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Photodynamic therapy provides a promising solution for treating various cancer types. In this study, three distinct asymmetric porphyrin–cisplatin complex photosensitizers (ZnPt-P1, ZnPt-P2, and ZnPt-P3) were synthesized, each having unique side chains. Through a set of experiments involving singlet oxygen detection and density functional theory, ZnPt-P1 was demonstrated to have excellent efficacy, exceeding that of ZnPt-P2 and ZnPt-P3. Notably, ZnPt-1 showed significant phototoxicity while maintaining low dark toxicity when tested on HepG2 cells. Additionally, further examination revealed that ZnPt-P1 had the capability to generate reactive oxygen species within cancer cells when exposed to light irradiation. Taken together, these results highlight the potential of ZnPt-P1 as a photosensitizer for use in photodynamic therapy. This study contributes to enhancing cancer treatment methodologies and provides insights for the future development of innovative drugs for photosensitization. [ABSTRACT FROM AUTHOR]

Lead (Pb) is one of the most widespread and highly toxic heavy metals in the environment. The design and synthesis of adsorbent materials for the selective and efficient removal of Pb2+ from aqueous solution has received much attention. Herein, the ligand 4,4′-azoxydibenzoic acid with the O− group was elaborately selected to construct a novel Pr-based MOF for Pb2+ removal. The as-prepared MOF adsorbents with high stability exhibited ultra-high selectivity for Pb2+, even in the presence of various highly concentrated competitive ions (with the ratios from 1 : 5 to 1 : 50). Also, a high uptake capacity (560.26 mg g−1) can be achieved for the MOF material, due to the availability of sufficient adsorption sites. The strong electrostatic attraction and coordination interaction between the numerous active O− sites on MOF adsorbents and Pb2+ can account for the good adsorption performance for Pb2+, which was systematically verified by zeta potential, FT-IR and XPS studies. [ABSTRACT FROM AUTHOR]

A " three platforms, five functions" multi-level comprehensive chemistry experiment platform was constructed by Chemical Experimental Teaching Demonstration Center of East China University of Science and Technology Engineering. The establishment of the professional and innovative labs in Fengxian campus is to strengthen resource sharing and promoting scientific research. In view of the construction and practice of this platform, some problems in the construction of the this platform were discussed from the management mode, the operation mode, the management team, etc. In order to raise students ' awareness of innovation and the capacity of scientific research, the platform comprehensively promotes the comprehensive utilization of resources and the full opening of laboratory work. This platform provides a reference for the use and construction of new campus university research resources and the building regional integrated multi-level comprehensive chemistry experiment platform. [ABSTRACT FROM AUTHOR]

Photodynamic therapy provides a promising solution for treating various cancer types. In this study, three distinct asymmetric porphyrin-cisplatin complex photosensitizers (ZnPt-P1, ZnPt-P2, and ZnPt-P3) were synthesized, each having unique side chains. Through a set of experiments involving singlet oxygen detection and density functional theory, ZnPt-P1 was demonstrated to have excellent efficacy, exceeding that of ZnPt-P2 and ZnPt-P3. Notably, ZnPt-1 showed significant phototoxicity while maintaining low dark toxicity when tested on HepG2 cells. Additionally, further examination revealed that ZnPt-P1 had the capability to generate reactive oxygen species within cancer cells when exposed to light irradiation. Taken together, these results highlight the potential of ZnPt-P1 as a photosensitizer for use in photodynamic therapy. This study contributes to enhancing cancer treatment methodologies and provides insights for the future development of innovative drugs for photosensitization.

Lead (Pb) is one of the most widespread and highly toxic heavy metals in the environment. The design and synthesis of adsorbent materials for the selective and efficient removal of Pb 2+ from aqueous solution has received much attention. Herein, the ligand 4,4'-azoxydibenzoic acid with the O - group was elaborately selected to construct a novel Pr-based MOF for Pb 2+ removal. The as-prepared MOF adsorbents with high stability exhibited ultra-high selectivity for Pb 2+ , even in the presence of various highly concentrated competitive ions (with the ratios from 1 : 5 to 1 : 50). Also, a high uptake capacity (560.26 mg g -1 ) can be achieved for the MOF material, due to the availability of sufficient adsorption sites. The strong electrostatic attraction and coordination interaction between the numerous active O - sites on MOF adsorbents and Pb 2+ can account for the good adsorption performance for Pb 2+ , which was systematically verified by zeta potential, FT-IR and XPS studies.

The development of WO 3 -based gas sensors for analysis of acetone in exhaled breath is significant for noninvasive diagnosis of diabetes. A series of Fe-doped hexagonal and monoclinic WO 3 phase-junction (Fe- h/m -WO 3 ) sensors were synthesized by the hydrothermal calcination method, and the influences of operating temperature and light irradiation on the response were studied. Under light emitting diode (LED) illumination, Fe- h/m -WO 3 exhibited higher responses to acetone than those of the undoped WO 3 -based sensors at an operating temperature of 260 °C with 90% relative humidity, and good linearity between response and acetone concentration (0.5 to 2.5 ppm) was achieved under the 90% relative humidity condition. Meanwhile, the optimal Fe- h/m -WO 3 sensor exhibited high selectivity and stability for a duration of three months. The excellent sensing performance of Fe- h/m -WO 3 was attributed to the formation of phase-junction and Fe doping, and these were beneficial for the separation of photon-generated carriers and oxygen adsorption on the WO 3 surface, promoting the generation of superoxide radicals, which was demonstrated by electron paramagnetic resonance and photocurrent tests. Additionally, the Fe-doped WO 3 phase-junction sample also showed good photocatalytic performance for rhodamine B degradation. This study may provide some insights into rational design of new types of gas sensors and offer an alternative for noninvasive diagnosis of diabetes., Competing Interests: The authors declare no conflict of interest.