Search

Your search keyword '"Sumey, Christopher"' showing total 25 results
Start Over Author "Sumey, Christopher"
25 results on '"Sumey, Christopher"'

1. Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study.

Author

Powell, Steven F, Gold, Kathryn A, Gitau, Mark M, Sumey, Christopher J, Lohr, Michele M, McGraw, Steven C, Nowak, Ryan K, Jensen, Ashley W, Blanchard, Miran J, Fischer, Christopher D, Bykowski, Julie, Ellison, Christie A, Black, Lora J, Thompson, Paul A, Callejas-Valera, Juan L, Lee, John H, Cohen, Ezra EW, and Spanos, William C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Research, Dental/Oral and Craniofacial Disease, Cancer, Clinical Trials and Supportive Activities, Orphan Drug, Immunotherapy, Infectious Diseases, Sexually Transmitted Infections, Digestive Diseases, Rare Diseases, Radiation Oncology, 6.1 Pharmaceuticals, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Immunological, Chemoradiotherapy, Female, Humans, Male, Middle Aged, Retrospective Studies, Squamous Cell Carcinoma of Head and Neck, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

PurposePembrolizumab is a humanized monoclonal antibody that blocks interaction between programmed death receptor-1 (PD-1) and its ligands (PD-L1, PD-L2). Although pembrolizumab is approved for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), its role in the management of locally advanced (LA) disease is not defined. We report a phase IB study evaluating the safety and efficacy of adding pembrolizumab to cisplatin-based chemoradiotherapy in patients with LA HNSCC.Patients and methodsEligible patients included those with oral cavity (excluding lip), oropharyngeal, hypopharyngeal, or laryngeal stage III to IVB HNSCC (according to American Joint Committee on Cancer, 7th edition, staging system) eligible for cisplatin-based, standard-dose (70 Gy) chemoradiotherapy. Pembrolizumab was administered concurrently with and after chemoradiotherapy with weekly cisplatin. Safety was the primary end point and was determined by incidence of chemoradiotherapy adverse events (AEs) and immune-related AEs (irAEs). Efficacy was defined as complete response (CR) rate on end-of-treatment (EOT) imaging or with pathologic confirmation at 100 days postradiotherapy completion. Key secondary end points included overall (OS) and progression-free survival (PFS).ResultsThe study accrued 59 patients (human papillomavirus [HPV] positive, n = 34; HPV negative, n = 25) from November 2015 to October 2018. Five patients (8.8%) required discontinuation of pembrolizumab because of irAEs, all of which occurred during concurrent chemoradiotherapy; 98.3% of patients completed the full planned treatment dose (70 Gy) of radiotherapy without any delays ≥ 5 days; 88.1% of patients completed the goal cisplatin dose of ≥ 200 mg/m2. EOT CR rates were 85.3% and 78.3% for those with HPV-positive and -negative HNSCC, respectively.ConclusionPembrolizumab in combination with weekly cisplatin-based chemoradiotherapy is safe and does not impair delivery of curative radiotherapy or chemotherapy in HNSCC. Early efficacy data support further investigation of this approach.

Published
2020

4. Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

Author

Batagelj, Emilio, Casarini, Ignacio, Pastor, Anea Viviana, Sena, Susana Noemi, Zarba, Juan Jose, Burghuber, Otto, Hartl, Sylvia, Hochmair, Maximilian J, Lamprecht, Bernd, Studnicka, Michael, Alberto Schlittler, Luis, Augusto Martinelli de Oliveira, Fabricio, Calabrich, Aknar, Colagiovanni Girotto, Gustavo, Dos Reis, Peo, Fausto Nino Gorini, Carlos, Rafael Martins De Marchi, Peo, Serodio da Rocha Baldotto, Clarissa, Sette, Claudia, Zukin, Mauro, Conev, Nikolay V, Dudov, Assen, Ilieva, Rumyana, Koynov, Krassimir, Krasteva, Rositsa, Tonev, Ivan, Valev, Spartak, Venkova, Violetka, Bi, Minghong, Chen, Chengshui, Chen, Yuan, Chen, Zhendong, Fang, Jian, Feng, Jifeng, Han, Zhigang, Hu, Jie, Hu, Yi, Li, Wei, Liang, Zongan, Lin, Zhong, Ma, Rui, Ma, Shenglin, Nan, Kejun, Shu, Yongqian, Wang, Kai, Wang, Mengzhao, Wu, Gang, Yang, Nong, Yang, Zhixiong, Zhang, Helong, Zhang, Wei, Zhao, Jun, Zhao, Yanqiu, Zhou, Caicun, Zhou, Jianying, Zhou, Xiangdong, Havel, Libor, Kolek, Vitezslav, Koubkova, Leona, Roubec, Jaromir, Skrickova, Jana, Zemanova, Milada, Chouaid, Christos, Hilgers, Werner, Lena, Hervé, Moro-Sibilot, Denis, Robinet, Gilles, Souquet, Pierre-Jean, Alt, Jürgen, Bischoff, Helge, Grohe, Christian, Laack, Eckart, Lang, Susanne, Panse, Jens, Reinmuth, Niels, Schulz, Christian, Bogos, Krisztina, Csánky, Eszter, Fülöp, Anea, Horváth, Zsolt, Kósa, Judit, Laczó, Ibolya, Losonczy, György, Pajkos, Gábor, Pápai, Zsuzsanna, Pápai Székely, Zsolt, Sárosi, Veronika, Somfay, Attila, Somogyiné Ezer, Éva, Telekes, Anás, Bar, Jair, Gottfried, Maya, Heching, Norman Isaac, Zer Kuch, Alona, Bartolucci, Roberta, Bettini, Anna Cecilia, Delmonte, Angelo, Garassino, Marina Chiara, Minelli, Mauro, Roila, Fausto, Verderame, Francesco, Atagi, Shinji, Azuma, Koichi, Goto, Hisatsugu, Goto, Koichi, Hara, Yu, Hayashi, Hidetoshi, Hida, Toyoaki, Hotta, Katsuyuki, Kanazawa, Kenya, Kanda, Shintaro, Kim, Young Hak, Kuyama, Shoichi, Maeda, Tadashi, Morise, Masahiro, Nakahara, Yasuharu, Nishio, Makoto, Nogami, Naoyuki, Okamoto, Isamu, Saito, Haruhiro, Shinoda, Masahiro, Umemura, Shigeki, Yoshida, Tatsuya, Claessens, Niels, Cornelissen, Robin, Heniks, Lizza, Hiltermann, Jeroen, Smit, Egbert, Staal van den Brekel, Agnes, Kazarnowicz, Andrzej, Kowalski, Dariusz, Mańdziuk, Slawomir, Mróz, Robert, Wojtukiewicz, Marek, Ciuleanu, Tudor, Ganea, Doina, Ungureanu, Anei, Dvorkin, Mikhail, Luft, Alexander, Moiseenko, Vladimir, Poltoratskiy, Artem, Sakaeva, Dina, Smolin, Alexey, Statsenko, Galina, Vasilyev, Alexander, Vladimirova, Lyubov, Anasina, Igor, Chovanec, Jozef, Demo, Pavol, Godal, Robert, Kasan, Peter, Stresko, Marian, Urda, Michal, Cho, Eun Kyung, Ji, Jun Ho, Kim, Joo-Hang, Kim, Sang-We, Lee, Gyeong-Won, Lee, Jong-Seok, Lee, Ki Hyeong, Lee, Kyung Hee, Lee, Yun Gyoo, Amelia Insa Molla, Maria, Domine Gomez, Manuel, Ignacio Delgado Mingorance, Juan, Isla Casado, Dolores, Lopez Brea, Marta, Majem Tarruella, Margarita, Morán Bueno, Teresa, Navarro Mendivil, Alejano, Paz-Ares Rodríguez, Luis, Ponce Aix, Santiago, Rosario Garcia Campelo, Maria, Chang, Gee-Chen, Chen, Yen-Hsun, Chiu, Chao-Hua, Hsia, Te-Chun, Lee, Kang-Yun, Li, Chien-Te, Wang, Chin-Chou, Wei, Yu-Feng, Wu, Shang-Yin, Alacacıoğlu, Ahmet, Çiçin, Irfan, Demirkazik, Ahmet, Erman, Mustafa, Göksel, Tuncay, Özgüroğlu, Mustafa, Adamchuk, Hryhoriy, Bondarenko, Igor, Kolesnik, Oleksii, Kryzhanivska, Anna, Ostapenko, Yuriv, Shevnia, Serhii, Shparyk, Yaroslav, Trukhin, Dmytro, Ursol, Grygorii, Voitko, Nataliia, Voitko, Oleksandr, Vynnychenko, Ihor, Babu, Sunil, Chen, Yuanbin, Chiang, Anne, Chua, Winston, Dakhil, Shaker, Dowlati, Afshin, Goldman, Jonathan W, Haque, Basir, Jamil, Rodney, Knoble, Jeanna, Lakhanpal, Shailena, Mi, Kailhong, Nikolinakos, Petros, Powell, Steven, Ross, Helen, Schaefer, Eric, Schneider, Jeffrey, Spahr, Joseph, Spigel, David, Stilwill, Joseph, Sumey, Christopher, Williamson, Michael, Paz-Ares, Luis, Ponce, Santiago, Armstrong, Jon, Byrne, Natalie, Shire, Norah, and Jiang, Haiyi

