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1. Cardiac troponin I directly binds and inhibits mitochondrial ATP synthase with a noncanonical role in the post-ischemic heart

Author

Elezaby, Aly, Lin, Amanda J., Vijayan, Vijith, Pokhrel, Suman, Kraemer, Benjamin R., Bechara, Luiz R. G., Larus, Isabel, Sun, Junhui, Baena, Valentina, Syed, Zulfeqhar A., Murphy, Elizabeth, Glancy, Brian, Ostberg, Nicolai P., Queliconi, Bruno B., Campos, Juliane C., Ferreira, Julio C. B., Haileselassie, Bereketeab, and Mochly-Rosen, Daria

Published
2024
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3. Association of nonmalignant portal vein thrombosis and clinical outcomes in patients with cirrhosis and acute variceal bleeding: a multicenter observational study

Author

Lv, Yong, Bai, Wei, Zhu, Xuan, Xue, Hui, Zhao, Jianbo, Zhuge, Yuzheng, Sun, Junhui, Zhang, Chunqing, Ding, Pengxu, Jiang, Zaibo, Zhu, Xiaoli, Ren, Weixin, LiZhang, Yingchun Kewei, Zhang, Wenguang, Li, Kai, Wang, Zhengyu, Luo, Bohan, Li, Xiaomei, Yuan, Jie, Yang, Zhiping, Guo, Wengang, Xia, Dongdong, Xie, Huahong, Yang, Changbing, Pan, Yanglin, Yin, Zhanxin, Fan, Daiming, and Han, Guohong

Published
2023
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11. Decoupling activation volume via dynamic electron transfer in stress-driven chemical reactions.

Author

Jiang, Yilong, Sun, Junhui, Lu, Yangyang, Chen, Lei, Jiang, Liang, Du, Shiyu, and Qian, Linmao

Subjects
*CHEMICAL reactions, *CHARGE exchange, *CHARGE transfer, *SURFACE chemistry, *COOPETITION
Abstract

The activation volume, which quantifies the response of the chemical reactions to the applied stress, plays a central role in controlling the mechanochemical reactions for applications including lubricity, wear, and the topographic fabrication of the surfaces under stress. However, the physical interpretations of the activation volume remain scientifically intriguing and largely unexplored. Here, density functional theory calculations are used to investigate the general rules of charge transfer underlying activation volume in controlling the typically mechanochemical reaction process. It is found that the activation volume could be decoupled into the electronic contributions from interface chemistry and bulk physical deformation, which are commonly linear dependent on the contact pressure. Therefore, the activation volume may, indeed, be derived from the stress-driven charge transfer underlying cooperative competition between interfacial chemistry and the bulk region. This competition is related to the stiffness change from the bulk to slab. The magnitude of the stiffness change represents the degree to which the interface atoms modify the bulk properties, which is directly related to the contribution of different regions to the activation volume. This work may open up the understanding of the activation volume from dynamic electron transfer to engineer mechanochemical reactions, different from the existing insights into the geometric dimensionality of the contact configuration. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Optimal time point of response assessment for predicting survival is associated with tumor burden in hepatocellular carcinoma receiving repeated transarterial chemoembolization

Author

Xia, Dongdong, Wang, Qiuhe, Bai, Wei, Wang, Enxin, Wang, Zhexuan, Mu, Wei, Sun, Junhui, Huang, Ming, Yin, Guowen, Li, Hailiang, Zhao, Hui, Zhang, Chunqing, Li, Jing, Wu, Jianbing, Zhu, Xiaoli, Yang, Shufa, Pan, Xingnan, Li, Jiaping, Li, Zixiang, Xu, Guohui, Shi, Haibin, Zhang, Hui, Zhang, Yuelin, Ding, Rong, Yu, Hui, Zheng, Lin, Yang, Xiaohu, Wang, Guangchuan, You, Nan, Feng, Long, Zhang, Shuai, Huang, Wukui, Xu, Tao, Fan, Wenzhe, Li, Xueda, Yang, Xuegang, Zhou, Weizhong, Wang, Wenjun, Li, Xiaomei, Wang, Zhengyu, Luo, Bohan, Niu, Jing, Yuan, Jie, Lv, Yong, Li, Kai, Guo, Wengang, Yin, Zhanxin, Fan, Daiming, Xia, Jielai, and Han, Guohong

