Pavoine, C, primary, Bukowska, A, primary, Van Linthout, S, primary, Miteva, K, primary, Sulzgruber, P, primary, Latet, S C, primary, Portnychenko, A, primary, Cannavo, A, primary, Kamilova, U, primary, Sagach, VF, primary, Santin, Y, primary, Octavia, Y, primary, Haller, PM, primary, Rubies, C, primary, Dei Zotti, F, primary, Wong, KHK, primary, Gonzalez Miqueo, A, primary, Kruithof, BPT, primary, Kadur Nagaraju, C, primary, Shaposhnikova, Y, primary, Songia, P, primary, Lindner, D, primary, Wilson, C, primary, Benzoni, P, primary, Fabbri, A, primary, Campostrini, G, primary, Jorge, E, primary, Casini, S, primary, Mengarelli, I, primary, Nikolov, A, primary, Bublikov, DS, primary, Kheloufi, M, primary, Walker, R E, primary, Van Dijk, RA, primary, Posthuma, JJ, primary, Dumitriu, I E, primary, Karshovska, E, primary, Sakic, A, primary, Alexandru, N, primary, Martin-Lorenzo, M, primary, Molica, F, primary, Taylor, RF, primary, Mcarthur, L, primary, Crocini, C, primary, Matsuyama, T-A, primary, Mazzoni, L, primary, Lin, W K, primary, Owen, TJ, primary, Scigliano, M, primary, Sheehan, A, primary, Bezerra Gurgel, A R, primary, Bromage, DI, primary, Kiss, A, primary, Ikeda, G, primary, Pickard, J M J, primary, Wirth, G, primary, Casos, K, primary, Khudiakov, A, primary, Nistal, JF, primary, Ferrantini, C, primary, Park, S-J, primary, Di Maggio, S, primary, Gentile, F, primary, Dini, L, primary, Buyandelger, B, primary, Larrasa-Alonso, J, primary, Schirmer, I, primary, Chin, SH, primary, Cimiotti, D, primary, Martini, H, primary, Hohensinner, P J, primary, Garabito, M, primary, Zeni, F, primary, Licholai, S, primary, De Bortoli, M, primary, Sivitskaya, L, primary, Viczenczova, C, primary, Rainer, PP, primary, Smith, LE, primary, Suna, G, primary, Gambardella, J, primary, Cozma, A, primary, De Gonzalo Calvo, D, primary, Scoditti, E, primary, Clark, B J, primary, Mansfield, C, primary, Gomez, L, primary, Llucia-Valldeperas, A, primary, De Pauw, A, additional, Porporato, P, additional, Bouzin, C, additional, Draoui, N, additional, Sonveaux, P, additional, Balligand, J-L, additional, Mougenot, N, additional, Formicola, L, additional, Nadaud, S, additional, Dierick, F, additional, Hajjar, RJ, additional, Marazzi, G, additional, Sassoon, D, additional, Hulot, J-S, additional, Zamora, VR, additional, Burton, FL, additional, Macquaide, N, additional, Smith, GL, additional, Hernandez, D, additional, Sivakumaran, P, additional, Millard, R, additional, Wong, RCB, additional, Pebay, A, additional, Shepherd, RK, additional, Lim, SY, additional, Owen, T, additional, Jabbour, RJ, additional, Kloc, M, additional, Kodagoda, T, additional, Denning, C, additional, Harding, SE, additional, Ramos, S, additional, Terracciano, C, additional, Gorelik, J, additional, Wei, K, additional, Bushway, P, additional, Ruiz-Lozano, P, additional, Mercola, M, additional, Moerkamp, AT, additional, Vegh, AMD, additional, Dronkers, E, additional, Lodder, K, additional, Van Herwaarden, T, additional, Goumans, MJ, additional, Pellet-Many, C, additional, Zachary, I, additional, Noack, K, additional, Bosio, A, additional, Feyen, DAM, additional, Demkes, EJ, additional, Dierickx, PJ, additional, Doevendans, PA, additional, Vos, MA, additional, Van Veen, AAB, additional, Van Laake, LW, additional, Fernandez Santos, ME, additional, Suarez Sancho, S, additional, Fuentes Arroyo, L, additional, Plasencia Martin, V, additional, Velasco Sevillano, P, additional, Casado Plasencia, A, additional, Climent, AM, additional, Guillem, M, additional, Atienza Fernandez, F, additional, Fernandez-Aviles, F, additional, Dingenouts, CKE, additional, Kruithof, BPT, additional, Smits, AM, additional, Knezl, V, additional, Szeiffova Bacova, B, additional, Egan Benova, T, additional, Viczenczova, C, additional, Goncalvesova, E, additional, Slezak, J, additional, Calderon-Sanchez, E, additional, Diaz, I, additional, Ordonez, A, additional, Salikova, S