482 results on '"Sun, Zh."'
Search Results
2. Exploring the Diagnostic Value of High-Frequency Ultrasound Technology for Subcutaneous Lipohypertrophy in Diabetes Patients Receiving Insulin Injections
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Sun ZH, Yu CH, and Wang X
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high-frequency ultrasound technology ,diabetes ,insulin injection ,subcutaneous lipohypertrophy ,diagnostic value ,Specialties of internal medicine ,RC581-951 - Abstract
Zhan-He Sun,* Cheng-Hong Yu,* Xin Wang Department of Ultrasound, Tongxiang First People’s Hospital, Tongxiang, Zhejiang Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Wang, Email xings137@163.comObjective: This study aims to investigate the clinical application value of high-frequency ultrasound technology in diagnosing subcutaneous lipohypertrophy at insulin injection sites in diabetes patients.Methods: All diabetes patients treated in our hospital from January 2022 to January 2023 were selected as the study subjects. The incidence of subcutaneous lipohypertrophy was calculated at the end of the study period. All patients were screened, and those meeting the inclusion criteria were registered, and basic data were collected. Patients were screened for subcutaneous lipohypertrophy using conventional clinical examination (control group) and high-frequency ultrasound technology (study group).Results: The study found that the incidence of subcutaneous lipohypertrophy in diabetes patients receiving insulin injections in our hospital from January 2022 to January 2023 was 80.99%. The average longitudinal diameter of subcutaneous lipohypertrophy in these patients was 11.66 (7.56, 21.44) mm, the transverse diameter was 12.04 (8.96, 18.29) mm, depth was (5.62± 2.17) mm, and the area was 188.79 (76.85, 331.78) mm². The clinical detection rate in the study group was higher than that in the control group (P< 0.05). The quantity of detected sites was greater in the study group compared to the control group (P< 0.05).Conclusion: The incidence of subcutaneous lipohypertrophy in diabetes patients receiving insulin injections is relatively high clinically, and high-frequency ultrasound technology demonstrates significant potential in diagnosis. By providing high-resolution imaging and quantitative data, it effectively improves the clinical detection rate and clarifies symptoms. This technology is likely to become an important auxiliary tool in future diabetes treatment, providing more precise treatment plans for patients.Keywords: high-frequency ultrasound technology, diabetes, insulin injection, subcutaneous lipohypertrophy, diagnostic value
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- 2024
3. Proton inelastic scattering reveals deformation in 8He
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Holl, M, Kanungo, R, Sun, ZH, Hagen, G, Lay, JA, Moro, AM, Navrátil, P, Papenbrock, T, Alcorta, M, Connolly, D, Davids, B, Varela, A Diaz, Gennari, M, Hackman, G, Henderson, J, Ishimoto, S, Kilic, AI, Krücken, R, Lennarz, A, Liang, J, Measures, J, Mittig, W, Paetkau, O, Psaltis, A, Quaglioni, S, Randhawa, JS, Smallcombe, J, Thompson, IJ, Vorabbi, M, and Williams, M
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Nuclear and Plasma Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Mathematical Physics ,Astronomical and Space Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Nuclear & Particles Physics ,Mathematical sciences ,Physical sciences - Abstract
A measurement of proton inelastic scattering of 8He at 8.25A MeV at TRIUMF shows a resonance at 3.54(6) MeV with a width of 0.89(11) MeV. The energy of the state is in good agreement with coupled cluster and no-core shell model with continuum calculations, with the latter successfully describing the measured resonance width as well. Its differential cross section analyzed with phenomenological collective excitation form factor and microscopic coupled reaction channels framework consistently reveals a large deformation parameter β2 = 0.40(3), consistent with no-core shell model predictions of a large neutron deformation. This deformed double-closed shell at the neutron drip-line opens a new paradigm.
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- 2021
4. Sphingomonas beigongshangi sp. nov., Isolated from Pit Mud of Baijiu
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Sun, Zh., Xu, J., Xing, X., Yan, Y., Hao, Sh., Li, J., Ren, Q., and Li, Sh.
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- 2023
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5. Application of 1H Low-Field NMR Spectroscopy for the Determination of the Concentration and Molecule Weight of Polycarboxylate Superplasticizers
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Ji, Y., Sun, Zh., Pang, M., and Yang, J.
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- 2021
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6. MIGRATION FORMS OF CHEMICAL ELEMENTS IN THE WATERS OF THE POYANG LAKE WETLAND, CHINA
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Soldatova, E. A., primary, Sidkina, E. S., additional, Ivanova, I. S., additional, Li, J., additional, Dong, Y., additional, and Sun, Zh., additional
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- 2020
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7. Impact of virtual reality simulation on learning barriers of phacoemulsification perceived by residents
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Ng DS, Sun ZH, Young AL, Ko STC, Lok JKH, Lai TYY, Sikder S, and Tham CC
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Virtual reality ,Simulation surgical education ,Cataract surgery. ,Ophthalmology ,RE1-994 - Abstract
Danny Siu-Chun Ng,1 Zihan Sun,1 Alvin Lerrmann Young,1,2 Simon Tak-Chuen Ko,3 Jerry Ka-Hing Lok,1 Timothy Yuk-Yau Lai,1 Shameema Sikder,4 Clement C Tham1 1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 2Department of Ophthalmology, Prince of Wales Hospital, 3Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong, People’s Republic of China; 4Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA Objective: To identify residents’ perceived barriers to learning phacoemulsification surgical procedures and to evaluate whether virtual reality simulation training changed these perceptions. Design: The ophthalmology residents undertook a simulation phacoemulsification course and proficiency assessment on the Eyesi system using the previously validated training modules of intracapsular navigation, anti-tremor, capsulorrhexis, and cracking/chopping. A cross-sectional, multicenter survey on the perceived difficulties in performing phacoemulsification tasks on patients, based on the validated International Council of Ophthalmology’s Ophthalmology Surgical Competency Assessment Rubric (ICO-OSCAR), using a 5-point Likert scale (1 = least and 5 = most difficulty), was conducted among residents with or without prior simulation training. Mann–Whitney U tests were carried out to compare the mean scores, and multivariate regression analyses were performed to evaluate the association of lower scores with the following potential predictors: 1) higher level trainee, 2) can complete phacoemulsification most of the time (>90%) without supervisor’s intervention, and 3) prior simulation training. Setting: The study was conducted in ophthalmology residency training programs in five regional hospitals in Hong Kong. Results: Of the 22 residents, 19 responded (86.3%), of which 13 (68.4%) had completed simulation training. Nucleus cracking/chopping was ranked highest in difficulty by all respondents followed by capsulorrhexis completion and nucleus rotation/manipulation. Respondents with prior simulation training had significantly lower difficulty scores on these three tasks (nucleus cracking/chopping 3.85 vs 4.75, P = 0.03; capsulorrhexis completion 3.31 vs 4.40, P = 0.02; and nucleus rotation/manipulation 3.00 vs 4.75, P = 0.01). In multivariate analyses, simulation training was significantly associated with lower difficulty scores on these three tasks. Conclusion: Residents who had completed Eyesi simulation training had higher confidence in performing the most difficult tasks perceived during phacoemulsification. Keywords: virtual reality, simulation surgical education, cataract surgery
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- 2018
8. Folate-modified Annonaceous acetogenins nanosuspensions and their improved antitumor efficacy
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Hong JY, Sun ZH, Li YJ, Guo YF, Liao YH, Liu MF, and Wang XT
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Annonaceous acetogenins ,Nanosuspensions ,Folate ,Targeted drug delivery ,Anti-tumor activity. ,Medicine (General) ,R5-920 - Abstract
Jingyi Hong,1 Zhonghao Sun,1 Yijing Li,1 Yifei Guo,1 Yonghong Liao,1 Meifeng Liu,2 Xiangtao Wang1 1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 2Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China Abstract: Annonaceous acetogenins (ACGs) are a large family of fatty acid derived natural products that are exclusively isolated from the Annonaceae species. Many members of this diverse family have a broad spectrum of biological activities, the most impressive of which is anticancer activity. However, their poor solubility and severe toxicity restrict their clinical application, and their complicated composition hinders their formulation and drug delivery. In this study, β-cyclodextrin was modified with folic acid (FA) and then combined with soybean lecithin to prepare FA-modified ACGs nanosuspensions (FA-ACGs-NSps). The obtained FA-ACGs-NSps had a high drug payload of 57.59% and average particle size of 199.5 nm, and they exhibited sustained drug release within 142 hours. In comparison with ACGs-NSps, FA-ACGs-NSps showed significantly enhanced cytotoxicity and higher cell uptake toward folate receptor-positive 4T1 cell lines. An in vivo study demonstrated that FA-ACGs-NSps more effectively accumulated in tumors and enhanced the antitumor therapeutic efficacy with less toxicity in 4T1 tumor bearing mice. Therefore, FA-ACGs-NSps may be a promising drug delivery system for ACGs to improve their therapeutic window and may be suitable for clinical application to treat folate-positive tumors. Keywords: Annonaceous acetogenins, nanosuspensions, folate, targeted drug delivery, antitumor activity
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- 2017
9. Influence of sediment, soil, and micro-relief conditions on vitality of Populus euphratica stands in the lower Tarim Riparian Ecosystem
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Ginau, A., Opp, Ch., Sun, Zh., and Halik, Ü.
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- 2013
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10. Spectroscopic Studies on Binding of Lotus Seedpod Oligomeric Procyanidins to Bovine Serum Albumin
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Wu, Q., Li, Sh., Fu, X., Yang, T., Chen, H., Guan, Y., Xie, B., and Sun, Zh.
