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2. Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma

Author

Mahmood, Mahnoor, Liu, Eric Minwei, Shergold, Amy L., Tolla, Elisabetta, Tait-Mulder, Jacqueline, Huerta-Uribe, Alejandro, Shokry, Engy, Young, Alex L., Lilla, Sergio, Kim, Minsoo, Park, Tricia, Boscenco, Sonia, Manchon, Javier L., Rodríguez-Antona, Crístina, Walters, Rowan C., Springett, Roger J., Blaza, James N., Mitchell, Louise, Blyth, Karen, Zanivan, Sara, Sumpton, David, Roberts, Edward W., Reznik, Ed, and Gammage, Payam A.

Published
2024
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3. ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota

Author

Eberhart, Tanja, Stanley, Federico Uchenna, Ricci, Luisa, Chirico, Tiziana, Ferrarese, Roberto, Sisti, Sofia, Scagliola, Alessandra, Baj, Andreina, Badurek, Sylvia, Sommer, Andreas, Culp-Hill, Rachel, Dzieciatkowska, Monika, Shokry, Engy, Sumpton, David, D’Alessandro, Angelo, Clementi, Nicola, Mancini, Nicasio, and Cardaci, Simone

Published
2024
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5. Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

Author

Vande Voorde, Johan, Steven, Rory T., Najumudeen, Arafath K., Ford, Catriona A., Dexter, Alex, Gonzalez-Fernandez, Ariadna, Nikula, Chelsea J., Xiang, Yuchen, Ford, Lauren, Maneta Stavrakaki, Stefania, Gilroy, Kathryn, Zeiger, Lucas B., Pennel, Kathryn, Hatthakarnkul, Phimmada, Elia, Efstathios A., Nasif, Ammar, Murta, Teresa, Manoli, Eftychios, Mason, Sam, Gillespie, Michael, Lannagan, Tamsin R. M., Vlahov, Nikola, Ridgway, Rachel A., Nixon, Colin, Raven, Alexander, Mills, Megan, Athineos, Dimitris, Kanellos, Georgios, Nourse, Craig, Gay, David M., Hughes, Mark, Burton, Amy, Yan, Bin, Sellers, Katherine, Wu, Vincen, De Ridder, Kobe, Shokry, Engy, Huerta Uribe, Alejandro, Clark, William, Clark, Graeme, Kirschner, Kristina, Thienpont, Bernard, Li, Vivian S. W., Maddocks, Oliver D. K., Barry, Simon T., Goodwin, Richard J. A., Kinross, James, Edwards, Joanne, Yuneva, Mariia O., Sumpton, David, Takats, Zoltan, Campbell, Andrew D., Bunch, Josephine, and Sansom, Owen J.

Published
2023
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7. PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

Author

Benzarti, Mohaned, Neises, Laura, Oudin, Anais, Krötz, Christina, Viry, Elodie, Gargiulo, Ernesto, Pulido, Coralie, Schmoetten, Maryse, Pozdeev, Vitaly, Lorenz, Nadia I., Ronellenfitsch, Michael W., Sumpton, David, Warmoes, Marc, Jaeger, Christian, Lesur, Antoine, Becker, Björn, Moussay, Etienne, Paggetti, Jerome, Niclou, Simone P., Letellier, Elisabeth, and Meiser, Johannes

Published
2024
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8. Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer

Author

Villar, Victor H., Allega, Maria Francesca, Deshmukh, Ruhi, Ackermann, Tobias, Nakasone, Mark A., Vande Voorde, Johan, Drake, Thomas M., Oetjen, Janina, Bloom, Algernon, Nixon, Colin, Müller, Miryam, May, Stephanie, Tan, Ee Hong, Vereecke, Lars, Jans, Maude, Blancke, Gillian, Murphy, Daniel J., Huang, Danny T., Lewis, David Y., Bird, Thomas G., Sansom, Owen J., Blyth, Karen, Sumpton, David, and Tardito, Saverio

Published
2023
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9. Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration

Author

May, Stephanie, Müller, Miryam, Livingstone, Callum R., Skalka, George L., Walsh, Peter J., Nixon, Colin, Hedley, Ann, Shaw, Robin, Clark, William, Vande Voorde, Johan, Officer-Jones, Leah, Ballantyne, Fiona, Powley, Ian R., Drake, Thomas M., Kiourtis, Christos, Keith, Andrew, Rocha, Ana Sofia, Tardito, Saverio, Sumpton, David, Le Quesne, John, Bushell, Martin, Sansom, Owen J., and Bird, Thomas G.

