Search

Your search keyword '"Sumanasuriya, Semini"' showing total 178 results
Start Over Author "Sumanasuriya, Semini"
178 results on '"Sumanasuriya, Semini"'

1. The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells

Author

Brina, Daniela, Ponzoni, Adele, Troiani, Martina, Calì, Bianca, Pasquini, Emiliano, Attanasio, Giuseppe, Mosole, Simone, Mirenda, Michela, D’Ambrosio, Mariantonietta, Colucci, Manuel, Guccini, Ilaria, Revandkar, Ajinkya, Alajati, Abdullah, Tebaldi, Toma, Donzel, Deborah, Lauria, Fabio, Parhizgari, Nahjme, Valdata, Aurora, Maddalena, Martino, Calcinotto, Arianna, Bolis, Marco, Rinaldi, Andrea, Barry, Simon, Rüschoff, Jan Hendrik, Sabbadin, Marianna, Sumanasuriya, Semini, Crespo, Mateus, Sharp, Adam, Yuan, Wei, Grinu, Mathew, Boyle, Alexandra, Miller, Cynthia, Trotman, Lloyd, Delaleu, Nicolas, Fassan, Matteo, Moch, Holger, Viero, Gabriella, de Bono, Johann, and Alimonti, Andrea

Published
2023
Full Text
View/download PDF

2. Applications of liquid biopsies in metastatic castration resistant prostate cancer

Author

Sumanasuriya, Semini and de Bono, J.

Subjects
Prostate Cancer--Therapy
Abstract

Despite many recent advances, treating advanced prostate cancer (PC) remains clinically challenging. The need for vaildated circulating biomarkers is well recognised in almost all cancers, including in PC. Whilst circulating biomarkers such as plasma cell-free DNA (cfDNA) and circulating tumour cells (CTCs) are being investigated for their clinical utility, there has been a lack of consensus with regard to analyses, reporting and clinical effectiveness of these biomarkers. I begin by presenting the findings of experts in the field addressing these issues at an international consensus meeting. Following this, I present analysis of cfDNA concentrations of patients treated with taxanes on two large Phase III trials. Here I show that baseline cfDNA concentrations correlate with radiographic progression free survival and overall survival, but not with response to taxanes, confirming their use as independent prognostic marker but not a predictive biomarker in this setting. Low pass whole genome sequencing of plasma cfDNA performed in this same cohort of patients had superior clinical utility, with changes in tumour purity associating with response to taxane therapy, suggesting that it may be acting as a response biomarker evaluating changes in overall tumour burden. Genomic changes identified require further validation but may provide key insights into understanding drivers of taxane resistance. I also explored the role of apheresis in increasing CTC numbers, finding it to be a well-tolerated and safe procedure which allowed significant enrichment of CTCs and facilitated the interrogation of tumour genomics and dissection of inter- and intra-patient heterogeneity. Together, this work has highlighted the possible utility of less invasive liquid biopsies, with both cfDNA and CTCs (acquired by apheresis) showing promise. Currently, interrogating tumour genomics by tissue biopsy remains the gold standard but liquid biopsies have huge potential as multi-purpose biomarkers to serially and safely evaluate changes imposed by therapeutic selective pressures.

Published
2020

3. Elucidating Prostate Cancer Behaviour During Treatment via Low-pass Whole-genome Sequencing of Circulating Tumour DNA

Author

Sumanasuriya, Semini, Seed, George, Parr, Harry, Christova, Rossitza, Pope, Lorna, Bertan, Claudia, Bianchini, Diletta, Rescigno, Pasquale, Figueiredo, Ines, Goodall, Jane, Fowler, Gemma, Flohr, Penelope, Mehra, Niven, Neeb, Antje, Rekowski, Jan, Eisenberger, Mario, Sartor, Oliver, Oudard, Stéphane, Geffriaud-Ricouard, Christine, Ozatilgan, Ayse, Chadjaa, Mustapha, Macé, Sandrine, Lord, Chris, Baxter, Joe, Pettitt, Stephen, Lambros, Maryou, Sharp, Adam, Mateo, Joaquin, Carreira, Suzanne, Yuan, Wei, and de Bono, Johann S.

Published
2021
Full Text
View/download PDF

4. CD38 in Advanced Prostate Cancers

Author

Robinson, Dan, Van Allen, Eliezer M., Wu, Yi-Mi, Schultz, Nikolaus, Lonigro, Robert J., Mosquera, Juan-Miguel, Montgomery, Bruce, Taplin, Mary-Ellen, Pritchard, Colin C., Attard, Gerhardt, Beltran, Himisha, Abida, Wassim, Bradley, Robert K., Vinson, Jake, Cao, Xuhong, Vats, Pankaj, Kunju, Lakshmi P., Hussain, Maha, Tomlins, Scott A., Cooney, Kathleen A., Smith, David C., Brennan, Christine, Siddiqui, Javed, Mehra, Rohit, Chen, Yu, Rathkopf, Dana E., Morris, Michael J., Solomon, Stephen B., Durack, Jeremy C., Reuter, Victor E., Gopalan, Anuradha, Gao, Jianjiong, Loda, Massimo, Lis, Rosina T., Bowden, Michaela, Balk, Stephen P., Gaviola, Glenn, Sougnez, Carrie, Gupta, Manaswi, Yu, Evan Y., Mostaghel, Elahe A., Cheng, Heather H., Mulcahy, Hyojeong, True, Lawrence D., Plymate, Stephen R., Dvinge, Heidi, Ferraldeschi, Roberta, Flohr, Penny, Miranda, Susana, Zafeiriou, Zafeiris, Tunariu, Nina, Mateo, Joaquin, Perez-Lopez, Raquel, Demichelis, Francesca, Robinson, Brian D., Schiffman, Marc, Nanus, David M., Tagawa, Scott T., Sigaras, Alexandros, Eng, Kenneth W., Elemento, Olivier, Sboner, Andrea, Heath, Elisabeth I., Scher, Howard I., Pienta, Kenneth J., Kantoff, Philip, de Bono, Johann S., Rubin, Mark A., Nelson, Peter S., Garraway, Levi A., Sawyers, Charles L., Chinnaiyan, Arul M., Guo, Christina, Crespo, Mateus, Gurel, Bora, Dolling, David, Rekowski, Jan, Sharp, Adam, Petremolo, Antonella, Sumanasuriya, Semini, Rodrigues, Daniel N., Ferreira, Ana, Pereira, Rita, Figueiredo, Ines, Mehra, Niven, Lambros, Maryou B.K., Neeb, Antje, Gil, Veronica, Seed, George, Terstappen, Leon, Alimonti, Andrea, Drake, Charles G., and Yuan, Wei