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- 2014
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11. Influence of afterburning suppression on the combustion of solid propellants: Recent progress and outlook
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Li, H J, primary, Yi, J H, additional, Qin, Zh, additional, Sun, Zh H, additional, Xu, Y, additional, Wang, Ch J, additional, and Zhao, F Q, additional
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- 2020
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12. Spectral-Domain OCT Measurements in Alzheimer's Disease A Systematic Review and Meta-analysis
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Chan, VTT, Sun, ZH, Tang, SM, Chen, LJ, Wong, A (Anna), Tham, CC, Wong, TY, Chen, C, Ikram, Kamran, Whitson, HE, Lad, EM, Mok, VCT, Cheung, CY, Epidemiology, and Neurology
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- 2019
13. ESTIMATION OF CIRCULATION TEMPERATURES OF THETMAL WATERS IN JIANGXI PROVINCE USING DIFFERENT GEOTHERMOMERERS
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Zippa, E.V., primary, Guseva, N.V., additional, Sun, Zh., additional, and Chen, G., additional
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- 2019
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14. NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/ mTOR phosphorylation
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Sun ZH, Li QH, Zhang S, Chen J, Huang LL, Ren JH, Chang Y, Liang YC, and Wu G
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lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 - Abstract
Zhihua Sun,2,* Qiuhui li,1,* Sheng Zhang,1 Jing Chen,1 Lili Huang,3 Jinghua Ren,1 Yu Chang,1 Yichen Liang,1 Gang Wu1 1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2Oncology department, Xiangyang central Hospital, Xiangyang, Hubei, People’s Republic of China; 3Radiation Oncology Department, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, People's Republic of China *These authors contributed equally to this work Background: Patients harboring activating mutations in epidermal growth factor receptors (EGFR) are particularly sensitive to EGFR tyrosine kinase inhibitors (TKIs). However, most patients develop an acquired resistance after a period of about 10 months. This study focuses on the therapeutic effect of NVP-BEZ235, a dual inhibitor of phosphatidylinositol- 3-kinase/mammalian target of rapamycin (PI3K/mTOR), in gefitinib-resistant non-small cell lung cancer. Methods: H1975 cell line was validated as a gefitinib-resistant cell model by the nucleotide-sequence analysis. We used the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to detect the growth of H1975 cell line in vitro. H1975 cells' migration was detected by the migration assay. Xenograft models were used to investigate the growth of gefitinib-resistant non-small cell lung cancer in vivo. Western blot and immunohistochemical analysis were used to investigate the level of PI3K/protein kinase B(AKT)/mTOR signaling pathway proteins. Results: We show that NVP-BEZ235 effectively inhibited the growth of H1975 cells in vivo as well as in vitro. Similarly, H1975 cell migration was reduced by NVP-BEZ235. Further experiments revealed that NVP-BEZ235 attenuated the phosphorylation of PI3K/AKT/mTOR signaling pathway proteins. Conclusion: Taken together, we suggest that NVP-BEZ235 inhibits gefitinib-resistant tumor growth by downregulating PI3K/AKT/mTOR phosphorylation. Keywords: gefitinib-acquired resistance, PI3K kinase, mTOR, NVP-BEZ235
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- 2015
15. Совместимость молибдена, вольфрама и нержавеющей стали 304 с жидким литием в высоком вакууме
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Meng, X., primary, Zuo, G., additional, Sun, Zh., additional, Xu, W., additional, Huang, M., additional, Xu, Ch., additional, Qian, Y., additional, Hu, W., additional, Hu, J. S., additional, and Deng, H. Q., additional
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- 2018
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16. NON-CARCINOGENIC HEALTH RISK ASSESSMENT OF FE AND AS IN DRINKING WATER: A CASE STUDY OF SHALLOW GROUNDWATER IN THE POYANG LAKE AREA, CHINA
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Soldatova, E. A., primary, Drebot, V. V., additional, Maier, S. E., additional, and Sun, Zh., additional
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- 2018
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17. THERMAL WATERS AS A STAGE OF GEOLOGICAL EVOLUTION OF WATER-ROCK SYSTEM, JIANGXI PROVINCE (CHINA)
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Zippa, E. V., primary, Shvartsev, S. L., additional, and Sun, Zh., additional
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- 2018
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18. CMS physics technical design report: Addendum on high density QCD with heavy ions RID B-1239-2012
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Chatrchyan S, Hmayakyan G, Sirunyan AM, Adam W, Bergauer T, Dragicevic M, Ero J, Friedl M, Fruehwirth R, Ghete V, Glaser P, Hrubec J, Jeitler M, Krammer M, Magrans I, Mikulec I, Noebauer T, Pernicka M, Rohringer H, Strauss J, Taurok A, Waltenberger W, Walzel G, Widl E, Chekhovsky V, Dvornikov O, Emeliantchik I, Litomin A, Marfin I, Mossolov V, Shumeiko N, Solin A, Stefanovitch R, Suarez Gonzalez J, Tikhonov A, Fedorov A, Korzhik M, Missevitch O, Zuyeuski R, D'Hondt J, De Weirdt S, Goorens R, Heyninck J, Lowette S, Tavernier S, Van Doninck W, Van Lancker L, Bouhali O, Clerbaux B, De Lentdecker G, Dewulf JP, Mahmoud T, Marage PE, Rugovac S, Sundararajan V, Vander Velde C, Vanlaer P, Wickens J, Assouak S, Bonnet JL, Bruno G, Caudron J, De Callatay B, De Favereau De Jeneret J, De Visscher S, Demin P, Favart D, Feltrin E, Forton E, Giammanco A, Gregoire G, Kalinin S, Kcira D, Keutgen T, Lemaitre V, Liu Y, Maltoni F, Michotte D, Militaru O, Ninane A, Ovyn S, Pierzchala T, Piotrzkowski K, Roberfroid V, Rouby X, Van der Aa O, Daubie E, Herquet P, Beaumont W, Cardaci M, De Langhe E, De Wolf EA, Rurua L, Van Mechelen P, Alves G, Souza MHG, Pol ME, Vaz M, Da Silva Di Calafiori DR, Meirelles Martinho D, Oguri V, Santoro A, Sznajder A, Vilela Pereira A, Gregores EM, Novaes SF, Anguelov G, Antchev G, Atanasov I, Damgov J, Darmenov N, Dimitrov L, Genchev V, Iaydjiev P, Panev B, Piperov S, Stoykova S, Sultanov G, Vankov I, Dimitrov A, Kozhuharov V, Litov L, Makariev M, Marinov A, Marinova E, Markov S, Mateev M, Pavlov B, Petkov P, Sabev C, Toteva Z, Verguilov V, Bai J, Chen GM, Chen HS, Guo YN, He KL, Jiang CH, Ke ZJ, Li B, Li J, Li WG, Liu HM, Qin G, Qiu JF, Shen XY, Sun G, Sun HS, Teng C, Wang YY, Xue Z, Yue X, Zhang SQ, Zhang Y, Zhao WR, Zhu GY, Zhuang HL, Ban Y, Cai J, Liu S, Qian SJ, Yang ZC, Ye YL, Ying J, Wu J, Zhang ZP, Carrillo Montoya CA, Godinovic N, Puljak I, Soric I, Antunovic Z, Dzelalija M, Marasovic K, Brigljevic V, Kadija K, Morovic S, Planinic M, Nicolaou C, Papadakis A, Ptochos F, Razis PA, Tsiakkouri D, Hektor A, Kadastik M, Kannike K, Lippmaa E, Muntel M, Raidal M, Aarnio PA, Czellar S, Heikkinen A, Harkonen J, Karimaki V, Kinnunen R, Lampen T, Lassila Perini K, Lehti S, Linden T, Luukka PR, Michal S, Maenpaa T, Nysten J, Tuominen E, Tuominiemi J, Wendland L, Polese G, Tuuva T, Guillaud JP, Nedelec P, Sillou D, Anfreville M, Bougamont E, Bredy P, Chipaux R, Dejardin M, Denegri D, Descamps J, Fabbro B, Faure JL, Ganjour S, Gentit FX, Givernaud A, Gras P, Hamel de Monchenault G, Jarry P, Kircher F, Lemaire MC, Levesy B, Locci E, Lottin JP, Mandjavidze I, Mur M, Pasquetto E, Payn A, Rander J, Reymond JM, Rondeaux F, Rosowsky A, Rousse JYA, Sun ZH, Verrecchia P, Baffioni S, Bercher M, Bernet C, Berthon U, Bimbot S, Bourotte J, Busson P, Busson M, Chamont D, Charlot C, Collard C, Decotigny D, Dobrzynski L, Gaillac AM, Geerebaert Y, Gilly J, Haguenauer M, Karar A, Mathieu A, Milleret G, Mine P, Paganini P, Romanteau T, Semeniouk I, Sirois Y, Agram JL, Andrea J, Berst JD, Bloch D, Brom JM, Didierjean F, Drouhin F, Fontaine JC, Goerlach U, Graehling P, Gross L, Houchu L, Juillot P, Lounis A, Maazouzi C, Mangeol D, Olivetto C, Todorov T, Van Hove P, Vintache D, Ageron M, Baulieu G, Bedjidian M, Blaha J, Bonnevaux A, Boudoul G, Chabanat E, Chabert EC, Combaret C, Contardo D, Della Negra R, Depasse P, Dupasquier T, El Mamouni H, Estre N, Fay J, Gascon S, Giraud N, Girerd C, Haroutunian R, Ianigro JC, Ille B, Lethuillier M, Lumb N, Mathez H, Maurelli G, Perries S, Ravat O, Verdier P, Roinishvili V, Adolphi R, Brauer R, Braunschweig W, Esser H, Feld L, Karpinski W, Klein K, Kukulies C, Olzem J, Ostapchuk A, Pandoulas D, Pierschel G, Raupach F, Schael S, Schwering G, Thomas M, Weber M, Wittmer B, Wlochal M, Adolf A, Biallass P, Bontenackels M, Erdmann M, Fesefeldt H, Hebbeker T, Hilgers G, Hoepfner K, Hof C, Kappler S, Kirsch M, Kreuzer P, Lanske D, Philipps B, Reithler H, Sowa M, Szczesny H, Teyssier D, Tsigenov O, Beissel F, Davids M, Duda M, Flugge G, Franke T, Giffels M, Hermanns T, Heydhausen D, Kasselmann S, Kaussen G, Kress T, Linn A, Nowack A, Poettgens M, Pooth O, Stahl A, Tornier D, Zoeller MH, Flossdorf A, Hegner B, Mnich J, Rosemann C, Bechtel F, Butz E, Flucke G, Holm U, Klanner R, Pein U, Schirm N, Schleper P, Steinbruck G, Stoye M, Van Staa R, Wick K, Blum P, Buege V, Cakir A, De Boer W, Dirkes G, Fahrer M, Feindt M, Felzmann U, Frey M, Furgeri A, Hartmann F, Heier S, Jung C, Ledermann B, Muller T, Niegel M, Oehler A, Ortega Gomez T, Piasecki C, Quast G, Rabbertz K, Sabellek A, Saout