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Bela Shah,1 Deval Mistry,2 Dharmender Jairam,1 Kajal Kansara,1 Rutvi Pandya,1 Presha Vasani,1 Dhiraj Dhoot,3 Namrata Mahadkar,3 Sumit Bhushan,3 Hanmant Barkate3 1Department of Dermatology, B J Medical College, Civil Hospital, Ahmedabad, Gujarat, India; 2Mistry Skin Clinic, Ahmedabad, Gujarat, India; 3Department of Global Medical Affairs, Glenmark Pharmaceuticals Ltd, Mumbai, Maharashtra, IndiaCorrespondence: Dhiraj Dhoot, Glenmark Pharmaceuticals Ltd., B D Sawant Marg, Near Bisleri Plant, Chakala, Andheri (E), Mumbai, 400099, India, Tel +919619811219, Email dddhoot@gmail.comIntroduction: Owing to pharmacokinetic challenges of itraconazole, super-bioavailable itraconazole (SB) was developed and recently approved in strengths of 50mg and 65mg. But comparative study was lacking between these two strengths in glabrous tinea (dermatophytosis) management. Hence, this study was planned to compare the efficacy of both these strengths in dermatophytosis.Methods: One hundred eligible patients were enrolled in this prospective, randomized, clinical study during May-2022 to September-2022 at tertiary hospital in Ahmedabad in adults. Efficacy and safety assessments were done at week-3 and 6 with follow up at week-10 for relapse. Primary objective was to assess the proportion of patients achieving complete cure at week-6 following treatment in both the groups. Secondary outcomes compared safety, clinical and mycological cure rates.Results: Of the 100 patients enrolled, 98 patients (50 in SB-50mg and 48 in SB-65mg group) included in the final analysis. At week 6, 20 patients (40%) and 30 patients (62.5%) achieved complete cure (p < 0.05) in SB-50mg and SB-65mg groups, respectively. In completely cured patients, relapse was reported in 3 (15%) and 5 (17%) patients of SB-50mg and SB-65mg groups, respectively (p = 1). A significant difference was noted in clearance of symptoms and lesions in SB-65mg group (p < 0.05). Moreover, similar results were also obtained in sub-group analysis of recalcitrant dermatophytosis. Both the treatments were found to be safe and well tolerated with no discontinuation.Conclusion: Study result concluded the superiority of SB-65mg over SB-50mg in terms of cure rate and resolution of symptoms in dermatophytosis management.Keywords: comparison, dermatophytosis, efficacy, super-bioavailable itraconazole, 50mg, 65mg

Objective The present study compared the pharmacokinetics of two (1 mg) tacrolimus formulations (test (generic from Panacea) and reference (innovator from Astellas)) after a single-dose administration as per the European Medicine Agency (EMA) guidelines to grant marketing authorization. Materials and methods This study was a randomized, open-label, balanced, two-treatment, two-period, two-sequences, single-dose, truncated-area, crossover design with a washout period of 19 days between the phases. Healthy subjects aged 18 - 45 years (both inclusive) were included. Eligible subjects received a single oral dose of 5 × 1-mg capsule of tacrolimus either test or reference formulation. Blood samples were collected until 72.00 hours postdose, and peak concentration (Cmax) and area under the curve (AUC0-72) were evaluated in whole blood using validated LC-MS/MS. Safety was also assessed in each period. Results Of 56 subjects enrolled, 52 completed both study periods. The arithmetic mean (SD) Cmax for the reference and test formulations was 40.62 (11.30) and 46.20 (10.73) ng/mL, and AUC0-72 was 348.34 (156.41) and 361.04 (158.71) ng×h/mL, respectively. The geometric least square mean ratio (90% confidence interval (CI)) was 115.07% (90% CI: 109.81, 120.59) for Cmax and 103.78 (90% CI: 97.40, 110.58) for AUC0-72, which fell within the acceptance range as per EMA guidelines for narrow therapeutic index drugs (Cmax: 80.00 - 125.00%; AUC: 90.00 - 111.11%). No serious adverse event was observed. Conclusion The generic tacrolimus was bioequivalent to the reference formulation, was well tolerated, and provides a well-acceptable alternative to the reference drug. Switching treatment to generic tacrolimus medication may reduce the cost and economic burden of treating transplanted patients.

In this paper, we describe a theoretical design for the realization of a high capacity (bandwidth) atomic quantum memory based on wavelength division multiplexing and electromagnetically induced tr...

