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268 results on '"Sumiyoshi, Remi"'

1. Evaluating the safety profile of calcineurin inhibitors: cancer risk in patients with systemic lupus erythematosus from the LUNA registry—a historical cohort study

Author

Ichinose, Kunihiro, Sato, Shuntaro, Igawa, Takashi, Okamoto, Momoko, Takatani, Ayuko, Endo, Yushiro, Tsuji, Sosuke, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Yajima, Nobuyuki, Sada, Ken-Ei, Miyawaki, Yoshia, Yoshimi, Ryusuke, Shimojima, Yasuhiro, Ohno, Shigeru, Kajiyama, Hiroshi, Sato, Shuzo, Fujiwara, Michio, and Kawakami, Atsushi

Published
2024
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5. The impact of glucocorticoid use on the outcomes of rheumatoid arthritis in a multicenter ultrasound cohort study

Author

Nonaka, Fumiaki, primary, Fukui, Shoichi, additional, Michitsuji, Tohru, additional, Endo, Yushiro, additional, Nishino, Ayako, additional, Shimizu, Toshimasa, additional, Umeda, Masataka, additional, Sumiyoshi, Remi, additional, Koga, Tomohiro, additional, Iwamoto, Naoki, additional, Origuchi, Tomoki, additional, Ueki, Yukitaka, additional, Eiraku, Nobutaka, additional, Suzuki, Takahisa, additional, Okada, Akitomo, additional, Matsuoka, Naoki, additional, Takaoka, Hirokazu, additional, Hamada, Hiroaki, additional, Tsuru, Tomomi, additional, Arinobu, Yojiro, additional, Hidaka, Toshihiko, additional, Fujikawa, Keita, additional, Yoshitama, Tamami, additional, Tada, Yoshifumi, additional, Ohtsubo, Hideo, additional, Ishizaki, Jun, additional, Asano, Tomoyuki, additional, Maeda, Takahiro, additional, Kawakami, Atsushi, additional, and Kawashiri, Shin‐ya, additional

Published
2024
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6. Diagnostic challenges of the idiopathic plasmacytic lymphadenopathy (IPL) subtype of idiopathic multicentric Castleman disease (iMCD): Factors to differentiate from IgG4-related disease

Author

Nishikori, Asami, primary, Nishimura, Midori Filiz, additional, Fajgenbaum, David C, additional, Nishimura, Yoshito, additional, Maehama, Kanna, additional, Haratake, Tomoka, additional, Tabata, Tetsuya, additional, Kawano, Mitsuhiro, additional, Nakamura, Naoya, additional, Momose, Shuji, additional, Sumiyoshi, Remi, additional, Koga, Tomohiro, additional, Yamamoto, Hidetaka, additional, van Rhee, Frits, additional, Kawakami, Atsushi, additional, and Sato, Yasuharu, additional

Published
2024
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7. Influences of advanced age in rheumatoid arthritis: A multicentre ultrasonography cohort study.

Author

Kawahara, Chieko, Fukui, Shoichi, Michitsuji, Tohru, Nishino, Ayako, Endo, Yushiro, Shimizu, Toshimasa, Umeda, Masataka, Sumiyoshi, Remi, Koga, Tomohiro, Iwamoto, Naoki, Origuchi, Tomoki, Ueki, Yukitaka, Eiraku, Nobutaka, Suzuki, Takahisa, Okada, Akitomo, Matsuoka, Naoki, Takaoka, Hirokazu, Hamada, Hiroaki, Tsuru, Tomomi, and Arinobu, Yojiro

Abstract

Objectives: We aimed to evaluate the effects of age on clinical characteristics and outcomes in biologic or targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD)-naïve patients with rheumatoid arthritis (RA). Methods: We analysed the cases of 234 Japanese b/tsDMARD-naïve RA patients who underwent b/tsDMARD treatment in a multicentre ultrasound prospective observational cohort. We compared the clinical characteristics at baseline and outcomes at 12 months between those aged ≥60 years and those <60 years. Results: Compared to the <60-year-old group (n = 78), the ≥60-year-old group (n = 156) had higher inflammatory marker values and ultrasound combined scores, especially wrist joints, at baseline. Age at baseline positively correlated significantly with the ultrasound scores at baseline; however, age was not a significant variable by the multiple regression analysis. The patients treated with different MOAs in the ≥60-year-old group had comparable outcomes and multiple regression analysis revealed that mechanism of action (MOA) was not a significant contributor to the Clinical Disease Activity Index at 12 months. Conclusions: RA patients with advanced age demonstrated distinctive clinical characteristics. The MOAs were not associated with clinical outcomes and ultrasound outcomes in RA patients with advanced age. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-α in combination is a useful diagnostic biomarker to distinguish familial Mediterranean fever from sepsis