P, additional, Zaccagnini, G, additional, Voellenkle, C, additional, Sadeghi, I, additional, Maimone, B, additional, Castelvecchio, S, additional, Gaetano, C, additional, Menicanti, L, additional, Martelli, F, additional, Hatcher, C, additional, D'aurizio, R, additional, Groth, M, additional, Baugmart, M, additional, Mercatanti, A, additional, Russo, F, additional, Mariani, L, additional, Magliaro, C, additional, Pitto, L, additional, Lozano-Velasco, E, additional, Jodar-Garcia, A, additional, Galiano-Torres, J, additional, Lopez-Navarrete, I, additional, Aranega, A, additional, Wagensteen, R, additional, Quesada, A, additional, Franco, D, additional, Finger, S, additional, Karbach, S, additional, Kossmann, S, additional, Muenzel, T, additional, Wenzel, P, additional, Keck, M, additional, Favier, S, additional, Fuand, A, additional, Atassi, F, additional, Barbier, C, additional, Lompre, AM, additional, Hulot, JS, additional, Nikonova, Y, additional, Pluteanu, F, additional, Kockskaemper, J, additional, Chilukoti, RK, additional, Wolke, C, additional, Lendeckel, U, additional, Gardemann, A, additional, Goette, A, additional, Miteva, K, additional, Pappritz, K, additional, Mueller, I, additional, El-Shafeey, M, additional, Ringe, J, additional, Tschoepe, C, additional, Van Linthout, S, additional, Koller, L, additional, Richter, B, additional, Blum, S, additional, Koprak, M, additional, Huelsmann, M, additional, Pacher, R, additional, Goliasch, G, additional, Wojta, J, additional, Niessner, A, additional, Van Herck, P L, additional, Claeys, M J, additional, Haine, S E, additional, Lenders, G D, additional, Miljoen, H P, additional, Segers, V F, additional, Vandendriescche, T R, additional, Hoymans, V Y, additional, Vrints, C J, additional, Lapikova-Bryhinska, T, additional, Gurianova, V, additional, Portnichenko, H, additional, Vasylenko, M, additional, Zapara, Y, additional, Portnichenko, V, additional, Liccardo, D, additional, Lymperopoulos, A, additional, Santangelo, M, additional, Leosco, D, additional, Koch, WJ, additional, Ferrara, N, additional, Rengo, G, additional, Alieva, T, additional, Rasulova, Z, additional, Masharipova, D, additional, Dorofeyeva, N A, additional, Drachuk, KO, additional, Sicard, P, additional, Yucel, Y, additional, Dutaur, M, additional, Vindis, C, additional, Parini, A, additional, Mialet-Perez, J, additional, Van Deel, ED, additional, De Boer, M, additional, De Waard, MC, additional, Duncker, DJ, additional, Nagel, F, additional, Inci, M, additional, Santer, D, additional, Hallstroem, S, additional, Podesser, BK, additional, Kararigas, G, additional, Kietadisorn, R, additional, Swinnen, M, additional, Duimel, H, additional, Verheyen, F, additional, Chrifi, I, additional, Brandt, MM, additional, Cheng, C, additional, Janssens, S, additional, Moens, AL, additional, Batlle, M, additional, Dantas, AP, additional, Sanz, M, additional, Sitges, M, additional, Mont, L, additional, Guasch, E, additional, Lobysheva, I, additional, Beauloye, C, additional, Vanhoutte, PM, additional, Tang, EHC, additional, Beaumont, J, additional, Lopez, B, additional, Ravassa, S, additional, Hermida, N, additional, Valencia, F, additional, Gomez-Doblas, JJ, additional, San Jose, G, additional, De Teresa, E, additional, Diez, J, additional, Van De Merbel, AF, additional, Kruithof-De Julio, M, additional, Claus, P, additional, Dries, E, additional, Angelo Singh, A, additional, Vermeulen, K, additional, Roderick, HL, additional, Sipido, KR, additional, Driesen, RB, additional, Ilchenko, I, additional, Bobronnikova, L, additional, Myasoedova, V, additional, Alamanni, F, additional, Tremoli, E, additional, Poggio, P, additional, Becher, PM, additional, Gotzhein, F, additional, Klingel, K, additional, Blankenberg, S, additional, Westermann, D, additional, Zi, M, additional, Cartwright, E, additional, Campostrini, G, additional, Bonzanni, M, additional, Milanesi, R, additional, Bucchi, A, additional, Baruscotti, M, additional, Difrancesco, D, additional, Barbuti, A, additional, Fantini, M, additional, Wilders, R, additional, Severi, S, additional, Benzoni, P, additional, Dell' Era, P, additional, Serzanti, M, additional, Olesen, MS, additional, Muneretto, C, additional, Bisleri, G, additional, Amoros-Figueras, G, additional, Raga, S, additional, Campos, B, additional, Alonso-Martin, C, additional, Rodriguez-Font, E, additional, Vinolas, X, additional, Cinca, J, additional, Guerra, JM, additional, Mengarelli, I, additional, Schumacher, CA, additional, Veldkamp, MW, additional, Verkerk, 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Published
2016
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47. Evaluation of local and systemic immune responses in pigs experimentally challenged with porcine reproductive and respiratory syndrome virus

