Search

Your search keyword '"Sultanem, Khalil"' showing total 218 results
Start Over Author "Sultanem, Khalil"
218 results on '"Sultanem, Khalil"'

1. Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Final Results of the ORATOR Randomized Trial

Author

Nichols, Anthony C., Theurer, Julie, Prisman, Eitan, Read, Nancy, Berthelet, Eric, Tran, Eric, Fung, Kevin, de Almeida, John R., Bayley, Andrew, Goldstein, David P., Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S. Danielle, Winquist, Eric, Hammond, J. Alex, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Chen, Jeff, Johnson-Obaseki, Stephanie, Odell, Michael, Corsten, Martin, Parker, Christina, Wehrli, Bret, Kwan, Keith, and Palma, David A.

Published
2024
Full Text
View/download PDF

2. 18F-FDG PET/CT Prediction of Treatment Outcomes in Human Papillomavirus-Positive, Locally Advanced Oropharyngeal Cancer Patients Receiving Deintensified Therapy: Results from NRG-HN002.

Author

Geiger, Jessica, Mell, Loren, Seaward, Samantha, Thorstad, Wade, Beitler, Jonathan, Sultanem, Khalil, Blakaj, Diagjin, Le, Quynh-Thu, Gillison, Maura, Caudell, Jimmy, Waldron, John, Xia, Ping, Chung, Christine, Truong, Minh, Echevarria, Michelle, Subramaniam, Rathan, DeMora, Lyudmila, Yao, Min, Yom, Sue, and Chan, Jason

Subjects
NRG-HN002, PET/CT negative predictive value, p16-positive oropharyngeal cancer, Humans, Positron Emission Tomography Computed Tomography, Fluorodeoxyglucose F18, Human Papillomavirus Viruses, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Treatment Outcome, Oropharyngeal Neoplasms, Chemoradiotherapy
Abstract

The purpose of this study was to determine the negative predictive value (NPV) of a 12- to 14-wk posttreatment PET/CT for 2-y progression-free survival (PFS) and locoregional control (LRC) in patients with p16-positive locoregionally advanced oropharyngeal cancer (LA-OPC). Study was a secondary endpoint in NRG-HN002, a noncomparative phase II trial in p16-positive LA-OPC, stage T1-T2, N1-N2b or T3, N0-N2b, and ≤10 pack-year smoking. Patients were randomized in a 1:1 ratio to reduced-dose intensity-modulated radiotherapy (IMRT) with or without cisplatin. Methods: PET/CT scans were reviewed centrally. Tumor response evaluations for the primary site, right neck, and left neck were performed using a 5-point ordinal scale (Hopkins criteria). Overall scores were then assigned as negative, positive, or indeterminate. Patients with a negative score for all 3 evaluation sites were given an overall score of negative. The hypotheses were NPV for PFS and LRC at 2-y posttreatment ≤ 90% versus >90% (1-sided P value, 0.10). Results: A total of 316 patients were enrolled, of whom 306 were randomized and eligible. Of these, 131 (42.8%) patients consented to a posttherapy PET/CT, and 117 (89.3%) patients were eligible for PET/CT analysis. The median time from the end of treatment to PET/CT scan was 94 d (range, 52-139 d). Estimated 2-y PFS and LRC rates in the analysis subgroup were 91.3% (95% CI, 84.6, 95.8%) and 93.8% (95% CI, 87.6, 97.5%), respectively. Posttreatment scans were negative for residual tumor for 115 patients (98.3%) and positive for 2 patients (1.7%). NPV for 2-y PFS was 92.0% (90% lower confidence bound [LCB] 87.7%; P = 0.30) and for LRC was 94.5% (90% LCB 90.6%; P = 0.07). Conclusion: In the context of deintensification with reduced-dose radiation, the NPV of a 12- to 14-wk posttherapy PET/CT for 2-y LRC is estimated to be >90%, similar to that reported for patients receiving standard chemoradiation. However, there is insufficient evidence to conclude that the NPV is >90% for PFS.