Author

Koga, Tomohiro, Furukawa, Kaori, Migita, Kiyoshi, Morimoto, Shimpei, Shimizu, Toshimasa, Fukui, Shoichi, Umeda, Masataka, Endo, Yushiro, Sumiyoshi, Remi, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Origuchi, Tomoki, Maeda, Takahiro, Yachie, Akihiro, and Kawakami, Atsushi

Published
2021
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10. Association between serum bone biomarker levels and therapeutic response to abatacept in patients with rheumatoid arthritis (RA): a multicenter, prospective, and observational RA ultrasound cohort study in Japan

Author

Kawashiri, Shin-ya, Endo, Yushiro, Nishino, Ayako, Okamoto, Momoko, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Aramaki, Toshiyuki, Ueki, Yukitaka, Yoshitama, Tamami, Eiraku, Nobutaka, Matsuoka, Naoki, Okada, Akitomo, Fujikawa, Keita, Hamada, Hiroaki, Nagano, Shuji, Tada, Yoshifumi, and Kawakami, Atsushi

Published
2021
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11. Real-world comparative effectiveness and safety of tofacitinib and baricitinib in patients with rheumatoid arthritis

Author

Iwamoto, Naoki, Sato, Shuntaro, Kurushima, Shota, Michitsuji, Toru, Nishihata, Shinya, Okamoto, Momoko, Tsuji, Yoshika, Endo, Yushiro, Shimizu, Toshimasa, Sumiyoshi, Remi, Suzuki, Takahisa, Okada, Akitomo, Koga, Tomohiro, Kawashiri, Shin-ya, Fujikawa, Keita, Igawa, Takashi, Aramaki, Toshiyuki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Mizokami, Akinari, Origuchi, Tomoki, Ueki, Yukitaka, Eguchi, Katsumi, and Kawakami, Atsushi

Published
2021
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12. Successful treatment of systemic lupus erythematosus with residual disease activity by switching from belimumab to anifrolumab.

Author

Umeda, Masataka, Kojima, Kanako, Michitsuji, Toru, Tsuji, Yoshika, Shimizu, Toshimasa, Fukui, Shoichi, Sumiyoshi, Remi, Koga, Tomohiro, Kawashiri, Shin-ya, Naoki, Iwamoto, Iagawa, Takashi, Tamai, Mami, Origuchi, Tomoki, Furuyama, Masako, Tsuboi, Masahiko, Matsuoka, Naoki, Okada, Akitomo, Aramaki, Toshiyuki, and Kawakami, Atsushi

Published
2024
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13. Denosumab is effective toward glucocorticoid-induced osteoporosis patients complicated with rheumatic diseases regardless of prior anti-osteoporotic drugs

Author

Iwamoto, Naoki, Okamoto, Momoko, Tsuji, Sosuke, Endo, Yushiro, Takatani, Ayuko, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Sumiyoshi, Remi, Igawa, Takashi, Koga, Tomohiro, Kawashiri, Shin-ya, Aramaki, Toshiyuki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Eguchi, Katsumi, Ueki, Yukitaka, and Kawakami, Atsushi

Published
2019
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14. Utility of a simplified ultrasonography scoring system among patients with rheumatoid arthritis: A multicenter cohort study

Author

Endo, Yushiro, Kawashiri, Shin-ya, Morimoto, Shimpei, Nishino, Ayako, Okamoto, Momoko, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Koga, Tomohiro, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Ueki, Yukitaka, Yoshitama, Tamami, Eiraku, Nobutaka, Matsuoka, Naoki, Okada, Akitomo, Fujikawa, Keita, Otsubo, Hideo, Takaoka, Hirokazu, Hamada, Hiroaki, Tsuru, Tomomi, Nagano, Shuji, Yojiro, Arinobu, Hidaka, Toshihiko, Tada, Yoshifumi, and Kawakami, Atsushi

Published
2021
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17. Comparison of complete renal response and mortality in early- and late-onset lupus nephritis: a multicenter retrospective study of a Japanese cohort

Author

Ichinose, Kunihiro, Kitamura, Mineaki, Sato, Shuntaro, Fujikawa, Keita, Horai, Yoshiro, Matsuoka, Naoki, Tsuboi, Masahiko, Nonaka, Fumiaki, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Nishino, Tomoya, and Kawakami, Atsushi