Published
2023
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11. Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia

Author

Khalaf, Ahmed, primary, de Beauchamp, Lucie, additional, Kalkman, Eric, additional, Rattigan, Kevin, additional, Himonas, Ekaterini, additional, Jones, Joe, additional, James, Daniel, additional, Shokry, Engy Shokry Abd, additional, Scott, Mary T., additional, Dunn, Karen, additional, Tardito, Saverio, additional, Copland, Mhairi, additional, Sumpton, David, additional, Shanks, Emma, additional, and Helgason, G. Vignir, additional

Published
2024
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12. Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

Author

Gounis, Michalis, primary, Campos, America, additional, Shokry, Engy, additional, Mitchell, Louise, additional, Dornier, Emmanuel, additional, Rooney, Nicholas, additional, Dhayade, Sandeep, additional, Pardo, Luis, additional, Moore, Madeleine, additional, Novo, David, additional, Mowat, Jenna, additional, Jamieson, Craig, additional, Kay, Emily, additional, Zanivan, Sara, additional, Nixon, Colin, additional, Macpherson, Iain, additional, Tardito, Saverio, additional, Sumpton, David, additional, Blyth, Karen, additional, Norman, James C., additional, and Clarke, Cassie, additional

Published
2024
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13. Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix

Author

Kay, Emily J., Paterson, Karla, Riero-Domingo, Carla, Sumpton, David, Däbritz, J. Henry M., Tardito, Saverio, Boldrini, Claudia, Hernandez-Fernaud, Juan R., Athineos, Dimitris, Dhayade, Sandeep, Stepanova, Ekaterina, Gjerga, Enio, Neilson, Lisa J., Lilla, Sergio, Hedley, Ann, Koulouras, Grigorios, McGregor, Grace, Jamieson, Craig, Johnson, Radia Marie, Park, Morag, Kirschner, Kristina, Miller, Crispin, Kamphorst, Jurre J., Loayza-Puch, Fabricio, Saez-Rodriguez, Julio, Mazzone, Massimiliano, Blyth, Karen, Zagnoni, Michele, and Zanivan, Sara

Published
2022
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16. The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

Author

Najumudeen, Arafath K., Ceteci, Fatih, Fey, Sigrid K., Hamm, Gregory, Steven, Rory T., Hall, Holly, Nikula, Chelsea J., Dexter, Alex, Murta, Teresa, Race, Alan M., Sumpton, David, Vlahov, Nikola, Gay, David M., Knight, John R. P., Jackstadt, Rene, Leach, Joshua D. G., Ridgway, Rachel A., Johnson, Emma R., Nixon, Colin, Hedley, Ann, Gilroy, Kathryn, Clark, William, Malla, Sudhir B., Dunne, Philip D., Rodriguez-Blanco, Giovanny, Critchlow, Susan E., Mrowinska, Agata, Malviya, Gaurav, Solovyev, Dmitry, Brown, Gavin, Lewis, David Y., Mackay, Gillian M., Strathdee, Douglas, Tardito, Saverio, Gottlieb, Eyal, Takats, Zoltan, Barry, Simon T., Goodwin, Richard J. A., Bunch, Josephine, Bushell, Martin, Campbell, Andrew D., and Sansom, Owen J.