Published
2023

6. Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study

Author

Henry, Melissa, Harvey, Raphaële, Chen, Lawrence M., Meaney, Michael, Nguyen, Thi Thu Thao, Kao, Han-Tin, Rosberger, Zeev, Frenkiel, Saul, Hier, Michael, Zeitouni, Anthony, Kost, Karen, Mlynarek, Alex, Richardson, Keith, Greenwood, Celia M.T., Melnychuk, David, Gold, Phil, Chartier, Gabrielle, Black, Martin, Mascarella, Marco, MacDonald, Christina, Sadeghi, Nader, Sultanem, Khalil, Shenouda, Georges, Cury, Fabio, and O'Donnell, Kieran John

Published
2023
Full Text
View/download PDF

8. Radiomics strategies for risk assessment of tumour failure in head-and-neck cancer

Author

Vallières, Martin, Kay-Rivest, Emily, Perrin, Léo Jean, Liem, Xavier, Furstoss, Christophe, Aerts, Hugo J. W. L., Khaouam, Nader, Nguyen-Tan, Phuc Felix, Wang, Chang-Shu, Sultanem, Khalil, Seuntjens, Jan, and Naqa, Issam El

Subjects
Computer Science - Computer Vision and Pattern Recognition, I.2.1, I.2.10, I.4.7, I.4.9, J.3
Abstract

Quantitative extraction of high-dimensional mineable data from medical images is a process known as radiomics. Radiomics is foreseen as an essential prognostic tool for cancer risk assessment and the quantification of intratumoural heterogeneity. In this work, 1615 radiomic features (quantifying tumour image intensity, shape, texture) extracted from pre-treatment FDG-PET and CT images of 300 patients from four different cohorts were analyzed for the risk assessment of locoregional recurrences (LR) and distant metastases (DM) in head-and-neck cancer. Prediction models combining radiomic and clinical variables were constructed via random forests and imbalance-adjustment strategies using two of the four cohorts. Independent validation of the prediction and prognostic performance of the models was carried out on the other two cohorts (LR: AUC = 0.69 and CI = 0.67; DM: AUC = 0.86 and CI = 0.88). Furthermore, the results obtained via Kaplan-Meier analysis demonstrated the potential of radiomics for assessing the risk of specific tumour outcomes using multiple stratification groups. This could have important clinical impact, notably by allowing for a better personalization of chemo-radiation treatments for head-and-neck cancer patients from different risk groups., Comment: (1) Paper: 33 pages, 4 figures, 1 table; (2) SUPP info: 41 pages, 7 figures, 8 tables

Published
2017

9. Neoadjuvant Capecitabine in Operable HPV‐Negative Head and Neck Cancer: Fortuitous Findings in a Resource Constrained Setting.

Author

Mascarella, Marco A., Richardson, Keith, Mlynarek, Alex, Hier, Michael P., Caglar, Derin, Florianova, Livia, Pusztaszeri, Marc Philippe, Sultanem, Khalil, Sadeghi, Nader, Bouganim, Nathaniel, and Esfahani, Khashayar

Abstract

Objective: Limited progress has occurred in treating operable human papillomavirus (HPV)‐negative head and neck squamous cell carcinoma (HNSCC). Accessing timely care remains challenging in public health care systems, potentially resulting in disease progression before treatment initiation. Study Design: A prospective cohort of patients receiving neoadjuvant capecitabine (NC) was compared to stage‐matched patients undergoing standard of care (SC). Setting: This study was performed at 2 academic centers in Montreal, Canada. Methods: To ascertain the effect of 2 cycles of NC in operable HPV‐negative HNSCC patients on clinical‐to‐pathologic stage migration. Comparison to an SC group was performed to site and TNM stage matched patients. Pathologic treatment response was measured using the modified Ryan score. Results: We compared 16 NC patients (11 oral cavity, 3 skin, 2 larynx) with 32 SC patients. Ten NC patients exhibited a pathologic response (1 complete, 3 major, 6 minor). Clinical‐to‐pathologic stage migration differed significantly between NC and SC groups: downstage (6 vs 1), upstage (3 vs 14), no change (7 vs 17, P =.0047). There was no severe treatment toxicity related to capecitabine. All patients in the NC group underwent surgery. Conclusion: NC followed by surgery demonstrates measurable pathologic response in HPV‐negative HNSCC, suggesting potential utility in resource‐limited health care settings. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Exploratory Factor Analysis of NRG Oncology's University of Washington Quality of Life Questionnaire—RTOG Modification

Author

Pugh, Stephanie L, Wyatt, Gwen, Wong, Raimond KW, Sagar, Stephen M, Yueh, Bevan, Singh, Anurag K, Yao, Min, Nguyen-Tan, Phuc Felix, Yom, Sue S, Cardinale, Francis S, Sultanem, Khalil, Hodson, D Ian, Krempl, Greg A, Chavez, Ariel, Yeh, Alexander M, and Bruner, Deborah W