Published
2020
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18. Interleukin-18 and fibroblast growth factor 2 in combination is a useful diagnostic biomarker to distinguish adult-onset Still’s disease from sepsis

Author

Koga, Tomohiro, Sumiyoshi, Remi, Furukawa, Kaori, Sato, Shuntaro, Migita, Kiyoshi, Shimizu, Toshimasa, Umeda, Masataka, Endo, Yushiro, Fukui, Shoichi, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Nonaka, Fumiaki, Yachie, Akihiro, Kondo, Hideaki, Maeda, Takahiro, and Kawakami, Atsushi

Published
2020
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19. The double shared epitope: Its impact on clinical features and ultrasound findings in rheumatoid arthritis.

Author

Michitsuji, Tohru, Fukui, Shoichi, Nishino, Ayako, Endo, Yushiro, Furukawa, Kaori, Shimizu, Toshimasa, Umeda, Masataka, Sumiyoshi, Remi, Koga, Tomohiro, Iwamoto, Naoki, Origuchi, Tomoki, Kawakami, Atsushi, and Kawashiri, Shin‐ya

Subjects
RHEUMATOID arthritis, GENOME-wide association studies, DISEASE remission, ULTRASONIC imaging, GRAYSCALE model
Abstract

Objectives: The link between the HLA‐DRB1 locus and the risk of rheumatoid arthritis (RA) shown in genome‐wide association studies strengthens the shared epitope (SE) hypothesis. We aimed to assess the impact of the double dose of the SE (double SE) on RA and explore its clinical associations, including the response to abatacept. Methods: We evaluated RA patients treated with csDMARDs or abatacept for HLA‐DRB1 typing, clinical characteristics at baseline, and disease activity and ultrasound findings over 12 months. Results: Patients with the double SE (n = 12) had significantly higher anti‐citrullinated protein antibody (ACPA) titers, higher total grayscale (GS) score, and power Doppler (PD) score at baseline than patients without the double SE. Patients with the double SE exhibited reduced rates of SDAI remission and pronounced improvements in multiple disease activity between baseline and 12 months, including SDAI, CDAI, total GS score, and total PD score. When focusing on abatacept‐treated patients, the decreases in SDAI, CDAI, and total PD score between baseline and 12 months were significantly larger in patients with the double SE. Conclusions: Patients with the double SE exhibited distinct characteristics, increased disease activity, and improved response to abatacept treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Discontinuation of biosimilar infliximab in Japanese patients with rheumatoid arthritis achieving sustained clinical remission or low disease activity during the IFX-SIRIUS STUDY I (the IFX-SIRIUS STUDY II): Study protocol for an interventional, multicenter, open-label, single-arm clinical trial with clinical, ultrasound and biomarker assessments

Author

Shimizu, Toshimasa, Kawashiri, Shin-Ya, Sato, Shuntaro, Morimoto, Shimpei, Minoda, Shuri, Kawazoe, Yurika, Kuroda, Shohei, Tashiro, Shigeki, Sumiyoshi, Remi, Hosogaya, Naoki, Yamamoto, Hiroshi, and Kawakami, Atsushi

Published
2020
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21. Switching from originator infliximab to biosimilar infliximab in Japanese patients with rheumatoid arthritis achieving clinical remission (the IFX-SIRIUS study I): Study protocol for an interventional, multicenter, open-label, single-arm and noninferiority clinical trial with clinical, ultrasound, and biomarker assessments

Author

Kawashiri, Shin-ya, Shimizu, Toshimasa, Sato, Shuntaro, Morimoto, Shimpei, Kawazoe, Yurika, Sumiyoshi, Remi, Hosogaya, Naoki, Fukushima, Chizu, Yamamoto, Hiroshi, and Kawakami, Atsushi

Published
2020
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25. Severe prolonged liver abnormality with jaundice during treatment for granulomatosis with polyangiitis with rituximab and avacopan.

Author

Kojima, Kanako, Fukui, Shoichi, Tanigawa, Mai, Sumiyoshi, Remi, Koga, Tomohiro, Shimakura, Akane, Okano, Shinji, and Kawakami, Atsushi

Subjects
GRANULOMATOSIS with polyangiitis diagnosis, RITUXIMAB, FEVER, ANTINEUTROPHIL cytoplasmic antibodies, GRANULOMATOSIS with polyangiitis, TREATMENT effectiveness, SINUSITIS, JAUNDICE, OTITIS media
Abstract

The article describes a case of a female patient who experienced complications after the treatment of her granulomatosis with polyangiitis using rituximab and avacopan. Topics mentioned include the manifestation of severe prolonged liver abnormality with jaundice, the results of viral serological tests for hepatitis B virus and hepatitis virus C, and the histological examination of liver biopsy.