Published
2021
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17. The pathogenesis of mesothelioma is driven by a dysregulated translatome

Author

Grosso, Stefano, Marini, Alberto, Gyuraszova, Katarina, Voorde, Johan Vande, Sfakianos, Aristeidis, Garland, Gavin D., Tenor, Angela Rubio, Mordue, Ryan, Chernova, Tanya, Morone, Nobu, Sereno, Marco, Smith, Claire P., Officer, Leah, Farahmand, Pooyeh, Rooney, Claire, Sumpton, David, Das, Madhumita, Teodósio, Ana, Ficken, Catherine, Martin, Maria Guerra, Spriggs, Ruth V., Sun, Xiao-Ming, Bushell, Martin, Sansom, Owen J., Murphy, Daniel, MacFarlane, Marion, Le Quesne, John P. C., and Willis, Anne E.

Published
2021
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18. Author Correction: Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix

Author

Kay, Emily J., Paterson, Karla, Riera-Domingo, Carla, Sumpton, David, Däbritz, J. Henry M., Tardito, Saverio, Boldrini, Claudia, Hernandez-Fernaud, Juan R., Athineos, Dimitris, Dhayade, Sandeep, Stepanova, Ekaterina, Gjerga, Enio, Neilson, Lisa J., Lilla, Sergio, Hedley, Ann, Koulouras, Grigorios, McGregor, Grace, Jamieson, Craig, Johnson, Radia Marie, Park, Morag, Kirschner, Kristina, Miller, Crispin, Kamphorst, Jurre J., Loayza-Puch, Fabricio, Saez-Rodriguez, Julio, Mazzone, Massimiliano, Blyth, Karen, Zagnoni, Michele, and Zanivan, Sara

Published
2022
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23. Mass Spectrometric Studies Of The Rhizobium-Legume Symbiosis

Author

Sumpton, David

Subjects
571.2
Abstract

The highly specific symbiotic interaction between leguminous plants and rhizobial bacteria culminates in the fixation of atmospheric nitrogen which is made available to the host plant and ultimately replenishes the soil. This has the potential to act as a natural means to the benefits now frequently derived through the use of fertilizers Within agriculture. We have been investigating this symbiosis for soybean cultivars cropped in China, where the level of soluble nitrogen often limits crop yields. Through the use of classic carbohydrate isolation methodologies and' state-of-the-art mass spectrometric approaches, the profiling and structural characterisation of key glycoconjugate mediators ofthe symbiosis was performed. The LPS profile fromMesorhizobium tianshanenese, a rhizobium strain which has surprising symbiotic properties, was established and compared to the LPS profiles of other strains of rhizobia. The isolation and the structural characterisation of the capsular polysaccharide from 'the efficient soybean nodulator S. fredii SMHI2, was attempted. It was shown that SMH12 does not produce KPS which resembles any of the other previously identified rhizobial KPSs. The capsular polysaccharide of a Sinorhizobium fredii HH103 mutant (HH103rif ) was also successfully isolated and its structure was shown to be identical to that ofthe HHI03 strain. The structures of the periplasmic and secreted forms ofthe ~-cycloglucan from S. fredii HHI03 were characterised. The degree of polymerisation of the secreted form was found to vary between GlcI8 and Glc26 glucose residues. The periplasmic form was found to vary between 21 and 23 glucoses, and was substituted with three phosphoglycerol moieties. The structures of the major Nod Factor species secreted from two Mesorhizobium loti nod gene mutants (nodZ, nolL) which had shown phenotypic variation in their nodulation behavior, were profiled. Through the analysis ofanother nod mutant ofm. loti, the minimum nodgenes required forM loti to be able to nodulate L. japonicus were identified, namely nodDI, nodD2, nodA and node. Modifications to the structure of rhizobial membrane lipids can significantly compromise the successful outcome of the symbiosis. The /px02 gene is involved in .the synthesis of lipids in Burkholderia cenocepacia and is thought to be important for pathogenesis. In order to investigate the activity of the B. cenocepacia lpx02 gene, the extractable lipids of B. enocepacia and a B. cenocepacia mutant in which extra copies of the lpx02 gene had been introduced were identified using mass spectrometry. The study focused on identifying the site of lipid hydroxylation catalysed by the Ipx02 gene product. The structures of a range of lipid classes (pG, CL, PE, PE-OR, OL, and OL-OR) were profiled in both the wild type and mutant strain. Introduction of extra copies of lpx02 into B. cenocepacia resuIt~d in two additional lipid species, the first of which was consistent with a hydroxylated ornithine lipid structure, hydroxylation being on the amide linked acyl chain. The second species was hydroxylated, on both fatty acid residues. These results suggest that the lpx02 gene is capable of hydroxylating both ornithine lipids and hydroxylated ornithine lipids. Several targeted studies ofthe proteomes ofthe two symbiotic partners were undertaken. Due to the inherent problems associated with plant proteomics, especially the recalcitrant nature of the sample, alternative monolithic LC-MS/MS based methods were developed that allowed the successful analysis of selected sub-proteomes, where classical approaches failed. These approaches were evaluated through the analysis of several different protein mixtures ranging in complexity and generated during the study of the rhizobium-legume symbiosis. These enabled the identification of two new proteins secreted via a type III secretion mechanism, by the beneficial soybean nitrogen fixing micro-symbiont S.fredii HHI03.

