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5. Volumetric Neural Correlates of Antisaccade Eye Movements in First-Episode Psychosis

Author

Ulrich Ettinger, Veena Kumari, Chitnis, Xavier A., Corr, Philip J., Trevor Crawford, Fannon, Dominic G., Séamus O’Ceallaigh, Sumich, Alex L., Doku, Victor C., and Tonmoy Sharma

Subjects
Adult, Cerebral Cortex, Male, Brain Mapping, Brain, Neural Inhibition, Magnetic Resonance Imaging, Psychiatry and Mental health, Task Performance and Analysis, Reaction Time, Saccades, Schizophrenia, Visual Perception, Humans, Regression Analysis, Female, Schizophrenic Psychology, Psychomotor Performance
Abstract

The authors investigated the structural brain correlates of antisaccade performance.Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography.Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate.These findings point to altered structure-function relationships in first-episode psychosis.

Published
2004

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