Subjects
Health Services and Systems, Health Sciences, Clinical Research, Cancer, Clinical Trials and Supportive Activities, Prevention, Activities of Daily Living, Aged, Eating, Factor Analysis, Statistical, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Pain, Quality of Life, Surveys and Questionnaires, Quality of life, factor analysis, xerostomia, Medical and Health Sciences, Anesthesiology, Biomedical and clinical sciences, Health sciences
Abstract

ContextThe 15-item University of Washington Quality of Life questionnaire-Radiation Therapy Oncology Group (RTOG) modification (UW-QOL-RTOG modification) has been used in several trials of head and neck cancer conducted by NRG Oncology such as RTOG 9709, RTOG 9901, RTOG 0244, and RTOG 0537.ObjectivesThis study is an exploratory factor analysis (EFA) to establish validity and reliability of the instrument subscales.MethodsEFA on the UW-QOL-RTOG modification was conducted using baseline data from NRG Oncology's RTOG 0537, a trial of acupuncture-like transcutaneous electrical nerve stimulation in treating radiation-induced xerostomia. Cronbach α coefficient was calculated to measure reliability; correlation with the University of Michigan Xerostomia Related Quality of Life Scale was used to evaluate concurrent validity; and correlations between consecutive time points were used to assess test-retest reliability.ResultsThe 15-item EFA of the modified tool resulted in 11 items split into four factors: mucus, eating, pain, and activities. Cronbach α ranged from 0.71 to 0.93 for the factors and total score, consisting of all 11 items. There were strong correlations (ρ ≥ 0.60) between consecutive time points and between total score and the Xerostomia Related Quality of Life Scale total score (ρ > 0.65).ConclusionThe UW-QOL-RTOG modification is a valid tool that can be used to assess symptom burden of head and neck cancer patients receiving radiation therapy or those who have recently completed radiation. The modified tool has acceptable reliability, concurrent validity, and test-retest reliability in this patient population, as well as the advantage of having being shortened from 15 to 11 items.

Published
2017

13. Sarcopenia predicts short‐term treatment‐related toxicity in patients undergoing curative‐intent therapy for head and neck cancer: A systematic review and meta‐analysis

Author

Mascarella, Marco A., primary, Ferdus, Jannatul, additional, Vendra, Varun, additional, Sridharan, Shaum, additional, Sultanem, Khalil, additional, Tsien, Christina, additional, Shenouda, George, additional, Bouganim, Nathaniel, additional, Esfahani, Khashayar, additional, Richardson, Keith, additional, Mlynarek, Alex, additional, Sadeghi, Nader, additional, Hier, Michael, additional, and Kergoat, Marie‐Jeanne, additional

Published
2024
Full Text
View/download PDF

14. Xerostomia health-related quality of life: NRG oncology RTOG 0537

Author

Wyatt, Gwen, Pugh, Stephanie L, Wong, Raimond KW, Sagar, Stephen, Singh, Anurag K, Koyfman, Shlomo A, Nguyen-Tân, Phuc F, Yom, Sue S, Cardinale, Francis S, Sultanem, Khalil, Hodson, Ian, Krempl, Greg A, Lukaszczyk, Barbara, Yeh, Alexander M, and Berk, Lawrence

Subjects
Health Sciences, Traditional, Complementary and Integrative Medicine, Clinical Trials and Supportive Activities, Brain Disorders, Digestive Diseases, Cancer, Acquired Cognitive Impairment, Clinical Research, Dental/Oral and Craniofacial Disease, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adult, Aged, Female, Head and Neck Neoplasms, Humans, Male, Medical Oncology, Middle Aged, Prospective Studies, Sickness Impact Profile, Transcutaneous Electric Nerve Stimulation, Xerostomia, Radiation-induced xerostomia, Symptom management, Head and neck cancer, Acupuncture-like transcutaneous electrical nerve stimulation, Public Health and Health Services, Psychology, Health Policy & Services, Health sciences, Human society
Abstract