C, Scheurer A, Schieferdecker D, Schilling FP, Schmidt A, Simonis HJ, Theel A, Vest A, Wagner W, Weiser C, Weng J, Zhukov V, Anagnostou G, Barone M, Geralis T, Karafasoulis K, Koimas A, Kyriakis A, Kyriazopoulou S, Loukas D, Markou A, Markou C, Mavrommatis C, Theofilatos K, Vermisoglou G, Zachariadou A, Karapostoli G, Katsas P, Lebeau M, Panagiotou A, Papadimitropoulos C, Evangelou I, Kokkas P, Manthos N, Papadopoulos I, Triantis FA, Bencze G, Boldizsar L, Debreczeni G, Hajdu C, Horvath D, Krajczar K, Laszlo A, Odor G, Patay G, Sikler F, Toth N, Vesztergombi G, Zalan P, Molnar J, Beni N, Kapusi A, Marian G, Raics R, Szabo Z, Szillasi Z, Zilizi G, Bawa HS, Beri SB, Bhandari V, Bhatnagar V, Jindal P, Kaur M, Kaur R, Kohli JM, Kumar A, Singh JB, Bhattacharya S, Chatterji S, Chauhan S, Choudhary BC, Gupta P, Jha M, Ranjan K, Shivpuri RK, Srivastava AK, Borkar S, Choudhury RK, Datar V, Dixit M, Dutta D, Ghodgaonkar M, Kataria SK, Lalwani SK, Mishra V, Mohanty AK, Pant L, Suryanarayana S, Topkar A, Aziz T, Banerjee S, Bose S, Chendvankar S, Deshpande PV, Guchait M, Gurtu A, Maity M, Majumder G, Mazumdar K, Nayak A, Patil MR, Sharma S, Sudhakar K, Acharya BS, Bheesette S, Dugad S, Kalmani SD, Lakkireddi VR, Mondal NK, Panyam N, Verma P, Arabgol M, Arfaei H, Hashemi M, Mohammadi M, Mohammadi Najafabadi M, Moshaii A, Paktinat Mehdiabadi S, Felcini M, Grunewald M, Abbrescia M, Barbone L, Colaleo A, Creanza D, De Filippis N, De Palma M, Donvito G, Fiore L, Giordano D, Iaselli G, Loddo F, Maggi G, Maggi M, Manna N, Marangelli B, Mennea MS, My S, Natali S, Nuzzo S, Pugliese G, Radicci V, Ranieri A, Romano F, Selvaggi G, Silvestris L, Tempesta P, Trentadue R, Zito G, Abbiendi G, Bacchi W, Battilana C, Benvenuti A, Bonacorsi D, Braibant Giacomelli S, Capiluppi P, Castro A, Cavallo FR, Ciocca C, Codispoti G, D'Antone I, Dallavalle GM, Fabbri F, Fanfani A, Giacomelli P, Grandi C, Guerzoni M, Guiducci L, Marcellini S, Masetti G, Montanari A, Navarria F, Odorici F, Perrotta A, Rossi A, Rovelli T, Siroli G, Travaglini R, Albergo S, Bellini V, Chiorboli M, Costa S, Galanti M, Potenza R, Sutera C, Tricomi A, Tuve C, Ciraolo G, Ciulli V, Civinini C, D'Alessandro R, Focardi E, Genta C, Landi G, Lenzi P, Macchiolo A, Magini N, Manolescu F, Marchettini C, Masetti L, Mersi S, Meshini M, Paoletti S, Parrini G, Sani M, Sguazzoni G, Benussi L, Bertani M, Bianco S, Caponero M, Colonna D, La Monaca A, Pallotta M, Paolozzi A, Bozzo M, Fabbricatore P, Farinon S, Ferro F, Greco M, Cattaneo G, De Min A, Dominoni M, Farina FM, Ferri F, Ghezzi A, Govoni P, Leporini R, Magni S, Malberti M, Malvezzi S, Marelli S, Menasce D, Moroni L, Negri P, Paganoni M, Pedrini D, Pullia A, Ragazzi S, Redaelli N, Rovere M, Sala L, Sala S, Salerno R, Tabarelli de Fatis T, Vigano S, Comunale G, Fabozzi F, Lomidze D, Mele S, Paolucci P, Piccolo D, Sciacca C, Azzi P, Bacchetta N, Bellato M, Benettoni M, Bisello D, Borsato E, Candelori A, Checchia P, Conti E, Dal Corso F, De Mattia M, Dorigo T, Dosselli U, Drollinger V, Gasparini F, Gasparini U, Giubilato P, Gonella F, Kaminskiy A, Karaevskii S, Khomenkov V, Lacaprara S, Lippi I, Loreti M, Lytovchenko O, Mazzucato M, Meneguzzo AT, Michelotto M, Montecassiano F, Nigro M, Pantano D, Parenti A, Passaseo M, Pegoraro M, Rampazzo G, Ronchese P, Sgaravatto M, Torassa E, Vanini S, Ventura S, Verlato M, Zanetti M, Zotto P, Zumerle G, Belli G, Berzano U, De Vecchi C, Grelli A, Necchi MM, Ratti SP, Riccardi C, Sani G, Torre P, Vitulo P, Ambroglini F, Babucci E, Benedetti D, Biasini M, Bilei GM, Caponeri B, Checcucci B, Fano L, Giorgi M, Lariccia P, Mantovani G, Passeri D, Placidi P, Postolache V, Santocchia A, Servoli L, Spiga D, Tonoiu D, Azzurri P, Bagliesi G, Basti A, Benucci L, Bernardini J, Boccali T, Bocci A, Borrello L, Bosi F, CALZOLARI, FEDERICO, Carboni A, Castaldi R, Cerri C, Cucoanes AS, Dell'Orso R, Dutta S, Foa L, Gennai S, Giassi A, Kartashov D, Linari S, Lomtadze T, Lungu GA, Mangano B, Martinelli G, Massa M, Messineo A, Moggi A, Palla F, Palmonari F, Petrucciani G, Raffaelli F, Rizzi A, Sanguinetti G, Segneri G, Sentenac D, Serban AT, Slav A, Spagnolo P, Tenchini R, Tonelli G, Venturi A, Verdini PG, Vos M, Baccaro S, Barone L, Bartoloni A, Cavallari F, Costantini S, Dafinei I, Del Re D, Diemoz M, Gargiulo C, Longo E, Meridiani P, Organtini G, Palma A, Paramatti R, Rahatlou S, Rovelli C, Santanastasio F, Valente V, Arcidiacono R, 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- Subjects
High Energy Physics::Phenomenology ,High Energy Physics::Experiment ,Nuclear Experiment - Abstract
This report presents the capabilities of the CMS experiment to explore the rich heavy-ion physics programme offered by the CERN Large Hadron Collider (LHC). The collisions of lead nuclei at energies root(NN)-N-S = 5(5 TeV, will probe quark and gluon matter at unprecedented values of energy density. The prime goal of this research is to study the fundamental theory of the strong interaction - Quantum Chromodynamics (QCD) - in extreme conditions of temperature, density and parton momentum fraction (low-x). This report covers in detail the potential of CMS to carry out a series of representative Pb-Pb measurements. These include "bulk" observables, (charged hadron multiplicity, low p(T) inclusive hadron identified spectra and elliptic flow) which provide information on the collective properties of the system, as well as perturbative probes such as quarkonia, heavy-quarks, jets and high p(T) hadrons which yield "tomographic" information of the hottest and densest phases of the reaction.
- Published
- 2007
19. CMS physics technical design report, volume II: Physics performance RID A-6508-2010 RID H-5657-2011 RID G-1804-2011 RID A-6796-2008 RID G-1145-2010 RID D-8853-2011 RID F-3783-2010 RID E-8846-2011 RID A-4009-2011 RID A-3408-2011 RID A-5848-2010 RID D-2463-2009 RID C-8364-2011 RID D-6993-2011 RID C-9693-2010 RID G-3964-2010
- Author
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Bayatian GL, Chatrchyan S, Hmayakyan G, Sirunyan AM, Adam W, Bergauer T, Dragicevic M, Ero J, Friedl M, Fruehwirth R, Ghete V, Glaser P, Hrubec J, Jeitler M, Krammer M, Magrans I, Mikulec I, Mitaroff W, Noebauer T, Pernicka M, Porth P, Rohringer H, Strauss J, Taurok A, Waltenberger W, Walzel G, Widl E, Wulz CE, Fedorov A, Korzhik M, Missevitch O, Zuyeuski R, Chekhovsky V, Dvornikov O, Emeliantchik I, Litomin A, Mossolov V, Shumeiko N, Solin A, Stefanovitch R, Gonzalez JS, Tikhonov A, Petrov V, D'Hondt J, De Weirdt S, Goorens R, Heyninck J, Lowette S, Tavernier S, Van Doninck W, Van Lancker L, Bouhali O, Clerbaux B, De Lentdecker G, Dewulf JP, Mahmoud T, Marage PE, Neukermans L, Sundararajan V, Vander Velde C, Vanlaer P, Wickens J, Assouak S, Bonnet JL, Bruno G, Caudron J, De Callatay B, De Jeneret JD, De Visscher S, Delaere C, Demin P, Favart D, Feltrin E, Forton E, Gregoire G, Kalinin S, Kcira D, Keutgen T, Leibenguth G, Lemaitre V, Liu Y, Michotte D, Militaru O, Ninane A, Ovyn S, 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Vanini, S, Breedon, R, Case, M, Chertok, M, Conway, J, Cox, Pt, Erbacher, R, Gunion, J, Holbrook, B, Ko, W, Lander, R, Pellett, D, Smith, J, Soha, A, Tripathi, M, Vogt, R, Andreev, V, Arisaka, K, Cline, D, Cousins, R, Erhan, S, Felcini, M, Hauser, J, Ignatenko, M, Lisowski, B, Matlock, D, Matthey, C, Mohr, B, Mumford, J, Otwinowski, S, Rakness, G, Schlein, P, Shi, Y, Tucker, J, Valuev, V, Wallny, R, Wang, Hg, Yang, X, Zheng, Y, Clare, R, Fortin, D, Futyan, D, Gary, Jw, Giunta, M, Hanson, G, Jeng, Gy, Kao, Sc, Liu, H, Pasztor, G, Satpathy, A, Shen, Bc, Stringer, R, Sytnik, V, Wilken, R, Zer Zion, D, Branson, Jg, Dusinberre, E, Letts, J, Martin, T, Mojaver, M, Paar, Hp, Pi, H, Pieri, M, Rana, A, Sharma, V, White, A, Wurthwein, F, Affolder, A, Campagnari, C, Hill, C, Incandela, J, Kyre, S, Lamb, J, Richman, J, Stuart, D, White, D, Albert, J, Bornheim, A, Bunn, J, Chen, J, Denis, G, Galvez, P, Gataullin, M, Legrand, I, Litvine, V, Ma, Y, Nae, D, Newman, Hb, Ravot, S, Shevchenko, S, Singh, S, Steenberg, C, Su, X, Timciuc, V, van Lingen, F, Veverka, J, Voicu, Br, Weinstein, A, Wilkinson, R, Yang, Y, Zhang, Ly, Zhu, K, Zhu, Ry, Ferguson, T, Paulini, M, Russ, J, Terentyev, N, Vogel, H, Vorobiev, I, Cumalat, Jp, Ford, Wt, Johnson, D, Nauenberg, U, Stenson, K, Wagner, Sr, Alexander, J, Cassel, D, Ecklund, K, Heltsley, B, Jones, Cd, Kuznetsov, V, Patterson, Jr, Ryd, A, Thom, J, Wittich, P, Beetz, Cp, Cirino, G, Podrasky, V, Sanzeni, C, Winn, D, Abdullin, S, Afaq, Ma, Albrow, M, Amundson, J, Apollinari, G, Atac, M, Badgett, W, Bakken, Ja, Baldin, B, Bauerdick, Lat, Baumbaugh, A, Baur, U, Bhat, Pc, Borcherding, F, Burkett, K, Butler, Jn, Cheung, H, Churin, I, Cihangir, S, Demarteau, M, Eartly, Dp, Elias, Je, Elvira, Vd, Fisk, I, Freeman, J, Gartung, P, Geurts, Fjm, Glenzinski, Da, Gottschalk, E, Graham, G, Green, D, Guglielmo, Gm, Guo, Y, Gutsche, O, Hahn, A, Hanlon, J, Hansen, S, Harris, Rm, Hesselroth, T, Holm, Sl, Holzman, B, Iqbal, S, James, E, Johnson, M, Joshi, U, Klima, B, Kowalkowski, J, Kramer, T, Kwan, S, La Vallie, E, Larwill, M, Los, S, Lueking, L, Lukhanin, G, Lusin, S, Maeshima, K, Mcbride, P, Murray, Sj, O'Dell, V, Paterno, M, Patrick, J, Petravick, D, Pordes, R, Prokofyev, O, Rasmislovich, V, Ratnikova, N, Ronzhin, A, Sekhri, V, Sexton