Published
2021
Full Text
View/download PDF

5. Clinical Utility of Circulating Tumour Cell Androgen Receptor Splice Variant-7 Status in Metastatic Castration-resistant Prostate Cancer

Author

Sharp, Adam, Welti, Jon C., Lambros, Maryou B.K., Dolling, David, Rodrigues, Daniel Nava, Pope, Lorna, Aversa, Caterina, Figueiredo, Ines, Fraser, Jennifer, Ahmad, Zai, Lu, Changxue, Rescigno, Pasquale, Kolinsky, Michael, Bertan, Claudia, Seed, George, Riisnaes, Ruth, Miranda, Susana, Crespo, Mateus, Pereira, Rita, Ferreira, Ana, Fowler, Gemma, Ebbs, Berni, Flohr, Penny, Neeb, Antje, Bianchini, Diletta, Petremolo, Antonella, Sumanasuriya, Semini, Paschalis, Alec, Mateo, Joaquin, Tunariu, Nina, Yuan, Wei, Carreira, Suzanne, Plymate, Stephen R., Luo, Jun, and de Bono, Johann S.

Published
2019
Full Text
View/download PDF

7. Plasma Cell-free DNA Concentration and Outcomes from Taxane Therapy in Metastatic Castration-resistant Prostate Cancer from Two Phase III Trials (FIRSTANA and PROSELICA)

Author

Mehra, Niven, Dolling, David, Sumanasuriya, Semini, Christova, Rossitza, Pope, Lorna, Carreira, Suzanne, Seed, George, Yuan, Wei, Goodall, Jane, Hall, Emma, Flohr, Penny, Boysen, Gunther, Bianchini, Diletta, Sartor, Oliver, Eisenberger, Mario A., Fizazi, Karim, Oudard, Stephane, Chadjaa, Mustapha, Macé, Sandrine, and de Bono, Johann S.

Published
2018
Full Text
View/download PDF

9. Consensus Statement on Circulating Biomarkers for Advanced Prostate Cancer

Author

Sumanasuriya, Semini, Omlin, Aurelius, Armstrong, Andrew, Attard, Gerhardt, Chi, Kim N., Bevan, Charlotte L., Shibakawa, Aki, IJzerman, Maarten J., De Laere, Bram, Lolkema, Martijn, Lorente, David, Luo, Jun, Mehra, Niven, Olmos, David, Scher, Howard, Soule, Howard, Stoecklein, Nikolas H., Terstappen, Leon W.M.M., Waugh, David, and de Bono, Johann S.

Published
2018
Full Text
View/download PDF

10. Docetaxel Treatment in PTEN- and ERG-aberrant Metastatic Prostate Cancers

Author

Rescigno, Pasquale, Lorente, David, Dolling, David, Ferraldeschi, Roberta, Rodrigues, Daniel Nava, Riisnaes, Ruth, Miranda, Susana, Bianchini, Diletta, Zafeiriou, Zafeiris, Sideris, Spyridon, Ferreira, Ana, Figueiredo, Ines, Sumanasuriya, Semini, Mateo, Joaquin, Perez-Lopez, Raquel, Sharp, Adam, Tunariu, Nina, and de Bono, Johann S.

Published
2018
Full Text
View/download PDF

11. BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer

Author

Li, Xiangyi, Baek, GuemHee, Ramanand, Susmita G., Sharp, Adam, Gao, Yunpeng, Yuan, Wei, Welti, Jon, Rodrigues, Daniel N., Dolling, David, Figueiredo, Ines, Sumanasuriya, Semini, Crespo, Mateus, Aslam, Adam, Li, Rui, Yin, Yi, Mukherjee, Bipasha, Kanchwala, Mohammed, Hughes, Ashley M., Halsey, Wendy S., Chiang, Cheng-Ming, Xing, Chao, Raj, Ganesh V., Burma, Sandeep, de Bono, Johann, and Mani, Ram S.

Published
2018
Full Text
View/download PDF

13. Effect on Overall Survival of Locoregional Treatment in a Cohort of De Novo Metastatic Prostate Cancer Patients: A Single Institution Retrospective Analysis From the Royal Marsden Hospital

Author

Bianchini, Diletta, Lorente, David, Rescigno, Pasquale, Zafeiriou, Zafeiris, Psychopaida, Elena, O'Sullivan, Hazel, Alaras, Mervyn, Kolinsky, Michael, Sumanasuriya, Semini, Sousa Fontes, Mariane, Mateo, Joaquin, Perez Lopez, Raquel, Tunariu, Nina, Fotiadis, Nikolaos, Kumar, Pardeep, Tree, Alison, Van As, Nicholas, Khoo, Vincent, Parker, Chris, Eeles, Rosalind, Thompson, Alan, Dearnaley, David, and de Bono, Johann S.

Published
2017
Full Text
View/download PDF

14. IL-23 secreted by myeloid cells drives castration-resistant prostate cancer

Author

Calcinotto, Arianna, Spataro, Clarissa, Zagato, Elena, Di Mitri, Diletta, Gil, Veronica, Crespo, Mateus, De Bernardis, Gaston, Losa, Marco, Mirenda, Michela, Pasquini, Emiliano, Rinaldi, Andrea, Sumanasuriya, Semini, Lambros, Maryou B., Neeb, Antje, Lucianò, Roberta, Bravi, Carlo A., Nava-Rodrigues, Daniel, Dolling, David, Prayer-Galetti, Tommaso, Ferreira, Ana, Briganti, Alberto, Esposito, Antonio, Barry, Simon, Yuan, Wei, Sharp, Adam, de Bono, Johann, and Alimonti, Andrea

Published
2018
Full Text
View/download PDF

15. Prostate-specific Antigen Decline After 4 Weeks of Treatment with Abiraterone Acetate and Overall Survival in Patients with Metastatic Castration-resistant Prostate Cancer

Author

Rescigno, Pasquale, Lorente, David, Bianchini, Diletta, Ferraldeschi, Roberta, Kolinsky, Michael P., Sideris, Spyridon, Zafeiriou, Zafeiris, Sumanasuriya, Semini, Smith, Alan D., Mehra, Niven, Jayaram, Anuradha, Perez-Lopez, Raquel, Mateo, Joaquin, Parker, Chris, Dearnaley, David P., Tunariu, Nina, Reid, Alison, Attard, Gerhardt, and de Bono, Johann S.