Author

Salik Nazki, Amina Khatun, Chang-Gi Jeong, Sameer ul Salam Mattoo, Suna Gu, Sim-In Lee, Seung-Chai Kim, Ji-Hyo Park, Myoun-Sik Yang, Bumseok Kim, Choi-Kyu Park, Sang-Myeong Lee, and Won-Il Kim

Subjects
Veterinary medicine, SF600-1100
Abstract

Abstract The host-associated defence system responsible for the clearance of porcine reproductive and respiratory syndrome virus (PRRSV) from infected pigs is currently poorly understood. To better understand the dynamics of host–pathogen interactions, seventy-five of 100 pigs infected with PRRSV-JA142 and 25 control pigs were euthanized at 3, 10, 21, 28 and 35 days post-challenge (dpc). Blood, lung, bronchoalveolar lavage (BAL) and bronchial lymph node (BLN) samples were collected to evaluate the cellular immune responses. The humoral responses were evaluated by measuring the levels of anti-PRRSV IgG and serum virus-neutralizing (SVN) antibodies. Consequently, the highest viral loads in the sera and lungs of the infected pigs were detected between 3 and 10 dpc, and these resulted in moderate to mild interstitial pneumonia, which resolved accompanied by the clearance of most of the virus by 28 dpc. At peak viremia, the frequencies of alveolar macrophages in infected pigs were significantly decreased, whereas the monocyte-derived DC/macrophage and conventional DC frequencies were increased, and these effects coincided with the early induction of local T-cell responses and the presence of proinflammatory cytokines/chemokines in the lungs, BAL, and BLN as early as 10 dpc. Conversely, the systemic T-cell responses measured in the peripheral blood mononuclear cells were delayed and significantly induced only after the peak viremic stage between 3 and 10 dpc. Taken together, our results suggest that activation of immune responses in the lung could be the key elements for restraining PRRSV through the early induction of T-cell responses at the sites of virus replication.

Published
2020
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48. Effect of polymorphisms in porcine guanylate-binding proteins on host resistance to PRRSV infection in experimentally challenged pigs

Author

Amina Khatun, Salik Nazki, Chang-Gi Jeong, Suna Gu, Sameer ul Salam Mattoo, Sim-In Lee, Myun-Sik Yang, Byeonghwi Lim, Kwan-Suk Kim, Bumseok Kim, Kyoung-Tae Lee, Choi-Kyu Park, Sang-Myeong Lee, and Won-Il Kim