Kennedy, E, Shaw, T, Skow, D, Smith, Rp, Spalding, Wj, Spiegel, L, Stavrianakou, M, Stiehr, G, Suzuki, I, Tan, P, Tanenbaum, W, Tkaczyk, S, Veseli, S, Vidal, R, Wenzel, H, Whitmore, J, Womersley, Wj, Wu, Wm, Wu, Y, Yagil, A, Yarba, J, Yun, Jc, Acosta, D, Avery, P, Barashko, V, Bartalini, P, Bourilkov, D, Cavanaugh, R, Drozdetskiy, A, Field, Rd, Fu, Y, Gray, L, Holmes, D, Kim, Bj, Klimenko, S, Konigsberg, J, Korytov, A, Kotov, K, Levchenko, P, Madorsky, A, Matchev, K, Mitselmakher, G, Pakhotin, Y, Prescott, C, Ramond, P, Rodriguez, Jl, Schmitt, M, Scurlock, B, Stoeck, H, Yelton, J, Boeglin, W, Gaultney, V, Kramer, L, Linn, S, Markowitz, P, Martinez, G, Raue, B, Reinhold, J, Askew, A, Bertoldi, M, Dharmaratna, Wgd, Gershtein, Y, Hagopian, S, Hagopian, V, Jenkins, M, Johnson, Kf, Prosper, H, Wahl, H, Baarmand, M, Baksay, L, Guragain, S, Hohlmann, M, Mermerkaya, H, Ralich, R, Vodopiyanov, I, Adams, Mr, Betts, Rr, Gerber, Ce, Shabalina, E, Smith, C, Ten, T, Akgun, U, Ayan, A, Cooper, A, Debbins, P, Duru, F, Fountain, M, George, N, Mccliment, E, Merlo, Jp, Mestvirishvili, A, Miller, Mj, Newsom, Cr, Norbeck, E, Onel, Y, Schmidt, I, Wang, S, Anderson, Ew, Atramentov, O, Hauptman, Jm, Lamsa, J, Barnett, Ba, Blumenfeld, B, Chien, Cy, Kim, Dw, Maksimovic, P, Spangler, S, Swartz, M, Baringer, P, Bean, A, Coppage, D, Grachov, O, Kim, Ej, Murray, M, Bandurin, D, Bolton, T, Khanov, A, Maravin, Y, Onoprienko, D, Rizatdinova, F, Sidwell, R, Stanton, N, Von Toerne, E, Baden, D, Bard, R, Eno, Sc, Grassi, T, Hadley, Nj, Kellogg, Rg, Kunori, S, Ratnikov, F, Skuja, A, Arcidiacono, R, Ballintijn, M, Bauer, G, Harris, P, Kravchenko, I, Loizides, C, Nahn, S, Paus, C, Pavlon, S, Roland, C, Roland, G, Sumorok, K, Vaurynovich, S, Veres, G, Wyslouch, B, Bailleux, D, Corum, S, Cushman, P, De Benedetti, A, Dolgopolov, A, Egeland, R, Franzoni, G, Gilbert, Wj, Grahl, J, Haupt, J, Kubota, Y, Mans, J, Pearson, N, Rusack, R, Singovsky, A, Cremaldi, Lm, Godang, R, Kroeger, R, Sanders, Da, Summers, D, Bloom, K, Claes, Dr, Dominguez, A, Eads, M, Lundstedt, C, Malik, S, Snow, Gr, Sobol, A, Iashvili, I, Kharchilava, A, Alverson, G, Barberis, E, Boeriu, O, Eulisse, G, Musienko, Y, Muzaffar, S, Osborne, I, Reucroft, S, Swain, J, Taylor, L, Tuura, L, Wood, D, Gobbi, B, Kubantsev, M, Schellman, H, Spencer, E, Velasco, M, Baumbaugh, B, Cason, Nm, Hildreth, M, Karmgard, Dj, Marinelli, N, Ruchti, R, Warchol, J, Wayne, M, Bylsma, B, Durkin, L, Gilmore, J, Gu, J, Herman, D, Killewald, P, Knobbe, K, Ling, Ty, Elmer, P, Marlow, D, Piroue, P, Stickland, D, Tully, C, Wildish, T, Wynhoff, S, Xie, Z, Apresyan, A, Arndt, K, Banicz, K, Barnes, Ve, Bolla, G, Bortoletto, D, Bujak, A, Garfinkel, Af, Lopez, Og, Gutay, L, Ippolito, N, Kozhevnikov, Y, Laasanen, At, Liu, C, Maroussov, V, Merkel, P, Miller, Dh, Miyamoto, J, Neumeister, N, Rott, C, Roy, A, Sedov, A, Shipsey, I, Parashar, N, Eppley, G, Lee, Sj, Liu, J, Matveev, M, Nussbaum, T, Padley, Bp, Roberts, J, Tumanov, A, Yepes, P, Bodek, A, Budd, H, Chung, Y, De Barbaro, P, Demina, R, Eusebi, R, Ginther, G, Gotra, Y, Hocker, A, Husemann, U, Korjenevski, S, Sakumoto, W, Slattery, P, Tipton, P, Zielinski, M, Bartz, E, Doroshenko, J, Halkiadakis, E, Jacques, Pf, Kalelkar, M, Khits, D, Lath, A, Macpherson, A, Perera, L, Plano, R, Rose, K, Schnetzer, S, Somalwar, S, Stone, R, Thomson, G, Watts, Tl, Akchurin, N, Carrell, Kw, Gumus, K, Jeong, C, Kim, H, Papadimitriou, V, Sill, A, Spezziga, M, Washington, E, Wigmans, R, Zhang, L, Bapty, T, Engh, D, Johns, W, Keskinpala, T, Lopez, El, Neema, S, Nordstrom, S, Pathak, S, Sheldon, P, Vaandering, Ew, Webster, M, Arenton, Mw, Conetti, S, Cox, B, Hirosky, R, Imlay, R, Ledovskoy, A, Phillips, D, Powell, H, Ronquest, M, Smith, D, Baek, Yw, Bellinger, Jn, Bradley, D, Carlsmith, D, Crotty, I, Dasu, S, Feyzi, F, Gorski, T, Grothe, M, Hogg, W, Jaworski, M, Klabbers, P, Lanaro, A, Loveless, R, de Abril, Mm, Reeder, D, Smith, Wh, Wenman, D, Atoyan, G, Dhawan, S, Issakov, V, Neal, H, Poblaguev, A, Zeller, Me, and Yuldashev, Bs
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High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
CMS is a general purpose experiment, designed to study the physics of pp collisions at 14 TeV at the Large Hadron Collider ( LHC). It currently involves more than 2000 physicists from more than 150 institutes and 37 countries. The LHC will provide extraordinary opportunities for particle physics based on its unprecedented collision energy and luminosity when it begins operation in 2007. The principal aim of this report is to present the strategy of CMS to explore the rich physics programme offered by the LHC. This volume demonstrates the physics capability of the CMS experiment. The prime goals of CMS are to explore physics at the TeV scale and to study the mechanism of electroweak symmetry breaking - through the discovery of the Higgs particle or otherwise. To carry out this task, CMS must be prepared to search for new particles, such as the Higgs boson or supersymmetric partners of the Standard Model particles, from the start- up of the LHC since new physics at the TeV scale may manifest itself with modest data samples of the order of a few fb(-1) or less. The analysis tools that have been developed are applied to study in great detail and with all the methodology of performing an analysis on CMS data specific benchmark processes upon which to gauge the performance of CMS. These processes cover several Higgs boson decay channels, the production and decay of new particles such as Z' and supersymmetric particles, B(s) production and processes in heavy ion collisions. The simulation of these benchmark processes includes subtle effects such as possible detector miscalibration and misalignment. Besides these benchmark processes, the physics reach of CMS is studied for a large number of signatures arising in the Standard Model and also in theories beyond the Standard Model for integrated luminosities ranging from 1 fb(-1) to 30 fb(-1). The Standard Model processes include QCD, B-physics, diffraction, detailed studies of the top quark properties, and electroweak physics topics such as the W and Z(0) boson properties. The production and decay of the Higgs particle is studied for many observable decays, and the precision with which the Higgs boson properties can be derived is determined. About ten different supersymmetry benchmark points are analysed using full simulation. The CMS discovery reach is evaluated in the SUSY parameter space covering a large variety of decay signatures. Furthermore, the discovery reach for a plethora of alternative models for new physics is explored, notably extra dimensions, new vector boson high mass states, little Higgs models, technicolour and others. Methods to discriminate between models have been investigated. This report is organized as follows. Chapter 1, the Introduction, describes the context of this document. Chapters 2-6 describe examples of full analyses, with photons, electrons, muons, jets, missing E(T), B-mesons and tau's, and for quarkonia in heavy ion collisions. Chapters 7-15 describe the physics reach for Standard Model processes, Higgs discovery and searches for new physics beyond the Standard Model.
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- 2007
20. Rural road extraction from high resolution remote sensing image
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Sun, Zh., primary, Meng, Q., additional, Miao, Z., additional, Gu, X., additional, Zhan, Y., additional, and Yang, J., additional
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- 2015
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21. AMS02 Tracker Thermal Control System overview and spin-off for future spacecraft cooling system developments
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Es, J. van, Pauw, A., Zwartbol, T., He Sun, Zh., Es, J. van, Pauw, A., Zwartbol, T., and He Sun, Zh.
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- 2009
22. Concurrent multi-scale modelling of civil infrastructures for analyses on structural deterioration - Part II: Modelling updating and verification
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Chan, Tommy, Li, Zhaoxia, Yu, Y, Sun, ZH, Chan, Tommy, Li, Zhaoxia, Yu, Y, and Sun, ZH
- Abstract
This paper is a continuation of the paper titled “Concurrent multi-scale modeling of civil infrastructure for analyses on structural deteriorating—Part I: Modeling methodology and strategy” with the emphasis on model updating and verification for the developed concurrent multi-scale model. The sensitivity-based parameter updating method was applied and some important issues such as selection of reference data and model parameters, and model updating procedures on the multi-scale model were investigated based on the sensitivity analysis of the selected model parameters. The experimental modal data as well as static response in terms of component nominal stresses and hot-spot stresses at the concerned locations were used for dynamic response- and static response-oriented model updating, respectively. The updated multi-scale model was further verified to act as the baseline model which is assumed to be finite-element model closest to the real situation of the structure available for the subsequent arbitrary numerical simulation. The comparison of dynamic and static responses between the calculated results by the final model and measured data indicated the updating and verification methods applied in this paper are reliable and accurate for the multi-scale model of frame-like structure. The general procedures of multi-scale model updating and verification were finally proposed for nonlinear physical-based modeling of large civil infrastructure, and it was applied to the model verification of a long-span bridge as an actual engineering practice of the proposed procedures.