Published
2016
Full Text
View/download PDF

16. Data from HER3 Is an Actionable Target in Advanced Prostate Cancer

Author

Gil, Veronica, primary, Miranda, Susana, primary, Riisnaes, Ruth, primary, Gurel, Bora, primary, D’Ambrosio, Mariantonietta, primary, Vasciaveo, Alessandro, primary, Crespo, Mateus, primary, Ferreira, Ana, primary, Brina, Daniela, primary, Troiani, Martina, primary, Sharp, Adam, primary, Sheehan, Beshara, primary, Christova, Rossitza, primary, Seed, George, primary, Figueiredo, Ines, primary, Lambros, Maryou, primary, Dolling, David, primary, Rekowski, Jan, primary, Alajati, Abdullah, primary, Clarke, Matthew, primary, Pereira, Rita, primary, Flohr, Penny, primary, Fowler, Gemma, primary, Boysen, Gunther, primary, Sumanasuriya, Semini, primary, Bianchini, Diletta, primary, Rescigno, Pasquale, primary, Aversa, Caterina, primary, Tunariu, Nina, primary, Guo, Christina, primary, Paschalis, Alec, primary, Bertan, Claudia, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Workman, Paul, primary, Swain, Amanda, primary, Califano, Andrea, primary, Shen, Michael M., primary, Alimonti, Andrea, primary, Neeb, Antje, primary, Welti, Jonathan, primary, Yuan, Wei, primary, and de Bono, Johann, primary

Published
2023
Full Text
View/download PDF

17. Figure S1 from HER3 Is an Actionable Target in Advanced Prostate Cancer

Author

Gil, Veronica, primary, Miranda, Susana, primary, Riisnaes, Ruth, primary, Gurel, Bora, primary, D’Ambrosio, Mariantonietta, primary, Vasciaveo, Alessandro, primary, Crespo, Mateus, primary, Ferreira, Ana, primary, Brina, Daniela, primary, Troiani, Martina, primary, Sharp, Adam, primary, Sheehan, Beshara, primary, Christova, Rossitza, primary, Seed, George, primary, Figueiredo, Ines, primary, Lambros, Maryou, primary, Dolling, David, primary, Rekowski, Jan, primary, Alajati, Abdullah, primary, Clarke, Matthew, primary, Pereira, Rita, primary, Flohr, Penny, primary, Fowler, Gemma, primary, Boysen, Gunther, primary, Sumanasuriya, Semini, primary, Bianchini, Diletta, primary, Rescigno, Pasquale, primary, Aversa, Caterina, primary, Tunariu, Nina, primary, Guo, Christina, primary, Paschalis, Alec, primary, Bertan, Claudia, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Workman, Paul, primary, Swain, Amanda, primary, Califano, Andrea, primary, Shen, Michael M., primary, Alimonti, Andrea, primary, Neeb, Antje, primary, Welti, Jonathan, primary, Yuan, Wei, primary, and de Bono, Johann, primary

Published
2023
Full Text
View/download PDF

18. Supplementary Data from HER3 Is an Actionable Target in Advanced Prostate Cancer

Author

Gil, Veronica, primary, Miranda, Susana, primary, Riisnaes, Ruth, primary, Gurel, Bora, primary, D’Ambrosio, Mariantonietta, primary, Vasciaveo, Alessandro, primary, Crespo, Mateus, primary, Ferreira, Ana, primary, Brina, Daniela, primary, Troiani, Martina, primary, Sharp, Adam, primary, Sheehan, Beshara, primary, Christova, Rossitza, primary, Seed, George, primary, Figueiredo, Ines, primary, Lambros, Maryou, primary, Dolling, David, primary, Rekowski, Jan, primary, Alajati, Abdullah, primary, Clarke, Matthew, primary, Pereira, Rita, primary, Flohr, Penny, primary, Fowler, Gemma, primary, Boysen, Gunther, primary, Sumanasuriya, Semini, primary, Bianchini, Diletta, primary, Rescigno, Pasquale, primary, Aversa, Caterina, primary, Tunariu, Nina, primary, Guo, Christina, primary, Paschalis, Alec, primary, Bertan, Claudia, primary, Buroni, Lorenzo, primary, Ning, Jian, primary, Carreira, Suzanne, primary, Workman, Paul, primary, Swain, Amanda, primary, Califano, Andrea, primary, Shen, Michael M., primary, Alimonti, Andrea, primary, Neeb, Antje, primary, Welti, Jonathan, primary, Yuan, Wei, primary, and de Bono, Johann, primary

Published
2023
Full Text
View/download PDF

19. Data from Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition

Author

Goodall, Jane, primary, Mateo, Joaquin, primary, Yuan, Wei, primary, Mossop, Helen, primary, Porta, Nuria, primary, Miranda, Susana, primary, Perez-Lopez, Raquel, primary, Dolling, David, primary, Robinson, Dan R., primary, Sandhu, Shahneen, primary, Fowler, Gemma, primary, Ebbs, Berni, primary, Flohr, Penny, primary, Seed, George, primary, Rodrigues, Daniel Nava, primary, Boysen, Gunther, primary, Bertan, Claudia, primary, Atkin, Mark, primary, Clarke, Matthew, primary, Crespo, Mateus, primary, Figueiredo, Ines, primary, Riisnaes, Ruth, primary, Sumanasuriya, Semini, primary, Rescigno, Pasquale, primary, Zafeiriou, Zafeiris, primary, Sharp, Adam, primary, Tunariu, Nina, primary, Bianchini, Diletta, primary, Gillman, Alexa, primary, Lord, Christopher J., primary, Hall, Emma, primary, Chinnaiyan, Arul M., primary, Carreira, Suzanne, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure S2 from Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition

Author

Goodall, Jane, primary, Mateo, Joaquin, primary, Yuan, Wei, primary, Mossop, Helen, primary, Porta, Nuria, primary, Miranda, Susana, primary, Perez-Lopez, Raquel, primary, Dolling, David, primary, Robinson, Dan R., primary, Sandhu, Shahneen, primary, Fowler, Gemma, primary, Ebbs, Berni, primary, Flohr, Penny, primary, Seed, George, primary, Rodrigues, Daniel Nava, primary, Boysen, Gunther, primary, Bertan, Claudia, primary, Atkin, Mark, primary, Clarke, Matthew, primary, Crespo, Mateus, primary, Figueiredo, Ines, primary, Riisnaes, Ruth, primary, Sumanasuriya, Semini, primary, Rescigno, Pasquale, primary, Zafeiriou, Zafeiris, primary, Sharp, Adam, primary, Tunariu, Nina, primary, Bianchini, Diletta, primary, Gillman, Alexa, primary, Lord, Christopher J., primary, Hall, Emma, primary, Chinnaiyan, Arul M., primary, Carreira, Suzanne, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