Published
2024
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29. Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan

Author

Endo, Yushiro, Koga, Tomohiro, Ishida, Midori, Fujita, Yuya, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Umeda, Masataka, Fukui, Shoichi, Nishino, Ayako, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Agematsu, Kazunaga, Yachie, Akihiro, Masumoto, Junya, Migita, Kiyoshi, and Kawakami, Atsushi

Published
2018
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30. Subclinical inflammation in a case of menstruation-induced familial Mediterranean fever: A case report

Author

Hara, Kazusato, Endo, Yushiro, Ishida, Midori, Fujita, Yuya, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Umeda, Masataka, Fukui, Shoichi, Nishino, Ayako, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Migita, Kiyoshi, Kawakami, Atsushi, and Koga, Tomohiro

Published
2018
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31. Recurrence of anti-MDA5 antibody-positive clinically amyopathic dermatomyositis after long-term remission: A case report

Author

Endo, Yushiro, Koga, Tomohiro, Ishida, Midori, Fujita, Yuya, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Umeda, Masataka, Fukui, Shoichi, Nishino, Ayako, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Kuwana, Masataka, Hosono, Yuji, Mimori, Tsuneyo, and Kawakami, Atsushi

Published
2018
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32. Prediction of radiographic progression during a treat-to-target strategy by the sequential application of MRI-proven bone marrow oedema and power-Doppler grade ≥2 articular synovitis in rheumatoid arthritis: Retrospective observational study.

Author

Takatani, Ayuko, Tamai, Mami, Ohki, Nozomi, Okamoto, Momoko, Endo, Yushiro, Tsuji, Sousuke, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Sumiyoshi, Remi, Nishino, Ayako, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Ichinose, Kunihiro, Arima, Kazuhiko, Nakamuraa, Hideki, Origuchia, Tomoki, and Uetani, Masataka

Subjects
BONE marrow, RHEUMATOID arthritis, SYNOVITIS, SCIENTIFIC observation, EDEMA
Abstract

Objectives: To investigate the appropriate timing, useful findings and combination of magnetic resonance imaging (MRI) and ultrasound (US) for predicting the radiographic progression in early rheumatoid arthritis (RA). Methods: Forty-four active RA patients, who examined by both of MRI and US in the symptomatic wrist and finger joints, were recruited in Nagasaki University Hospital from 2010 to 2017 and treated by the treat-to-target therapeutic strategy for 1 year. MRI was evaluated by RA MRI scoring and US by Outcomes Measures in Rheumatology Clinical Trial, respectively. Plain radiographs were assessed by the Genant-modified Sharp score for the symptomatic side in the same manner as MRI and US. Radiographic progression was defined as an annual increase ≥0.75 at 1 year. Factors associated with radiographic progression were analysed. Also, the optimal combination of MRI and US at each timepoint was considered. Results: Logistic regression model revealed that MRI-proven bone marrow oedema at baseline and 6 months and joint counts of power-Doppler grade ≥2 articular synovitis at 3 or 6 months were significantly associated with radiographic progression at 1 year. Conclusion: This study may suggest the favourable timing and combination of MRI and US at each point to predict radiographic progression in patients with early-stage RA. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Prediction of radiographic progression during a treat-to-target strategy by the sequential application of MRI-proven bone marrow oedema and power-Doppler grade ≥2 articular synovitis in rheumatoid arthritis: Retrospective observational study

Author

Takatani, Ayuko, primary, Tamai, Mami, additional, Ohki, Nozomi, additional, Okamoto, Momoko, additional, Endo, Yushiro, additional, Tsuji, Sousuke, additional, Shimizu, Toshimasa, additional, Umeda, Masataka, additional, Fukui, Shoichi, additional, Sumiyoshi, Remi, additional, Nishino, Ayako, additional, Koga, Tomohiro, additional, Kawashiri, Shin-ya, additional, Iwamoto, Naoki, additional, Igawa, Takashi, additional, Ichinose, Kunihiro, additional, Arima, Kazuhiko, additional, Nakamura, Hideki, additional, Origuchi, Tomoki, additional, Uetani, Masataka, additional, and Kawakami, Atsushi, additional

