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3. American Society for Gastrointestinal Endoscopy–European Society of Gastrointestinal Endoscopy guideline on primary endoscopic bariatric and metabolic therapies for adults with obesity

Author

Jirapinyo, Pichamol, Hadefi, Alia, Thompson, Christopher C., Patai, Árpád V., Pannala, Rahul, Goelder, Stefan K., Kushnir, Vladimir, Barthet, Marc, Apovian, Caroline M., Boskoski, Ivo, Chapman, Christopher G., Davidson, Paul, Donatelli, Gianfranco, Kumbhari, Vivek, Hayee, Bu, Esker, Janelle, Hucl, Tomas, Pryor, Aurora D., Maselli, Roberta, Schulman, Allison R., Pattou, Francois, Zelber-Sagi, Shira, Bain, Paul A., Durieux, Valérie, Triantafyllou, Konstantinos, Thosani, Nirav, Huberty, Vincent, and Sullivan, Shelby

Published
2024
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8. Aspiration therapy for the treatment of obesity: 4-year results of a multicenter randomized controlled trial

Author

Thompson, Christopher C, Abu Dayyeh, Barham K, Kushnir, Vladimir, Kushner, Robert F, Jirapinyo, Pichamol, Schorr, Alan B, Aronne, Louis J, Amaro, Anastassia, Jaffe, David L, Schulman, Allison R, Early, Dayna, Stein, Adam C, Sharaiha, Reem, Edmundowicz, Steven A, Bohning, J Matthew, Jensen, Michael D, Shukla, Alpana P, Apovian, Caroline, Kim, Dong Wook, Tran, Daniel, Zarrinpar, Amir, Ryan, Michele B, Young, Meredith, Lowe, Abigail, Haas, Miki, Goldsmith, Heidi, McCrea, Jennifer, and Sullivan, Shelby

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Patient Safety, Digestive Diseases, Clinical Research, Nutrition, Prevention, Behavioral and Social Science, Obesity, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Oral and gastrointestinal, Cancer, Metabolic and endocrine, Adult, Bariatric Surgery, Body Mass Index, Drainage, Endoscopy, Gastrointestinal, Gastrostomy, Humans, Middle Aged, Obesity, Morbid, Treatment Outcome, Weight Loss, Endoscopic bariatric therapy, Aspiration therapy, Metabolic, Diet, Public Health and Health Services, Surgery, Clinical sciences, Public health
Abstract

BackgroundThe AspireAssist is the first Food and Drug Administration-approved endoluminal device indicated for treatment of class II and III obesity.ObjectivesWe earlier reported 1-year results of the PATHWAY study. Here, we report 4-year outcomes.SettingUnited States-based, 10-center, randomized controlled trial involving 171 participants with the treatment arm receiving Aspiration Therapy (AT) plus Lifestyle Therapy and the control arm receiving Lifestyle Therapy (2:1 randomization).MethodsAT participants were permitted to continue in the study for an additional year up to a maximum of 5 years providing they maintained at least 10% total weight loss (TWL) from baseline at each year end. For AT participants who continued the study, 5 medical monitoring visits were provided at weeks 60, 68, 76, 90, and 104 and thereafter once every 13 weeks up to week 260. Exclusion criteria were a history of eating disorder or evidence of eating disorder on a validated questionnaire. Follow-up weight, quality of life, and co-morbidities were compared with the baseline levels. In addition, rates of serious adverse event, persistent fistula, withdrawal, and A-tube replacement were reported. All analyses were performed using a per-protocol analysis.ResultsOf the 82 AT participants who completed 1 year, 58 continued to this phase of the trial. Mean baseline body mass index of these 58 patients was 41.6 ± 4.5 kg/m2. At the end of first year (at the beginning of the follow-up study), these 58 patients had a body mass index of 34.1 ± 5.4 kg/m2 and had achieved an 18.3 ± 8.0% TWL. On a per protocol basis, patients experienced 14.2%, 15.3%, 16.6%, and 18.7% TWL at 1, 2, 3, and 4 years, respectively (P < .01 for all). Forty of 58 patients (69%) achieved at least 10% TWL at 4 years or at time of study withdrawal. Improvements in quality of life scores and select cardiometabolic parameters were also maintained through 4 years. There were 2 serious adverse events reported in the second through fourth years, both of which resolved with removal or replacement of the A tube. Two persistent fistulas required surgical repair, representing approximately 2% of all tube removals. There were no clinically significant metabolic or electrolytes disorders observed, nor any evidence for development of any eating disorders.ConclusionsThe results of this midterm study have shown that AT is a safe, effective, and durable weight loss alternative for people with class II and III obesity and who are willing to commit to using the therapy and adhere to adjustments in eating behavior.