Published
2007

24. Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells

Author

Rattigan, Kevin M, primary, Zarou, Martha M, additional, Brabcova, Zuzana, additional, Prasad, Bodhayan, additional, Zerbst, Désirée, additional, Sarnello, Daniele, additional, Kalkman, Eric R, additional, Ianniciello, Angela, additional, Scott, Mary T, additional, Dunn, Karen, additional, Shokry, Engy, additional, Sumpton, David, additional, Copland, Mhairi, additional, Tardito, Saverio, additional, Vande Voorde, Johan, additional, Mussai, Francis, additional, Cheng, Paul, additional, and Helgason, G Vignir, additional

Published
2023
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27. 2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

Author

Blomme, Arnaud, Ford, Catriona A., Mui, Ernest, Patel, Rachana, Ntala, Chara, Jamieson, Lauren E., Planque, Mélanie, McGregor, Grace H., Peixoto, Paul, Hervouet, Eric, Nixon, Colin, Salji, Mark, Gaughan, Luke, Markert, Elke, Repiscak, Peter, Sumpton, David, Blanco, Giovanny Rodriguez, Lilla, Sergio, Kamphorst, Jurre J., Graham, Duncan, Faulds, Karen, MacKay, Gillian M., Fendt, Sarah-Maria, Zanivan, Sara, and Leung, Hing Y.

Published
2020
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29. Supplementary Methods from Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Author

Port, Jennifer, primary, Muthalagu, Nathiya, primary, Raja, Meera, primary, Ceteci, Fatih, primary, Monteverde, Tiziana, primary, Kruspig, Björn, primary, Hedley, Ann, primary, Kalna, Gabriela, primary, Lilla, Sergio, primary, Neilson, Lisa, primary, Brucoli, Martina, primary, Gyuraszova, Katarina, primary, Tait-Mulder, Jacqueline, primary, Mezna, Mokdad, primary, Svambaryte, Silvija, primary, Bryson, Amy, primary, Sumpton, David, primary, McVie, Allan, primary, Nixon, Colin, primary, Drysdale, Martin, primary, Esumi, Hiroyasu, primary, Murray, Graeme I., primary, Sansom, Owen J., primary, Zanivan, Sara R., primary, and Murphy, Daniel J., primary

Published
2023
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30. Supplementary Table 3 from Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Author