Published
2022
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34. Prediction of radiographic progression during a treat-to-target strategy by the sequential application of MRI-proven bone marrow oedema and power-Doppler grade ≥2 articular synovitis in rheumatoid arthritis: Retrospective observational study

Author

Takatani, Ayuko, Tamai, Mami, Ohki, Nozomi, Okamoto, Momoko, Endo, Yushiro, Tsuji, Sousuke, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Sumiyoshi, Remi, Nishino, Ayako, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Ichinose, Kunihiro, Arima, Kazuhiko, Nakamura, Hideki, Origuchi, Tomoki, Uetani, Masataka, Kawakami, Atsushi, Takatani, Ayuko, Tamai, Mami, Ohki, Nozomi, Okamoto, Momoko, Endo, Yushiro, Tsuji, Sousuke, Shimizu, Toshimasa, Umeda, Masataka, Fukui, Shoichi, Sumiyoshi, Remi, Nishino, Ayako, Koga, Tomohiro, Kawashiri, Shin-ya, Iwamoto, Naoki, Igawa, Takashi, Ichinose, Kunihiro, Arima, Kazuhiko, Nakamura, Hideki, Origuchi, Tomoki, Uetani, Masataka, and Kawakami, Atsushi

Abstract

Objectives: To investigate the appropriate timing, useful findings and combination of magnetic resonance imaging (MRI) and ultrasound (US) for predicting the radiographic progression in early rheumatoid arthritis (RA). Methods:Forty-four active RA patients, who examined by both of MRI and US in the symptomatic wrist and finger joints, were recruited in Nagasaki University Hospital from 2010 to 2017 and treated by the treat-to-target therapeutic strategy for 1 year. MRI was evaluated by RA MRI scoring and US by Outcomes Measures in Rheumatology Clinical Trial, respectively. Plain radiographs were assessed by the Genant-modified Sharp score for the symptomatic side in the same manner as MRI and US. Radiographic progression was defined as an annual increase ≥0.75 at 1 year. Factors associated with radiographic progression were analysed. Also, the optimal combination of MRI and US at each timepoint was considered. Results:Logistic regression model revealed that MRI-proven bone marrow oedema at baseline and 6 months and joint counts of power-Doppler grade ≥2 articular synovitis at 3 or 6 months were significantly associated with radiographic progression at 1 year. Conclusion:This study may suggest the favourable timing and combination of MRI and US at each point to predict radiographic progression in patients with early-stage RA., Modern rheumatology, 33(4), pp.708-714; 2023

Published
2022

35. Japanese Society of Internal Medicine

Author

Toyama, Shiho, Takatani, Ayuko, Koga, Tomohiro, Eguchi, Mizuna, Okamoto, Momoko, Tsuji, Sosuke, Endo, Yushiro, Shimizu, Toshimasa, Sumiyoshi, Remi, Igawa, Takashi, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Furuyama, Masako, Tabuchi, Maiko, Kobayashi, Shinichiro, Kanetaka, Kengo, Hashisako, Mikiko, Abe, Kuniko, Niino, Daisuke, Sato, Shinya, Miyazaki, Yasushi, and Kawakami, Atsushi

Subjects
rheumatoid arthritis, hemic and lymphatic diseases, iatrogenic immunodeficiency-associated lymphoproliferative disorder, gastric perforation, tacrolimus, methotrexate
Abstract

A 71-year-old woman being treated with methotrexate (MTX) and tacrolimus (TAC) for rheumatoid arthritis (RA) was admitted to our hospital and underwent surgery for gastric perforation and peritonitis. An endoscopic examination six days post-surgery showed an extensive ulcer in the stomach, and a biopsy revealed diffused large B-cell lymphoma. We diagnosed her with immunodeficiency-associated lymphoproliferative disorder (LPD) and discontinued the MTX and TAC. She underwent gastrectomy due to stenosis approximately two months after the first operation, but the histopathological findings of lymphoma had disappeared. LPD should be considered as a potential cause of gastric perforation during RA treatment. c 2019 Japanese Society of Internal Medicine.