Published
2019
Full Text
View/download PDF

5. Supplementary Table S1 from Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study

Author

Kelly, William K., primary, Danila, Daniel C., primary, Lin, Chia-Chi, primary, Lee, Jae-Lyun, primary, Matsubara, Nobuaki, primary, Ward, Patrick J., primary, Armstrong, Andrew J., primary, Pook, David, primary, Kim, Miso, primary, Dorff, Tanya B., primary, Fischer, Stefanie, primary, Lin, Yung-Chang, primary, Horvath, Lisa G., primary, Sumey, Christopher, primary, Yang, Zhao, primary, Jurida, Gabor, primary, Smith, Kristen M., primary, Connarn, Jamie N., primary, Penny, Hweixian L., primary, Stieglmaier, Julia, primary, and Appleman, Leonard J., primary

Published
2024
Full Text
View/download PDF

6. Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study

Author

Kelly, William K., Danila, Daniel C., Lin, Chia-Chi, Lee, Jae-Lyun, Matsubara, Nobuaki, Ward, Patrick J., Armstrong, Andrew J., Pook, David, Kim, Miso, Dorff, Tanya B., Fischer, Stefanie, Lin, Yung-Chang, Horvath, Lisa G., Sumey, Christopher, Yang, Zhao, Jurida, Gabor, Smith, Kristen M., Connarn, Jamie N., Penny, Hweixian L., Stieglmaier, Julia, Appleman, Leonard J., Kelly, William K., Danila, Daniel C., Lin, Chia-Chi, Lee, Jae-Lyun, Matsubara, Nobuaki, Ward, Patrick J., Armstrong, Andrew J., Pook, David, Kim, Miso, Dorff, Tanya B., Fischer, Stefanie, Lin, Yung-Chang, Horvath, Lisa G., Sumey, Christopher, Yang, Zhao, Jurida, Gabor, Smith, Kristen M., Connarn, Jamie N., Penny, Hweixian L., Stieglmaier, Julia, and Appleman, Leonard J.

Abstract

Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)-targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer cells, such as those in advanced prostate cancer. This first-in-human study reports monotherapy dose exploration for patients with metastatic castration-resistant prostate cancer (mCRPC), primarily taxane pretreated. Ninety-seven patients received ≥1 intravenous dose ranging from 0.001 to 2.0 mg weekly or every 2 weeks. MTD was identified as 1.5 mg i.v. weekly via a 3-step dose. The most common treatment-related adverse events were cytokine release syndrome (CRS; 72%), fatigue (45%), and myalgia (34%). CRS occurred primarily during cycle 1 and improved with premedication and step dosing. Prostate-specific antigen (PSA) and RECIST responses across cohorts were encouraging [49% PSA50; 24% objective response rate (ORR)], with greater frequency at target doses ≥0.75 mg (59% PSA50; 41% ORR). Xaluritamig is a novel immunotherapy for prostate cancer that has shown encouraging results supporting further development. SIGNIFICANCE : Xaluritamig demonstrated encouraging responses (PSA and RECIST) compared with historical established treatments for patients with late-line mCRPC. This study provides proof of concept for T-cell engagers as a potential treatment for prostate cancer, validates STEAP1 as a target, and supports further clinical investigation of xaluritamig in prostate cancer. See related commentary by Hage Chehade et al., p. 20. See related article by Nolan-Stevaux et al., p. 90. This article is featured in Selected Articles from This Issue, p. 5.

Published
2023

7. A phase 1 study of AMG 509 in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC).

Author

Danila, Daniel Costin, primary, Waterhouse, David Michael, additional, Appleman, Leonard Joseph, additional, Pook, David William, additional, Matsubara, Nobuaki, additional, Dorff, Tanya B., additional, Lee, Jae-Lyun, additional, Armstrong, Andrew J., additional, Kim, Miso, additional, Horvath, Lisa, additional, Sumey, Christopher Joseph, additional, Cooner, Freda, additional, Salvati, Mark, additional, Stieglmaier, Julia, additional, and Kelly, William Kevin, additional

Published
2022
Full Text
View/download PDF

9. Phase I study of AMG 509, a STEAP1 x CD3 T-cell recruiting XmAb 2+1 immune therapy, in patients with metastatic castration-resistant prostate cancer (mCRPC).

Author

Kelly, William Kevin, primary, Pook, David William, additional, Appleman, Leonard Joseph, additional, Waterhouse, David Michael, additional, Horvath, Lisa, additional, Edenfield, William Jeffery, additional, Matsubara, Nobuaki, additional, Danila, Daniel Costin, additional, Aggarwal, Rahul Raj, additional, Petrylak, Daniel Peter, additional, Sartor, A. Oliver, additional, Sumey, Christopher Joseph, additional, Adra, Nabil, additional, Armstrong, Andrew J., additional, Cheng, Fu-Chih, additional, Stieglmaier, Julia, additional, Kouros-Mehr, Hosein, additional, and Dorff, Tanya B., additional

Published
2021
Full Text
View/download PDF

10. Durvalumab, with or without tremelimumab, plus platinum–etoposide versus platinum–etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial

Author

Goldman, Jonathan W, primary, Dvorkin, Mikhail, additional, Chen, Yuanbin, additional, Reinmuth, Niels, additional, Hotta, Katsuyuki, additional, Trukhin, Dmytro, additional, Statsenko, Galina, additional, Hochmair, Maximilian J, additional, Özgüroğlu, Mustafa, additional, Ji, Jun Ho, additional, Garassino, Marina Chiara, additional, Voitko, Oleksandr, additional, Poltoratskiy, Artem, additional, Ponce, Santiago, additional, Verderame, Francesco, additional, Havel, Libor, additional, Bondarenko, Igor, additional, Każarnowicz, Andrzej, additional, Losonczy, György, additional, Conev, Nikolay V, additional, Armstrong, Jon, additional, Byrne, Natalie, additional, Thiyagarajah, Piruntha, additional, Jiang, Haiyi, additional, Paz-Ares, Luis, additional, Voitko, Nataliia, additional, Kazarnowicz, Andrzej, additional, Özgüroglu, Mustafa, additional, Conev, Nikolay, additional, Hochmair, Maximilian, additional, Burghuber, Otto, additional, Çiçin, Irfan, additional, Moiseenko, Vladimir, additional, Erman, Mustafa, additional, Kowalski, Dariusz, additional, Wojtukiewicz, Marek, additional, Adamchuk, Hryhoriy, additional, Vasilyev, Alexander, additional, Shevnia, Serhii, additional, Valev, Spartak, additional, Insa Molla, Maria Amelia, additional, Ursol, Grygorii, additional, Chiang, Anne, additional, Hartl, Sylvia, additional, Horváth, Zsolt, additional, Pajkos, Gábor, additional, Kim, Sang-We, additional, Smolin, Alexey, additional, Göksel, Tuncay, additional, Dakhil, Shaker, additional, Roubec, Jaromir, additional, Bogos, Krisztina, additional, Cornelissen, Robin, additional, Lee, Jong-Seok, additional, Garcia Campelo, Maria Rosario, additional, Lopez Brea, Marta, additional, Alacacioglu, Ahmet, additional, Casarini, Ignacio, additional, Ilieva, Rumyana, additional, Tonev, Ivan, additional, Somfay, Attila, additional, Bar, Jair, additional, Zer Kuch, Alona, additional, Minelli, Mauro, additional, Bartolucci, Roberta, additional, Roila, Fausto, additional, Saito, Haruhiro, additional, Azuma, Koichi, additional, Lee, Gyeong-Won, additional, Luft, Alexander, additional, Urda, Michal, additional, Delgado Mingorance, Juan Ignacio, additional, Majem Tarruella, Margarita, additional, Spigel, David, additional, Koynov, Krassimir, additional, Zemanova, Milada, additional, Panse, Jens, additional, Schulz, Christian, additional, Pápai Székely, Zsolt, additional, Sárosi, Veronika, additional, Delmonte, Angelo, additional, Bettini, Anna Cecilia, additional, Nishio, Makoto, additional, Okamoto, Isamu, additional, Hendriks, Lizza, additional, Mandziuk, Slawomir, additional, Lee, Yun Gyoo, additional, Vladimirova, Lyubov, additional, Isla Casado, Dolores, additional, Domine Gomez, Manuel, additional, Navarro Mendivil, Alejandro, additional, Morán Bueno, Teresa, additional, Wu, Shang-Yin, additional, Knoble, Jeanna, additional, Skrickova, Jana, additional, Venkova, Violetka, additional, Hilgers, Werner, additional, Laack, Eckart, additional, Bischoff, Helge, additional, Fülöp, Andrea, additional, Laczó, Ibolya, additional, Kósa, Judit, additional, Telekes, András, additional, Yoshida, Tatsuya, additional, Kanda, Shintaro, additional, Hida, Toyoaki, additional, Hayashi, Hidetoshi, additional, Maeda, Tadashi, additional, Kawamura, Tetsuji, additional, Nakahara, Yasuharu, additional, Claessens, Niels, additional, Lee, Ki Hyeong, additional, Chiu, Chao-Hua, additional, Lin, Sheng-Hao, additional, Li, Chien-Te, additional, Demirkazik, Ahmet, additional, Schaefer, Eric, additional, Nikolinakos, Petros, additional, Schneider, Jeffrey, additional, Babu, Sunil, additional, Lamprecht, Bernd, additional, Studnicka, Michael, additional, Fausto Nino Gorini, Carlos, additional, Kultan, Juraj, additional, Kolek, Vitezslav, additional, Souquet, Pierre-Jean, additional, Moro-Sibilot, Denis, additional, Gottfried, Maya, additional, Smit, Egbert, additional, Lee, Kyung Hee, additional, Kasan, Peter, additional, Chovanec, Jozef, additional, Goloborodko, Olexandr, additional, Kolesnik, Oleksii, additional, Ostapenko, Yuriy, additional, Lakhanpal, Shailendra, additional, Haque, Basir, additional, Chua, Winston, additional, Stilwill, Joseph, additional, Sena, Susana Noemi, additional, Girotto, Gustavo Colagiovanni, additional, De Marchi, Pedro Rafael Martins, additional, Martinelli de Oliveira, Fabricio Augusto, additional, Dos Reis, Pedro, additional, Krasteva, Rositsa, additional, Zhao, Yanqiu, additional, Chen, Chengshui, additional, Koubkova, Leona, additional, Robinet, Gilles, additional, Chouaid, Christos, additional, Grohe, Christian, additional, Alt, Jürgen, additional, Csánky, Eszter, additional, Somogyiné Ezer, Éva, additional, Heching, Norman Isaac, additional, Kim, Young Hak, additional, Aatagi, Shinji, additional, Kuyama, Shoichi, additional, Harada, Daijiro, additional, Nogami, Naoyuki, additional, Nokihara, Hiroshi, additional, Goto, Hisatsugu, additional, Staal van den Brekel, Agnes, additional, Cho, Eun Kyung, additional, Kim, Joo-Hang, additional, Ganea, Doina, additional, Ciuleanu, Tudor, additional, Popova, Ekaterina, additional, Sakaeva, Dina, additional, Stresko, Marian, additional, Demo, Pavol, additional, Godal, Robert, additional, Wei, Yu-Feng, additional, Chen, Yen-Hsun, additional, Hsia, Te-Chun, additional, Lee, Kang-Yun, additional, Chang, Huang-Chih, additional, Wang, Chin-Chou, additional, Dowlati, Afshin, additional, Sumey, Christopher, additional, Powell, Steven, additional, Goldman, Jonathan, additional, Zarba, Juan Jose, additional, Batagelj, Emilio, additional, Pastor, Andrea Viviana, additional, Zukin, Mauro, additional, Baldotto, Clarissa Serodio da Rocha, additional, Schlittler, Luis Alberto, additional, Calabrich, Aknar, additional, Sette, Claudia, additional, Dudov, Asen, additional, Zhou, Caicun, additional, Lena, Hervé, additional, Lang, Susanne, additional, Pápai, Zsuzsanna, additional, Goto, Koichi, additional, Umemura, Shigeki, additional, Kanazawa, Kenya, additional, Hara, Yu, additional, Shinoda, Masahiro, additional, Morise, Masahiro, additional, Hiltermann, Jeroen, additional, Mróz, Robert, additional, Ungureanu, Andrei, additional, Andrasina, Igor, additional, Chang, Gee-Chen, additional, Vynnychenko, Ihor, additional, Shparyk, Yaroslav, additional, Kryzhanivska, Anna, additional, Ross, Helen, additional, Mi, Kailhong, additional, Jamil, Rodney, additional, Williamson, Michael, additional, Spahr, Joseph, additional, Han, Zhigang, additional, Wang, Mengzhao, additional, Yang, Zhixiong, additional, Hu, Jie, additional, Li, Wei, additional, Zhao, Jun, additional, Feng, Jifeng, additional, Ma, Shenglin, additional, Zhou, Xiangdong, additional, Liang, Zongan, additional, Hu, Yi, additional, Chen, Yuan, additional, Bi, Minghong, additional, Shu, Yongqian, additional, Nan, Kejun, additional, Zhou, Jianying, additional, Zhang, Wei, additional, Ma, Rui, additional, Yang, Nong, additional, Lin, Zhong, additional, Wu, Gang, additional, Fang, Jian, additional, Zhang, Helong, additional, Wang, Kai, additional, and Chen, Zhendong, additional

Published
2021
Full Text
View/download PDF

11. Phase I study of AMG 509, a STEAP1 x CD3 T cell-recruiting XmAb 2+1 immune therapy, in patients with metastatic castration-resistant prostate cancer (mCRPC).

Author

Kelly, W. Kevin, primary, Danila, Daniel Costin, additional, Edenfield, William Jeffery, additional, Aggarwal, Rahul Raj, additional, Petrylak, Daniel Peter, additional, Sartor, A. Oliver, additional, Sumey, Christopher Joseph, additional, Dorff, Tanya B., additional, Yu, Evan Y., additional, Adra, Nabil, additional, Waterhouse, David Michael, additional, Armstrong, Andrew J., additional, Horvath, Lisa, additional, Pook, David William, additional, Appleman, Leonard Joseph, additional, Lau, Aubrey, additional, Salvati, Mark, additional, and Kouros-Mehr, Hosein, additional

Published
2020
Full Text
View/download PDF

12. Randomized phase II clinical trial of cisplatin/carboplatin and etoposide (CE) alone or in combination with nivolumab as frontline therapy for extensive-stage small cell lung cancer (ES-SCLC): ECOG-ACRIN EA5161.