Quantum communication with terahertz (THz) frequency signals has many advantages like reduced attenuation and scintillation effects in certain atmospheric conditions along with very high level of data security. In this work, we propose a scheme to realize Quantum Memory (QM) for efficient storage of terahertz (THz) frequency signals using Electromagnetically Induced Transparency (EIT) in an ultracold atomic medium of 87Rb Rydberg atoms prepared in a Two Dimensional Magneto Optical Trap (2D-MOT). The uniqueness of our scheme lies in the choice of the energy levels involved in the EIT process, all three of which have been chosen to be the Rydberg levels (enabling signal beam to be in THz) in a lambda type arrangement. This first of its kind proposal reveals that atomic media are a potential candidate for devising QMs which can store THz frequency signals. We have estimated that the Optical Depth (OD) in our scheme can reach a very high value of 690, very high maximum obtainable storage efficiency (η) of ∼99%, the group velocity ( v g ) can be as low as 5.07 × 103 m/s, and the Delay Bandwidth Product (DBP) can be as high as 9.5. All of these estimates emphasize the feasibility of our scheme as a QM device for efficient storage of THz pulses.

We outline a proposal to realize Electromagnetically Induced Transparency (EIT) with the potential to store Terahertz (THz) optical pulses in Cesium atoms. Such a system, when experimentally realized, has a potential to make Quantum Communication possible with THz signals.

We have constructed in our laboratory two rectangular shaped current carrying coils in accordance with the parameters used in our design so that they can be put in use in the Two Dimensional Magneto Optical Trap (2D-MOT)to obtain very high value of Optical Depth(OD). The dimensions of the coils are 8cm x 10cm. When put in anti-Helmholtz configuration as required in a 2D-MOT, these coils generate magnetic field such that it becomes zero along a line bisecting the space between the two coils. The magnetic field gradient near the zero magnetic field line is measured to be 3.33 Gauss/cm when the current passing through the coils is 3.5A. We have also made measurements at other values of current and found, as expected, this gradient increases with current. These results match nicely with the estimated values and hence a significant step forward towards the experimental realization of the design proposed by us.

In this letter, we have measured the dispersive profile of the multi window Electromagnetically Induced Transparency(EIT) signals in Rubidium (Rb) atomic medium at room temperature. Weak probe laser light and strong coupling light in counter propagating direction are used to excite the atomic medium via ladder type configuration of 87Rb D2 line to obtain multiple EIT peaks. The uniqueness of our work is in the experimental setup which is used for the measurement of dispersion. We have used transmissive Spatial Light Modulator(SLM) in one arm of the Mach–Zehnder(M–Z) interferometer to obtain the desired phase shift between two interfering arms for the measurement of dispersive properties of multi window EIT in Rb vapor medium. One can easily obtain the phase shift without disturbing the alignment of the M-Z interferometer by using this setup.

In this paper, we present a theoretical proposal to realize Quantum Memory (QM) for storage of blue light pulses (420 nm) using Electromagnetically Induced Transparency (EIT). Three-level lambda-type EIT configuration system is solved in a fully quantum mechanical approach. Storing blue light has the potential application in the field of underwater quantum communication as it experiences less attenuation inside the sea water. Our model works by exciting the relevant transitions of [Formula: see text]Rb atoms using a three-level lambda-type configuration in a Two-Dimensional Magneto-Optical Trap (2D MOT) with an optical cavity inside it. We have estimated Optical Depth inside the cavity (ODc) of [Formula: see text], group velocity ([Formula: see text]) [Formula: see text][Formula: see text]ms[Formula: see text], Delay Bandwidth Product(DBP) of 23 and maximum storage efficiency as [Formula: see text] in our system.

In this paper, we propose a novel technique for slow light experiments using electromagnetically induced transparency using a two-dimensional magneto optical trap (2D-MOT). A compact 2D-MOT design efficient for quantum memory applications with adjustable optical depth (OD) is proposed. We estimated the OD for our 2D-MOT setup and found that light group velocities as low as 1.4 m/s can be attained. Our design for 2D-MOT allows precise control and optimization of the OD such that high storage efficiencies could also be achieved. With our design, it is possible to obtain a delay bandwidth product of 163, which is very high in comparison to previously obtained values.

In this work, we experimentally study the effect of externally applied magnetic field on a ladder type EIT in a vapour cell consisting of 87Rb atoms. The introduction of magnetic field causes the Zeeman splitting of the hyperfine levels of 87Rb atoms and hence the number of available windows of transparency increases. We report the observation of nine such windows. Such multi window EIT systems are capable of storing pulses at the different frequencies, corresponding to these windows hence paving the way for realization of multi frequency quantum memories. Also, the total bandwidth of storage is 218.4 MHz which is two orders of magnitude higher than that typically obtained in single window EIT based storage systems. These systems have tremendous applications in the field of speedy transmission of data over a long distance quantum communication channel.