Published
2019

38. Comparison of the quantitative measurement of 18F-FDG PET/CT and histopathological findings in IgG4-related disease

Author

Tsuji, Sosuke, primary, Iwamoto, Naoki, additional, Horai, Yoshiro, additional, Fujikawa, Keita, additional, Fujita, Yuya, additional, Fukui, Shoichi, additional, Ideguchi, Reiko, additional, Michitsuji, Toru, additional, Nishihata, Shinya, additional, Okamoto, Momoko, additional, Tsuji, Yoshika, additional, Endo, Yushiro, additional, Shimizu, Toshimasa, additional, Sumiyoshi, Remi, additional, Koga, Tomohiro, additional, Kawashiri, Shin-Ya, additional, Igawa, Takashi, additional, Ichinose, Kunihiro, additional, Tamai, Mami, additional, Nakamura, Hideki, additional, Origuchi, Tomoki, additional, Kudo, Takashi, additional, and Kawakami, Atsushi, additional

Published
2021
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39. Effect of abatacept treatment on serum osteoclast-related biomarkers in patients with rheumatoid arthritis (RA)

Author

Kawashiri, Shin-Ya, Endo, Yushiro, Nishino, Ayako, Okamoto, Momoko, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Aramaki, Toshiyuki, Ueki, Yukitaka, Yoshitama, Tamami, Eiraku, Nobutaka, Matsuoka, Naoki, Okada, Akitomo, Fujikawa, Keita, Hamada, Hiroaki, Nagano, Shuji, Tada, Yoshifumi, and Kawakami, Atsushi

Subjects
musculoskeletal diseases, rheumatoid arthritis, TRACP-5b, Male, abatacept, Observational Study, Osteoclasts, Severity of Illness Index, Arthritis, Rheumatoid, Japan, Humans, Prospective Studies, Aged, sRANKL, Aged, 80 and over, Tartrate-Resistant Acid Phosphatase, RANK Ligand, Remission Induction, C-Reactive Protein, Methotrexate, Antirheumatic Agents, Female, musculoskeletal ultrasound, Biomarkers, Research Article
Abstract

We evaluated the effect of abatacept treatment on osteoclast-related biomarkers and explored whether the biomarkers are associated with the therapeutic response in rheumatoid arthritis (RA) patients treated with abatacept. We enrolled 44 RA patients treated with abatacept from a multicenter prospective ultrasound cohort study of patients who received biologic or targeted synthetic disease-modifying antirheumatic drug therapy. We evaluated the disease activity score (DAS) 28-CRP (C-reactive protein), musculoskeletal ultrasound scores including the total grayscale score (GS)/power Doppler (PD) score and the serum concentrations of isoform 5b of tartrate-resistant acid phosphate (TRACP-5b) and soluble receptor activator of nuclear factor-κB ligand (sRANKL) at baseline and at 3 and 6 months of treatment. “PD responder” was defined as a patient whose Δtotal PD score over 6 months was greater than the median change of that. Abatacept significantly improved DAS28-CRP as well as the total GS/PD score over 6 months. Serum TRACP-5b was significantly elevated and serum sRANKL was significantly decreased at 6 months (P

Published
2021

40. Methotrexate Alters the Expression of microRNA in Fibroblast-like Synovial Cells in Rheumatoid Arthritis

Author

Iwamoto, Naoki, primary, Furukawa, Kaori, additional, Endo, Yushiro, additional, Shimizu, Toshimasa, additional, Sumiyoshi, Remi, additional, Umeda, Masataka, additional, Koga, Tomohiro, additional, Kawashiri, Shin-ya, additional, Igawa, Takashi, additional, Ichinose, Kunihiro, additional, Tamai, Mami, additional, Origuchi, Tomoki, additional, and Kawakami, Atsushi, additional

Published
2021
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41. The Japanese Society of Internal Medicine

Author

Umetsu, Ayaka, Shimizu, Toshimasa, Iwamoto, Naoki, Hashiguchi, Keiichi, Eguchi, Mizuna, Okamoto, Momoko, Endo, Yushiro, Tsuji, Sosuke, Takatani, Ayuko, Igawa, Takashi, Sumiyoshi, Remi, Koga, Tomohiro, Kawashiri, Shin-ya, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, and Kawakami, Atsushi

Subjects
musculoskeletal diseases, 18F-FDG/PET-CT, paraneoplastic syndrome, polymyalgia rheumatica
Abstract

A 70-year-old woman presented with a fever and pain in both lower extremities and the right shoulder and right upper arm continuously for approximately 3 months. 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG/PET-CT) revealed the accumulation of FDG in the right shoulder, lumbar spinous processes, both ischial tuberosities, and both hips and greater trochanters, indicating polymyalgia rheumatica (PMR). In addition, upper gastrointestinal endoscopy revealed esophageal carcinoma.After endoscopic submucosal dissection was performed, her musculoskeletal symptoms spontaneously improved,and the 18F-FDG/PET-CT findings decreased. In light of these findings, she was diagnosed with paraneoplastic syndrome. When atypical features of PMR, such as asymmetric symptoms occur, we should search for malignancies.