Author

Leal, Ticiana, primary, Wang, Yating, additional, Dowlati, Afshin, additional, Lewis, DeQuincy Andrew, additional, Chen, Yuanbin, additional, Mohindra, Amit Ramesh, additional, Razaq, Mohammad, additional, Ahuja, Harish G., additional, Liu, Jijun, additional, King, David M., additional, Sumey, Christopher Joseph, additional, and Ramalingam, Suresh S., additional

Published
2020
Full Text
View/download PDF

13. Implementation of a Standardized Approach to Borderline Resectable Pancreatic Cancer in a Multisite Community Oncology Program

Author

Bleeker, Jonathan S., primary, Sumey, Christopher J., additional, Powell, Steven F., additional, Steen, Preston D., additional, Keppen, Michael D., additional, Lohr, Michele, additional, Thambi-Pillai, Thavam, additional, Kurniali, Peter, additional, Mazurczak, Miroslaw, additional, Gitau, Mark M., additional, Blanchard, Miran J., additional, Nowak, Ryan K., additional, McGraw, Steven, additional, Sticca, Robert, additional, Tuvin, Daniel, additional, and Timmerman, Gary, additional

Published
2020
Full Text
View/download PDF

14. Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

Author

Paz-Ares, Luis, primary, Dvorkin, Mikhail, additional, Chen, Yuanbin, additional, Reinmuth, Niels, additional, Hotta, Katsuyuki, additional, Trukhin, Dmytro, additional, Statsenko, Galina, additional, Hochmair, Maximilian J, additional, Özgüroğlu, Mustafa, additional, Ji, Jun Ho, additional, Voitko, Oleksandr, additional, Poltoratskiy, Artem, additional, Ponce, Santiago, additional, Verderame, Francesco, additional, Havel, Libor, additional, Bondarenko, Igor, additional, Kazarnowicz, Andrzej, additional, Losonczy, György, additional, Conev, Nikolay V, additional, Armstrong, Jon, additional, Byrne, Natalie, additional, Shire, Norah, additional, Jiang, Haiyi, additional, Goldman, Jonathan W, additional, Batagelj, Emilio, additional, Casarini, Ignacio, additional, Pastor, Anea Viviana, additional, Sena, Susana Noemi, additional, Zarba, Juan Jose, additional, Burghuber, Otto, additional, Hartl, Sylvia, additional, Lamprecht, Bernd, additional, Studnicka, Michael, additional, Alberto Schlittler, Luis, additional, Augusto Martinelli de Oliveira, Fabricio, additional, Calabrich, Aknar, additional, Colagiovanni Girotto, Gustavo, additional, Dos Reis, Peo, additional, Fausto Nino Gorini, Carlos, additional, Rafael Martins De Marchi, Peo, additional, Serodio da Rocha Baldotto, Clarissa, additional, Sette, Claudia, additional, Zukin, Mauro, additional, Dudov, Assen, additional, Ilieva, Rumyana, additional, Koynov, Krassimir, additional, Krasteva, Rositsa, additional, Tonev, Ivan, additional, Valev, Spartak, additional, Venkova, Violetka, additional, Bi, Minghong, additional, Chen, Chengshui, additional, Chen, Yuan, additional, Chen, Zhendong, additional, Fang, Jian, additional, Feng, Jifeng, additional, Han, Zhigang, additional, Hu, Jie, additional, Hu, Yi, additional, Li, Wei, additional, Liang, Zongan, additional, Lin, Zhong, additional, Ma, Rui, additional, Ma, Shenglin, additional, Nan, Kejun, additional, Shu, Yongqian, additional, Wang, Kai, additional, Wang, Mengzhao, additional, Wu, Gang, additional, Yang, Nong, additional, Yang, Zhixiong, additional, Zhang, Helong, additional, Zhang, Wei, additional, Zhao, Jun, additional, Zhao, Yanqiu, additional, Zhou, Caicun, additional, Zhou, Jianying, additional, Zhou, Xiangdong, additional, Kolek, Vitezslav, additional, Koubkova, Leona, additional, Roubec, Jaromir, additional, Skrickova, Jana, additional, Zemanova, Milada, additional, Chouaid, Christos, additional, Hilgers, Werner, additional, Lena, Hervé, additional, Moro-Sibilot, Denis, additional, Robinet, Gilles, additional, Souquet, Pierre-Jean, additional, Alt, Jürgen, additional, Bischoff, Helge, additional, Grohe, Christian, additional, Laack, Eckart, additional, Lang, Susanne, additional, Panse, Jens, additional, Schulz, Christian, additional, Bogos, Krisztina, additional, Csánky, Eszter, additional, Fülöp, Anea, additional, Horváth, Zsolt, additional, Kósa, Judit, additional, Laczó, Ibolya, additional, Pajkos, Gábor, additional, Pápai, Zsuzsanna, additional, Pápai Székely, Zsolt, additional, Sárosi, Veronika, additional, Somfay, Attila, additional, Somogyiné Ezer, Éva, additional, Telekes, Anás, additional, Bar, Jair, additional, Gottfried, Maya, additional, Heching, Norman Isaac, additional, Zer Kuch, Alona, additional, Bartolucci, Roberta, additional, Bettini, Anna Cecilia, additional, Delmonte, Angelo, additional, Garassino, Marina Chiara, additional, Minelli, Mauro, additional, Roila, Fausto, additional, Atagi, Shinji, additional, Azuma, Koichi, additional, Goto, Hisatsugu, additional, Goto, Koichi, additional, Hara, Yu, additional, Hayashi, Hidetoshi, additional, Hida, Toyoaki, additional, Kanazawa, Kenya, additional, Kanda, Shintaro, additional, Kim, Young Hak, additional, Kuyama, Shoichi, additional, Maeda, Tadashi, additional, Morise, Masahiro, additional, Nakahara, Yasuharu, additional, Nishio, Makoto, additional, Nogami, Naoyuki, additional, Okamoto, Isamu, additional, Saito, Haruhiro, additional, Shinoda, Masahiro, additional, Umemura, Shigeki, additional, Yoshida, Tatsuya, additional, Claessens, Niels, additional, Cornelissen, Robin, additional, Heniks, Lizza, additional, Hiltermann, Jeroen, additional, Smit, Egbert, additional, Staal van den Brekel, Agnes, additional, Kowalski, Dariusz, additional, Mańdziuk, Slawomir, additional, Mróz, Robert, additional, Wojtukiewicz, Marek, additional, Ciuleanu, Tudor, additional, Ganea, Doina, additional, Ungureanu, Anei, additional, Luft, Alexander, additional, Moiseenko, Vladimir, additional, Sakaeva, Dina, additional, Smolin, Alexey, additional, Vasilyev, Alexander, additional, Vladimirova, Lyubov, additional, Anasina, Igor, additional, Chovanec, Jozef, additional, Demo, Pavol, additional, Godal, Robert, additional, Kasan, Peter, additional, Stresko, Marian, additional, Urda, Michal, additional, Cho, Eun Kyung, additional, Kim, Joo-Hang, additional, Kim, Sang-We, additional, Lee, Gyeong-Won, additional, Lee, Jong-Seok, additional, Lee, Ki Hyeong, additional, Lee, Kyung Hee, additional, Lee, Yun Gyoo, additional, Amelia Insa Molla, Maria, additional, Domine Gomez, Manuel, additional, Ignacio Delgado Mingorance, Juan, additional, Isla Casado, Dolores, additional, Lopez Brea, Marta, additional, Majem Tarruella, Margarita, additional, Morán Bueno, Teresa, additional, Navarro Mendivil, Alejano, additional, Paz-Ares Rodríguez, Luis, additional, Ponce Aix, Santiago, additional, Rosario Garcia Campelo, Maria, additional, Chang, Gee-Chen, additional, Chen, Yen-Hsun, additional, Chiu, Chao-Hua, additional, Hsia, Te-Chun, additional, Lee, Kang-Yun, additional, Li, Chien-Te, additional, Wang, Chin-Chou, additional, Wei, Yu-Feng, additional, Wu, Shang-Yin, additional, Alacacıoğlu, Ahmet, additional, Çiçin, Irfan, additional, Demirkazik, Ahmet, additional, Erman, Mustafa, additional, Göksel, Tuncay, additional, Adamchuk, Hryhoriy, additional, Kolesnik, Oleksii, additional, Kryzhanivska, Anna, additional, Ostapenko, Yuriv, additional, Shevnia, Serhii, additional, Shparyk, Yaroslav, additional, Ursol, Grygorii, additional, Voitko, Nataliia, additional, Vynnychenko, Ihor, additional, Babu, Sunil, additional, Chiang, Anne, additional, Chua, Winston, additional, Dakhil, Shaker, additional, Dowlati, Afshin, additional, Haque, Basir, additional, Jamil, Rodney, additional, Knoble, Jeanna, additional, Lakhanpal, Shailena, additional, Mi, Kailhong, additional, Nikolinakos, Petros, additional, Powell, Steven, additional, Ross, Helen, additional, Schaefer, Eric, additional, Schneider, Jeffrey, additional, Spahr, Joseph, additional, Spigel, David, additional, Stilwill, Joseph, additional, Sumey, Christopher, additional, and Williamson, Michael, additional

