Search

Your search keyword '"Sun, Yongming"' showing total 997 results
Start Over Author "Sun, Yongming"
997 results on '"Sun, Yongming"'

9. Risky effort

Author

Mason, Alice, Sun, Yongming, Simonsen, Nick, Madan, Christopher R., Spetch, Marcia L., and Ludvig, Elliot A.

Published
2024
Full Text
View/download PDF

12. High-level correction of the sickle mutation is amplified in vivo during erythroid differentiation.

Author

Magis, Wendy, DeWitt, Mark A, Wyman, Stacia K, Vu, Jonathan T, Heo, Seok-Jin, Shao, Shirley J, Hennig, Finn, Romero, Zulema G, Campo-Fernandez, Beatriz, Said, Suzanne, McNeill, Matthew S, Rettig, Garrett R, Sun, Yongming, Wang, Yu, Behlke, Mark A, Kohn, Donald B, Boffelli, Dario, Walters, Mark C, Corn, Jacob E, and Martin, David IK

Subjects
genetic engineering, genetics, molecular genetics, Stem Cell Research, Biotechnology, Sickle Cell Disease, Hematology, Genetics, Rare Diseases, Stem Cell Research - Nonembryonic - Human, Blood
Abstract

BackgroundA point mutation in sickle cell disease (SCD) alters one amino acid in the β-globin subunit of hemoglobin, with resultant anemia and multiorgan damage that typically shortens lifespan by decades. Because SCD is caused by a single mutation, and hematopoietic stem cells (HSCs) can be harvested, manipulated, and returned to an individual, it is an attractive target for gene correction.ResultsAn optimized Cas9 ribonucleoprotein (RNP) with an ssDNA oligonucleotide donor together generated correction of at least one β-globin allele in more than 30% of long-term engrafting human HSCs. After adopting a high-fidelity Cas9 variant, efficient correction with minimal off-target events also was observed. In vivo erythroid differentiation markedly enriches for corrected β-globin alleles, indicating that erythroblasts carrying one or more corrected alleles have a survival advantage.SignificanceThese findings indicate that the sickle mutation can be corrected in autologous HSCs with an optimized protocol suitable for clinical translation.

Published
2022

23. IoT Lakehouse: A New Data Management Paradigm for AIoT

Author

Liu, Guochuan, Pang, Zhenjiang, Zeng, Jing, Hong, Haimin, Sun, Yongming, Su, Mingjie, Ma, Nan, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Zhang, Shunli, editor, Hu, Bo, editor, and Zhang, Liang-Jie, editor

Published
2023
Full Text
View/download PDF

24. EIMDC: A New Model for Designing Digital Twin Applications

Author

Wang, Xiang, Hong, Haimin, Zeng, Jing, Sun, Yongming, Liu, Guochuan, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Tekinerdogan, Bedir, editor, Wang, Yingwei, editor, and Zhang, Liang-Jie, editor

Published
2023
Full Text
View/download PDF

49. Integrated Dual‐Phase Ion Transport Design Within Electrode for Fast‐Charging Lithium‐Ion Batteries.

Author

Tu, Shuibin, Zhang, Yan, Ren, Dongsheng, Chen, Zihe, Wang, Wenyu, Zhan, Renming, Wang, Xiancheng, Cheng, Kai, Ou, Yangtao, Duan, Xiangrui, Wang, Li, and Sun, Yongming

Subjects
ENERGY density, SOLID electrolytes, SLURRY, ELECTRODES, GRAPHITE
Abstract

The development of fast‐charging lithium‐ion batteries with high energy density is hindered by the sluggish Li+ transport and substantial polarization within graphite electrodes. Herein, this study proposes that the integrated design of liquid electrolyte and solid electrolyte, a dual‐phase electrolyte (DP‐electrolyte), can facilitate Li+ transport within a thick electrode. A 3D Li3PS4 (LPS) network is constructed within the graphite electrode to form the LPS/graphite electrode. This is achieved through the in situ conversion of the P4S16 into the LPS, a process introduced during the slurry processing. Both experimental findings and simulation outcomes indicate that this design mitigates the concentration polarization due to the improved Li+ transport capability with an overall high Li+ transference number within the electrode. With a high capacity of ≈3.1 mAh cm−2 attributed to the graphite electrode, the LiNi0.6Co0.2Mn0.2O2 (NCM622)||LPS/graphite cells demonstrate superior fast‐charging capability (4 C, 15 min, charging to ≈87.7%) and stable cycling performance (4 C, 700 cycles, ≈80% capacity retention). Furthermore, they exhibit commendable low‐temperature performance. The Ah‐level pouch cell achieves 87.5% recharge in 15 min with an energy density of ≈221.5 Wh kg−1. This work offers an alternative avenue for the advancement of fast‐charging lithium‐ion batteries with practical high energy density. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results