21. Supplemental Table S1 from Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition

Author

Goodall, Jane, primary, Mateo, Joaquin, primary, Yuan, Wei, primary, Mossop, Helen, primary, Porta, Nuria, primary, Miranda, Susana, primary, Perez-Lopez, Raquel, primary, Dolling, David, primary, Robinson, Dan R., primary, Sandhu, Shahneen, primary, Fowler, Gemma, primary, Ebbs, Berni, primary, Flohr, Penny, primary, Seed, George, primary, Rodrigues, Daniel Nava, primary, Boysen, Gunther, primary, Bertan, Claudia, primary, Atkin, Mark, primary, Clarke, Matthew, primary, Crespo, Mateus, primary, Figueiredo, Ines, primary, Riisnaes, Ruth, primary, Sumanasuriya, Semini, primary, Rescigno, Pasquale, primary, Zafeiriou, Zafeiris, primary, Sharp, Adam, primary, Tunariu, Nina, primary, Bianchini, Diletta, primary, Gillman, Alexa, primary, Lord, Christopher J., primary, Hall, Emma, primary, Chinnaiyan, Arul M., primary, Carreira, Suzanne, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

22. Table S2 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Lambros, Maryou B., primary, Seed, George, primary, Sumanasuriya, Semini, primary, Gil, Veronica, primary, Crespo, Mateus, primary, Fontes, Mariane, primary, Chandler, Rob, primary, Mehra, Niven, primary, Fowler, Gemma, primary, Ebbs, Berni, primary, Flohr, Penny, primary, Miranda, Susana, primary, Yuan, Wei, primary, Mackay, Alan, primary, Ferreira, Ana, primary, Pereira, Rita, primary, Bertan, Claudia, primary, Figueiredo, Ines, primary, Riisnaes, Ruth, primary, Rodrigues, Daniel Nava, primary, Sharp, Adam, primary, Goodall, Jane, primary, Boysen, Gunther, primary, Carreira, Suzanne, primary, Bianchini, Diletta, primary, Rescigno, Pasquale, primary, Zafeiriou, Zafeiris, primary, Hunt, Joanne, primary, Moloney, Deirdre, primary, Hamilton, Lucy, primary, Neves, Rui P., primary, Swennenhuis, Joost, primary, Andree, Kiki, primary, Stoecklein, Nikolas H., primary, Terstappen, Leon W.M.M., primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure 2 from SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity

Author

Boysen, Gunther, primary, Rodrigues, Daniel N., primary, Rescigno, Pasquale, primary, Seed, George, primary, Dolling, David, primary, Riisnaes, Ruth, primary, Crespo, Mateus, primary, Zafeiriou, Zafeiris, primary, Sumanasuriya, Semini, primary, Bianchini, Diletta, primary, Hunt, Joanne, primary, Moloney, Deirdre, primary, Perez-Lopez, Raquel, primary, Tunariu, Nina, primary, Miranda, Susana, primary, Figueiredo, Inês, primary, Ferreira, Ana, primary, Christova, Rossitza, primary, Gil, Veronica, primary, Aziz, Sara, primary, Bertan, Claudia, primary, de Oliveira, Flavia M., primary, Atkin, Mark, primary, Clarke, Matthew, primary, Goodall, Jane, primary, Sharp, Adam, primary, MacDonald, Theresa, primary, Rubin, Mark A., primary, Yuan, Wei, primary, Barbieri, Christopher E., primary, Carreira, Suzanne, primary, Mateo, Joaquin, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

24. Figure S1 from RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer

Author

Nava Rodrigues, Daniel, primary, Casiraghi, Nicola, primary, Romanel, Alessandro, primary, Crespo, Mateus, primary, Miranda, Susana, primary, Rescigno, Pasquale, primary, Figueiredo, Ines, primary, Riisnaes, Ruth, primary, Carreira, Suzanne, primary, Sumanasuriya, Semini, primary, Gasperini, Paola, primary, Sharp, Adam, primary, Mateo, Joaquin, primary, Makay, Alan, primary, McNair, Christopher, primary, Schiewer, Matthew, primary, Knudsen, Karen, primary, Boysen, Gunther, primary, Demichelis, Francesca, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

25. Supplementary Figure 3 from SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity

Author

Boysen, Gunther, primary, Rodrigues, Daniel N., primary, Rescigno, Pasquale, primary, Seed, George, primary, Dolling, David, primary, Riisnaes, Ruth, primary, Crespo, Mateus, primary, Zafeiriou, Zafeiris, primary, Sumanasuriya, Semini, primary, Bianchini, Diletta, primary, Hunt, Joanne, primary, Moloney, Deirdre, primary, Perez-Lopez, Raquel, primary, Tunariu, Nina, primary, Miranda, Susana, primary, Figueiredo, Inês, primary, Ferreira, Ana, primary, Christova, Rossitza, primary, Gil, Veronica, primary, Aziz, Sara, primary, Bertan, Claudia, primary, de Oliveira, Flavia M., primary, Atkin, Mark, primary, Clarke, Matthew, primary, Goodall, Jane, primary, Sharp, Adam, primary, MacDonald, Theresa, primary, Rubin, Mark A., primary, Yuan, Wei, primary, Barbieri, Christopher E., primary, Carreira, Suzanne, primary, Mateo, Joaquin, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

26. Figure S5 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Lambros, Maryou B., primary, Seed, George, primary, Sumanasuriya, Semini, primary, Gil, Veronica, primary, Crespo, Mateus, primary, Fontes, Mariane, primary, Chandler, Rob, primary, Mehra, Niven, primary, Fowler, Gemma, primary, Ebbs, Berni, primary, Flohr, Penny, primary, Miranda, Susana, primary, Yuan, Wei, primary, Mackay, Alan, primary, Ferreira, Ana, primary, Pereira, Rita, primary, Bertan, Claudia, primary, Figueiredo, Ines, primary, Riisnaes, Ruth, primary, Rodrigues, Daniel Nava, primary, Sharp, Adam, primary, Goodall, Jane, primary, Boysen, Gunther, primary, Carreira, Suzanne, primary, Bianchini, Diletta, primary, Rescigno, Pasquale, primary, Zafeiriou, Zafeiris, primary, Hunt, Joanne, primary, Moloney, Deirdre, primary, Hamilton, Lucy, primary, Neves, Rui P., primary, Swennenhuis, Joost, primary, Andree, Kiki, primary, Stoecklein, Nikolas H., primary, Terstappen, Leon W.M.M., primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