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- 2009
23. Concurrent multi-scale modelling of civil infrastructures for analyses on structural deterioration - Part 1: modelling methodology and strategy
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Li, Zhaoxia, Chan, Tommy, Yu, Y, Sun, ZH, Li, Zhaoxia, Chan, Tommy, Yu, Y, and Sun, ZH
- Abstract
This paper aims to develop the methodology and strategy for concurrent finite element modeling of civil infrastructures at the different scale levels for the purposes of analyses of structural deteriorating. The modeling strategy and method were investigated to develop the concurrent multi-scale model of structural behavior (CMSM-of-SB) in which the global structural behavior and nonlinear damage features of local details in a large complicated structure could be concurrently analyzed in order to meet the needs of structural-state evaluation as well as structural deteriorating. In the proposed method, the “large-scale” modeling is adopted for the global structure with linear responses between stress and strain and the “small-scale” modeling is available for nonlinear damage analyses of the local welded details. A longitudinal truss in steel bridge decks was selected as a case to study how a CMSM-of-SB was developed. The reduced-scale specimen of the longitudinal truss was studied in the laboratory to measure its dynamic and static behavior in global truss and local welded details, while the multi-scale models using constraint equations and substructuring were developed for numerical simulation. The comparison of dynamic and static response between the calculated results by different models indicated that the proposed multi-scale model was found to be the most efficient and accurate. The verification of the model with results from the tested truss under the specific loading showed that, responses at the material scale in the vicinity of local details as well as structural global behaviors could be obtained and fit well with the measured results. The proposed concurrent multi-scale modeling strategy and implementation procedures were applied to Runyang cable-stayed bridge (RYCB) and the CMSM-of-SB of the bridge deck system was accordingly constructed as a practical application.
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- 2009
24. Concurrent Multi-scale Modeling of Structures and Damage Analyses (in Chinese)
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Li, ZX, Sun, ZH, Guo, L, Chan, Tommy, Yu, Y, Li, ZX, Sun, ZH, Guo, L, Chan, Tommy, and Yu, Y
- Abstract
The methodology and strategy for concurrent multi-scale modeling of large structures such as long span bridges were studied in order to perform the multi-scale numerical analysis on structural, dynamic response and local damage. The multi-scale finite element modeling was first studied by using substructure method and the multi-point constraints. A multi-scale model of Tsing Ma Bridge (TMB) was then developed by using the design drawings and the proposed strategy on the basis of the software ABAQUS and the developed programs via the user interface. The model updating and verification were carried out based on the online data from the structural health monitoring system installed on TMB. The procedure for damage analysis using the developed model was proposed, in which locally deteriorating process at welded details of interconnects is able to account for the major effect of the damage and nonlinear influence on structural response. The calculated result shows that damage features can be successfully performed via multi-scale modeling and analysis; and fatigue damage accumulation on the weld details shows significantly local effect. The fatigue life obtained from the fully coupled calculation on stress and damage is shorter than that from the uncouple computation, which suggests that the significant interaction between the damage and the structural response should be considered in the structural damage analyses using the multi-scale numerical analysis
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- 2007
25. Optimal Configuration of Ambient Vibration Sensors Based on Structural Modeling for Long Cable-Stayed Bridge' (in Chinese)
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Sun, ZH, Li, ZX, Chan, Tommy, Han, XL, Sun, ZH, Li, ZX, Chan, Tommy, and Han, XL
- Abstract
This paper studies the finite element (FE) modeling oriented to structural health monitoring (SHM) of long cable-stayed bridge and the optimal sensor configuration based on the structural dynamic response. Firstly , the FE model oriented SHMof Runyang Cable-Stayed Bridge (RYCB) is developed using ANSYS. Modal analysis of RYCB is carried out using the developed FE model . Taking the non-diagonal elements of the MAC matrix as target function , and increasing or decreasing the number of degree of freedom (DOF) , the optimal sensor placement of the bridge is obtained by minimizing the target function. Validation of the sensor placement is checked with the results obtained from the ambient vibration test of RYCB. It is shown that the sensor placement obtained from the measured data of RYCB is coincident with the result calculated from the FE model . The sensor placement obtained from the FE model of RYCB is valid from the experimental point of view.
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- 2007
26. Simulation on Structural Response by Finite Element Model Dealing with Local Details (in Chinese)
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Sun, ZH, Li, ZX, Chan, Tommy, Yin, AG, Sun, ZH, Li, ZX, Chan, Tommy, and Yin, AG
- Abstract
This paper studies how to develop the multi2scale FE models in which the feature of local detailed such as the stress concentration on the welded components can be considered and to make the simulation on the structural response as well as local stress on hot-spots . Therefore , the multi-scale FE model including welded components of the longitudinal fortified truss of bridge steel box girder is developed based on substructure and coupling equations respectively , then modal and static analysis are carried out by using the developed FE model in this paper. The results of the dynamic properties and stresses calculated by the multi-scale FE model are compared with those from the experiment and those calculated by traditional FE models , which suggests that the developed multi-scale FE model of the studied truss based on substructure would be valid in the analyses on both structural and local hotspot behavior. The proposed approach for FE modeling can be used to develop the multi-scale models of long-span bridges as the basic model of the structure in the further nonlinear static simulation such as the hot spot stress analysis.
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- 2007
27. Real Urban Traffic Flow Chaotic Phase Space Study
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Zhang, L.D., primary, Wang, Y. L., additional, Sun, Zh. Q., additional, and Pan, J.Sh., additional
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- 2008
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28. FORMATION OF HOLLOW CAVITIES ON {100} FACES OF LAP CRYSTALS INVESTIGATED BY AFM
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GENG, Y. L., primary, SUN, ZH. H., additional, and XU, D., additional
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- 2007
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29. Insecticidal activities of secondary metabolites of endophytic Pencillium sp. in Derris elliptica Benth
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Hu, M. Y., primary, Zhong, G. H., additional, Sun, Zh. T., additional, Sh, G, additional, Liu, H. M., additional, and Liu, X. Q., additional
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- 2005
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30. Repeated intrathecal administration of ropivacaine causes neurotoxicity in rats.
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Sun Zh, Xu X, Song Z, Zhang Z, Wang N, Guo Q, Sun, Z H, Xu, X P, Song, Z B, Zhang, Z, Wang, N, and Guo, Q L
- Abstract
Previous studies have shown that ropivacaine is the least neurotoxic local anaesthetic. Most of the data derive from short-term ropivacaine injection into the subarachnoid space. Intrathecal administration for a prolonged period, and the histological changes and behavioural effects of repeated intrathecal administration, have not previously been investigated. We studied the possible neurotoxicity of intrathecal injection of ropivacaine in a rat model. Rats received 0.12 ml/kg body weight of ropivacaine at concentrations of 0.5 or 1%, or normal saline only, via an implanted intrathecal catheter at 90-minute intervals for 12 hours. On days 1, 3, 5, 7, 14 and 28, the spinal cord was examined by light and electron microscopy at the L3 level. We assessed sensory thresholds to noxious stimulation, behavioural change and protein kinase B immunoreactivity for possible neuronal injury within the spinal cord. Ropivacaine 1% induced thermal hyperalgesia and mechanical allodynia, neuronal injury characterised by tissue oedema, proliferation of glial cells, neuronal morphology changes and degeneration and protein kinase B expression. There were no significant differences in motor function as a result of different concentrations of ropivacaine. Repeated intrathecal injection of ropivacaine 1% can induce neurotoxicity in rats. Our data suggests that expression of protein kinase B might be involved in this neurotoxicity. [ABSTRACT FROM AUTHOR]
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- 2012
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31. Influence of consumption of probiotics on the plasma lipid profile: A meta-analysis of randomised controlled trials.
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Guo Z, Liu XM, Zhang QX, Shen Z, Tian FW, Zhang H, Sun ZH, Zhang HP, and Chen W
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- 2011
32. Variations in online self-regulated learning abilities among Chinese K-12 teachers across different regions and levels.
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Zhao Y, Li Y, Sun ZH, Jiang Q, and Zhao S
- Abstract
Introduction: Online self-regulated learning (OSRL) is crucial for online learners' success and lifelong learning. This study investigated the OSRL characteristics of K-12 teachers in China, who embody the dual roles of learners and educators. It also analyzed the differences in OSRL abilities across different genders, education stages, and school locations, and examined the correlation between education qualifications, years of service, and OSRL abilities., Methods: A self-report measure was used to assess K-12 teachers' OSRL, with data collected from 1,443 K-12 teachers (394 males and 1,049 females) in northeastern China. Descriptive statistical analysis was utilized to explore the characteristics of their OSRL. Independent t -tests and ANOVA were employed to investigate differences in OSRL among different genders, regions, and educational stages. Correlation analysis was conducted to examine the relationships between education qualifications, years of service, and OSRL among K-12 teachers., Results: The data analysis revealed that K-12 teachers scored the lowest in Online Learning Self-Efficacy (OLSE), followed by Online Learning Management Strategies (OLMS), and then Online Learning Resource Management (OLRM). Notably, urban K-12 teachers exhibited higher OLSE abilities than their rural counterparts, while high school teachers scored higher in OLSE and OLMS compared to primary school teachers. Furthermore, a positive correlation was observed between education qualifications and K-12 teachers' OLSE, whereas a negative correlation was identified between years of service and K-12 teachers' OLSE., Conclusion: The findings reveal an uneven development across various dimensions of online self-regulated learning among K-12 teachers, necessitating support for the advancement of OLSE, OLMS, and OLRM. Particular attention should be given to the OLSE of teachers with longer teaching years and rural teachers. Encouraging K-12 teachers with lower education qualifications to pursue further education is also recommended. This study provides evidence and a novel perspective for teacher educators to develop online professional development programs, which is significant for optimizing online learning experiences and enhancing educational outcomes., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhao, Li, Sun, Jiang and Zhao.)
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- 2024
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33. Preoperative localization for pulmonary nodules: a meta-analysis of coil and liquid materials.
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Sun ZH, Cheng H, Su J, and Sun QL
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- Humans, Preoperative Care methods, Solitary Pulmonary Nodule surgery, Solitary Pulmonary Nodule diagnostic imaging, Lung Neoplasms surgery, Multiple Pulmonary Nodules surgery, Multiple Pulmonary Nodules diagnostic imaging, Thoracic Surgery, Video-Assisted methods, Tomography, X-Ray Computed
- Abstract
Purpose: This study was designed to conduct pooled comparisons of the relative clinical efficacy and safety of computed tomography (CT)-guided localization for pulmonary nodules (PNs) using either coil- or liquid material-based approaches., Material and Methods: Relevant articles published as of July 2023 were identified in the Web of Science, PubMed, and Wanfang databases, and pooled analyses of relevant endpoints were then conducted., Results: Six articles that enrolled 287 patients (341 PNs) and 247 patients (301 PNs) that had respectively undergone CT-guided localization procedures using coil- and liquid material-based approaches prior to video-assisted thoracic surgery (VATS) were included in this meta-analysis. The liquid material group exhibited a significantly higher pooled successful localization rate as compared to the coil group ( p = 0.01), together with significantly lower pooled total complication rates ( p = 0.0008) and pneumothorax rates ( p = 0.01). Both groups exhibited similar rates of pulmonary hemorrhage ( p = 0.44) and successful wedge resection ( p = 0.26). Liquid-based localization was also associated with significant reductions in pooled localization and VATS procedure durations ( p = 0.004 and 0.007)., Conclusions: These data are consistent with CT-guided localization procedures performed using liquid materials being safer and more efficacious than coil-based localization in patients with PNs prior to VATS resection.