Published
2019

42. Paraneoplastic Syndrome Presenting with Polymyalgia Rheumatica-like Accumulations on 18F-fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography

Author

Umetsu, Ayaka, Shimizu, Toshimasa, Iwamoto, Naoki, Hashiguchi, Keiichi, Eguchi, Mizuna, Okamoto, Momoko, Endo, Yushiro, Tsuji, Sosuke, Takatani, Ayuko, Igawa, Takashi, Sumiyoshi, Remi, Koga, Tomohiro, Kawashiri, Shin-ya, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, and Kawakami, Atsushi

Subjects
musculoskeletal diseases, Esophageal Neoplasms, Paraneoplastic Syndromes, Case Report, paraneoplastic syndrome, polymyalgia rheumatica, Diagnosis, Differential, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Humans, Female, Esophagoscopy, Radiopharmaceuticals, 18F-FDG/PET-CT, Aged
Abstract

A 70-year-old woman presented with a fever and pain in both lower extremities and the right shoulder and right upper arm continuously for approximately 3 months. 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG/PET-CT) revealed the accumulation of FDG in the right shoulder, lumbar spinous processes, both ischial tuberosities, and both hips and greater trochanters, indicating polymyalgia rheumatica (PMR). In addition, upper gastrointestinal endoscopy revealed esophageal carcinoma.After endoscopic submucosal dissection was performed, her musculoskeletal symptoms spontaneously improved,and the 18F-FDG/PET-CT findings decreased. In light of these findings, she was diagnosed with paraneoplastic syndrome. When atypical features of PMR, such as asymmetric symptoms occur, we should search for malignancies., Internal medicine, 58(6), pp.861-864; 2019

Published
2019

43. The Japanese Society of Internal Medicine

Author

Shimizu, Toshimasa, Iwamoto, Naoki, Okamoto, Momoko, Endo, Yushiro, Tsuji, Sosuke, Takatani, Ayuko, Igawa, Takashi, Umeda, Masataka, Fukui, Shoichi, Sumiyoshi, Remi, Kitamura, Mineaki, Koga, Tomohiro, Kawashiri, Shin-ya, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Nishino, Tomoya, and Kawakami, Atsushi

Subjects
Scleroderma renal crisis, hemic and lymphatic diseases, TMA, Influenza virus, SSc
Abstract

A 44-year-old Japanese man with a 14-year history of limited cutaneous systemic sclerosis (SSc) was admitted with a fever, hypertension, anemia, thrombocytopenia, and renal dysfunction. On admission, hypertension, hyperreninemia, acute renal dysfunction,hemolytic anemia, and thrombocytopenia led to the diagnosis of scleroderma renal crisis (SRC) complicated with thrombotic microangiopathy (TMA). The patient had also been infected with influenza B virus almost six days before admission. Following treatment with plasma exchange,an angiotensin-converting enzyme inhibitor, and an anti-virus agent, his general condition improved. He had no risk factors for SRC.In SSc patients, an influenza virus infection might trigger SRC complicated with TMA.

Published
2019

47. Additional file 1 of Association between serum bone biomarker levels and therapeutic response to abatacept in patients with rheumatoid arthritis (RA): a multicenter, prospective, and observational RA ultrasound cohort study in Japan

Author

Kawashiri, Shin-ya, Endo, Yushiro, Nishino, Ayako, Okamoto, Momoko, Tsuji, Sosuke, Takatani, Ayuko, Shimizu, Toshimasa, Sumiyoshi, Remi, Koga, Tomohiro, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Aramaki, Toshiyuki, Ueki, Yukitaka, Yoshitama, Tamami, Eiraku, Nobutaka, Matsuoka, Naoki, Okada, Akitomo, Fujikawa, Keita, Hamada, Hiroaki, Nagano, Shuji, Tada, Yoshifumi, and Kawakami, Atsushi

Subjects
musculoskeletal diseases
Abstract

Additional file 1: Fig. S1. Changes in the serum levels of OPG over the 6-month abatacept treatment period. Serum OPG was significantly elevated at 6 months after the introduction of abatacept (Wilcoxon signed ranks test). Horizontal bar, median; boxes, 25th and 75th percentiles; bars, 5th and 95th percentiles. OPG: osteoprotegerin. Fig. S2. Comparison of the changes in the SDAI and total PD score between the patients with a low Dkk-1 (n = 30) and those with a high Dkk-1 (n = 29). Wilcoxon signed ranks test. Horizontal bar, median; boxes, 25th and 75th percentiles; bars, 5th and 95th percentiles. PD: power Doppler, SDAI: Simple Disease Activity Index. Fig. S3. Comparison of the changes in the SDAI and total PD score between the patients with a low SOST (n = 30) and those with a high SOST (n = 29). Wilcoxon signed ranks test. Horizontal bar, median; boxes, 25th and 75th percentiles; bars, 5th and 95th percentiles.