27. Supplementary Table 1 from SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity

Author

Boysen, Gunther, primary, Rodrigues, Daniel N., primary, Rescigno, Pasquale, primary, Seed, George, primary, Dolling, David, primary, Riisnaes, Ruth, primary, Crespo, Mateus, primary, Zafeiriou, Zafeiris, primary, Sumanasuriya, Semini, primary, Bianchini, Diletta, primary, Hunt, Joanne, primary, Moloney, Deirdre, primary, Perez-Lopez, Raquel, primary, Tunariu, Nina, primary, Miranda, Susana, primary, Figueiredo, Inês, primary, Ferreira, Ana, primary, Christova, Rossitza, primary, Gil, Veronica, primary, Aziz, Sara, primary, Bertan, Claudia, primary, de Oliveira, Flavia M., primary, Atkin, Mark, primary, Clarke, Matthew, primary, Goodall, Jane, primary, Sharp, Adam, primary, MacDonald, Theresa, primary, Rubin, Mark A., primary, Yuan, Wei, primary, Barbieri, Christopher E., primary, Carreira, Suzanne, primary, Mateo, Joaquin, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

28. Supplementary Figure 1 from SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity

Author

Boysen, Gunther, primary, Rodrigues, Daniel N., primary, Rescigno, Pasquale, primary, Seed, George, primary, Dolling, David, primary, Riisnaes, Ruth, primary, Crespo, Mateus, primary, Zafeiriou, Zafeiris, primary, Sumanasuriya, Semini, primary, Bianchini, Diletta, primary, Hunt, Joanne, primary, Moloney, Deirdre, primary, Perez-Lopez, Raquel, primary, Tunariu, Nina, primary, Miranda, Susana, primary, Figueiredo, Inês, primary, Ferreira, Ana, primary, Christova, Rossitza, primary, Gil, Veronica, primary, Aziz, Sara, primary, Bertan, Claudia, primary, de Oliveira, Flavia M., primary, Atkin, Mark, primary, Clarke, Matthew, primary, Goodall, Jane, primary, Sharp, Adam, primary, MacDonald, Theresa, primary, Rubin, Mark A., primary, Yuan, Wei, primary, Barbieri, Christopher E., primary, Carreira, Suzanne, primary, Mateo, Joaquin, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

29. Supplementary Table 2 from SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity

Author

Boysen, Gunther, primary, Rodrigues, Daniel N., primary, Rescigno, Pasquale, primary, Seed, George, primary, Dolling, David, primary, Riisnaes, Ruth, primary, Crespo, Mateus, primary, Zafeiriou, Zafeiris, primary, Sumanasuriya, Semini, primary, Bianchini, Diletta, primary, Hunt, Joanne, primary, Moloney, Deirdre, primary, Perez-Lopez, Raquel, primary, Tunariu, Nina, primary, Miranda, Susana, primary, Figueiredo, Inês, primary, Ferreira, Ana, primary, Christova, Rossitza, primary, Gil, Veronica, primary, Aziz, Sara, primary, Bertan, Claudia, primary, de Oliveira, Flavia M., primary, Atkin, Mark, primary, Clarke, Matthew, primary, Goodall, Jane, primary, Sharp, Adam, primary, MacDonald, Theresa, primary, Rubin, Mark A., primary, Yuan, Wei, primary, Barbieri, Christopher E., primary, Carreira, Suzanne, primary, Mateo, Joaquin, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

30. Supplementary Legends from RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer

Author

Nava Rodrigues, Daniel, primary, Casiraghi, Nicola, primary, Romanel, Alessandro, primary, Crespo, Mateus, primary, Miranda, Susana, primary, Rescigno, Pasquale, primary, Figueiredo, Ines, primary, Riisnaes, Ruth, primary, Carreira, Suzanne, primary, Sumanasuriya, Semini, primary, Gasperini, Paola, primary, Sharp, Adam, primary, Mateo, Joaquin, primary, Makay, Alan, primary, McNair, Christopher, primary, Schiewer, Matthew, primary, Knudsen, Karen, primary, Boysen, Gunther, primary, Demichelis, Francesca, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

31. Legends supplementary figures/ tables from SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity

Author

Boysen, Gunther, primary, Rodrigues, Daniel N., primary, Rescigno, Pasquale, primary, Seed, George, primary, Dolling, David, primary, Riisnaes, Ruth, primary, Crespo, Mateus, primary, Zafeiriou, Zafeiris, primary, Sumanasuriya, Semini, primary, Bianchini, Diletta, primary, Hunt, Joanne, primary, Moloney, Deirdre, primary, Perez-Lopez, Raquel, primary, Tunariu, Nina, primary, Miranda, Susana, primary, Figueiredo, Inês, primary, Ferreira, Ana, primary, Christova, Rossitza, primary, Gil, Veronica, primary, Aziz, Sara, primary, Bertan, Claudia, primary, de Oliveira, Flavia M., primary, Atkin, Mark, primary, Clarke, Matthew, primary, Goodall, Jane, primary, Sharp, Adam, primary, MacDonald, Theresa, primary, Rubin, Mark A., primary, Yuan, Wei, primary, Barbieri, Christopher E., primary, Carreira, Suzanne, primary, Mateo, Joaquin, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

32. Supplementary Methods from Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)

Author

Welti, Jonathan, primary, Sharp, Adam, primary, Yuan, Wei, primary, Dolling, David, primary, Nava Rodrigues, Daniel, primary, Figueiredo, Ines, primary, Gil, Veronica, primary, Neeb, Antje, primary, Clarke, Matthew, primary, Seed, George, primary, Crespo, Mateus, primary, Sumanasuriya, Semini, primary, Ning, Jian, primary, Knight, Eleanor, primary, Francis, Jeffrey C., primary, Hughes, Ashley, primary, Halsey, Wendy S., primary, Paschalis, Alec, primary, Mani, Ram S., primary, Raj, Ganesh V., primary, Plymate, Stephen R., primary, Carreira, Suzanne, primary, Boysen, Gunther, primary, Chinnaiyan, Arul M., primary, Swain, Amanda, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