PurposeThe purpose of this secondary analysis was to determine change in overall health-related quality of life (HRQOL) based on patient data obtained from NRG Oncology RTOG 0537 as measured by the RTOG-modified University of Washington Head and Neck Symptom Score (RM-UWHNSS).MethodsA multi-site prospective randomized clinical trial design stratified 137 patients with post-radiation therapy xerostomia according to prior pilocarpine (PC) treatment and time after radiation therapy and/or chemotherapy and randomized patients into two groups. Patients were assigned to acupuncture or PC. Twenty-four sessions of acupuncture-like transcutaneous electrical nerve stimulation (ALTENS) were administered over 12 weeks, or oral PC (5 mg) three times daily over the same 12 weeks. The RM-UWHNSS was administered at baseline and at 4, 6, 9, and 15 months after the date of randomization.ResultsThere were no between-arm differences in change scores on the RM-UWHNSS in the individual items, total score, or factor scores. For statistical modeling, race and time were significant for all outcomes (total and factor scores), while treatment arm was not significant. The ALTENS arm showed greater yet nonsignificant improvement in outcomes compared to the PC arm.ConclusionAlthough no significant treatment differences were seen in this trial, patients receiving ALTENS consistently had lower scores, indicating better function, as compared to those receiving PC. Radiation-induced xerostomia improved over time for all patients.

Published
2016

15. Acupuncture-Like Transcutaneous Electrical Nerve Stimulation Versus Pilocarpine in Treating Radiation-Induced Xerostomia: Results of RTOG 0537 Phase 3 Study

Author

Wong, Raimond KW, Deshmukh, Snehal, Wyatt, Gwen, Sagar, Stephen, Singh, Anurag K, Sultanem, Khalil, Nguyen-Tân, Phuc F, Yom, Sue S, Cardinale, Joseph, Yao, Min, Hodson, Ian, Matthiesen, Chance L, Suh, John, Thakrar, Harish, Pugh, Stephanie L, and Berk, Lawrence

Subjects
Medical and Biological Physics, Biomedical and Clinical Sciences, Chemical Sciences, Theoretical and Computational Chemistry, Physical Sciences, Oncology and Carcinogenesis, Clinical Research, Prevention, Cancer, Digestive Diseases, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Acupuncture Therapy, Adult, Aged, Drug Administration Schedule, Female, Humans, Intention to Treat Analysis, Male, Middle Aged, Pilocarpine, Quality of Life, Radiotherapy, Salivation, Time Factors, Transcutaneous Electric Nerve Stimulation, Xerostomia, Other Physical Sciences, Clinical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis, Theoretical and computational chemistry, Medical and biological physics
Abstract

Purpose and objectivesThis report presents the analysis of the RTOG 0537 multicenter randomized study that compared acupuncture-like transcutaneous stimulation (ALTENS) with pilocarpine (PC) for relieving radiation-induced xerostomia.Methods and materialsEligible patients were randomized to twice-weekly 20-minute ALTENS sessions for 24 sessions during 12 weeks or PC (5 mg 3 times daily for 12 weeks). The primary endpoint was the change in the University of Michigan Xerostomia-Related Quality of Life Scale (XeQOLS) scores from baseline to 9 months from randomization (MFR). Secondary endpoints included basal and citric acid primed whole salivary production (WSP), ratios of positive responders (defined as patients with ≥20% reduction in overall radiation-induced xerostomia symptom burden), and the presence of adverse events based on the Common Terminology Criteria for Adverse Events version 3. An intention-to-treat analysis was conducted.ResultsOne hundred forty-eight patients were randomized. Only 96 patients completed the required XeQOLS and were evaluable at 9 MFR (representing merely 68.6% statistical power). Seventy-six patients were evaluable at 15 MFR. The median change in the overall XeQOLS in ALTENS and PC groups at 9 and 15 MFR were -0.53 and -0.27 (P=.45) and -0.6 and -0.47 (P=.21). The corresponding percentages of positive responders were 81% and 72% (P=.34) and 83% and 63% (P=.04). Changes in WSP were not significantly different between the groups. Grade 3 or less adverse events, mostly consisting of grade 1, developed in 20.8% of patients in the ALTENS group and in 61.6% of the PC group.ConclusionsThe observed effect size was smaller than hypothesized, and statistical power was limited because only 96 of the recruited 148 patients were evaluable. The primary endpoint-the change in radiation-induced xerostomia symptom burden at 9 MFR-was not significantly different between the ALTENS and PC groups. There was significantly less toxicity in patients receiving ALTENS.