Port, Jennifer, primary, Muthalagu, Nathiya, primary, Raja, Meera, primary, Ceteci, Fatih, primary, Monteverde, Tiziana, primary, Kruspig, Björn, primary, Hedley, Ann, primary, Kalna, Gabriela, primary, Lilla, Sergio, primary, Neilson, Lisa, primary, Brucoli, Martina, primary, Gyuraszova, Katarina, primary, Tait-Mulder, Jacqueline, primary, Mezna, Mokdad, primary, Svambaryte, Silvija, primary, Bryson, Amy, primary, Sumpton, David, primary, McVie, Allan, primary, Nixon, Colin, primary, Drysdale, Martin, primary, Esumi, Hiroyasu, primary, Murray, Graeme I., primary, Sansom, Owen J., primary, Zanivan, Sara R., primary, and Murphy, Daniel J., primary

Published
2023
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31. Data from Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Author

Port, Jennifer, primary, Muthalagu, Nathiya, primary, Raja, Meera, primary, Ceteci, Fatih, primary, Monteverde, Tiziana, primary, Kruspig, Björn, primary, Hedley, Ann, primary, Kalna, Gabriela, primary, Lilla, Sergio, primary, Neilson, Lisa, primary, Brucoli, Martina, primary, Gyuraszova, Katarina, primary, Tait-Mulder, Jacqueline, primary, Mezna, Mokdad, primary, Svambaryte, Silvija, primary, Bryson, Amy, primary, Sumpton, David, primary, McVie, Allan, primary, Nixon, Colin, primary, Drysdale, Martin, primary, Esumi, Hiroyasu, primary, Murray, Graeme I., primary, Sansom, Owen J., primary, Zanivan, Sara R., primary, and Murphy, Daniel J., primary

Published
2023
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32. Figures S1-S6 & Tables S1 & S2 from Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Author

Port, Jennifer, primary, Muthalagu, Nathiya, primary, Raja, Meera, primary, Ceteci, Fatih, primary, Monteverde, Tiziana, primary, Kruspig, Björn, primary, Hedley, Ann, primary, Kalna, Gabriela, primary, Lilla, Sergio, primary, Neilson, Lisa, primary, Brucoli, Martina, primary, Gyuraszova, Katarina, primary, Tait-Mulder, Jacqueline, primary, Mezna, Mokdad, primary, Svambaryte, Silvija, primary, Bryson, Amy, primary, Sumpton, David, primary, McVie, Allan, primary, Nixon, Colin, primary, Drysdale, Martin, primary, Esumi, Hiroyasu, primary, Murray, Graeme I., primary, Sansom, Owen J., primary, Zanivan, Sara R., primary, and Murphy, Daniel J., primary

Published
2023
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33. Data from SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer

Author

Martinez, Rafael S., primary, Salji, Mark J., primary, Rushworth, Linda, primary, Ntala, Chara, primary, Rodriguez Blanco, Giovanny, primary, Hedley, Ann, primary, Clark, William, primary, Peixoto, Paul, primary, Hervouet, Eric, primary, Renaude, Elodie, primary, Kung, Sonia H.Y., primary, Galbraith, Laura C.A., primary, Nixon, Colin, primary, Lilla, Sergio, primary, MacKay, Gillian M., primary, Fazli, Ladan, primary, Gaughan, Luke, primary, Sumpton, David, primary, Gleave, Martin E., primary, Zanivan, Sara, primary, Blomme, Arnaud, primary, and Leung, Hing Y., primary

Published
2023
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34. Data from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

Author

Rath, Nicola, primary, Munro, June, primary, Cutiongco, Marie Francene, primary, Jagiełło, Alicja, primary, Gadegaard, Nikolaj, primary, McGarry, Lynn, primary, Unbekandt, Mathieu, primary, Michalopoulou, Evdokia, primary, Kamphorst, Jurre J., primary, Sumpton, David, primary, Mackay, Gillian, primary, Vennin, Claire, primary, Pajic, Marina, primary, Timpson, Paul, primary, and Olson, Michael F., primary

Published
2023
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36. Supplemental Figures S1 to S5 from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