Published
2022
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19. CLIF-C AD score predicts survival benefit from pre-emptive TIPS in individuals with Child-Pugh B cirrhosis and acute variceal bleeding

Author

Lv, Yong, Bai, Wei, Zhu, Xuan, Xue, Hui, Zhao, Jianbo, Zhuge, Yuzheng, Sun, Junhui, Zhang, Chunqing, Ding, Pengxu, Jiang, Zaibo, Zhu, Xiaoli, Ren, Weixin, Li, Yingchun, Zhang, Kewei, Zhang, Wenguang, Li, Kai, Wang, Zhengyu, Luo, Bohan, Li, Xiaomei, Yang, Zhiping, Wang, Qiuhe, Guo, Wengang, Xia, Dongdong, Yang, Changbing, Pan, Yanglin, Yin, Zhanxin, Fan, Daiming, and Han, Guohong

Published
2022
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24. Association between famine exposure during infancy and childhood and the risk of chronic kidney disease in adulthood.

Author

Liu, Xiao, Sun, Junhui, Ge, Bing, Pan, Chi, Yan, Hongxuan, Sun, Xiaohui, Peng, Jiahui, Wang, Weijing, Lin, Yongfeng, Zhang, Dongfeng, and Ning, Feng

Subjects
*RISK assessment, *CROSS-sectional method, *BODY mass index, *EARLY medical intervention, *RESIDENTIAL patterns, *FOOD security, *DESCRIPTIVE statistics, *CHRONIC kidney failure, *ODDS ratio, *FAMINES, *CONFIDENCE intervals, *COMPARATIVE studies, *NATURAL disasters, *GLOMERULAR filtration rate, *DISEASE risk factors, *CHILDREN, *ADULTS
Abstract

Background: Famine exposure in childhood is proven to be associated with multiple chornic disease in adult but has not been studied with chronic kidney disease (CKD). Aims: This study was conducted to identify the relationship between famine exposure during infancy and childhood – specifically, the Chinese famine of 1959–1961 – and the risk of adult‐onset chronic kidney disease (CKD) among Chinese individuals. Methods: This study included 2937 individuals from the Qingdao Diabetes Prevention Program. They were stratified by birth year into infancy‐exposed (1956–1958), childhood‐exposed (1950–1955) and unexposed (1963–1971) groups. The estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. CKD was defined as an eGFR of <90 mL/min/1.73 m2. Results: The mean eGFR values for the infancy‐exposed and childhood‐exposed groups were 107.23 ± 12.53 and 103.23 ± 12.44 mL/min/1.73 m2, respectively, both of which were lower than that of the unexposed group (114.82 ± 13.39 mL/min/1.73 m2; P < 0.05). In the crude model, the odds ratio (OR) for CKD was 2.00 (95% confidence interval (CI): 1.39–2.88) in the infancy‐exposed group and 2.92 (95% CI: 2.17–3.93) in the childhood‐exposed group. Further adjustments for urban/rural residence, body mass index, age, current smoking, type 2 diabetes, systolic blood pressure, diastolic blood pressure and total cholesterol did not significantly alter the association between famine exposure and CKD. The corresponding ORs were 1.71 (95% CI: 1.17–2.50) and 2.48 (95% CI: 1.81–3.40) for the infancy‐exposed and childhood‐exposed groups respectively. Conclusions: Famine exposure during infancy and childhood is associated with a long‐term decline in eGFR and an increased adult‐onset CKD risk. Early intervention for high‐risk individuals may mitigate the risk of adult‐onset CKD. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Multiview confocal super-resolution microscopy