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- 2024
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34. Aurantiamide mitigates acute kidney injury by suppressing renal necroptosis and inflammation via GRPR-dependent mechanism.
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He RB, Li W, Yao R, Xu MY, Dong W, Chen Y, Ni WJ, Xie SS, Sun ZH, Li C, Liu D, Li SJ, Ji ML, Ru YX, Zhao T, Zhu Q, Wen JG, Li J, Jin J, Yao RS, and Meng XM
- Subjects
- Animals, Humans, Mice, Male, Cell Line, Inflammation drug therapy, Disease Models, Animal, Kidney pathology, Kidney drug effects, Kidney metabolism, Reperfusion Injury drug therapy, Reperfusion Injury metabolism, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Acute Kidney Injury drug therapy, Acute Kidney Injury pathology, Necroptosis drug effects, Mice, Inbred C57BL, Mice, Knockout, Receptors, Bombesin metabolism, Receptors, Bombesin antagonists & inhibitors
- Abstract
Acute kidney injury (AKI) manifests as a clinical syndrome characterised by the rapid accumulation of metabolic wastes, such as blood creatinine and urea nitrogen, leading to a sudden decline in renal function. Currently, there is a lack of specific therapeutic drugs for AKI. Previously, we identified gastrin-releasing peptide receptor (GRPR) as a pathogenic factor in AKI. In this study, we investigated the therapeutic potential of a novel Chinese medicine monomer, aurantiamide (AA), which exhibits structural similarities to our previously reported GRPR antagonist, RH-1402. We compared the therapeutic efficacy of AA with RH-1402 both in vitro and in vivo using various AKI models. Our results demonstrated that, in vitro, AA attenuated injury, necroptosis, and inflammatory responses in human renal tubular epithelial cells subjected to repeated hypoxia/reoxygenation and lipopolysaccharide stimulation. In vivo, AA ameliorated renal tubular injury and inflammation in mouse models of ischemia/reperfusion and cecum ligation puncture-induced AKI, surpassing the efficacy of RH-1402. Furthermore, molecular docking and cellular thermal shift assay confirmed GRPR as a direct target of AA, which was further validated in primary cells. Notably, in GRPR-silenced HK-2 cells and GRPR systemic knockout mice, AA failed to mitigate renal inflammation and injury, underscoring the importance of GRPR in AA's mechanism of action. In conclusion, our study has demonstrated that AA serve as a novel antagonist of GRPR and a promising clinical candidate for AKI treatment., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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35. A preliminary study of renal function for renal artery stenosis using multiparametric magnetic resonance imaging.
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Zhao L, Tong XY, Ning ZH, Wang GQ, Xu FB, Liu JY, Li S, Zhang N, Sun ZH, Zhao XH, and Xu L
- Abstract
Objective: To comprehensively evaluate the renal structure and function of patients with renal artery stenosis (RAS) using multiparametric magnetic resonance imaging (MRI), and analyze the correlation between magnetic resonance (MR) parameters and renal function., Materials and Methods: Renal multiparametric MRI was conducted on 62 patients with RAS utilizing a Philips Ingenia CX 3.0 T MRI system. The scanning protocols encompassed arterial spin labeling, phase contrast MRI, diffusion weighted imaging, T1 mapping, and blood oxygen level-dependent MRI. All patients underwent radionuclide renal dynamic imaging to calculate the glomerular filtration rate (GFR) for assessing renal function., Results: Most MR parameters were correlated with GFR: renal parenchymal volume (R = 0.603), whole kidney renal blood flow (RBF) (R = 0.192), renal cortical RBF (R = 0.294), renal artery mean velocity (R = 0.593), stroke volume (R = 0.599), mean flux (R = 0.629), renal cortical apparent diffusion coefficient (ADC) (R = 0.466), medullary ADC (R = 0.332), cortical T1 value (R = - 0.206), corticomedullary T1 difference (R = 0.204), cortical T2
* value (R = 0.448), and medullary T2* value (R = 0.272). The best prediction model for GFR using multiparametric MRI was obtained, including renal PV, whole kidney RBF, cortical RBF, mean velocity, mean flux, and CMD T1., Conclusion: Multiparametric MRI is a novel noninvasive examination method that can effectively and comprehensively assess the renal structure and function of RAS., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)- Published
- 2024
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36. Individualized dosing parameters for tacrolimus in the presence of voriconazole: a real-world PopPK study.
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Zhao YC, Sun ZH, Li JK, Liu HY, Zhang BK, Xie XB, Fang CH, Sandaradura I, Peng FH, and Yan M
- Abstract
Objectives: Significant increase in tacrolimus exposure was observed during co-administration with voriconazole, and no population pharmacokinetic model exists for tacrolimus in renal transplant recipients receiving voriconazole. To achieve target tacrolimus concentrations, an optimal dosage regimen is required. This study aims to develop individualized dosing parameters through population pharmacokinetic analysis and simulate tacrolimus concentrations under different dosage regimens., Methods: We conducted a retrospective study of renal transplant recipients who were hospitalized at the Second Xiangya Hospital of Central South University between January 2016 and March 2021. Subsequently, pharmacokinetic analysis and Monte Carlo simulation were employed for further analysis., Results: Nineteen eligible patients receiving tacrolimus and voriconazole co-therapy were included in the study. We collected 167 blood samples and developed a one-compartment model with first-order absorption and elimination to describe the pharmacokinetic properties of tacrolimus. The final typical values for tacrolimus elimination rate constant (Ka), apparent volume of distribution (V/F), and apparent oral clearance (CL/F) were 8.39 h
-1 , 2690 L, and 42.87 L/h, respectively. Key covariates in the final model included voriconazole concentration and serum creatinine. Patients with higher voriconazole concentration had lower tacrolimus CL/F and V/F. In addition, higher serum creatinine levels were associated with lower tacrolimus CL/F., Conclusion: Our findings suggest that clinicians can predict tacrolimus concentration and estimate optimal tacrolimus dosage based on voriconazole concentration and serum creatinine. The effect of voriconazole concentration on tacrolimus concentration was more significant than serum creatinine. These findings may inform clinical decision-making in the management of tacrolimus and voriconazole therapy in solid organ transplant recipients., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhao, Sun, Li, Liu, Zhang, Xie, Fang, Sandaradura, Peng and Yan.)- Published
- 2024
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37. Talaesthanes A-C, three new meroterpenoids from the endophytic fungus Talaromyces primulinus H21.
- Author
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Chen JQ, Li S, Fan RZ, Sun ZH, Zhu XY, Yin AP, Tang GH, and Yin S
- Subjects
- Mice, Molecular Structure, Animals, RAW 264.7 Cells, Endophytes chemistry, China, Talaromyces chemistry, Nitric Oxide metabolism, Terpenes isolation & purification, Terpenes pharmacology
- Abstract
Three new meroterpenoids (1-3) and ten known ones (4-13) were obtained from the endophytic fungus Talaromyces primulinus H21 isolated from the plant of Euphorbia sikkimensis. Their structures including their absolute configurations were elucidated by extensive analysis of spectroscopic data such as HR-ESI-MS, 1D/2D NMR, and X-ray diffraction of single crystal together with comparison of experimental ECD with calculated ECD. All compounds were examined for their inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 cells, and compounds 3, 9, 12, and 13 exhibited certain inhibition on NO production, with IC
50 values of 27.19, 41.55, 25.23, and 24.71 μM, respectively., Competing Interests: Declaration of competing interest The authors declare that there are no competing interests associated with this work., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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38. Factors affecting the effectiveness and safety of polymyxin B in the treatment of Gram-negative bacterial infections: A meta-analysis of 96 articles.
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Zhao YC, Wang CY, Liu JY, Li JK, Liu HY, Sun ZH, Zhang BK, and Yan M
- Subjects
- Humans, Gram-Negative Bacteria drug effects, Treatment Outcome, Survival Analysis, Polymyxin B therapeutic use, Polymyxin B adverse effects, Polymyxin B administration & dosage, Gram-Negative Bacterial Infections drug therapy, Gram-Negative Bacterial Infections mortality, Gram-Negative Bacterial Infections microbiology, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents adverse effects
- Abstract
Purpose: Polymyxin B, with its unique structure and mechanism of action, has emerged as a key therapeutic agent against Gram-negative bacteria. The study aims to explore potential factors to influence its effectiveness and safety., Methods: A model-based meta-analysis of 96 articles was conducted, focusing on factors like dosage, bacterial species, and combined antibiotic therapy. The analysis evaluated mortality rates and incidence rate of renal dysfunction, also employing parametric survival models to assess 30-d survival rates., Results: In the study involving 96 articles and 9716 patients, polymyxin B's daily dose showed minimal effect on overall mortality, with high-dose group mortality at 33.57% (95% confidence intervals [CI]: 29.15-38.00) compared to the low-dose group at 35.44% (95% CI: 28.99-41.88), P = 0.64. Mortality significantly varied by bacterial species, with Pseudomonas aeruginosa infections at 58.50% (95% CI: 55.42-63.58). Monotherapy exhibited the highest mortality at 40.25% (95% CI: 34.75-45.76), P < 0.01. Renal dysfunction was more common in high-dose patients at 29.75% (95% CI: 28.52-30.98), with no significant difference across antibiotic regimens, P = 0.54. The 30-d overall survival rate for monotherapy therapy was 63.6% (95% CI: 59.3-67.5) and 70.2% (95% CI: 64.4-76.2) for association therapy with β-lactam drugs., Conclusions: The dosage of polymyxin B does not significantly change death rates, but its effectiveness varies based on the bacterial infection. Certain bacteria like P. aeruginosa are associated with higher mortality. Combining polymyxin B with other antibiotics, especially β-lactam drugs, improves survival rates. Side effects depend on the dose, with lower doses being safer. These findings emphasize the importance of customizing treatment to balance effectiveness and safety., (Copyright © 2024. Published by Elsevier Ltd.)
- Published
- 2024
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39. High-entropy selenides derived from Prussian blue analogues as electrode materials for sodium-ion batteries.
