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A constant demand in engineering design is to couple aesthetics and functionality of design. In this paper, a method is proposed to rapidly update the structural analysis models given the modifications made in the styling/packaging designs, forming a concurrent mechanism for developing the automotive styling and body structure. The seemingly disparate domains are represented by and thus coupled through a pair of wireframes. A joint mapping based on the hard points in packaging and a part mapping encoding local influences between wireframes are established. The deformation transfer from one of the wireframes to the other is solved as an optimization with constraints obtained from the two mappings. Finally, the finite element mesh model is adapted in accordance with the deformed structural wireframe, using a mesh morphing method based on the free-form deformation technique. Numerical results validate the proposed method and demonstrate its effectiveness. [ABSTRACT FROM AUTHOR]

Background: This study employed a severed finger rat model to analyze the effects of human mesenchymal stem cells (MSCs) on angiogenesis, inflammatory response, apoptosis, and oxidative stress, to evaluate the possible mechanism of the repair effect of MSCs on severed finger (SF) rats., Methods: Sixty Sprague-Dawley (SD) rats were categorized into five groups (n = 12). The pathological changes of severed finger tissues were investigated by Hematoxylin and eosin (H&E) staining on day 14 after the rats were sacrificed. The levels of inflammatory factors and oxidative stress factors were detected by ELISA. Terminal Deoxynucleotidyl Transferase (TdT) dUTP Nick End Labeling (TUNEL) was employed to assess the apoptosis of chondrocytes in severed finger tissues. The expression of osteocalcin (OCN), osteopontin (OPN), Collagen I (Col-1), and CD31 were detected by immunohistochemistry or immunofluorescence assay, respectively. The expression levels of related proteins were determined by western blot., Result: Our study presented evidence that MSCs treatment improved pathological changes of skin and bone tissue, diminished the inflammatory response, prevented oxidative stress injury, suppressed chondrocyte apoptosis, and promoted angiogenesis, and bone formation compared to the model group. In addition, EX527 treatment attenuated the effect of MSCs, SRT1720 and ML385 co-treatment also attenuated the effect of MSCs. Importantly, the MSCs treatment increased the expression of Sirtuin 1(SIRT1)/Nuclear factor erythroid2-related factor 2(Nrf2) relate proteins., Conclusion: Our study indicated that the mechanism of the effect of MSCs on a severed finger was related to the SIRT1/ Nrf2 signaling pathway., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)