Published
2019
Full Text
View/download PDF

15. Diagnostic Challenge With Auto-Immune Pancreatitis and IgG4-Related Disease.

Author

Staum, Ben, Sumey, Christopher, Bohy, Kimberlee C., White, Karah, Thambi-Pillai, Thavam, Ridgway, Tim, and Atiq, Muslim

Abstract

IgG4-related disease (IgG4RD) is a chronic immune mediated condition primarily affecting the hepato-pancreatico- biliary system. We report a case of IgG4RD with extensive pancreatic and hepatic involvement masquerading as metastatic pancreatic malignancy posing a diagnostic and therapeutic dilemma. [ABSTRACT FROM AUTHOR]

Published
2020

17. Implementation of a standardized approach to borderline resectable pancreatic cancer in a community oncology program.

Author

Bleeker, Jonathan Scott, primary, Sumey, Christopher Joseph, additional, Powell, Steven Francis, additional, Steen, Preston D., additional, Keppen, Michael D., additional, Lohr, Michele, additional, Thambi-Pillai, Thavam C., additional, Kurniali, Peter, additional, Mazurczak, Miroslaw, additional, Gitau, Mark Mutuota, additional, Blanchard, Miran Joel, additional, Nowak, Ryan Kenneth, additional, McGraw, Steven, additional, Sticca, Robert, additional, Tuvin, Daniel, additional, and Timmerman, Gary, additional

Published
2018
Full Text
View/download PDF

18. Safety of pembrolizumab with chemoradiation (CRT) in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN).

Author

Powell, Steven Francis, primary, Gitau, Mark Mutuota, additional, Sumey, Christopher Joseph, additional, Reynolds, John T., additional, Lohr, Michele, additional, McGraw, Steven, additional, Nowak, Ryan Kenneth, additional, Terrell, Andrew M, additional, Jensen, Ashley Wayne, additional, Blanchard, Miran Joel, additional, Ellison, Christie, additional, Black, Lora Jane, additional, Thompson, Paul A., additional, Gold, Kathryn A., additional, Cohen, Ezra E.W., additional, Lee, John H., additional, and Spanos, William Charles, additional

Published
2017
Full Text
View/download PDF

19. Large Solitary Fibrous Tumor of the Kidney.

Author

Klubben, Kellan, Anderson, Susan M., Park, Eugene, and Sumey, Christopher

Abstract

Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms that can affect any soft tissue in the body. Given their infrequency, no definitive risk factors have been identified. Typically, surgical extrication en bloc is the only known curative treatment option for SFTs; however, systemic therapy can be used for metastatic or unresectable disease. Only 10 perent to 15 perent of SFTs are aggressive in behavior and termed malignant, leading to a high survival rate for affected patients. Surveillance is required post-operatively to detect recurrence. [ABSTRACT FROM AUTHOR]