Published
2021
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48. Additional file 1 of Real-world comparative effectiveness and safety of tofacitinib and baricitinib in patients with rheumatoid arthritis

Author

Iwamoto, Naoki, Sato, Shuntaro, Kurushima, Shota, Michitsuji, Toru, Nishihata, Shinya, Okamoto, Momoko, Tsuji, Yoshika, Endo, Yushiro, Shimizu, Toshimasa, Sumiyoshi, Remi, Suzuki, Takahisa, Okada, Akitomo, Koga, Tomohiro, Kawashiri, Shin-ya, Fujikawa, Keita, Igawa, Takashi, Aramaki, Toshiyuki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Mizokami, Akinari, Origuchi, Tomoki, Ueki, Yukitaka, Eguchi, Katsumi, and Kawakami, Atsushi

Abstract

Additional file 1: Supplementary Table S1. Comparison of baseline characteristics in patients with different backgrounds.

Published
2021
Full Text
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49. Additional file 1 of Granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-α in combination is a useful diagnostic biomarker to distinguish familial Mediterranean fever from sepsis

Author

Koga, Tomohiro, Furukawa, Kaori, Migita, Kiyoshi, Morimoto, Shimpei, Shimizu, Toshimasa, Fukui, Shoichi, Umeda, Masataka, Endo, Yushiro, Sumiyoshi, Remi, Kawashiri, Shin-ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Origuchi, Tomoki, Maeda, Takahiro, Yachie, Akihiro, and Kawakami, Atsushi

Abstract

Additional file 1: Supplementary Table S1 Age adjusted ROC curve in each subset determined by multivariable logistic regression analysis

Published
2021
Full Text
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50. Methotrexate Alters the Expression of microRNA in Fibroblast-like Synovial Cells in Rheumatoid Arthritis

Author

Iwamoto, Naoki, Furukawa, Kaori, Endo, Yushiro, Shimizu, Toshimasa, Sumiyoshi, Remi, Umeda, Masataka, Koga, Tomohiro, Kawashiri, Shin-ya, Igawa, Takashi, Ichinose, Kunihiro, Tamai, Mami, Origuchi, Tomoki, Kawakami, Atsushi, Iwamoto, Naoki, Furukawa, Kaori, Endo, Yushiro, Shimizu, Toshimasa, Sumiyoshi, Remi, Umeda, Masataka, Koga, Tomohiro, Kawashiri, Shin-ya, Igawa, Takashi, Ichinose, Kunihiro, Tamai, Mami, Origuchi, Tomoki, and Kawakami, Atsushi

Abstract

We aimed to investigate the effect of methotrexate (MTX) on microRNA modulation in rheumatoid arthritis fibroblast-like synovial cells (RA-FLS). RA-FLS were treated with MTX for 48 h. We then performed miRNA array analysis to investigate differentially expressed miRNAs. Transfection with miR-877-3p precursor and inhibitor were used to investigate the functional role of miR-877-3p in RA-FLS. Gene ontology analysis was used to investigate the cellular processes involving miR-877-3p. The production of cytokines/chemokines was screened by multiplex cytokine/chemokine bead assay and confirmed by ELISA and quantitative real-time PCR. The migratory and proliferative activities of RA-FLS were analyzed by wound healing assay and MKI-67 expression. MTX treatment altered the expression of 13 miRNAs (seven were upregulated and six were downregulated). Among them, quantitative real-time PCR confirmed that miR-877-3p was upregulated in response to MTX (1.79 ± 0.46-fold, p < 0.05). The possible target genes of miR-877-3p in RA-FLS revealed by the microarray analysis were correlated with biological processes. The overexpression of miR-877-3p decreased the production of GM-CSF and CCL3, and the overexpression of miR-877-3p inhibited migratory and proliferative activity. MTX altered the miR-877-3p expression on RA-FLS, and this alteration of miR-877-3p attenuated the abundant production of cytokines/chemokines and proliferative property of RA-FLS., International Journal of Molecular Sciences, 22(21), art. no. 11561; 2021

Published
2021

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