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To prevent foodborne diseases and minimize their impacts, it is extremely important to develop a cost‐effective and efficient bacterial detection assay for diagnostics, particularly in resource‐poor settings. In this study, 16S rRNA from foodborne Salmonella was coupled with multiple HCR (hybridization chain reaction) concatemers and functionalized in a signal structure for lateral flow nucleic acid biosensor (LFNAB) detection. The 16S rRNA was incubated with two specific capture probes and multiple helper probes carrying the same initiator, to unwind its secondary structure and form an "initiators‐on‐a‐string" complex. Through use of the initiators, each target 16S rRNA yielded multiple HCR concatemers tethered to numerous biotins, and numerous streptavidin‐labeled gold nanoparticles were introduced on the LFNAB. The limit of detection was 53.65 CFU/mL for Salmonella. Notably, this method has high specificity and applicability for the detection of Salmonella in food and water samples. [ABSTRACT FROM AUTHOR]

Constructing acid–base pairs is one of the efficient strategies for the design of proton conductors with high conductivity, due to the ultrafast proton-hopping with a low energy barrier between a proton donor (acid group) and an acceptor (base group). In this study, an acid–base adduct polyamine–P2Mo5 model system was established, including adducts [C6N4H22][H2P2Mo5O23]·H2O (P2Mo5-TETA), [C4N3H16]2[P2Mo5O23]·H2O (P2Mo5-DETA), and [C2N2H10]2[H2P2Mo5O23] (P2Mo5-EN), (TETA = triethylenetetramine, DETA = diethylenetriamine, EN = ethanediamine). Proton conductivity analyses showed that adduct P2Mo5-EN exhibited the highest proton conductivity 1.13 × 10−2 S cm−1 at 65 °C and 95% RH, which was one and three orders of magnitude greater than those of P2Mo5-DETA and P2Mo5-TETA under the same conditions. Ea values of all three adducts are lower than 0.4 eV, which indicates that their proton transfer is attributed to the Grotthuss mechanism. Combined with visual structure analysis, the proton transport pathways of three adducts are highlighted. Moreover, we use this model system to discuss in detail the effect of pKa, proton density and size of polyamine molecules on the proton conductivity of organic amine-POM adducts. [ABSTRACT FROM AUTHOR]

The primary contradiction in Zheng village is due to a severe disconnection between the demands of the superstructure and the lifestyle ideals of the villagers. The problems can be solved depending on coordinated social, economic, political, cultural, and legal development, as well as continuous adaptation and hard work on the part of all citizens.

A sandwich‐type tungstogermanate, namely, {H2[Co(2,2′‐bpy)3][Co(2,2′‐bpy)]2[Co(2,2′‐bpy)2(H2O)]2[Co4(H2O)2(Ge‐W9O34)2]}⋅4H2O (1) was isolated by hydrothermal method. 1 has been identified by single crystal X‐ray diffraction, elemental analysis, thermogravimetric analysis, powder X‐ray diffraction and FTIR. Structural analysis revealed that 1 was composed of sandwich‐like polyoxoanion [Co4(H2O)2(GeW9O34)2]12− and two [Co(2,2'‐bpy)]2+ and two [Co(2,2'‐bpy)2(H2O)]2+ units. 1 showed excellent Lewis acid catalytic activity for synthesis of cyclohexanone glycol ketal with 98% conversion. The energy gap (Eg) of 1 was 1.67 eV indicating 1 is a semiconductor material and its photodecomposition rate of RhB was 99%. In addition, the magnetic properties showed that antiferromagnetic interactions exist between Co2+ ions. A novel decorative sandwich‐type germanotungstate, namely, {H2[Co(2,2'‐bpy)3][Co(2,2'‐bpy)]2[Co(2,2'‐bpy)2(H2O)]2[Co4(H2O)2(GeW9O34)2]}. 4H2O (1) was isolated by hydrothermal method, which displays remarkable Lewis acid catalytic activity for the synthesis of cyclohexanone ethylene ketal and photocatalytic degradation for RhB. [ABSTRACT FROM AUTHOR]

Background: Excision repair cross-complimentary group 1 (ERCC1) is an essential component of the nucleotide excision repair system that is responsible for repairing damaged DNA. Functional genetic variations in the ERCC1 gene may alter DNA repair capacity and modulate cancer risk. The putative roles of ERCC1 gene polymorphisms in lung cancer susceptibility have been widely investigated. However, the results remain controversial. Objectives: An updated meta-analysis was conducted to explore whether lung cancer risk could be attributed to the following ERCC1 polymorphisms: rs11615 (T>C), rs3212986 (C>A), rs3212961 (A>C), rs3212948 (G>C), rs2298881 (C>A). Methods: Several major databases (MEDLINE, EMBASE and Scopus) and the Chinese Biomedical database were searched for eligible studies. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to measure the strength of associations. Results: Sixteen studies with 10,106 cases and 13,238 controls were included in this meta-analysis. Pooled ORs from 11 eligible studies (8,215 cases vs. 11,402 controls) suggested a significant association of ERCC1 rs11615 with increased risk for lung cancer (homozygous: CC versus TT, OR = 1.24, 95% CI: 1.04–1.48, P = 0.02). However, such an association was disproportionately driven by a single study. Removal of that study led to null association. Moreover, initial analyses suggested that ERCC1 rs11615 exerts a more profound effect on the susceptibility of non-smokers to lung cancer than that of smokers. Moreover, no statistically significant association was found between remaining ERCC1 polymorphisms of interest and lung cancer risk, except for rs3212948 variation (heterozygous: CG vs.GG, OR = 0.78, 95% CI: 0.67–0.90, P = 0.001; dominant: CG/CC vs.GG, OR = 0.79, 95% CI: 0.69–0.91, P = 0.001). Conclusion: Overall, this meta-analysis suggests that ERCC1 rs3212948 G>C, but not others, is a lung cancer risk-associated polymorphism. Carefully designed studies with large sample size involving different ethnicity, smoking status, and cancer types are needed to validate these findings. [ABSTRACT FROM AUTHOR]