Published
2015

17. Radiotherapy versus transoral robotic surgery and neck dissection for oropharyngeal squamous cell carcinoma (ORATOR): an open-label, phase 2, randomised trial

Author

Nichols, Anthony C, Theurer, Julie, Prisman, Eitan, Read, Nancy, Berthelet, Eric, Tran, Eric, Fung, Kevin, de Almeida, John R, Bayley, Andrew, Goldstein, David P, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S Danielle, Winquist, Eric, Hammond, J Alex, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Chen, Jeff, Corsten, Martin, Johnson-Obaseki, Stephanie, Eapen, Libni, Odell, Michael, Parker, Christina, Wehrli, Bret, Kwan, Keith, and Palma, David A

Published
2019
Full Text
View/download PDF

18. Tumor volumes in T3 supraglottic cancers treated with radiotherapy in the modern era: A study of the Canadian Head & Neck Collaborative Research Initiative

Author

Malik, Nauman H., primary, Fu, Rui, additional, Hainc, Nicolin, additional, Noel, Christopher W., additional, de Almeida, John R., additional, Hosni, Ali, additional, Huang, Shao Hui, additional, Yu, Eugene, additional, Dzioba, Agnieszka, additional, Leung, Andrew, additional, Mangat, Arvindpaul, additional, MacNeil, Danielle, additional, Nichols, Anthony C., additional, Hiremath, Shivaprakash B., additional, Chakraborty, Santanu, additional, Jooya, Alborz, additional, Gaudet, Marc, additional, Johnson‐Obaseki, Stephanie, additional, Whelan, Jonathan, additional, Forghani, Reza, additional, Hier, Michael P., additional, Morand, Grégoire, additional, Sultanem, Khalil, additional, Dort, Joseph, additional, Lysack, John, additional, Matthews, Wayne, additional, Nakoneshny, Steven, additional, Gill, Gia, additional, Globerman, Adam, additional, Kerr, Paul, additional, Maralani, Pejman, additional, Karam, Irene, additional, and Eskander, Antoine, additional

Published
2023
Full Text
View/download PDF

19. Quality of life and swallowing with standard chemoradiotherapy versus accelerated radiotherapy and panitumumab in locoregionally advanced carcinoma of the head and neck: A phase III randomised trial from the Canadian Cancer Trials Group (HN.6)

Author

Ringash, Jolie, Waldron, John N., Siu, Lillian L., Martino, Rosemary, Winquist, Eric, Wright, Jim R., Nabid, Abdenour, Hay, John H., Hammond, Alex, Sultanem, Khalil, Hotte, Sebastien, Leong, Carson, El-Gayed, Ali Abdel Halim, Naz, Farah, Ramchandar, Kevin, Owen, Timothy E., Montenegro, Alexander, O'Sullivan, Brian, Chen, Bingshu E., and Parulekar, Wendy R.

Published
2017
Full Text
View/download PDF

21. Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony C., Lang, Pencilla, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, de Almeida, John R., Bayley, Andrew, Goldstein, David P., Eskander, Antoine, Husain, Zain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S. Danielle, Mendez, Adrian, Winquist, Eric, Read, Nancy, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Rajaraman, Murali, Johnson-Obaseki, Stephanie, Eapen, Libni, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, Matthews, T. Wayne, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David A.

Published
2020
Full Text
View/download PDF

22. Association of Primary Tumor Volume With Survival in Patients With T3 Glottic Cancer Treated With Radiotherapy

Author

Malik, Nauman H., primary, Fu, Rui, additional, Hainc, Nicolin, additional, Noel, Christopher W., additional, de Almeida, John R., additional, Hosni, Ali, additional, Hui Huang, Shao, additional, Yu, Eugene, additional, Dzioba, Agnieszka, additional, Leung, Andrew, additional, Mangat, Arvindpaul, additional, MacNeil, Danielle, additional, Nichols, Anthony C., additional, Hiremath, Shivaprakash B., additional, Chakraborty, Santanu, additional, Jooya, Alboorz, additional, Gaudet, Marc, additional, Johnson-Obaseki, Stephanie, additional, Whelan, Jonathan, additional, Forghani, Reza, additional, Hier, Michael P., additional, Morand, Grégoire, additional, Sultanem, Khalil, additional, Dort, Joseph, additional, Lysack, John, additional, Matthews, Wayne, additional, Nakoneshny, Steven, additional, Gill, Gia, additional, Globerman, Adam, additional, Kerr, Paul, additional, Maralani, Pejman, additional, Karam, Irene, additional, and Eskander, Antoine, additional

Published
2023
Full Text
View/download PDF

23. Long-Term Results of Radiation Therapy Oncology Group 9903: A Randomized Phase 3 Trial to Assess the Effect of Erythropoietin on Local-Regional Control in Anemic Patients Treated With Radiation Therapy for Squamous Cell Carcinoma of the Head and Neck