Published
2019

10. Enhanced EUS imaging (with videos)

Author

Krishnan, Kumar, Bhutani, Manoop S., Aslanian, Harry R., Melson, Joshua, Navaneethan, Udayakumar, Pannala, Rahul, Parsi, Mansour A., Schulman, Allison R., Sethi, Amrita, Sullivan, Shelby, Trikudanathan, Guru, Trindade, Arvind J., Watson, Rabindra R., Maple, John T., and Lichtenstein, David R.

Published
2021
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13. Changes in Transient Elastography with Glucagon-Like Peptide-1 Receptor Agonist Use in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Real-World Retrospective Analysis.

Author

Akhverdyan, Nazar, Wieland, Amanda, Sullivan, Shelby, Lindsay, Mark, Swartwood, Sheila, Arndt, Gretchen, Kaizer, Laura Katherine, and Jensen, Thomas

Abstract

Introduction: Current guidelines recommend the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD), especially in patients with comorbid diabetes and obesity. This study investigated the effects of GLP-1RAs on hepatic steatosis and fibrosis in patients with MASLD, as measured by changes in vibration-controlled transient elastography (VCTE) and other clinical parameters in a real-world clinical setting. Methods: We conducted a single-center, retrospective analysis of 96 patients with MASLD from a multidisciplinary care clinic who completed VCTE at baseline and follow-up within 6–24 months to compare changes in controlled attenuation parameter (CAP) and liver stiffness measurement (LSM), as well as other metabolic markers, between GLP-1RA users and nonusers using two-sample t-tests and Wilcoxon rank-sum tests. We also assessed whether improvements in hepatic steatosis, defined as a change in CAP >38 dB/m as previously described in the literature, were associated with improvement in fibrosis. Results: GLP-1RA use resulted in significant improvements in weight (−8.1 kg vs. −3.5 kg, P = 0.009), body mass index (BMI) (−2.9 kg/m2 vs. −1.3 kg/m2, P = 0.012), alanine aminotransferase (−15.0 IU/L vs. −4.0 IU/L, P = 0.017), aspartate aminotransferase (−5.0 IU/L vs. −1.0 IU/L, P = 0.021), glycated hemoglobin (HbA1c) (−0.7% vs. 0.1%, P = 0.019), and CAP (−59.9 dB/m vs. −29.1 dB/m, P = 0.016). Responders also had significant improvements in weight (−9.2 kg vs. −1.9 kg, P < 0.001), BMI (−3.3 kg/m2 vs. −0.7 kg/m2, P < 0.001), diastolic blood pressure (−6.1 mmHg vs. −0.7 mmHg, P = 0.028), HbA1c (−0.8% vs. 0.3%, P < 0.001), and LSM (−1.5 kPa vs. 0.1 kPa, P < 0.001). Conclusions: Patients with MASLD treated with GLP-1RAs showed significant improvements in hepatic steatosis and multiple other metabolic parameters, with weight loss as the proposed mechanism for this liver improvement. In addition, change in CAP >38 dB/m was associated with improvements in LSM and other metabolic parameters, suggesting the clinical utility of VCTE in the surveillance of MASLD. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Endoscopic simulators

Author

Goodman, Adam J., Melson, Joshua, Aslanian, Harry R., Bhutani, Manoop S., Krishnan, Kumar, Lichtenstein, David R., Navaneethan, Udayakumar, Pannala, Rahul, Parsi, Mansour A., Schulman, Allison R., Sethi, Amrita, Sullivan, Shelby A., Thosani, Nirav, Trikudanathan, Guru, Trindade, Arvind J., Watson, Rabindra R., and Maple, John T.

Published
2019
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24. Randomized sham-controlled trial of the 6-month swallowable gas-filled intragastric balloon system for weight loss

Author

Sullivan, Shelby, Swain, James, Woodman, George, Edmundowicz, Steven, Hassanein, Tarek, Shayani, Vafa, Fang, John C., Noar, Mark, Eid, George, English, Wayne J., Tariq, Nabil, Larsen, Michael, Jonnalagadda, Sreenivasa S., Riff, Dennis S., Ponce, Jaime, Early, Dayna, Volckmann, Eric, Ibele, Anna R., Spann, Matthew D., Krishnan, Kumar, Bucobo, Juan Carlos, and Pryor, Aurora

Published
2018
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25. Biliary and pancreatic lithotripsy devices

Author

Watson, Rabindra R., Parsi, Mansour A., Aslanian, Harry R., Goodman, Adam J., Lichtenstein, David R., Melson, Joshua, Navaneethan, Udayakumar, Pannala, Rahul, Sethi, Amrita, Sullivan, Shelby A., Thosani, Nirav C., Trikudanathan, Guru, Trindade, Arvind J., and Maple, John T.