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Wei C, Li C, Qu D, Liao B, Han D, Sun ZH, and Niu L
- Abstract
Transition metal selenides (TMS) have received much attention as anode materials for sodium-ion batteries (SIBs) because of their high theoretical capacity and excellent redox reversibility. However, their further development is constrained by the dissolution of transition metal ions and substantial volume changes experienced during cycling. Herein, the high-entropy Prussian blue analogues were selenized by the vapor infiltration method, resulting in the formation of a core-shell structured high-entropy selenides (HESe-6). The core-shell structure with voids and abundant selenium vacancies on the surface effectively mitigates bulk expansion and enhances electronic conductivity. Furthermore, the high-entropy property endows an ultra-stable crystal structure and inhibits the dissolution of metal ions. The ex-situ EIS and in-situ XRD results show that HESe-6 is able to be reversibly transformed into highly conductive ultrafine metal particles upon Na
+ embedding, providing more Na+ reactive active sites. In addition, despite the incorporation of up to seven different elements, it exhibits minimal phase transitions during discharge/charge cycles, effectively mitigating stress accumulation. HESe-6 could retain an ultralong-term stability of 765.83 mAh g-1 after 1000 loops even at 1 A g-1 . Furthermore, when coupled with the Na3 V2 (PO4 )2 O2 F cathode, it maintains a satisfactory charge energy density of 303 Wh kg-1 after 300 cycles, which shows promising application prospect in the future., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)- Published
- 2024
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40. Probing spin hydrodynamics on a superconducting quantum simulator.
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Shi YH, Sun ZH, Wang YY, Wang ZA, Zhang YR, Ma WG, Liu HT, Zhao K, Song JC, Liang GH, Mei ZY, Zhang JC, Li H, Chen CT, Song X, Wang J, Xue G, Yu H, Huang K, Xiang Z, Xu K, Zheng D, and Fan H
- Abstract
Characterizing the nature of hydrodynamical transport properties in quantum dynamics provides valuable insights into the fundamental understanding of exotic non-equilibrium phases of matter. Experimentally simulating infinite-temperature transport on large-scale complex quantum systems is of considerable interest. Here, using a controllable and coherent superconducting quantum simulator, we experimentally realize the analog quantum circuit, which can efficiently prepare the Haar-random states, and probe spin transport at infinite temperature. We observe diffusive spin transport during the unitary evolution of the ladder-type quantum simulator with ergodic dynamics. Moreover, we explore the transport properties of the systems subjected to strong disorder or a tilted potential, revealing signatures of anomalous subdiffusion in accompany with the breakdown of thermalization. Our work demonstrates a scalable method of probing infinite-temperature spin transport on analog quantum simulators, which paves the way to study other intriguing out-of-equilibrium phenomena from the perspective of transport., (© 2024. The Author(s).)
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- 2024
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41. Effect of infarct location and volume on cognitive dysfunction in elderly patients with acute insular cerebral infarction.
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Liang FF, Liu XX, Liu JH, Gao Y, Dai JG, and Sun ZH
- Abstract
Background: The aging of the population has become increasingly obvious in recent years, and the incidence of cerebral infarction has shown an increasing trend annually, with high death and disability rates., Aim: To analyze the effects of infarct location and volume on cognitive dysfunction in elderly patients with acute insular cerebral infarction., Methods: Between January 2020 and December 2023, we treated 98 cases of elderly acute insula, patients with cerebral infarction in the cerebral infarction acute phase (3-4 weeks) and for the course of 6 months in Montreal Cognitive Assessment Scale (MoCA) for screening of cognition. Notably, 58 and 40 patients were placed in the cognitive impairment group and without-cognitive impairment group, respectively. In patients with cerebral infarction, magnetic resonance imaging was used to screen and clearly analyze the MoCA scores of two groups of patients with different infarctions, the relationship between the parts of the infarction volume, and analysis of acute insula cognitive disorder in elderly patients with cerebral infarction and the relationship between the two., Results: The number of patients with cognitive impairment in the basal ganglia and thalamus was significantly higher than that without cognitive impairment ( P < 0.05). The total infarct volume in the cognitive impairment group was higher than that in the non-cognitive impairment group, and the difference was statistically significant ( P < 0.05). The infarct volumes at different sites in the cognitive impairment group was higher than in the non-cognitive impairment group ( P < 0.05). In the cognitive impairment group, the infarct volumes in the basal ganglia, thalamus, and mixed lesions were negatively correlated with the total MoCA score, with correlation coefficients of -0.67, -0.73, and -0.77, respectively., Conclusion: In elderly patients with acute insular infarction, infarction in the basal ganglia, thalamus, and mixed lesions were more likely to lead to cognitive dysfunction than in other areas, and patients with large infarct volumes were more likely to develop cognitive dysfunction. The infarct volume in the basal ganglia, thalamus, and mixed lesions was significantly negatively correlated with the MoCA score., Competing Interests: Conflict-of-interest statement: The authors declare no conflicts of interest for this article., (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Published
- 2024
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42. [Risk factors for pancreatitis after endoscopic retrograde cholangiopancreatography in children].
- Author
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Yang L, Fu Y, Sun ZH, Zhou J, Tang J, and Ni J
- Subjects
- Humans, Child, Male, Female, Risk Factors, Retrospective Studies, Child, Preschool, Adolescent, Logistic Models, Infant, Cholangiopancreatography, Endoscopic Retrograde adverse effects, Pancreatitis etiology, Pancreatitis prevention & control
- Abstract
Objectives: To investigate the application of endoscopic retrograde cholangiopancreatography (ERCP) in children and the risk factors for post-ERCP pancreatitis (PEP)., Methods: A retrospective analysis was conducted on the clinical data of 66 children, aged ≤16 years, who underwent ERCP for pancreaticobiliary diseases at the Gastrointestinal Endoscopy Center of the Second Affiliated Hospital of Kunming Medical University from September 2013 to September 2023. The incidence rate of PEP and the risk factors for the development of PEP were analyzed., Results: A total of 78 ERCP procedures were performed on 66 children, with 5 diagnostic ERCPs, 69 therapeutic ERCPs, and 4 failed procedures. The success rate of ERCP operations was 95% (74/78). There were 17 cases of PEP in total, with an incidence rate of 22%. In the PEP group, the proportion of children with normal preoperative bilirubin and the proportion of guidewire insertion into the pancreatic duct during surgery were higher than in the non-PEP group ( P <0.05). The multivariate logistic regression analysis showed that guidewire insertion into the pancreatic duct was an independent risk factor for PEP ( P <0.05)., Conclusions: With the increasing application of ERCP in children with pancreaticobiliary diseases, it is important to select an appropriate intubation technique during surgery to avoid blindly entering the guidewire into the pancreatic duct and reduce the occurrence of PEP.
- Published
- 2024
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43. Photoinduced Pd-Catalyzed Intramolecular 6- endo Heck Reaction of Alkyl Halides.
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Shu L, Dong X, Sun ZH, Zhao A, Jiang M, Ren X, Yan F, Cao K, Liu Q, and Liu H
- Abstract
A novel photocatalytic palladium-induced 6- endo -selective alkyl Heck reaction of unactivated alkyl iodides and alkyl bromides has been described. This strategy facilitates the gentle and efficient synthesis of a variety of 5-phenyl-1,2,3,6-tetrahydropyridine derivatives. It demonstrates a broad substrate tolerance and excellent 6- endo selectivity. Unlike the high-temperature requirements of traditional alkyl Heck reactions, this transformation efficiently proceeds at room temperature and shows significant promise for industrial-scale applications. Mechanistic investigations reveal that this alkyl Heck reaction proceeds via a hybrid palladium-radical process.
- Published
- 2024
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44. A novel role for microtubule affinity-regulating kinases in neuropathic pain.
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Shi YQ, Sun ZH, Wang ZZ, Su CY, Zhang W, Yu LY, Xu Y, Gao YL, Wang HB, Tian JW, and Li CM
- Subjects
- Animals, Male, Rats, Amygdala metabolism, Amygdala drug effects, Neuronal Plasticity drug effects, Spinal Nerves, Neuralgia drug therapy, Neuralgia metabolism, Rats, Sprague-Dawley, Protein Serine-Threonine Kinases metabolism, Protein Serine-Threonine Kinases antagonists & inhibitors, Protein Serine-Threonine Kinases genetics
- Abstract
Background and Purpose: Neuropathic pain affects millions of patients, but there are currently few viable therapeutic options available. Microtubule affinity-regulating kinases (MARKs) regulate the dynamics of microtubules and participate in synaptic remodelling. It is unclear whether these changes are involved in the central sensitization of neuropathic pain. This study examined the role of MARK1 or MARK2 in regulating neurosynaptic plasticity induced by neuropathic pain., Experimental Approach: A rat spinal nerve ligation (SNL) model was established to induce neuropathic pain. The role of MARKs in nociceptive regulation was assessed by genetically knocking down MARK1 or MARK2 in amygdala and systemic administration of PCC0105003, a novel small molecule MARK inhibitor. Cognitive function, anxiety-like behaviours and motor coordination capability were also examined in SNL rats. Synaptic remodelling-associated signalling changes were detected with electrophysiological recording, Golgi-Cox staining, western blotting and qRT-PCR., Key Results: MARK1 and MARK2 expression levels in amygdala and spinal dorsal horn were elevated in SNL rats. MARK1 or MARK2 knockdown in amygdala and PCC0105003 treatment partially attenuated pain-like behaviours along with improving cognitive deficit, anxiogenic-like behaviours and motor coordination in SNL rats. Inhibition of MARKs signalling reversed synaptic plasticity at the functional and structural levels by suppressing NR2B/GluR1 and EB3/Drebrin signalling pathways both in amygdala and spinal dorsal horn., Conclusion and Implications: These results suggest that MARKs-mediated synaptic remodelling plays a key role in the pathogenesis of neuropathic pain and that pharmacological inhibitors of MARKs such as PCC0105003 could represent a novel therapeutic strategy for the management of neuropathic pain., (© 2023 British Pharmacological Society.)
- Published
- 2024
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45. Cardiovascular computed tomography in cardiovascular disease: An overview of its applications from diagnosis to prediction.
- Author
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Sun ZH
- Abstract
Cardiovascular computed tomography angiography (CTA) is a widely used imaging modality in the diagnosis of cardiovascular disease. Advancements in CT imaging technology have further advanced its applications from high diagnostic value to minimising radiation exposure to patients. In addition to the standard application of assessing vascular lumen changes, CTA-derived applications including 3D printed personalised models, 3D visualisations such as virtual endoscopy, virtual reality, augmented reality and mixed reality, as well as CT-derived hemodynamic flow analysis and fractional flow reserve (FFRCT) greatly enhance the diagnostic performance of CTA in cardiovascular disease. The widespread application of artificial intelligence in medicine also significantly contributes to the clinical value of CTA in cardiovascular disease. Clinical value of CTA has extended from the initial diagnosis to identification of vulnerable lesions, and prediction of disease extent, hence improving patient care and management. In this review article, as an active researcher in cardiovascular imaging for more than 20 years, I will provide an overview of cardiovascular CTA in cardiovascular disease. It is expected that this review will provide readers with an update of CTA applications, from the initial lumen assessment to recent developments utilising latest novel imaging and visualisation technologies. It will serve as a useful resource for researchers and clinicians to judiciously use the cardiovascular CT in clinical practice., (© 2024 JGC All rights reserved; www.jgc301.com.)
- Published
- 2024
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46. [Analysis of early changes in lymphocyte subpopulations after liver transplantation and their correlation with clinical manifestations].
