1. DIFR3CT: Latent Diffusion for Probabilistic 3D CT Reconstruction from Few Planar X-Rays
- Author
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Sun, Yiran, Baroudi, Hana, Netherton, Tucker, Court, Laurence, Mawlawi, Osama, Veeraraghavan, Ashok, and Balakrishnan, Guha
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Computed Tomography (CT) scans are the standard-of-care for the visualization and diagnosis of many clinical ailments, and are needed for the treatment planning of external beam radiotherapy. Unfortunately, the availability of CT scanners in low- and mid-resource settings is highly variable. Planar x-ray radiography units, in comparison, are far more prevalent, but can only provide limited 2D observations of the 3D anatomy. In this work we propose DIFR3CT, a 3D latent diffusion model, that can generate a distribution of plausible CT volumes from one or few (<10) planar x-ray observations. DIFR3CT works by fusing 2D features from each x-ray into a joint 3D space, and performing diffusion conditioned on these fused features in a low-dimensional latent space. We conduct extensive experiments demonstrating that DIFR3CT is better than recent sparse CT reconstruction baselines in terms of standard pixel-level (PSNR, SSIM) on both the public LIDC and in-house post-mastectomy CT datasets. We also show that DIFR3CT supports uncertainty quantification via Monte Carlo sampling, which provides an opportunity to measure reconstruction reliability. Finally, we perform a preliminary pilot study evaluating DIFR3CT for automated breast radiotherapy contouring and planning -- and demonstrate promising feasibility. Our code is available at https://github.com/yransun/DIFR3CT., Comment: 11 pages, 9 figures
- Published
- 2024