Author

Wu, Yicong, Han, Xiaofei, Su, Yijun, Glidewell, Melissa, Daniels, Jonathan S., Liu, Jiamin, Sengupta, Titas, Rey-Suarez, Ivan, Fischer, Robert, Patel, Akshay, Combs, Christian, Sun, Junhui, Wu, Xufeng, Christensen, Ryan, Smith, Corey, Bao, Lingyu, Sun, Yilun, Duncan, Leighton H., Chen, Jiji, Pommier, Yves, Shi, Yun-Bo, Murphy, Elizabeth, Roy, Sougata, Upadhyaya, Arpita, Colón-Ramos, Daniel, La Riviere, Patrick, and Shroff, Hari

Published
2021
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32. Integrated analysis reveals critical cisplatin-resistance regulators E2F7 contributed to tumor progression and metastasis in lung adenocarcinoma

Author

Mao, Xiaomin, primary, Xu, Shumin, additional, Wang, Huan, additional, Xiao, Peng, additional, Li, Shumin, additional, Wu, Jiaji, additional, Sun, Junhui, additional, Cheng, Jin, additional, Shen, Mo, additional, Shi, Yueli, additional, Tang, Bufu, additional, Yang, Ying, additional, Chen, Weiyu, additional, Xu, Zhiyong, additional, and Xu, Yun, additional

Published
2024
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37. Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data

Author

Bureau, Christophe, Abraldes, Juan G., Nevens, Frederik, Caca, Karel, Laleman, Wim, Appenrodt, Beate, Luca, Angelo, Vinel, Jean Pierre, Mössner, Joachim, Di Pascoli, Marco, Zipprich, Alexander, Sauerbruch, Tilman, Martinez-Lagares, Francisco, Ruiz-del-Arbol, Luis, Sierra, Angel, Guevara, Clemencia, Jimenez, Elena, Marrero, Jose Miguel, Buceta, Enrique, Sanchez, Juan, Castellot, Ana, Penate, Monica, Cruz, Ana, Pena, Elena, Procopeț, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Trebicka, Jonel, Llop, Elba, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell’Era, Alessandra, Senzolo, Marco, Romero-Gómez, Manuel, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Alvarado, Edilmar, Guardascione, Maria Anna, Tanțău, Marcel, Zuo, Luo, Zhu, Xuan, Zhao, Jianbo, Xue, Hui, Jiang, Zaibo, Zhuge, Yuzheng, Zhang, Chunqing, Sun, Junhui, Ding, Pengxu, Ren, Weixin, Li, Yingchun, Zhang, Kewei, Zhang, Wenguang, He, Chuangye, Zhong, Jiawei, Peng, Qifeng, Ma, Fuquan, Luo, Junyang, Zhang, Ming, Wang, Guangchuan, Sun, Minhuang, Dong, Junjiao, Bai, Wei, Guo, Wengang, Wang, Qiuhe, Yuan, Xulong, Wang, Zhengyu, Yu, Tianlei, Luo, Bohan, Li, Xiaomei, Yuan, Jie, Han, Na, Zhu, Ying, Niu, Jing, Li, Kai, Yin, Zhanxin, Nie, Yongzhan, Fischer, Petra, Horia Ștefănescu, Pop, Andreea, Laursen, Stig B., Turon, Fanny, Baiges, Anna, Ferrusquía-Acosta, José, Magaz, Marta, Cerda, Eira, Tellez, Luis, Allegretti, Giulia, Macedo, Guilherme, Haldrup, David, Santos, Patricia, Moura, Miguel, Reis, Daniela, Meireles, Liliane, Sousa, Patricia, Alexandrino, Paula, Navascues, Carmen, Augustin, Salvador, La Mura, Vincenzo, Bañares, Rafael, Diaz, Raquel, Gómez, Marta López, Ripoll, Cristina, Nicoară-Farcău, Oana, Han, Guohong, Rudler, Marika, Angrisani, Debora, Monescillo, Alberto, Torres, Ferran, Casanovas, Georgina, Bosch, Jaime, Lv, Yong, Thabut, Dominique, Fan, Daiming, Hernández-Gea, Virginia, and García-Pagán, Juan Carlos

Published
2021
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47. Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria

Author

Sun, Junhui, Nguyen, Tiffany, Aponte, Angel M, Menazza, Sara, Kohr, Mark J, Roth, David M, Patel, Hemal H, Murphy, Elizabeth, and Steenbergen, Charles

Subjects
Cardiovascular, Aetiology, 2.1 Biological and endogenous factors, Animals, Caveolin 3, Ischemic Preconditioning, Myocardial, Male, Mice, Inbred C57BL, Mitochondria, Heart, Myocardium, Nitric Oxide Synthase Type III, Protein Processing, Post-Translational, Sarcolemma, Protein S-nitrosylation, Ischaemic preconditioning, Caveolae, Subsarcolemmal and interfibrillar mitochondria
Abstract

Nitric oxide (NO) and protein S-nitrosylation (SNO) have been shown to play important roles in ischaemic preconditioning (IPC)-induced acute cardioprotection. The majority of proteins that show increased SNO following IPC are localized to the mitochondria, and our recent studies suggest that caveolae transduce acute NO/SNO cardioprotective signalling in IPC hearts. Due to the close association between subsarcolemmal mitochondria (SSM) and the sarcolemma/caveolae, we tested the hypothesis that SSM, rather than the interfibrillar mitochondria (IFM), are major targets for NO/SNO signalling derived from caveolae-associated eNOS. Following either control perfusion or IPC, SSM and IFM were isolated from Langendorff perfused mouse hearts, and SNO was analysed using a modified biotin switch method with fluorescent maleimide fluors. In perfusion control hearts, the SNO content was higher in SSM compared with IFM (1.33 ± 0.19, ratio of SNO content Perf-SSM vs. Perf-IFM), and following IPC SNO content significantly increased preferentially in SSM, but not in IFM (1.72 ± 0.17 and 1.07 ± 0.04, ratio of SNO content IPC-SSM vs. Perf-IFM, and IPC-IFM vs. Perf-IFM, respectively). Consistent with these findings, eNOS, caveolin-3, and connexin-43 were detected in SSM, but not in IFM, and IPC resulted in a further significant increase in eNOS/caveolin-3 levels in SSM. Interestingly, we did not observe an IPC-induced increase in SNO or eNOS/caveolin-3 in SSM isolated from caveolin-3(-/-) mouse hearts, which could not be protected with IPC. In conclusion, these results suggest that SSM may be the preferential target of sarcolemmal signalling-derived post-translational protein modification (caveolae-derived eNOS/NO/SNO), thus providing an important role in IPC-induced cardioprotection.

Published
2015

48. Development of a prognostic score for recommended TACE candidates with hepatocellular carcinoma: A multicentre observational study

Author

Wang, Qiuhe, Xia, Dongdong, Bai, Wei, Wang, Enxin, Sun, Junhui, Huang, Ming, Mu, Wei, Yin, Guowen, Li, Hailiang, Zhao, Hui, Li, Jing, Zhang, Chunqing, Zhu, Xiaoli, Wu, Jianbing, Li, Jiaping, Gong, Weidong, Li, Zixiang, Lin, Zhengyu, Pan, Xingnan, Shi, Haibin, Shao, Guoliang, Liu, Jueshi, Yang, Shufa, Zheng, Yanbo, Xu, Jian, Song, Jinlong, Wang, Wenhui, Wang, Zhexuan, Zhang, Yuelin, Ding, Rong, Zhang, Hui, Yu, Hui, Zheng, Lin, Gu, Weiwei, You, Nan, Wang, Guangchuan, Zhang, Shuai, Feng, Long, Liu, Lin, Zhang, Peng, Li, Xueda, Chen, Jian, Xu, Tao, Zhou, Weizhong, Zeng, Hui, Zhang, Yongjin, Huang, Wukui, Jiang, Wenjin, Zhang, Wen, Shao, Wenbo, Li, Lei, Niu, Jing, Yuan, Jie, Li, Xiaomei, Lv, Yong, Li, Kai, Yin, Zhanxin, Xia, Jielai, Fan, Daiming, and Han, Guohong

Published
2019
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