A sandwich‐type tungstogermanate, namely, {H2[Co(2,2′‐bpy)3][Co(2,2′‐bpy)]2[Co(2,2′‐bpy)2(H2O)]2[Co4(H2O)2(Ge‐W9O34)2]}⋅4H2O (1) was isolated by hydrothermal method. 1 has been identified by single crystal X‐ray diffraction, elemental analysis, thermogravimetric analysis, powder X‐ray diffraction and FTIR. Structural analysis revealed that 1 was composed of sandwich‐like polyoxoanion [Co4(H2O)2(GeW9O34)2]12− and two [Co(2,2'‐bpy)]2+ and two [Co(2,2'‐bpy)2(H2O)]2+ units. 1 showed excellent Lewis acid catalytic activity for synthesis of cyclohexanone glycol ketal with 98% conversion. The energy gap (Eg) of 1 was 1.67 eV indicating 1 is a semiconductor material and its photodecomposition rate of RhB was 99%. In addition, the magnetic properties showed that antiferromagnetic interactions exist between Co2+ ions. A novel decorative sandwich‐type germanotungstate, namely, {H2[Co(2,2'‐bpy)3][Co(2,2'‐bpy)]2[Co(2,2'‐bpy)2(H2O)]2[Co4(H2O)2(GeW9O34)2]}. 4H2O (1) was isolated by hydrothermal method, which displays remarkable Lewis acid catalytic activity for the synthesis of cyclohexanone ethylene ketal and photocatalytic degradation for RhB. [ABSTRACT FROM AUTHOR]

To explore potential indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors, we designed a series of compounds incorporating urea and 1,2,3-triazole structures. IDO1 enzymatic activity experiments with the synthesized compounds were used to verify their molecular-level activity; for instance, the half maximal inhibitory concentration value of compound 3c was 0.07 μM. Our research has yielded a series of novel IDO1 inhibitors which may be beneficial in the development of drugs targeting IDO1 for cancer treatment.

BACKGROUND Postoperative delirium (POD) seriously affects the rapid postoperative recovery of elderly patients. We investigated the effect of abdominal wall blocks on POD in elderly patients undergoing laparoscopic radical resection of colon cancer and underlying mechanisms. MATERIAL AND METHODS A total of 100 patients undergoing laparoscopic radical resection of colon cancer were randomly assigned to group C (control) and group R (regional nerve blocks). In group R, 20 mL of local anesthesia-mixed solution was injected into the bilateral transverse abdominis muscle plane and 10 mL was injected into the bilateral posterior sheath of the rectus abdominis muscle. In group C, the same amount of saline was used for nerve block. The consumption of propofol and remifentanil during surgery was recorded. Levels of serum interleukin (IL)-6 and highly sensitive C-reactive protein (hs-CRP) during surgery were evaluated. The Confusion Assessment Method for the Intensive Care Unit Scale and the Richmond Agitation-Sedation Scale were adopted to evaluate POD. RESULTS The incidence of POD was lower in group R than in group C (P=0.048). The consumption of propofol and remifentanil was significantly reduced in group R, compared with group C (P<0.05). Compared with T0, serum IL-6 and hs-CRP levels in both groups were significantly increased at T1 and T2 (P<0.05). Moreover, serum IL-6 and hs-CRP were lower at T1 and T2 in group R compared with group C (P<0.05). CONCLUSIONS Abdominal wall blocks may alleviate POD in elderly patients undergoing laparoscopic surgery, which may be related to the reduction of anesthetic consumption and inflammatory response.

Constructing acid-base pairs is one of the efficient strategies for the design of proton conductors with high conductivity, due to the ultrafast proton-hopping with a low energy barrier between a proton donor (acid group) and an acceptor (base group). In this study, an acid-base adduct polyamine-P 2 Mo 5 model system was established, including adducts [C 6 N 4 H 22 ][H 2 P 2 Mo 5 O 23 ]·H 2 O (P 2 Mo 5 -TETA), [C 4 N 3 H 16 ] 2 [P 2 Mo 5 O 23 ]·H 2 O (P 2 Mo 5 -DETA), and [C 2 N 2 H 10 ] 2 [H 2 P 2 Mo 5 O 23 ] (P 2 Mo 5 -EN), (TETA = triethylenetetramine, DETA = diethylenetriamine, EN = ethanediamine). Proton conductivity analyses showed that adduct P 2 Mo 5 -EN exhibited the highest proton conductivity 1.13 × 10 -2 S cm -1 at 65 °C and 95% RH, which was one and three orders of magnitude greater than those of P 2 Mo 5 -DETA and P 2 Mo 5 -TETA under the same conditions. E a values of all three adducts are lower than 0.4 eV, which indicates that their proton transfer is attributed to the Grotthuss mechanism. Combined with visual structure analysis, the proton transport pathways of three adducts are highlighted. Moreover, we use this model system to discuss in detail the effect of pK a , proton density and size of polyamine molecules on the proton conductivity of organic amine-POM adducts.