Subjects
Veterinary medicine, SF600-1100
Abstract

Abstract Guanylate-binding proteins (GBP1 and GBP5) are known to be important for host resistance against porcine reproductive and respiratory syndrome virus (PRRSV) infection. In this study, the effects of polymorphisms in GBP1 (GBP1E2 and WUR) and GBP5 on host immune responses against PRRSV were investigated to elucidate the mechanisms governing increased resistance to this disease. Seventy-one pigs [pre-genotyped based on three SNP markers (GBP1E2, WUR, and GBP5)] were assigned to homozygous (n = 36) and heterozygous (n = 35) groups and challenged with the JA142 PRRSV strain. Another group of nineteen pigs was kept separately as a negative control group. Serum and peripheral blood mononuclear cells (PBMCs) were collected at 0, 3, 7, 14, 21 and 28 days post-challenge (dpc). Viremia and weight gain were measured in all pigs at each time point, and a flow cytometry analysis of PBMCs was performed to evaluate T cell activation. In addition, 15 pigs (5 pigs per homozygous, heterozygous and negative groups) were sacrificed at 3, 14 and 28 dpc, and the local T cell responses were evaluated in the lungs, bronchoalveolar lavage cells (BALc), lymph nodes and tonsils. The heterozygous pigs showed lower viral loads in the serum and lungs and higher weight gains than the homozygous pigs based on the area under the curve calculation. Consistently, compared with the homozygous pigs, the heterozygous pigs exhibited significantly higher levels of IFN-α in the serum, proliferation of various T cells (γδT, Th1, and Th17) in PBMCs and tissues, and cytotoxic T cells in the lungs and BALc. These results indicate that the higher resistance in the pigs heterozygous for the GBP1E2, WUR and GBP5 markers could be mediated by increased antiviral cytokine (IFN-α) production and T cell activation.

Published
2020
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49. In vitro immune responses of porcine alveolar macrophages reflect host immune responses against porcine reproductive and respiratory syndrome viruses

Author

Nadeem Shabir, Amina Khatun, Salik Nazki, Suna Gu, Sang-Myoung Lee, Tai-Young Hur, Myoun-Sik Yang, Bumseok Kim, and Won-Il Kim

Subjects
PRRSV, Immune response, Alveolar macrophages, Peripheral blood mononuclear cells, Flow cytometry, Veterinary medicine, SF600-1100
Abstract

Abstract Background Currently, an in vitro immunogenicity screening system for the immunological assessment of potential porcine reproductive and respiratory syndrome virus (PRRSV) vaccine candidates is highly desired. Thus, in the present study, two genetically divergent PRRSVs were characterized in vitro and in vivo to identify an in vitro system and immunological markers that predict the host immune response. Porcine alveolar macrophages (PAMs) and peripheral blood mononuclear cells (PBMCs) collected from PRRSV-negative pigs were used for in vitro immunological evaluation, and the response of these cells to VR2332c or JA142c were compared with those elicited in pigs challenged with the same viruses. Results Compared with VR2332c or mock infection, JA142c induced increased levels of type I interferons and pro-inflammatory cytokines (TNF-α, IL-1α/β, IL-6, IL-8, and IL-12) in PAMs, and these elevated levels were comparable to the cytokine induction observed in PRRSV-challenged pigs. Furthermore, significantly greater numbers of activated CD4+ T cells, type I helper T cells, cytotoxic T cells and total IFN-γ+ cells were observed in JA142c-challenged pigs than in VR2332c- or mock-challenged pigs. Conclusions Based on these results, the innate immune response patterns (particularly IFN-α, TNF-α and IL-12) to specific PRRSV strains in PAMs might reflect those elicited by the same viruses in pigs.

Published
2018
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50. Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

Author

Suna Gulay, Neha Gupta, Jon R Lorsch, and Alan G Hinnebusch

Subjects
Ded1/Ddx3, RNA helicase, eIF4E, eIF4A, eIF4G, translation initiation, Medicine, Science, Biology (General), QH301-705.5
Abstract

Yeast DEAD-box helicase Ded1 stimulates translation initiation, particularly of mRNAs with structured 5'UTRs. Interactions of the Ded1 N-terminal domain (NTD) with eIF4A, and Ded1-CTD with eIF4G, subunits of eIF4F, enhance Ded1 unwinding activity and stimulation of preinitiation complex (PIC) assembly in vitro. However, the importance of these interactions, and of Ded1-eIF4E association, in vivo were poorly understood. We identified separate amino acid clusters in the Ded1-NTD required for binding to eIF4A or eIF4E in vitro. Disrupting each cluster selectively impairs native Ded1 association with eIF4A or eIF4E, and reduces cell growth, polysome assembly, and translation of reporter mRNAs with structured 5'UTRs. It also impairs Ded1 stimulation of PIC assembly on a structured mRNA in vitro. Ablating Ded1 interactions with eIF4A/eIF4E unveiled a requirement for the Ded1-CTD for robust initiation. Thus, Ded1 function in vivo is stimulated by independent interactions of its NTD with eIF4E and eIF4A, and its CTD with eIF4G.

Published
2020
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