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Chen-Yu Chen,1,2 Ying-Hao Wang,1 Chie-Pein Chen,1 Fang-Ju Sun,3 Yi-Yung Chen,1 Yu-Jun Huang,1 Nan-Fu Chiu4,5 1Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, 10449, Taiwan; 2Department of Medicine, MacKay Medical College, New Taipei City, 252005, Taiwan; 3Department of Medical Research, MacKay Memorial Hospital, Taipei, 10449, Taiwan; 4Laboratory of Nano-Photonics and Biosensors, Institute of Electro-Optical Engineering, National Taiwan Normal University, Taipei, 11677, Taiwan; 5Department of Life Science, National Taiwan Normal University, Taipei, 11677, TaiwanCorrespondence: Chen-Yu Chen, Department of Obstetrics and Gynecology, MacKay Memorial Hospital, No. 92, Section 2, Zhong-Shan North Road, Taipei, 10449, Taiwan, Tel +886-2-25433535, Fax +886-2-25433642, Email f122481@mmh.org.tw Nan-Fu Chiu, Laboratory of Nano-Photonics and Biosensors, Institute of Electro-Optical Engineering, National Taiwan Normal University, No. 88, Section 4, Ting-Chou Road, Taipei, 11677, Taiwan, Tel +886-2-77496722, Fax +886-2-86631954, Email nfchiu@ntnu.edu.twBackground: Preeclampsia, a major cause of adverse pregnancy outcomes, involves metalloproteinases pregnancy-associated plasma protein (PAPP)-A and PAPP-A2 from placental trophoblasts. The graphene oxide (GO)-based surface plasmon resonance (SPR) biosensor has higher sensitivity, affinity, and selective ability than the traditional SPR biosensor. The aim of this study was to explore the feasibility of measuring first-trimester serum PAPP-A/PAPP-A2 ratio as a novel predictor of preeclampsia using the GO-SPR biosensor.Methods: This prospective case-control study of pregnant women was conducted at MacKay Memorial Hospital, Taipei, Taiwan between January 2018 and June 2020. The SPR angle shifts of first-trimester serum PAPP-A, PAPP-A2, and PAPP-A/PAPP-A2 ratio measured using the GO-SPR biosensor were compared between preeclampsia and control groups.Results: Serum samples from 185 pregnant women were collecte

Tsung-han Lee,1 Hui-Ching Liu,1 Yu-Hsin Huang,1 Fang-Ju Sun,2 Shen-Ing Liu1 1Department of Child and Adolescent Psychiatry, MacKay Memorial Hospital, Taipei City, Taiwan; 2Department of Medical Research, MacKay Memorial Hospital, Taipei City, TaiwanCorrespondence: Shen-Ing Liu, Email maryliuyip@gmail.comBackground: Some risk/protective factors of adolescent depression have been proposed but have not been comprehensively studied. Recent advances in neuroimaging techniques have provided greater insight into the underlying neuropsychiatric mechanisms of depression-related factors such as impulsivity, substance use, gender difference and social support. However, how these factors are interconnected and how they affect depression in the real world is poorly understood. This study aimed to explore the relationships between adolescent depression with trait impulsivity, substance use and gender. We also tested the hypothesis that social support may play a buffering role in preventing depression. By expanding the diathesis-stress model.Methods: The adolescents enrolled in this study were grade 1 senior high school students from northern Taiwan (N = 5879), and they were assessed for depression, trait impulsivity, and tobacco/alcohol use. Hierarchical multiple linear regression was performed to control possible confounders, including other depression-related diathesis and sociodemographic variables. Gender differences were also analyzed by separately examining variables significantly associated with depression.Results: A higher level of depression was associated with female gender, trait impulsivity, low self-esteem, negative attitude towards the future, tobacco use, alcohol use, family discord and difficulty in basic family needs. Good parental health, living with their biological family and social support were protective factors. Trait impulsivity was significantly associated with depression after controlling for the confounding factors. Gender-specific analysis showed that