Published
2021

20. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Author

Althammer, Sonja, primary, Steele, Keith, additional, Rebelatto, Marlon, additional, Tan, Tze Heng, additional, Wiestler, Tobias, additional, Schmidt, Guenter, additional, Higgs, Brandon, additional, Li, Xia, additional, Shi, Li, additional, Jin, Xiaoping, additional, Antal, Joyce, additional, Gupta, Ashok, additional, Ranade, Koustubh, additional, Binning, Gerd, additional, Bellmunt, Joaquim, additional, de Wit, Ronald, additional, Vaughn, David J., additional, Fradet, Yves, additional, Lee, Jae Lyun, additional, Fong, Lawrence, additional, Vogelzang, Nicholas J., additional, Climent, Miguel A., additional, Petrylak, Daniel P., additional, Choueiri, Toni K., additional, Necchi, Andrea, additional, Gerritsen, Winald, additional, Gurney, Howard, additional, Quinn, David I., additional, Culine, Stéphane, additional, Sternberg, Cora N., additional, Mai, Yabing, additional, Puhlmann, Markus, additional, Perini, Rodolfo F., additional, Bajorin, Dean F., additional, Sharma, Padmanee, additional, Callahan, Margaret K., additional, Calvo, Emiliano, additional, Kim, Joseph W., additional, de Braud, Filipo, additional, Ott, Patrick A., additional, Bono, Petri, additional, Pillai, Rathi N., additional, Morse, Michael, additional, Le, Dung T., additional, Taylor, Matthew, additional, Spilliopoulou, Pavlina, additional, Bendell, Johanna, additional, Jaeger, Dirk, additional, Chan, Emily, additional, Antonia, Scott J., additional, Ascierto, Paolo A., additional, Hennicken, Delphine, additional, Tschaika, Marina, additional, Azrilevich, Alex, additional, Rosenberg, Jonathan, additional, Levy, Ofer, additional, Chan, Christopher, additional, Cojocaru, Gady, additional, Liang, Spencer, additional, Ophir, Eran, additional, Ganguly, Sudipto, additional, Toporik, Amir, additional, Kotturi, Maya, additional, Kfir, Tal Fridman, additional, Murter, Benjamin M., additional, Logronio, Kathryn, additional, Dassa, Liat, additional, Leung, Ling, additional, Greenwald, Shirley, additional, Azulay, Meir, additional, Kumar, Sandeep, additional, Alteber, Zoya, additional, Pan, Xiaoyu, additional, Machlenkin, Arthur, additional, Benita, Yair, additional, Drake, Andrew W., additional, Chajut, Ayelet, additional, Salomon, Ran, additional, Vankin, Ilan, additional, Safyon, Einav, additional, Hunter, John, additional, Levine, Zurit, additional, White, Mark, additional, Leidner, Rom, additional, Kang, Hyunseok, additional, Haddad, Robert, additional, Segal, Neil H., additional, Wirth, Lori J., additional, Ferris, Robert L., additional, Hodi, F. Stephen, additional, Sanborn, Rachel E., additional, Gajewski, Thomas F., additional, Sharfman, William, additional, McDonald, Dan, additional, Srivastava, Shivani, additional, Gu, Xuemin, additional, Phillips, Penny, additional, Passey, Chaitali, additional, Seiwert, Tanguy, additional, Habtetsion, Tsadik, additional, Zhou, Gang, additional, Sakellariou-Thompson, Donastas, additional, Haymaker, Cara, additional, Creasy, Caitlin, additional, Hurd, Mark, additional, Uraoka, Naohiro, additional, Canales, Jaime Rodriguez, additional, Koptez, Scott, additional, Hwu, Patrick, additional, Maitra, Anirban, additional, Bernatchez, Chantale, additional, Coyle, Scott M., additional, Roybel, Kole T., additional, Rupp, Levi J., additional, Santoro, Stephen P., additional, Secrest, Stephanie, additional, Spelman, Michael, additional, Ho, Hanson, additional, Gomes, Tina, additional, Tse, Tiffany, additional, Yung-Wu, Chia, additional, Taunton, Jack, additional, Lim, Wendell, additional, Emtage, Peter, additional, Moudgil, Tarsem, additional, Ballesteros-Merino, Carmen, additional, Hilton, Traci, additional, Paustian, Christopher, additional, Page, David, additional, Urba, Walter, additional, Fox, Bernard, additional, Bell, Bryan, additional, Patel, Ashish, additional, Olafsen, Tove, additional, Satpayev, Daulet, additional, Torgov, Michael, additional, Marchioni, Filippo, additional, Romero, Jason, additional, Jiang, Ziyue Karen, additional, Zamilpa, Charles, additional, Keppler, Jennifer S., additional, Mascioni, Alessandro, additional, Jia, Fang, additional, Lee, Chen-Yu, additional, Gudas, Jean, additional, Sullivan, Ryan J., additional, Hoshida, Yujin, additional, Logan, Theodore, additional, Khushalani, Nikhil, additional, Giobbie-Hurder, Anita, additional, Margolin, Kim, additional, Roder, Joanna, additional, Bhatt, Rupal, additional, Koon, Henry, additional, Olencki, Thomas, additional, Hutson, Thomas, additional, Curti, Brendan, additional, Blackmon, Shauna, additional, Mier, James W., additional, Puzanov, Igor, additional, Roder, Heinrich, additional, Stewart, John, additional, Amin, Asim, additional, Ernstoff, Marc S., additional, Clark, Joseph I., additional, Atkins, Michael B., additional, Kaufman, Howard L., additional, Sosman, Jeffrey, additional, Signoretti, Sabina, additional, McDermott, David F., additional, Anderson, Abraham A., additional, Milhem, Mohammed M., additional, Andtbacka, Robert H. I., additional, Minor, David, additional, Gorski, Kevin S., additional, Baker, Daniel M., additional, Hamid, Omid, additional, Akporiaye, Emmanuel, additional, Koguchi, Yoshinobu, additional, Sutcliffe, Kim, additional, Conder, Kristie, additional, Marron, Thomas, additional, Bhardwaj, Nina, additional, Hammerich, Linda, additional, George, Fiby, additional, Kim-Schulze, Seunghee, additional, Keler, Tibor, additional, Davis, Tom, additional, Crowley, Elizabeth, additional, Salazar, Andres, additional, Brody, Joshua, additional, Monjazeb, Arta, additional, Daly, Megan E., additional, Riess, Jonathan, additional, Li, Tianhong, additional, Murphy, William J., additional, Kelly, Karen, additional, Hu, Zhiwei, additional, Shen, Rulong, additional, Campbell, Amanda, additional, McMichael, Elizabeth, additional, Yu, Lianbo, additional, Ramaswam, Bhuvaneswari, additional, London, Cheryl A., additional, Xu, Tian, additional, Carson, William, additional, Kokolus, Kathleen M., additional, Repasky, Elizabeth A., additional, Schell, Todd D., additional, Drabick, Joseph D., additional, Messenheimer, David J., additional, Jensen, Shawn, additional, Rubinstein, Mark, additional, Andrijauskaite, Kristina, additional, Swiderska-syn, Marzena, additional, Lind, Kristin, additional, Choppin, Agnes, additional, Roell, Marina K., additional, Wrangle, John, additional, Rhode, Peter, additional, Wong, Hing, additional, Ahmad, Shamim, additional, Webb, Mason, additional, Abu-Eid, Rasha, additional, Shrimali, Rajeev, additional, Verma, Vivek, additional, Doroodchi, Atbin, additional, Berrong, Zuzana, additional, Yashar, David, additional, Samara, Raed, additional, Mkrtichyan, Mikayel, additional, Khleif, Samir, additional, Powell, Steven, additional, Gitau, Mark, additional, Sumey, Christopher, additional, Terrell, Andrew, additional, Lohr, Michele, additional, Nowak, Ryan K., additional, McGraw, Steven, additional, Jensen, Ash, additional, Blanchard, Miran, additional, Gold, Kathryn A., additional, Cohen, Ezra E. W., additional, Ellison, Christie, additional, Black, Lora, additional, Lee, John, additional, Spanos, William Chad, additional, Wennerberg, Erik, additional, Schwitzer, Emily, additional, Lhuillier, Claire, additional, Koelwyn, Graeme, additional, Hiner, Rebecca, additional, Jones, Lee, additional, Demaria, Sandra, additional, Amanda, Vandeveer, additional, Greiner, John W., additional, Schlom, Jeffrey, additional, Bookstaver, Michelle, additional, Jewell, Christopher M., additional, Gunderson, Andrew, additional, Boulmay, Brian, additional, Li, Rui, additional, Spieler, Bradley, additional, Happel, Kyle, additional, Feng, Zipei, additional, Dubay, Christopher, additional, Fisher, Brenda, additional, Aung, Sandra, additional, Mederos, Eileen, additional, Bifulco, Carlo B., additional, McNamara, Michael, additional, Bahjat, Keith, additional, Redmond, William, additional, Ochoa, Augusto, additional, Hu, Hong-Ming, additional, Mehta, Adi, additional, Lund-Johansen, Fridtjof, additional, Bedu-Addo, Frank, additional, Conn, Greg, additional, King, Michael, additional, Dutta, Panna, additional, Shepard, Robert, additional, Einstein, Mark, additional, Adams, Sylvia, additional, Wang, Ena, additional, Jin, Ping, additional, Novik, Yelena, additional, Morrison, Debra, additional, Oratz, Ruth, additional, Marincola, Franco M., additional, Stroncek, David, additional, Goldberg, Judith, additional, Formenti, Silvia C., additional, Galon, Jérôme, additional, Mlecnik, Bernhard, additional, Marliot, Florence, additional, Ou, Fang-Shu, additional, Lugli, Alessandro, additional, Zlobec, Inti, additional, Rau, Tilman T., additional, Nagtegaal, Iris D., additional, Vink-Borger, Elisa, additional, Hartmann, Arndt, additional, Geppert, Carol, additional, Roehrl, Michael H., additional, Bavi, Prashant, additional, Ohashi, Pamela S., additional, Wang, Julia Y., additional, Nguyen, Linh T., additional, Han, SeongJun, additional, MacGregor, Heather L., additional, Hafezi-Bakhtiari, Sara, additional, Wouters, Bradley G., additional, Kawakami, Yutaka, additional, Papivanova, Boryana, additional, Xu, Mingli, additional, Fujita, Tomonobu, additional, Hazama, Shoichi, additional, Suzuki, Nobuaki, additional, Nagano, Hiroaki, additional, Okuno, Kiyotaka, additional, Itoh, Kyogo, additional, Zavadova, Eva, additional, Vocka, Michal, additional, Spacek, Jan, additional, Petruzelka, Lubos, additional, Konopasek, Bohuslav, additional, Dundr, Pavel, additional, Skalova, Helena, additional, Torigoe, Toshihiko, additional, Sato, Noriyuki, additional, Furuhata, Tomohisa, additional, Takemasa, Ichiro, additional, Van den Eynde, Marc, additional, Jouret-Mourin, Anne, additional, Machiels, Jean-Pascal, additional, Fredriksen, Tessa, additional, Lafontaine, Lucie, additional, Buttard, Bénédicte, additional, Church, Sarah, additional, Maby, Pauline, additional, Angell, Helen, additional, Angelova, Mihaela, additional, Vasaturo, Angela, additional, Bindea, Gabriela, additional, Berger, Anne, additional, Lagorce, Christine, additional, Patel, Prabhu S., additional, Vora, Hemangini H., additional, Shah, Birva, additional, Patel, Jayendrakumar B., additional, Rajvik, Kruti N., additional, Pandya, Shashank J., additional, Shukla, Shilin N., additional, Wang, Yili, additional, Zhang, Guanjun, additional, Masucci, Giuseppe V., additional, Andersson, Emilia K., additional, Grizzi, Fabio, additional, Laghi, Luigi, additional, Botti, Gerardo, additional, Tatangelo, Fabiana, additional, Delrio, Paolo, additional, Cilberto, Gennaro, additional, Marincola, Franco, additional, Sargent, Daniel J., additional, Fox, Bernard A., additional, Algazi, Alain, additional, Tsai, Katy, additional, Rosenblum, Michael, additional, Nandoskar, Prachi, additional, Li, Amy, additional, Nonomura, John, additional, Takamura, Kathryn, additional, Dwyer, Mary, additional, Browning, Erica, additional, Talia, Reneta, additional, Twitty, Chris, additional, Gargosky, Sharron, additional, Campbell, Jean, additional, Le, Mai, additional, Pierce, Robert H., additional, Daud, Adil, additional, Gartrell, Robyn, additional, Marks, Douglas, additional, Stack, Edward, additional, Lu, Yan, additional, Izaki, Daisuke, additional, Beck, Kristen, additional, Jia, Dan Tong, additional, Armenta, Paul, additional, White-Stern, Ashley, additional, Fu, Yichun, additional, Blake, Zoe, additional, Taback, Bret, additional, Horst, Basil, additional, Saenger, Yvonne M., additional, Leonardo, Steven, additional, Gorden, Keith, additional, Fulton, Ross B., additional, Fraser, Kathryn, additional, Kangas, Takashi O., additional, Walsh, Richard, additional, Ertelt, Kathleen, additional, Graff, Jeremy, additional, Uhlik, Mark, additional, Sims, Jennifer S., additional, Lei, Liang, additional, Tsujiuchi, Takashi, additional, Bruce, Jeffrey N., additional, Canoll, Peter, additional, Tolcher, Anthony W, additional, Alley, Evan W, additional, Chichili, Gurunadh, additional, Canoll, Jan E, additional, Moore, Paul, additional, Bonvini, Ezio, additional, Johnson, Syd, additional, Shankar, Sadhna, additional, Vasselli, James, additional, Wigginton, Jon, additional, and Powderly, John, additional