Author

Shenouda, George, Zhang, Qiang, Ang, K. Kian, Machtay, Mitchell, Parliament, Matthew B., Hershock, Diane, Suntharalingam, Mohan, Lin, Alexander, Rotman, Marvin, Nabid, Abdenour, Hong, Susan, Shehata, Sarwat, Cmelak, Anthony J., Sultanem, Khalil, and Le, Quynh-Thu

Published
2015
Full Text
View/download PDF

24. The Impact of COVID-19 on the Diagnosis and Treatment of Lung Cancer over a 2-Year Period at a Canadian Academic Center

Author

Kasymjanova, Goulnar, primary, Rizzolo, Angelo, additional, Pepe, Carmela, additional, Friedmann, Jennifer E., additional, Small, David, additional, Spicer, Jonathan, additional, Lecavalier-Barsoum, Magali, additional, Sultanem, Khalil, additional, Wang, Hangjun, additional, Spatz, Alan, additional, Cohen, Victor, additional, and Agulnik, Jason S., additional

Published
2022
Full Text
View/download PDF

25. Oncologic Significance of Therapeutic Delays in Patients With Oral Cavity Cancer

Author

Dayan, Gabriel S., Bahig, Houda, Johnson-Obaseki, Stephanie, Eskander, Antoine, Hong, Xinyuan, Chandarana, Shamir, de Almeida, John R., Nichols, Anthony C., Hier, Michael, Belzile, Mathieu, Gaudet, Marc, Dort, Joseph, Matthews, T. Wayne, Hart, Robert, Goldstein, David P., Yao, Christopher M. K. L., Hosni, Ali, MacNeil, Danielle, Fowler, James, Higgins, Kevin, Khalil, Carlos, Khoury, Mark, Mlynarek, Alex M., Morand, Gregoire, Sultanem, Khalil, Maniakas, Anastasios, Ayad, Tareck, and Christopoulos, Apostolos

Abstract

IMPORTANCE: Oral cavity cancer often requires multidisciplinary management, subjecting patients to complex therapeutic trajectories. Prolonged treatment intervals in oral cavity cancer have been associated with poor oncological outcomes, but there has yet to be a study investigating treatment times in Canada. OBJECTIVE: To report treatment delays for patients with oral cavity cancer in Canada and evaluate the outcomes of treatment delays on overall survival. DESIGN, SETTING, AND PARTICIPANTS: This multicenter cohort study was performed at 8 Canadian academic centers from 2005 to 2019. Participants were patients with oral cavity cancer who underwent surgery and adjuvant radiation therapy. Analysis was performed in January 2023. MAIN OUTCOMES AND MEASURES: Treatment intervals evaluated were surgery to initiation of postoperative radiation therapy interval (S-PORT) and radiation therapy interval (RTI). The exposure variables were prolonged intervals, respectively defined as index S-PORT greater than 42 days and RTI greater than 46 days. Patient demographics, Charlson Comorbidity Index, smoking status, alcohol status, and cancer staging were also considered. Univariate (log rank and Kaplan-Meier) and multivariate (Cox regression) analyses were performed to determine associations with overall survival (OS). RESULTS: Overall, 1368 patients were included; median (IQR) age at diagnosis was 61 (54-70) years, and 896 (65%) were men. Median (IQR) S-PORT was 56 (46-68) days, with 1093 (80%) patients waiting greater than 42 days, and median (IQR) RTI was 43 (41-47) days, with 353 (26%) patients having treatment time interval greater than 46 days. There were variations in treatment time intervals between institutions for S-PORT (institution with longest vs shortest median S-PORT, 64 days vs 48 days; η2 = 0.023) and RTI (institution with longest vs shortest median RTI, 44 days vs 40 days; η2 = 0.022). Median follow-up was 34 months. The 3-year OS was 68%. In univariate analysis, patients with prolonged S-PORT had worse survival at 3 years (66% vs 77%; odds ratio 1.75; 95% CI, 1.27-2.42), whereas prolonged RTI (67% vs 69%; odds ratio 1.06; 95% CI, 0.81-1.38) was not associated with OS. Other factors associated with OS were age, Charlson Comorbidity Index, alcohol status, T category, N category, and institution. In the multivariate model, prolonged S-PORT remained independently associated with OS (hazard ratio, 1.39; 95% CI, 1.07-1.80). CONCLUSIONS AND RELEVANCE: In this multicenter cohort study of patients with oral cavity cancer requiring multimodal therapy, initiation of radiation therapy within 42 days from surgery was associated with improved survival. However, in Canada, only a minority completed S-PORT within the recommended time, whereas most had an appropriate RTI. An interinstitution variation existed in terms of treatment time intervals. Institutions should aim to identify reasons for delays in their respective centers, and efforts and resources should be directed toward achieving timely completion of S-PORT.