Published
2018
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30. ASGE EndoVators Summit: Defining the Role and Value of Endoscopic Therapies in Obesity Management

Author

Ryou, Marvin, McQuaid, Kenneth R., Thompson, Christopher C., Edmundowic, Steven, Mergener, Klaus, Edmundowicz, Steven, Dayyeh, Barham Abu, Apovian, Caroline, Burke, Carol, Chand, Bipan, Chandraker, Anil, Deas, Thomas, Dietz, William, Dunkin, Brian, Ernest, Opella, Faigel, Douglas, Garber, Shawn, Hamdy, Osama, Kaplan, Lee, Kumar, Nitin, Kushner, Robert, Larsen, Michael C., Lerner, Herbert, Littenberg, Glenn, Mantzoros, Christos, Mattar, Samer, Moore, Rachel, Rinella, Mary, Rothstein, Richard, Schillinger, Dean, Spring, Bonnie, Sullivan, Shelby, Tice, Jeffrey, Vargo, John, Wilson, Erik, Woods, Karen, and Zundel, Natan

Published
2018
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33. ASGE EndoVators Summit: Defining the role and value of endoscopic therapies in obesity management

Author

Ryou, Marvin, McQuaid, Kenneth R., Thompson, Christopher C., Edmundowicz, Steven, Mergener, Klaus, Dayyeh, Barham Abu, Apovian, Caroline, Burke, Carol, Chand, Bipan, Chandraker, Anil, Deas, Thomas, Dietz, William, Dunkin, Brian, Ernest, Opella, Faigel, Douglas, Garber, Shawn, Hamdy, Osama, Kaplan, Lee, Kumar, Nitin, Kushner, Robert, Larsen, Michael C., Lerner, Herbert, Littenberg, Glenn, Mantzoros, Christos, Mattar, Samer, Moore, Rachel, Rinella, Mary, Rothstein, Richard, Schillinger, Dean, Spring, Bonnie, Sullivan, Shelby, Tice, Jeffrey, Vargo, John, Wilson, Erik, Woods, Karen, and Zundel, Natan

Published
2017
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34. Radiofrequency ablation devices

Author

Navaneethan, Udayakumar, Thosani, Nirav, Goodman, Adam, Manfredi, Michael, Pannala, Rahul, Parsi, Mansour A., Smith, Zachary L., Sullivan, Shelby A., Banerjee, Subhas, and Maple, John T.

Published
2017
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39. Devices for use with EUS

Author

Hwang, Joo Ha, Aslanian, Harry R., Thosani, Nirav, Goodman, Adam, Manfredi, Michael, Navaneethan, Udayakumar, Pannala, Rahul, Parsi, Mansour A., Smith, Zachary L., Sullivan, Shelby A., Banerjee, Subhas, and Maple, John T.

Published
2017
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40. Interventional EUS (with videos)

Author

Maple, John T., Pannala, Rahul, Abu Dayyeh, Barham K., Aslanian, Harry R., Enestvedt, Brintha K., Goodman, Adam, Komanduri, Sri, Manfredi, Michael, Navaneethan, Udayakumar, Parsi, Mansour A., Smith, Zachary L., Thosani, Nirav, Sullivan, Shelby A., and Banerjee, Subhas

Published
2017
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43. Automated endoscope reprocessors

Author

Parsi, Mansour A., Sullivan, Shelby A., Goodman, Adam, Manfredi, Michael, Navaneethan, Udayakumar, Pannala, Rahul, Smith, Zachary L., Thosani, Nirav, Banerjee, Subhas, and Maple, John T.

Published
2016
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44. Cholangiopancreatoscopy

Author

Komanduri, Sri, Thosani, Nirav, Abu Dayyeh, Barham K., Aslanian, Harry R., Enestvedt, Brintha K., Manfredi, Michael, Maple, John T., Navaneethan, Udayakumar, Pannala, Rahul, Parsi, Mansour A., Smith, Zachary L., Sullivan, Shelby A., and Banerjee, Subhas

Published
2016
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45. Per-oral endoscopic myotomy (with video)

Author

Pannala, Rahul, Abu Dayyeh, Barham K., Aslanian, Harry R., Enestvedt, Brintha K., Komanduri, Sri, Manfredi, Michael, Maple, John T., Navaneethan, Udayakumar, Parsi, Mansour A., Smith, Zachary L., Sullivan, Shelby A., Thosani, Nirav, and Banerjee, Subhas

Published
2016
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46. ASGE Technology Committee systematic review and meta-analysis assessing the ASGE Preservation and Incorporation of Valuable Endoscopic Innovations thresholds for adopting real-time imaging–assisted endoscopic targeted biopsy during endoscopic surveillance of Barrett’s esophagus

Author

Thosani, Nirav, Abu Dayyeh, Barham K., Sharma, Prateek, Aslanian, Harry R., Enestvedt, Brintha K., Komanduri, Sri, Manfredi, Michael, Navaneethan, Udayakumar, Maple, John T., Pannala, Rahul, Parsi, Mansour A., Smith, Zachary L., Sullivan, Shelby A., and Banerjee, Subhas

Published
2016
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