Published
2016
Full Text
View/download PDF

23. Adjuvant medical therapy for prostate cancer

Author

Sumey, Christopher and Flaig, Thomas W

Abstract

Importance of the field:Prostate cancer is a common cancer and the role of adjuvant medical therapy continues to be investigated. An understanding of the use of adjuvant medical therapy is essential for the appropriate care of prostate cancer patients, especially for those with locally advanced or high-risk disease.Areas covered in this review:This article reviews the role of adjuvant treatment of non-metastatic prostate cancer. To identify all pertinent publications, a literature search of the National Library of Medicine (PubMed) from inception to 22 June 2010 was conducted for ‘adjuvant prostate cancer’, with these results filtered for clinical trials and systematic reviews.What the reader will gain:This work reviews the uses of adjuvant androgen deprivation therapy and chemotherapy for prostate cancer. There is a clear benefit from the use of androgen deprivation therapy in conjunction with radiation therapy for selected patients, but the role of postoperative chemotherapy is poorly defined. Identifying appropriate patients for adjuvant therapy continues to be a challenge.Take home message:There is a complex literature describing the role of adjuvant medical therapy in prostate cancer, which is reviewed here. Continuing and future clinical trials will define the utility of adjuvant therapy in this setting and require the support of the clinical community.

Published
2011
Full Text
View/download PDF

24. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts

Author

Althammer, Sonja, Steele, Keith, Rebelatto, Marlon, Tan, Tze Heng, Wiestler, Tobias, Schmidt, Guenter, Higgs, Brandon, Li, Xia, Shi, Li, Jin, Xiaoping, Antal, Joyce, Gupta, Ashok, Ranade, Koustubh, Binning, Gerd, Bellmunt, Joaquim, de Wit, Ronald, Vaughn, David J., Fradet, Yves, Lee, Jae Lyun, Fong, Lawrence, Vogelzang, Nicholas J., Climent, Miguel A., Petrylak, Daniel P., Choueiri, Toni K., Necchi, Andrea, Gerritsen, Winald, Gurney, Howard, Quinn, David I., Culine, Stéphane, Sternberg, Cora N., Mai, Yabing, Puhlmann, Markus, Perini, Rodolfo F., Bajorin, Dean F., Sharma, Padmanee, Callahan, Margaret K., Calvo, Emiliano, Kim, Joseph W., de Braud, Filipo, Ott, Patrick A., Bono, Petri, Pillai, Rathi N., Morse, Michael, Le, Dung T., Taylor, Matthew, Spilliopoulou, Pavlina, Bendell, Johanna, Jaeger, Dirk, Chan, Emily, Antonia, Scott J., Ascierto, Paolo A., Hennicken, Delphine, Tschaika, Marina, Azrilevich, Alex, Rosenberg, Jonathan, Levy, Ofer, Chan, Christopher, Cojocaru, Gady, Liang, Spencer, Ophir, Eran, Ganguly, Sudipto, Toporik, Amir, Kotturi, Maya, Kfir, Tal Fridman, Murter, Benjamin M., Logronio, Kathryn, Dassa, Liat, Leung, Ling, Greenwald, Shirley, Azulay, Meir, Kumar, Sandeep, Alteber, Zoya, Pan, Xiaoyu, Machlenkin, Arthur, Benita, Yair, Drake, Andrew W., Chajut, Ayelet, Salomon, Ran, Vankin, Ilan, Safyon, Einav, Hunter, John, Levine, Zurit, White, Mark, Leidner, Rom, Kang, Hyunseok, Haddad, Robert, Segal, Neil H., Wirth, Lori J., Ferris, Robert L., Hodi, F. Stephen, Sanborn, Rachel E., Gajewski, Thomas F., Sharfman, William, McDonald, Dan, Srivastava, Shivani, Gu, Xuemin, Phillips, Penny, Passey, Chaitali, Seiwert, Tanguy, Habtetsion, Tsadik, Zhou, Gang, Sakellariou-Thompson, Donastas, Haymaker, Cara, Creasy, Caitlin, Hurd, Mark, Uraoka, Naohiro, Canales, Jaime Rodriguez, Koptez, Scott, Hwu, Patrick, Maitra, Anirban, Bernatchez, Chantale, Coyle, Scott M., Roybel, Kole T., Rupp, Levi J., Santoro, Stephen P., Secrest, Stephanie, Spelman, Michael, Ho, Hanson, Gomes, Tina, Tse, Tiffany, Yung-Wu, Chia, Taunton, Jack, Lim, Wendell, Emtage, Peter, Moudgil, Tarsem, Ballesteros-Merino, Carmen, Hilton, Traci, Paustian, Christopher, Page, David, Urba, Walter, Fox, Bernard, Bell, Bryan, Patel, Ashish, Olafsen, Tove, Satpayev, Daulet, Torgov, Michael, Marchioni, Filippo, Romero, Jason, Jiang, Ziyue Karen, Zamilpa, Charles, Keppler, Jennifer S., Mascioni, Alessandro, Jia, Fang, Lee, Chen-Yu, Gudas, Jean, Sullivan, Ryan J., Hoshida, Yujin, Logan, Theodore, Khushalani, Nikhil, Giobbie-Hurder, Anita, Margolin, Kim, Roder, Joanna, Bhatt, Rupal, Koon, Henry, Olencki, Thomas, Hutson, Thomas, Curti, Brendan, Blackmon, Shauna, Mier, James W., Puzanov, Igor, Roder, Heinrich, Stewart, John, Amin, Asim, Ernstoff, Marc S., Clark, Joseph I., Atkins, Michael B., Kaufman, Howard L., Sosman, Jeffrey, Signoretti, Sabina, McDermott, David F., Anderson, Abraham A., Milhem, Mohammed M., Andtbacka, Robert H. I., Minor, David, Gorski, Kevin S., Baker, Daniel M., Hamid, Omid, Akporiaye, Emmanuel, Koguchi, Yoshinobu, Sutcliffe, Kim, Conder, Kristie, Marron, Thomas, Bhardwaj, Nina, Hammerich, Linda, George, Fiby, Kim-Schulze, Seunghee, Keler, Tibor, Davis, Tom, Crowley, Elizabeth, Salazar, Andres, Brody, Joshua, Monjazeb, Arta, Daly, Megan E., Riess, Jonathan, Li, Tianhong, Murphy, William J., Kelly, Karen, Hu, Zhiwei, Shen, Rulong, Campbell, Amanda, McMichael, Elizabeth, Yu, Lianbo, Ramaswam, Bhuvaneswari, London, Cheryl A., Xu, Tian, Carson, William, Kokolus, Kathleen M., Repasky, Elizabeth A., Schell, Todd D., Drabick, Joseph D., Messenheimer, David J., Jensen, Shawn, Rubinstein, Mark, Andrijauskaite, Kristina, Swiderska-syn, Marzena, Lind, Kristin, Choppin, Agnes, Roell, Marina K., Wrangle, John, Rhode, Peter, Wong, Hing, Ahmad, Shamim, Webb, Mason, Abu-Eid, Rasha, Shrimali, Rajeev, Verma, Vivek, Doroodchi, Atbin, Berrong, Zuzana, Yashar, David, Samara, Raed, Mkrtichyan, Mikayel, Khleif, Samir, Powell, Steven, Gitau, Mark, Sumey, Christopher, Terrell, Andrew, Lohr, Michele, Nowak, Ryan