Author

Rath, Nicola, primary, Munro, June, primary, Cutiongco, Marie Francene, primary, Jagiełło, Alicja, primary, Gadegaard, Nikolaj, primary, McGarry, Lynn, primary, Unbekandt, Mathieu, primary, Michalopoulou, Evdokia, primary, Kamphorst, Jurre J., primary, Sumpton, David, primary, Mackay, Gillian, primary, Vennin, Claire, primary, Pajic, Marina, primary, Timpson, Paul, primary, and Olson, Michael F., primary

Published
2023
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38. Supplementary Data from Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression

Author

Patel, Rachana, primary, Ford, Catriona A., primary, Rodgers, Lisa, primary, Rushworth, Linda K., primary, Fleming, Janis, primary, Mui, Ernest, primary, Zhang, Tong, primary, Watson, David, primary, Lynch, Victoria, primary, Mackay, Gillian, primary, Sumpton, David, primary, Sansom, Owen J., primary, Vande Voorde, Johan, primary, and Leung, Hing Y., primary

Published
2023
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39. Supplementary Data 2 from SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer

Author

Martinez, Rafael S., primary, Salji, Mark J., primary, Rushworth, Linda, primary, Ntala, Chara, primary, Rodriguez Blanco, Giovanny, primary, Hedley, Ann, primary, Clark, William, primary, Peixoto, Paul, primary, Hervouet, Eric, primary, Renaude, Elodie, primary, Kung, Sonia H.Y., primary, Galbraith, Laura C.A., primary, Nixon, Colin, primary, Lilla, Sergio, primary, MacKay, Gillian M., primary, Fazli, Ladan, primary, Gaughan, Luke, primary, Sumpton, David, primary, Gleave, Martin E., primary, Zanivan, Sara, primary, Blomme, Arnaud, primary, and Leung, Hing Y., primary

Published
2023
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40. Supplementary Information from SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer

Author

Martinez, Rafael S., primary, Salji, Mark J., primary, Rushworth, Linda, primary, Ntala, Chara, primary, Rodriguez Blanco, Giovanny, primary, Hedley, Ann, primary, Clark, William, primary, Peixoto, Paul, primary, Hervouet, Eric, primary, Renaude, Elodie, primary, Kung, Sonia H.Y., primary, Galbraith, Laura C.A., primary, Nixon, Colin, primary, Lilla, Sergio, primary, MacKay, Gillian M., primary, Fazli, Ladan, primary, Gaughan, Luke, primary, Sumpton, David, primary, Gleave, Martin E., primary, Zanivan, Sara, primary, Blomme, Arnaud, primary, and Leung, Hing Y., primary

Published
2023
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41. Data from Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression

Author

Patel, Rachana, primary, Ford, Catriona A., primary, Rodgers, Lisa, primary, Rushworth, Linda K., primary, Fleming, Janis, primary, Mui, Ernest, primary, Zhang, Tong, primary, Watson, David, primary, Lynch, Victoria, primary, Mackay, Gillian, primary, Sumpton, David, primary, Sansom, Owen J., primary, Vande Voorde, Johan, primary, and Leung, Hing Y., primary

Published
2023
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42. Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

Author

Mahmood, Mahnoor, primary, Liu, Eric Minwei, additional, Shergold, Amy L., additional, Tolla, Elisabetta, additional, Tait-Mulder, Jacqueline, additional, Uribe, Alejandro Huerta, additional, Shokry, Engy, additional, Young, Alex L., additional, Lilla, Sergio, additional, Kim, Minsoo, additional, Park, Tricia, additional, Manchon, Javier L, additional, Rodriguez-Antona, Cristina, additional, Walters, Rowan C., additional, Springett, Roger J., additional, Blaza, James N., additional, Zanivan, Sara, additional, Sumpton, David A, additional, Roberts, Edward W., additional, Reznik, Ed, additional, and Gammage, Payam A, additional

Published
2023
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43. Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