Published
2023
Full Text
View/download PDF

26. 18F-FDG PET/CT Prediction of Treatment Outcomes in Human Papillomavirus–Positive, Locally Advanced Oropharyngeal Cancer Patients Receiving Deintensified Therapy: Results from NRG-HN002

Author

Subramaniam, Rathan M., primary, DeMora, Lyudmila, additional, Yao, Min, additional, Yom, Sue S., additional, Gillison, Maura, additional, Caudell, Jimmy J., additional, Waldron, John, additional, Xia, Ping, additional, Chung, Christine H., additional, Truong, Minh Tam, additional, Echevarria, Michelle, additional, Chan, Jason W., additional, Geiger, Jessica L., additional, Mell, Loren, additional, Seaward, Samantha, additional, Thorstad, Wade L., additional, Beitler, Jonathan Jay, additional, Sultanem, Khalil, additional, Blakaj, Diagjin, additional, and Le, Quynh-Thu, additional

Published
2022
Full Text
View/download PDF

28. Biopsychosocial Markers of Body Image Concerns in Patients with Head and Neck Cancer: A Prospective Longitudinal Study

Author

Albert, Justine G., primary, Lo, Christopher, additional, Rosberger, Zeev, additional, Frenkiel, Saul, additional, Hier, Michael, additional, Zeitouni, Anthony, additional, Kost, Karen, additional, Mlynarek, Alex, additional, Black, Martin, additional, MacDonald, Christina, additional, Richardson, Keith, additional, Mascarella, Marco, additional, Morand, Gregoire B., additional, Chartier, Gabrielle, additional, Sadeghi, Nader, additional, Sultanem, Khalil, additional, Shenouda, George, additional, Cury, Fabio L., additional, and Henry, Melissa, additional

Published
2022
Full Text
View/download PDF

29. Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Author

Palma, David A., primary, Prisman, Eitan, additional, Berthelet, Eric, additional, Tran, Eric, additional, Hamilton, Sarah, additional, Wu, Jonn, additional, Eskander, Antoine, additional, Higgins, Kevin, additional, Karam, Irene, additional, Poon, Ian, additional, Husain, Zain, additional, Enepekides, Danny, additional, Hier, Michael, additional, Sultanem, Khalil, additional, Richardson, Keith, additional, Mlynarek, Alex, additional, Johnson-Obaseki, Stephanie, additional, Odell, Michael, additional, Bayley, Andrew, additional, Dowthwaite, Samuel, additional, Jackson, James E., additional, Dzienis, Marcin, additional, O’Neil, John, additional, Chandarana, Shamir, additional, Banerjee, Robyn, additional, Hart, Robert, additional, Chung, Jeffson, additional, Tenenholtz, Todd, additional, Krishnan, Suren, additional, Le, Hien, additional, Yoo, John, additional, Mendez, Adrian, additional, Winquist, Eric, additional, Kuruvilla, Sara, additional, Stewart, Paul, additional, Warner, Andrew, additional, Mitchell, Sylvia, additional, Chen, Jeff, additional, Parker, Christina, additional, Wehrli, Bret, additional, Kwan, Keith, additional, Theurer, Julie, additional, Sathya, Jinka, additional, Hammond, J. Alex, additional, Read, Nancy, additional, Venkatesan, Varagur, additional, MacNeil, S. Danielle, additional, Fung, Kevin, additional, and Nichols, Anthony C., additional

Published
2022
Full Text
View/download PDF

30. The longitudinal impact of COVID-19 on the diagnosis and treatment of lung cancer at a Canadian academic center: Interim analysis from a retrospective chart review.

Author

Rizzolo, Angelo, primary, Kasymjanova, Goulnar, additional, Pepe, Carmela, additional, Friedmann, Jennifer Elisabeth, additional, Small, David I., additional, Price-Gallagher, Colton, additional, Spicer, Jonathan, additional, Sirois, Christian, additional, Lecavalier-Barsoum, Magali, additional, Sultanem, Khalil, additional, Wang, Hangjun, additional, Spatz, Alan, additional, Cohen, Victor, additional, and Agulnik, Jason S., additional

Published
2022
Full Text
View/download PDF

32. Framing Concerns about Body Image during Pre- and Post-Surgical Consultations for Head and Neck Cancer: A Qualitative Study of Patient–Physician Interactions