33. Data from SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity

Author

Boysen, Gunther, primary, Rodrigues, Daniel N., primary, Rescigno, Pasquale, primary, Seed, George, primary, Dolling, David, primary, Riisnaes, Ruth, primary, Crespo, Mateus, primary, Zafeiriou, Zafeiris, primary, Sumanasuriya, Semini, primary, Bianchini, Diletta, primary, Hunt, Joanne, primary, Moloney, Deirdre, primary, Perez-Lopez, Raquel, primary, Tunariu, Nina, primary, Miranda, Susana, primary, Figueiredo, Inês, primary, Ferreira, Ana, primary, Christova, Rossitza, primary, Gil, Veronica, primary, Aziz, Sara, primary, Bertan, Claudia, primary, de Oliveira, Flavia M., primary, Atkin, Mark, primary, Clarke, Matthew, primary, Goodall, Jane, primary, Sharp, Adam, primary, MacDonald, Theresa, primary, Rubin, Mark A., primary, Yuan, Wei, primary, Barbieri, Christopher E., primary, Carreira, Suzanne, primary, Mateo, Joaquin, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

34. Figure Legends from Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)

Author

Welti, Jonathan, primary, Sharp, Adam, primary, Yuan, Wei, primary, Dolling, David, primary, Nava Rodrigues, Daniel, primary, Figueiredo, Ines, primary, Gil, Veronica, primary, Neeb, Antje, primary, Clarke, Matthew, primary, Seed, George, primary, Crespo, Mateus, primary, Sumanasuriya, Semini, primary, Ning, Jian, primary, Knight, Eleanor, primary, Francis, Jeffrey C., primary, Hughes, Ashley, primary, Halsey, Wendy S., primary, Paschalis, Alec, primary, Mani, Ram S., primary, Raj, Ganesh V., primary, Plymate, Stephen R., primary, Carreira, Suzanne, primary, Boysen, Gunther, primary, Chinnaiyan, Arul M., primary, Swain, Amanda, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

35. Supplementary Figures from Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)

Author

Welti, Jonathan, primary, Sharp, Adam, primary, Yuan, Wei, primary, Dolling, David, primary, Nava Rodrigues, Daniel, primary, Figueiredo, Ines, primary, Gil, Veronica, primary, Neeb, Antje, primary, Clarke, Matthew, primary, Seed, George, primary, Crespo, Mateus, primary, Sumanasuriya, Semini, primary, Ning, Jian, primary, Knight, Eleanor, primary, Francis, Jeffrey C., primary, Hughes, Ashley, primary, Halsey, Wendy S., primary, Paschalis, Alec, primary, Mani, Ram S., primary, Raj, Ganesh V., primary, Plymate, Stephen R., primary, Carreira, Suzanne, primary, Boysen, Gunther, primary, Chinnaiyan, Arul M., primary, Swain, Amanda, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

36. Supplementary Tables from Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)

Author

Welti, Jonathan, primary, Sharp, Adam, primary, Yuan, Wei, primary, Dolling, David, primary, Nava Rodrigues, Daniel, primary, Figueiredo, Ines, primary, Gil, Veronica, primary, Neeb, Antje, primary, Clarke, Matthew, primary, Seed, George, primary, Crespo, Mateus, primary, Sumanasuriya, Semini, primary, Ning, Jian, primary, Knight, Eleanor, primary, Francis, Jeffrey C., primary, Hughes, Ashley, primary, Halsey, Wendy S., primary, Paschalis, Alec, primary, Mani, Ram S., primary, Raj, Ganesh V., primary, Plymate, Stephen R., primary, Carreira, Suzanne, primary, Boysen, Gunther, primary, Chinnaiyan, Arul M., primary, Swain, Amanda, primary, and de Bono, Johann S., primary

Published
2023
Full Text
View/download PDF

37. Abstract 3415: The neutrophil-to-lymphocyte ratio (NLR) reflects intratumor myeloid derived suppressor cell (MDSC) infiltration in metastatic castration-resistant prostate cancers (mCRPC)

Author

Guo, Christina, primary, Rekowski, Jan, additional, Crespo, Mateus, additional, Gurel, Bora, additional, Yuan, Wei, additional, Sharp, Adam, additional, Grochot, Rafael, additional, Chandran, Khobe, additional, Sumanasuriya, Semini, additional, Ferreira, Ana, additional, Alimonti, Andrea, additional, and de Bono, Johann S., additional

Published
2022
Full Text
View/download PDF

39. HER3 Is an Actionable Target in Advanced Prostate Cancer

Author

Gil, Veronica, primary, Miranda, Susana, additional, Riisnaes, Ruth, additional, Gurel, Bora, additional, D'Ambrosio, Mariantonietta, additional, Vasciaveo, Alessandro, additional, Crespo, Mateus, additional, Ferreira, Ana, additional, Brina, Daniela, additional, Troiani, Martina, additional, Sharp, Adam, additional, Sheehan, Beshara, additional, Christova, Rossitza, additional, Seed, George, additional, Figueiredo, Ines, additional, Lambros, Maryou, additional, Dolling, David, additional, Rekowski, Jan, additional, Alajati, Abdullah, additional, Clarke, Matthew, additional, Pereira, Rita, additional, Flohr, Penny, additional, Fowler, Gemma, additional, Boysen, Gunther, additional, Sumanasuriya, Semini, additional, Bianchini, Diletta, additional, Rescigno, Pasquale, additional, Aversa, Caterina, additional, Tunariu, Nina, additional, Guo, Christina, additional, Paschalis, Alec, additional, Bertan, Claudia, additional, Buroni, Lorenzo, additional, Ning, Jian, additional, Carreira, Suzanne, additional, Workman, Paul, additional, Swain, Amanda, additional, Califano, Andrea, additional, Shen, Michael M., additional, Alimonti, Andrea, additional, Neeb, Antje, additional, Welti, Jonathan, additional, Yuan, Wei, additional, and de Bono, Johann, additional