Author

Voorde, Johan Vande, primary, Najumudeen, Arafath K., additional, Steven, Rory T., additional, Nikula, Chelsea J., additional, Dexter, Alex, additional, Zeiger, Lucas B., additional, Elia, Efstathios A., additional, Nasif, Ammar, additional, Gonzalez-Fernandez, Ariadna, additional, Murta, Teresa, additional, Gillespie, Michael, additional, Ford, Catriona A., additional, Lannagan, Tamsin R.M., additional, Vlahov, Nikola, additional, Ridgway, Rachel A., additional, Nixon, Colin, additional, Gilroy, Kathryn, additional, Gay, David M., additional, Burton, Amy, additional, Yan, Bin, additional, Sellers, Katherine, additional, Wu, Vincen, additional, Xiang, Yuchen, additional, Shokry, Engy, additional, Clark, William, additional, Li, Vivian S.W., additional, Barry, Simon T., additional, Goodwin, Richard J.A., additional, Takats, Zoltan, additional, Maddocks, Oliver D.K., additional, Sumpton, David, additional, Yuneva, Mariia O., additional, Campbell, Andrew D., additional, Bunch, Josephine, additional, and Sansom, Owen J., additional

Published
2023
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45. PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

Author

Benzarti, Mohaned, primary, Oudin, Anais, additional, Viry, Elodie, additional, Gargiulo, Ernesto, additional, Schmoetten, Maryse, additional, Neises, Laura, additional, Pulido, Coralie, additional, Lorenz, Nadia I., additional, Ronellenfitsch, Michael W., additional, Sumpton, David, additional, Warmoes, Marc, additional, Jaeger, Christian, additional, Lesur, Antoine, additional, Moussay, Etienne, additional, Paggetti, Jerome, additional, Niclou, Simone P., additional, Letellier, Elisabeth, additional, and Meiser, Johannes, additional

Published
2023
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47. Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer

Author

Villar, Victor H., primary, Allega, Maria Francesca, additional, Deshmukh, Ruhi, additional, Ackermann, Tobias, additional, Nakasone, Mark A., additional, Vande Voorde, Johan, additional, Drake, Thomas M., additional, Oetjen, Janina, additional, Bloom, Algernon, additional, Nixon, Colin, additional, Müller, Miryam, additional, May, Stephanie, additional, Tan, Ee Hong, additional, Vereecke, Lars, additional, Jans, Maude, additional, Blancke, Gillian, additional, Murphy, Daniel J., additional, Huang, Danny T., additional, Lewis, David Y., additional, Bird, Thomas G., additional, Sansom, Owen J., additional, Blyth, Karen, additional, Sumpton, David, additional, and Tardito, Saverio, additional

Published
2022
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48. Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis

Author

Taurino, Giuseppe, primary, Deshmukh, Ruhi, additional, Villar, Victor H., additional, Chiu, Martina, additional, Shaw, Robin, additional, Hedley, Ann, additional, Shokry, Engy, additional, Sumpton, David, additional, Dander, Erica, additional, D'Amico, Giovanna, additional, Bussolati, Ovidio, additional, and Tardito, Saverio, additional

Published
2022
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49. Phase II proof‐of‐concept study of atorvastatin in castration‐resistant prostate cancer

Author

Rushworth, Linda K., primary, Loveridge, Carolyn, additional, Salji, Mark, additional, MacLeod, Martin, additional, Mui, Ernest, additional, Sumpton, David, additional, Neilson, Matthew, additional, Hedley, Ann, additional, Alexander, Laura, additional, McCartney, Elaine, additional, Patel, Rachana, additional, Wallace, Jan, additional, Delles, Christian, additional, Jones, Rob, additional, and Leung, Hing Y., additional

Published
2022
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50. Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression

Author

Patel, Rachana, primary, Ford, Catriona A., additional, Rodgers, Lisa, additional, Rushworth, Linda K., additional, Fleming, Janis, additional, Mui, Ernest, additional, Zhang, Tong, additional, Watson, David, additional, Lynch, Victoria, additional, Mackay, Gillian, additional, Sumpton, David, additional, Sansom, Owen J., additional, Vande Voorde, Johan, additional, and Leung, Hing Y., additional

Published
2022
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