Author

Cherba, Maria, primary, Brummans, Boris H. J. M., additional, Hier, Michael P., additional, Giguère, Lauriane, additional, Chartier, Gabrielle, additional, Jacobs, Hannah, additional, Forest, Véronique-Isabelle, additional, Mlynarek, Alex, additional, Sultanem, Khalil, additional, and Henry, Melissa, additional

Published
2022
Full Text
View/download PDF

34. Randomized Trial of Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Long-Term Results of the ORATOR Trial

Author

Nichols, Anthony C., primary, Theurer, Julie, additional, Prisman, Eitan, additional, Read, Nancy, additional, Berthelet, Eric, additional, Tran, Eric, additional, Fung, Kevin, additional, de Almeida, John R., additional, Bayley, Andrew, additional, Goldstein, David P., additional, Hier, Michael, additional, Sultanem, Khalil, additional, Richardson, Keith, additional, Mlynarek, Alex, additional, Krishnan, Suren, additional, Le, Hien, additional, Yoo, John, additional, MacNeil, S. Danielle, additional, Winquist, Eric, additional, Hammond, J. Alex, additional, Venkatesan, Varagur, additional, Kuruvilla, Sara, additional, Warner, Andrew, additional, Mitchell, Sylvia, additional, Chen, Jeff, additional, Corsten, Martin, additional, Johnson-Obaseki, Stephanie, additional, Odell, Michael, additional, Parker, Christina, additional, Wehrli, Bret, additional, Kwan, Keith, additional, and Palma, David A., additional

Published
2022
Full Text
View/download PDF

36. 18F-FDG PET/CT Prediction of Treatment Outcomes in Human Papillomavirus-Positive, Locally Advanced Oropharyngeal Cancer Patients Receiving Deintensified Therapy: Results from NRG-HN002.

Author

Subramaniam, Rathan M., DeMora, Lyudmila, Min Yao, Yom, Sue S., Gillison, Maura, Caudell, Jimmy J., Waldron, John, Ping Xia, Chung, Christine H., Minh Tam Truong, Echevarria, Michelle, Chan, Jason W., Geiger, Jessica L., Mell, Loren, Seaward, Samantha, Thorstad, Wade L., Beitler, Jonathan Jay, Sultanem, Khalil, Blakaj, Diagjin, and Quynh-Thu Le

Published
2023
Full Text
View/download PDF

40. 18F FDG PET/CT Prediction of Treatment Outcomes in HPV-positive, Locally Advanced Oropharyngeal Cancer Receiving De-intensified Therapy: Results from NRG-HN002.

Author

Subramaniam, Rathan M., DeMora, Lyudmila, Min Yao, Yom, Sue S., Gillison, Maura, Caudell, Jimmy J., Waldron, John, Ping Xia, Chung, Christine H., Minh Tam Truong, Echevarria, Michelle, Chan, Jason W., Geiger, Jessica L., Mell, Loren, Seaward, Samantha, Thorstad, Wade L., Beitler, Jonathan Jay, Sultanem, Khalil, Blakaj, Diagjin, and Quynh-Thu Le

Published
2022
Full Text
View/download PDF

44. Additional file 5 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 5. Study Information and Informed Consent Form.

Published
2020
Full Text
View/download PDF

45. Additional file 4 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Subjects
ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES
Abstract

Additional file 4. Lab Guidelines.

Published
2020
Full Text
View/download PDF

46. Additional file 6 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 6. World Health Organization Trial Registration Dataset.

Published
2020
Full Text
View/download PDF

47. Additional file 1 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 1. Treatment Planning Guidelines.

Published
2020
Full Text
View/download PDF

48. Additional file 2 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Abstract

Additional file 2. Surgical Credentialling Form.

Published
2020
Full Text
View/download PDF

49. Additional file 3 of Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

Author

Nichols, Anthony, Pencilla Lang, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, Almeida, John, Bayley, Andrew, Goldstein, David, Eskander, Antoine, Zain Husain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, S. MacNeil, Mendez, Adrian, Winquist, Eric, Read, Nancy, Varagur Venkatesan, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Murali Rajaraman, Johnson-Obaseki, Stephanie, Libni Eapen, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, T. Matthews, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, and Palma, David

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION, Data_FILES, ComputingMilieux_COMPUTERSANDEDUCATION, ComputingMilieux_MISCELLANEOUS
Abstract

Additional file 3. Schedule of Enrolment, Interventions and Assessments.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results