Published
2021
Full Text
View/download PDF

40. CD38 in Advanced Prostate Cancers

Author

Guo, Christina, primary, Crespo, Mateus, additional, Gurel, Bora, additional, Dolling, David, additional, Rekowski, Jan, additional, Sharp, Adam, additional, Petremolo, Antonella, additional, Sumanasuriya, Semini, additional, Rodrigues, Daniel N., additional, Ferreira, Ana, additional, Pereira, Rita, additional, Figueiredo, Ines, additional, Mehra, Niven, additional, Lambros, Maryou B.K., additional, Neeb, Antje, additional, Gil, Veronica, additional, Seed, George, additional, Terstappen, Leon, additional, Alimonti, Andrea, additional, Drake, Charles G., additional, Yuan, Wei, additional, de Bono, Johann S., additional, Robinson, Dan, additional, Van Allen, Eliezer M., additional, Wu, Yi-Mi, additional, Schultz, Nikolaus, additional, Lonigro, Robert J., additional, Mosquera, Juan-Miguel, additional, Montgomery, Bruce, additional, Taplin, Mary-Ellen, additional, Pritchard, Colin C., additional, Attard, Gerhardt, additional, Beltran, Himisha, additional, Abida, Wassim, additional, Bradley, Robert K., additional, Vinson, Jake, additional, Cao, Xuhong, additional, Vats, Pankaj, additional, Kunju, Lakshmi P., additional, Hussain, Maha, additional, Tomlins, Scott A., additional, Cooney, Kathleen A., additional, Smith, David C., additional, Brennan, Christine, additional, Siddiqui, Javed, additional, Mehra, Rohit, additional, Chen, Yu, additional, Rathkopf, Dana E., additional, Morris, Michael J., additional, Solomon, Stephen B., additional, Durack, Jeremy C., additional, Reuter, Victor E., additional, Gopalan, Anuradha, additional, Gao, Jianjiong, additional, Loda, Massimo, additional, Lis, Rosina T., additional, Bowden, Michaela, additional, Balk, Stephen P., additional, Gaviola, Glenn, additional, Sougnez, Carrie, additional, Gupta, Manaswi, additional, Yu, Evan Y., additional, Mostaghel, Elahe A., additional, Cheng, Heather H., additional, Mulcahy, Hyojeong, additional, True, Lawrence D., additional, Plymate, Stephen R., additional, Dvinge, Heidi, additional, Ferraldeschi, Roberta, additional, Flohr, Penny, additional, Miranda, Susana, additional, Zafeiriou, Zafeiris, additional, Tunariu, Nina, additional, Mateo, Joaquin, additional, Perez-Lopez, Raquel, additional, Demichelis, Francesca, additional, Robinson, Brian D., additional, Schiffman, Marc, additional, Nanus, David M., additional, Tagawa, Scott T., additional, Sigaras, Alexandros, additional, Eng, Kenneth W., additional, Elemento, Olivier, additional, Sboner, Andrea, additional, Heath, Elisabeth I., additional, Scher, Howard I., additional, Pienta, Kenneth J., additional, Kantoff, Philip, additional, Rubin, Mark A., additional, Nelson, Peter S., additional, Garraway, Levi A., additional, Sawyers, Charles L., additional, and Chinnaiyan, Arul M., additional

Published
2021
Full Text
View/download PDF

41. Abstract PO003: CD38 in the advanced prostate cancer

Author

Guo, Christina, primary, Crespo, Mateus, additional, Gurel, Bora, additional, Dolling, David, additional, Rekowski, Jan, additional, Sharp, Adam, additional, Petremolo, Antonella, additional, Sumanasuriya, Semini, additional, Rodrigues, Daniel N., additional, Ferreira, Ana, additional, Pereira, Rita, additional, Figueiredo, Ines, additional, Mehra, Niven, additional, Lambros, Maryou B.K., additional, Neeb, Antje, additional, Gil, Veronica, additional, Terstappen, Leon, additional, Alimonti, Andrea, additional, Drake, Charles G., additional, Yuan, Wei, additional, and de Bono, Johann S., additional

Published
2021
Full Text
View/download PDF

42. Abstract LB-270: Discovery of genomic correlates and tumor purity as an independent clinical factor of poor outcome in advanced prostate cancer lpWGS CNA data

Author

Seed, George, primary, Sumanasuriya, Semini, additional, Bertan, Claudia, additional, Parr, Harry, additional, Fowler, Gemma, additional, Christova, Rossitza, additional, Pope, Lorna, additional, Goodall, Jane, additional, Lambros, Maryou, additional, Rescigno, Pasquale, additional, Flohr, Penelope, additional, Carreira, Suzanne, additional, Yuan, Wei, additional, Chadjaa, Mustapha, additional, Mace, Sandrine, additional, and De Bono, Johann, additional

Published
2020
Full Text
View/download PDF

43. Genomics of lethal prostate cancer at diagnosis and castration resistance

Author

Mateo, Joaquin, primary, Seed, George, additional, Bertan, Claudia, additional, Rescigno, Pasquale, additional, Dolling, David, additional, Figueiredo, Ines, additional, Miranda, Susana, additional, Nava Rodrigues, Daniel, additional, Gurel, Bora, additional, Clarke, Matthew, additional, Atkin, Mark, additional, Chandler, Rob, additional, Messina, Carlo, additional, Sumanasuriya, Semini, additional, Bianchini, Diletta, additional, Barrero, Maialen, additional, Petermolo, Antonella, additional, Zafeiriou, Zafeiris, additional, Fontes, Mariane, additional, Perez-Lopez, Raquel, additional, Tunariu, Nina, additional, Fulton, Ben, additional, Jones, Robert, additional, McGovern, Ursula, additional, Ralph, Christy, additional, Varughese, Mohini, additional, Parikh, Omi, additional, Jain, Suneil, additional, Elliott, Tony, additional, Sandhu, Shahneen, additional, Porta, Nuria, additional, Hall, Emma, additional, Yuan, Wei, additional, Carreira, Suzanne, additional, and de Bono, Johann S., additional

Published
2020
Full Text
View/download PDF

44. PSMA heterogeneity and DNA repair defects in prostate cancer.

Author

Paschalis, Alec, primary, Sheehan, Beshara, additional, Riisnaes, Ruth, additional, Nava Rodrigues, Daniel, additional, Gurel, Bora, additional, Bertan, Claudia, additional, Ferreira, Ana, additional, Lambros, Maryou B., additional, Seed, George, additional, Yuan, Wei, additional, Dolling, David, additional, Welti, Jon, additional, Neeb, Antje, additional, Sumanasuriya, Semini, additional, Rescigno, Pasquale, additional, Bianchini, Diletta, additional, Tunariu, Nina, additional, Carreira, Suzanne, additional, Sharp, Adam, additional, and De Bono, Johann S., additional

