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In public health, it is critical for policymakers to assess the relationship between the disease prevalence and associated risk factors or clinical characteristics, facilitating effective resources allocation. However, for diseases like female breast cancer (FBC), reliable prevalence data at specific geographical levels, such as the county-level, are limited because the gold standard data typically come from long-term cancer registries, which do not necessarily collect needed risk factors. In addition, it remains unclear whether fitting each model separately or jointly results in better estimation. In this paper, we identify two data sources to produce reliable county-level prevalence estimates in Missouri, USA: the population-based Missouri Cancer Registry (MCR) and the survey-based Missouri County-Level Study (CLS). We propose a two-stage Bayesian model to synthesize these sources, accounting for their differences in the methodological design, case definitions, and collected information. The first stage involves estimating the county-level FBC prevalence using the raking method for CLS data and the counting method for MCR data, calibrating the differences in the methodological design and case definition. The second stage includes synthesizing two sources with different sets of covariates using a Bayesian generalized linear mixed model with Zeller-Siow prior for the coefficients. Our data analyses demonstrate that using both data sources have better results than at least one data source, and including a data source membership matters when there exist systematic differences in these sources. Finally, we translate results into policy making and discuss methodological differences for data synthesis of registry and survey data.

Relevance Vector Machine (RVM) is a supervised learning algorithm extended from Support Vector Machine (SVM) based on the Bayesian sparsity model. Compared with the regression problem, RVM classification is difficult to be conducted because there is no closed-form solution for the weight parameter posterior. Original RVM classification algorithm used Newton's method in optimization to obtain the mode of weight parameter posterior then approximated it by a Gaussian distribution in Laplace's method. It would work but just applied the frequency methods in a Bayesian framework. This paper proposes a Generic Bayesian approach for the RVM classification. We conjecture that our algorithm achieves convergent estimates of the quantities of interest compared with the nonconvergent estimates of the original RVM classification algorithm. Furthermore, a Fully Bayesian approach with the hierarchical hyperprior structure for RVM classification is proposed, which improves the classification performance, especially in the imbalanced data problem. By the numeric studies, our proposed algorithms obtain high classification accuracy rates. The Fully Bayesian hierarchical hyperprior method outperforms the Generic one for the imbalanced data classification., Comment: The extended and final version of this paper has been published with open access modality in the CAAI Transactions on Intelligence Technology and can be found at link https://ietresearch.onlinelibrary.wiley.com/doi/full/10.1049/cit2.12111. Please refer to the TRIT published version in your scientific papers

Radial basis functions are a common mathematical tool used to construct a smooth interpolating function from a set of data points. A spatial prior based on thin-plate spline radial basis functions can be easily implemented resulting in a posterior that can be sampled directly using Monte Carlo integration, avoiding the computational burden and potential inefficiency of an Monte Carlo Markov Chain (MCMC) sampling scheme. The derivation of the prior and sampling scheme are demonstrated.

Rejoinder to Overall Objective Priors by James O. Berger, Jose M. Bernardo, Dongchu Sun [arXiv:1504.02689], Comment: Published at http://dx.doi.org/10.1214/15-BA943 in the Bayesian Analysis (http://projecteuclid.org/euclid.ba) by the International Society of Bayesian Analysis (http://bayesian.org/)

In multi-parameter models, reference priors typically depend on the parameter or quantity of interest, and it is well known that this is necessary to produce objective posterior distributions with optimal properties. There are, however, many situations where one is simultaneously interested in all the parameters of the model or, more realistically, in functions of them that include aspects such as prediction, and it would then be useful to have a single objective prior that could safely be used to produce reasonable posterior inferences for all the quantities of interest. In this paper, we consider three methods for selecting a single objective prior and study, in a variety of problems including the multinomial problem, whether or not the resulting prior is a reasonable overall prior., Comment: Published at http://dx.doi.org/10.1214/14-BA915 in the Bayesian Analysis (http://projecteuclid.org/euclid.ba) by the International Society of Bayesian Analysis (http://bayesian.org/)

Reference analysis produces objective Bayesian inference, in the sense that inferential statements depend only on the assumed model and the available data, and the prior distribution used to make an inference is least informative in a certain information-theoretic sense. Reference priors have been rigorously defined in specific contexts and heuristically defined in general, but a rigorous general definition has been lacking. We produce a rigorous general definition here and then show how an explicit expression for the reference prior can be obtained under very weak regularity conditions. The explicit expression can be used to derive new reference priors both analytically and numerically., Comment: Published in at http://dx.doi.org/10.1214/07-AOS587 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)

Objective priors for sequential experiments are considered. Common priors, such as the Jeffreys prior and the reference prior, will typically depend on the stopping rule used for the sequential experiment. New expressions for reference priors are obtained in various contexts, and computational issues involving such priors are considered., Comment: Published in at http://dx.doi.org/10.1214/074921708000000020 the IMS Collections (http://www.imstat.org/publications/imscollections.htm) by the Institute of Mathematical Statistics (http://www.imstat.org)

Study of the bivariate normal distribution raises the full range of issues involving objective Bayesian inference, including the different types of objective priors (e.g., Jeffreys, invariant, reference, matching), the different modes of inference (e.g., Bayesian, frequentist, fiducial) and the criteria involved in deciding on optimal objective priors (e.g., ease of computation, frequentist performance, marginalization paradoxes). Summary recommendations as to optimal objective priors are made for a variety of inferences involving the bivariate normal distribution. In the course of the investigation, a variety of surprising results were found, including the availability of objective priors that yield exact frequentist inferences for many functions of the bivariate normal parameters, including the correlation coefficient., Comment: Published in at http://dx.doi.org/10.1214/07-AOS501 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)