- Author
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Li WQ, Zhang WY, Li X, Zhang YM, and Sun ZH
- Subjects
- Humans, Retrospective Studies, Postoperative Period, Lymphocyte Count, Male, Female, Graft Rejection immunology, Liver Transplantation, Lymphocyte Subsets immunology
- Abstract
This study aimed to investigate the differences in peripheral blood lymphocyte subsets among patients with different immune statuses in the early postoperative period after liver transplantation, as well as the dynamic changes during the early post-transplantation period. A retrospective study was conducted, selecting a total of 82 patients who underwent liver transplantation at the General Hospital of PLA Southern Theater Command from January, 2018 to December, 2023. Based on the patients' postoperative immune status, they were categorized into stable group ( n =40), infection group ( n =21), and rejection group ( n =21). Peripheral blood samples of 2-3 ml were collected from patients at weeks 1 to 4 postoperatively, and flow cytometry was employed to measure the absolute values of peripheral blood lymphocyte subsets. For metric data conforming to normal distribution and homogeneity of variance, multiple group comparisons were conducted using ANOVA and Bonferroni multiple comparisons; for non-normally distributed data, the Kruskal Wallis test was used. Friedman test was used to compare different time periods within 4 weeks after liver transplantation. The results showed that there were no statistically significant differences in the absolute values of lymphocyte subsets among the three groups in the first week after liver transplantation ( P >0.05); however, significant differences were observed in the absolute values of lymphocyte subsets among the three groups in the second, third, and fourth weeks postoperatively ( P <0.05). In the second week, the rejection group showed significantly higher absolute counts of T cells, CD4
+ T cells, CD8+ T cells, NK cells, and B cells compared to the infection group (585.0 vs. 199.0; 324.0 vs. 113.0; 188.0 vs. 56.0; 57.0 vs. 11.0; 145.0 vs. 65.0 cells/μl), with statistically significant differences ( Z =-3.972, P <0.001; Z =-3.590, P =0.001; Z =-3.978, P <0.001; Z =-3.072, P =0.006; Z =-2.472, P =0.040). In the third week, the rejection group showed significantly higher absolute counts of T cells, CD4+ T cells, and CD8+ T cells compared to the infection group (660.0 vs. 216.0; 350.0 vs. 123.0; 184.0 vs. 76.0 cells/μl), with statistically significant differences ( Z =-3.019, P =0.008; Z =-3.492, P =0.001; Z =-2.845, P =0.013). In the fourth week, the rejection group showed significantly higher absolute counts of T cells, CD4+ T cells, CD8+ T cells, and B cells compared to the infection group (690.0 vs. 273.0; 405.0 vs. 168.0; 214.0 vs. 96.0; 117.0 vs. 48.0 cells/μl), with statistically significant differences ( Z =-3.379, P =0.002; Z =-3.068, P =0.006; Z =-3.007, P =0.0086; Z =-2.330, P =0.020). Within 4 weeks after liver transplantation, the absolute values of T cells, CD8+ T cells, and NK cells in the fourth week were higher than those in the first week, with statistically significant differences ( Z =-3.825, P =0.001; Z =-3.466, P =0.003; Z =-3.526, P =0.003); however, the absolute values of B cells showed an overall decreasing trend, and were significantly lower in the fourth week than in the first and second weeks, with statistically significant differences ( Z =3.705, P =0.001; Z =2.630, P =0.009). The changes in lymphocyte subset absolute values in the rejection group were more significant than those in the infection group, with T cells, CD4+ T cells, and CD8+ T cells showing significant increases in the second, third, and fourth weeks postoperatively compared with the first week, with statistically significant differences ( Z =-3.466, P =0.003; Z =-4.661, P <0.001; Z =-5.020, P <0.001; Z =-2.749, P =0.036; Z =-4.422, P <0.001; Z =-4.542, P <0.001; Z =-3.466, P =0.003; Z =-3.765, P =0.001; Z =-4.482, P <0.001); NK cell absolute values in the third and fourth weeks postoperatively were significantly higher than those in the first week, with statistically significant differences ( Z =-2.570, P =0.061; Z =-3.765, P =0.001). In summary, monitoring the differences and dynamic changes of lymphocyte subsets in patients after liver transplantation may have certain guiding significance for evaluating the immune function status of patients and adjusting treatment plans.- Published
- 2024
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47. Mechanism and Origins of Enantioselectivity in the Nickel-catalyzed Asymmetric Synthesis of Silicon-Stereogenic Benzosiloles.
- Author
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Sun ZH, Wang Q, and Xu LP
- Abstract
As important π-skeletons, benzosiloles often possess unique electronic and optical properties and have been widely used in semiconductor materials. Therefore, great attention has been drawn to the area of developing novel synthetic methods for various benzosiloles. However, the synthesis of enantioenriched silicon-stereogenic benzosiloles is still at an early stage and remains to be explored. Herein, we performed systematic density functional theory studies on the recently reported nickel-catalyzed asymmetric synthesis of silicon-stereogenic benosiloles, which was enabled by an enantioselective desymmetrization of (2-alkenyl)aryl-substituted silacyclobutanes. Our computational study shows that the reaction mechanism involves ligand exchange, oxidative addition, alkene insertion, and hydrogen-transfer coupled reductive-demetalation steps. The proposed transmetalation and β-hydride elimination mechanism was not found, which might be due to the unfavorable ring strain of the multicyclic intermediates. The novel hydrogen-transfer coupled reductive-demetalation mechanism was shown to be reasonable for the generation of the silicon-stereogenic benzosilole. Noncovalent interactions (including C-H···π and hydrogen bonding) in the rate-determining alkene insertion transition state account for the origins of the enantioselectivity. Our computational study sheds light on the detailed reaction mechanism and also provides insights for the development of novel approaches for synthesis of high-value silicon-stereogenic compounds.
- Published
- 2024
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48. Two Cytochrome P450 Enzymes Form the Tricyclic Nested Skeleton of Meroterpenoids by Sequential Oxidative Reactions.
- Author
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Yang E, Yao Y, Su H, Sun Z, Gao SS, Sureram S, Kittakoop P, Fan K, Pan Y, Xu X, Sun ZH, Ma G, and Liu G
- Abstract
Meroterpenoid clavilactones feature a unique benzo-fused ten-membered carbocyclic ring unit with an α,β-epoxy-γ-lactone moiety, forming an intriguing 10/5/3 tricyclic nested skeleton. These compounds are good inhibitors of the tyrosine kinase, attracting a lot of chemical synthesis studies. However, the natural enzymes involved in the formation of the 10/5/3 tricyclic nested skeleton remain unexplored. Here, we identified a gene cluster responsible for the biosynthesis of clavilactone A in the basidiomycetous fungus Clitocybe clavipes . We showed that a key cytochrome P450 monooxygenase ClaR catalyzes the diradical coupling reaction between the intramolecular hydroquinone and allyl moieties to form the benzo-fused ten-membered carbocyclic ring unit, followed by the P450 ClaT that exquisitely and stereoselectively assembles the α,β-epoxy-γ-lactone moiety in clavilactone biosynthesis. ClaR unprecedentedly acts as a macrocyclase to catalyze the oxidative cyclization of the isopentenyl to the nonterpenoid moieties to form the benzo-fused macrocycle, and a multifunctional P450 ClaT catalyzes a ten-electron oxidation to accomplish the biosynthesis of the 10/5/3 tricyclic nested skeleton in clavilactones. Our findings establish the foundation for the efficient production of clavilactones using synthetic biology approaches and provide the mechanistic insights into the macrocycle formation in the biosynthesis of fungal meroterpenoids.
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- 2024
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49. Ionic liquid post-modified carboxylate-rich MOFs for efficient catalytic CO 2 cycloaddition under solvent-free conditions.
- Author
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Bao WL, Kuai J, Gao HY, Zheng MQ, Sun ZH, He MY, Chen Q, and Zhang ZH
- Abstract
The synthesis of cyclic carbonates through cycloaddition reactions between epoxides and carbon dioxide (CO
2 ) is an important industrial process. Metal-Organic Frameworks (MOFs) have functional and ordered pore structures, making them attractive catalysts for converting gas molecules into valuable products. One approach to enhance the catalytic activity of MOFs in CO2 cycloaddition reactions is to create open metal sites within MOFs. In this study, the amino-functionalized rare earth Gd-MOF (Gd-TPTC-NH2 ) and its ionic liquid composite catalysts (Gd-TPTC-NH-[BMIM]Br) were synthesized using 2'-amino-[1,1':4',1''-terphenyl]-3,3'',5,5''-tetracarboxylic acid (H4 TPTC-NH2 ) as the ligand. The catalytic performance of these two catalysts was observed in the cycloaddition reaction of CO2 and epoxides. Under the optimized reaction conditions, Gd-TPTC-NH-[BMIM]Br can effectively catalyze the cycloaddition reaction of a variety of epoxide substrates with good to excellent yields of cyclic carbonate products. Comparatively, epichlorohydrin and epibromohydrin, which possess halogen substituents, promote higher yields of cyclic carbonates due to the electron-withdrawing nature of Cl and Br substituents. Additionally, the Gd-TPTC-NH-[BMIM]Br catalyst demonstrated good recyclability and reproducibility, maintaining its catalytic activity without any changes in its structure or properties after five reuse cycles.- Published
- 2024
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50. A multicenter propensity score analysis of significance of hepatic resection type for early-stage hepatocellular carcinoma.
- Author
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Tang SC, Zhang KL, Lin KY, Tang YD, Fu J, Zhou WP, Zhang JX, Kong J, He XL, Sun ZH, Luo C, Liu HZ, Lai YP, and Zeng YY
- Subjects
- Humans, Propensity Score, Retrospective Studies, Hepatectomy, Neoplasm Recurrence, Local, Carcinoma, Hepatocellular pathology, Liver Neoplasms pathology
- Abstract
Background: The impact of hepatic resection type on long-term oncological prognosis of patients with early-stage hepatocellular carcinoma (HCC) has not been systematically investigated. We sought to determine risk factors, recurrence patterns, and survival outcomes after anatomical resection (AR) versus non-anatomical resection (NAR) for early-stage HCC., Methods: From a prospectively collected multicenter database, consecutive patients undergoing curative hepatectomy for early-stage HCC were identified. Recurrence patterns, overall survival (OS), recurrence-free survival (RFS), and risk factors were investigated in patients undergoing AR versus NAR using propensity score matching (PSM), subgroup analysis, and COX regression analysis., Results: A total of 3585 patients with early-stage HCC were enrolled, including 1287 and 2298 in the AR and NAR groups, respectively. After PSM, the OS and RFS of patients in the AR group were 58.8% and 42.7%, which were higher than those in the NAR group (52.2% and 30.6%, both p < 0.01). The benefits of AR were consistent across most subgroup analyses of OS and RFS. Multivariable COX regression analysis showed that AR was independently associated with better OS and RFS. Notably, although recurrence patterns were comparable, the risk factors for recurrence were not identical for AR versus NAR. Microvascular invasion and narrow resection margin were only associated with a higher recurrence rate after NAR., Conclusions: This study demonstrated that AR decreases the risk of tumor recurrence and improves OS and RFS in patients with early-stage HCC. AR should be adopted as long as such a surgical maneuver is feasible for initial treatment of early-stage HCC., (© 2023. Asian Pacific Association for the Study of the Liver.)
- Published
- 2024
- Full Text
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