Published
2019
Full Text
View/download PDF

45. Cell-free DNA as a biomarker for taxane treatment in advanced prostate cancer.

Author

Sumanasuriya, Semini, primary, Seed, George, additional, Mehra, Niven, additional, Christova, Rossitza, additional, Pope, Lorna, additional, Goodall, Jane, additional, Flohr, Penelope, additional, Fowler, Gemma, additional, Bianchini, Diletta, additional, Rescigno, Pasquale, additional, Carreira, Suzanne, additional, Yuan, Wei, additional, Macé, Sandrine, additional, Chadjaa, Mustapha, additional, and De Bono, Johann S., additional

Published
2019
Full Text
View/download PDF

46. Circulating Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition

Author

Goodall, Jane, Mateo, Joaquin, Yuan, Wei, Mossop, Helen, Porta, Nuria, Miranda, Susana, Perez-Lopez, Raquel, Dolling, David, Robinson, Dan, Sandhu, Shahneen, Fowler, Gemma, Ebbs, Berni, Flohr, Penny, Seed, George, Rodrigues, Daniel Nava, Boysen, Gunther, Bertan, Claudia, Atkin, Mark, Clarke, Matthew, Crespo, Mateus, Figueiredo, Ines, Riisnaes, Ruth, Sumanasuriya, Semini, Rescigno, Pasquale, Zafeiriou, Zafeiris, Sharp, Adam, Tunariu, Nina, Bianchini, Diletta, Gillman, Alexa, Lord, Christopher J, Hall, Emma, Chinnaiyan, Arul M., Carreira, Suzanne, and de Bono, Johann S.

Subjects
Male, Humans, Prostatic Neoplasms, DNA, Poly(ADP-ribose) Polymerase Inhibitors, Cell-Free Nucleic Acids, Article, Biomarkers
Abstract

Biomarkers for a more precise patient care are needed in metastatic prostate cancer (mPC). We have reported a Phase II trial (TOPARP-A) of the poly(ADP)-ribose polymerase (PARP) inhibitor olaparib in mPC, demonstrating antitumor activity associating with homologous recombination DNA repair defects. We now report targeted and whole exome sequencing of serial circulating-free DNA (cfDNA) samples collected during this trial. Decreases in cfDNA concentration independently associated with outcome in multivariable analyses (HR for overall survival at week 8: 0.19; 95%CI 0.06-0.56 p=0.003). All tumor tissue somatic DNA repair mutations were detectable in cfDNA; allele frequency of somatic mutations decreased selectively in responding patients (Chi-squared p

Published
2017

47. RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer

Author

Nava Rodrigues, Daniel, primary, Casiraghi, Nicola, additional, Romanel, Alessandro, additional, Crespo, Mateus, additional, Miranda, Susana, additional, Rescigno, Pasquale, additional, Figueiredo, Ines, additional, Riisnaes, Ruth, additional, Carreira, Suzanne, additional, Sumanasuriya, Semini, additional, Gasperini, Paola, additional, Sharp, Adam, additional, Mateo, Joaquin, additional, Makay, Alan, additional, McNair, Christopher, additional, Schiewer, Matthew, additional, Knudsen, Karen, additional, Boysen, Gunther, additional, Demichelis, Francesca, additional, and de Bono, Johann S., additional

Published
2019
Full Text
View/download PDF

48. Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency

Author

Zafeiriou, Zafeiris, primary, Bianchini, Diletta, additional, Chandler, Robert, additional, Rescigno, Pasquale, additional, Yuan, Wei, additional, Carreira, Suzanne, additional, Barrero, Maialen, additional, Petremolo, Antonella, additional, Miranda, Susana, additional, Riisnaes, Ruth, additional, Rodrigues, Daniel Nava, additional, Gurel, Bora, additional, Sumanasuriya, Semini, additional, Paschalis, Alec, additional, Sharp, Adam, additional, Mateo, Joaquin, additional, Tunariu, Nina, additional, Chinnaiyan, Arul M., additional, Pritchard, Colin C., additional, Kelly, Kevin, additional, and de Bono, Johann S., additional

Published
2019
Full Text
View/download PDF

49. Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis

Author

Lambros, Maryou B., primary, Seed, George, additional, Sumanasuriya, Semini, additional, Gil, Veronica, additional, Crespo, Mateus, additional, Fontes, Mariane, additional, Chandler, Rob, additional, Mehra, Niven, additional, Fowler, Gemma, additional, Ebbs, Berni, additional, Flohr, Penny, additional, Miranda, Susana, additional, Yuan, Wei, additional, Mackay, Alan, additional, Ferreira, Ana, additional, Pereira, Rita, additional, Bertan, Claudia, additional, Figueiredo, Ines, additional, Riisnaes, Ruth, additional, Rodrigues, Daniel Nava, additional, Sharp, Adam, additional, Goodall, Jane, additional, Boysen, Gunther, additional, Carreira, Suzanne, additional, Bianchini, Diletta, additional, Rescigno, Pasquale, additional, Zafeiriou, Zafeiris, additional, Hunt, Joanne, additional, Moloney, Deirdre, additional, Hamilton, Lucy, additional, Neves, Rui P., additional, Swennenhuis, Joost, additional, Andree, Kiki, additional, Stoecklein, Nikolas H., additional, Terstappen, Leon W.M.M., additional, and de Bono, Johann S., additional

Published
2018
Full Text
View/download PDF

50. SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity

Author

Boysen, Gunther, primary, Rodrigues, Daniel N., additional, Rescigno, Pasquale, additional, Seed, George, additional, Dolling, David, additional, Riisnaes, Ruth, additional, Crespo, Mateus, additional, Zafeiriou, Zafeiris, additional, Sumanasuriya, Semini, additional, Bianchini, Diletta, additional, Hunt, Joanne, additional, Moloney, Deirdre, additional, Perez-Lopez, Raquel, additional, Tunariu, Nina, additional, Miranda, Susana, additional, Figueiredo, Inês, additional, Ferreira, Ana, additional, Christova, Rossitza, additional, Gil, Veronica, additional, Aziz, Sara, additional, Bertan, Claudia, additional, de Oliveira, Flavia M., additional, Atkin, Mark, additional, Clarke, Matthew, additional, Goodall, Jane, additional, Sharp, Adam, additional, MacDonald, Theresa, additional, Rubin, Mark A., additional, Yuan, Wei, additional, Barbieri, Christopher E., additional, Carreira, Suzanne, additional, Mateo, Joaquin, additional, and de Bono, Johann S., additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results