K., McGraw, Steven, Jensen, Ash, Blanchard, Miran, Gold, Kathryn A., Cohen, Ezra E. W., Ellison, Christie, Black, Lora, Lee, John, Spanos, William Chad, Wennerberg, Erik, Schwitzer, Emily, Lhuillier, Claire, Koelwyn, Graeme, Hiner, Rebecca, Jones, Lee, Demaria, Sandra, Amanda, Vandeveer, Greiner, John W., Schlom, Jeffrey, Bookstaver, Michelle, Jewell, Christopher M., Gunderson, Andrew, Boulmay, Brian, Li, Rui, Spieler, Bradley, Happel, Kyle, Feng, Zipei, Dubay, Christopher, Fisher, Brenda, Aung, Sandra, Mederos, Eileen, Bifulco, Carlo B., McNamara, Michael, Bahjat, Keith, Redmond, William, Ochoa, Augusto, Hu, Hong-Ming, Mehta, Adi, Lund-Johansen, Fridtjof, Bedu-Addo, Frank, Conn, Greg, King, Michael, Dutta, Panna, Shepard, Robert, Einstein, Mark, Adams, Sylvia, Wang, Ena, Jin, Ping, Novik, Yelena, Morrison, Debra, Oratz, Ruth, Marincola, Franco M., Stroncek, David, Goldberg, Judith, Formenti, Silvia C., Galon, Jérôme, Mlecnik, Bernhard, Marliot, Florence, Ou, Fang-Shu, Lugli, Alessandro, Zlobec, Inti, Rau, Tilman T., Nagtegaal, Iris D., Vink-Borger, Elisa, Hartmann, Arndt, Geppert, Carol, Roehrl, Michael H., Bavi, Prashant, Ohashi, Pamela S., Wang, Julia Y., Nguyen, Linh T., Han, SeongJun, MacGregor, Heather L., Hafezi-Bakhtiari, Sara, Wouters, Bradley G., Kawakami, Yutaka, Papivanova, Boryana, Xu, Mingli, Fujita, Tomonobu, Hazama, Shoichi, Suzuki, Nobuaki, Nagano, Hiroaki, Okuno, Kiyotaka, Itoh, Kyogo, Zavadova, Eva, Vocka, Michal, Spacek, Jan, Petruzelka, Lubos, Konopasek, Bohuslav, Dundr, Pavel, Skalova, Helena, Torigoe, Toshihiko, Sato, Noriyuki, Furuhata, Tomohisa, Takemasa, Ichiro, Van den Eynde, Marc, Jouret-Mourin, Anne, Machiels, Jean-Pascal, Fredriksen, Tessa, Lafontaine, Lucie, Buttard, Bénédicte, Church, Sarah, Maby, Pauline, Angell, Helen, Angelova, Mihaela, Vasaturo, Angela, Bindea, Gabriela, Berger, Anne, Lagorce, Christine, Patel, Prabhu S., Vora, Hemangini H., Shah, Birva, Patel, Jayendrakumar B., Rajvik, Kruti N., Pandya, Shashank J., Shukla, Shilin N., Wang, Yili, Zhang, Guanjun, Masucci, Giuseppe V., Andersson, Emilia K., Grizzi, Fabio, Laghi, Luigi, Botti, Gerardo, Tatangelo, Fabiana, Delrio, Paolo, Cilberto, Gennaro, Marincola, Franco, Sargent, Daniel J., Fox, Bernard A., Algazi, Alain, Tsai, Katy, Rosenblum, Michael, Nandoskar, Prachi, Li, Amy, Nonomura, John, Takamura, Kathryn, Dwyer, Mary, Browning, Erica, Talia, Reneta, Twitty, Chris, Gargosky, Sharron, Campbell, Jean, Le, Mai, Pierce, Robert H., Daud, Adil, Gartrell, Robyn, Marks, Douglas, Stack, Edward, Lu, Yan, Izaki, Daisuke, Beck, Kristen, Jia, Dan Tong, Armenta, Paul, White-Stern, Ashley, Fu, Yichun, Blake, Zoe, Taback, Bret, Horst, Basil, Saenger, Yvonne M., Leonardo, Steven, Gorden, Keith, Fulton, Ross B., Fraser, Kathryn, Kangas, Takashi O., Walsh, Richard, Ertelt, Kathleen, Graff, Jeremy, Uhlik, Mark, Sims, Jennifer S., Lei, Liang, Tsujiuchi, Takashi, Bruce, Jeffrey N., Canoll, Peter, Tolcher, Anthony W, Alley, Evan W, Chichili, Gurunadh, Canoll, Jan E, Moore, Paul, Bonvini, Ezio, Johnson, Syd, Shankar, Sadhna, Vasselli, James, Wigginton, Jon, and Powderly, John

Subjects
Meeting Abstracts
Full Text
View/download PDF

25. Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study.

Author

Kelly WK, Danila DC, Lin CC, Lee JL, Matsubara N, Ward PJ, Armstrong AJ, Pook D, Kim M, Dorff TB, Fischer S, Lin YC, Horvath LG, Sumey C, Yang Z, Jurida G, Smith KM, Connarn JN, Penny HL, Stieglmaier J, and Appleman LJ

Subjects
Male, Humans, Immunotherapy, Treatment Outcome, Antigens, Neoplasm, Oxidoreductases therapeutic use, Prostate-Specific Antigen therapeutic use, Prostatic Neoplasms, Castration-Resistant drug therapy, Prostatic Neoplasms, Castration-Resistant pathology
Abstract

Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)-targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer cells, such as those in advanced prostate cancer. This first-in-human study reports monotherapy dose exploration for patients with metastatic castration-resistant prostate cancer (mCRPC), primarily taxane pretreated. Ninety-seven patients received ≥1 intravenous dose ranging from 0.001 to 2.0 mg weekly or every 2 weeks. MTD was identified as 1.5 mg i.v. weekly via a 3-step dose. The most common treatment-related adverse events were cytokine release syndrome (CRS; 72%), fatigue (45%), and myalgia (34%). CRS occurred primarily during cycle 1 and improved with premedication and step dosing. Prostate-specific antigen (PSA) and RECIST responses across cohorts were encouraging [49% PSA50; 24% objective response rate (ORR)], with greater frequency at target doses ≥0.75 mg (59% PSA50; 41% ORR). Xaluritamig is a novel immunotherapy for prostate cancer that has shown encouraging results supporting further development., Significance: Xaluritamig demonstrated encouraging responses (PSA and RECIST) compared with historical established treatments for patients with late-line mCRPC. This study provides proof of concept for T-cell engagers as a potential treatment for prostate cancer, validates STEAP1 as a target, and supports further clinical investigation of xaluritamig in prostate cancer. See related commentary by Hage Chehade et al., p. 20. See related article by Nolan-Stevaux et al., p. 90. This article is featured in Selected Articles from This Issue, p. 5., (©2023 The Authors; Published by the American Association for Cancer Research.)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results