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44 results on '"Sullivan, S.A."'

2. Evolution of sensory complexity recorded in a myxobacterial genome

Author

Goldman, B.S., Nierman, W.C., Kaiser, D., Slater, S.C., Durkin, A.S., Eisen, J., Ronning, C.M., Barbazuk, W.B., Blanchard, M., Field, C., Halling, C., Hinkle, G., Iartchuk, O., Kim, H.S., Mackenzie, C., Madupu, R., Miller, N., Shvartsbeyn, A., Sullivan, S.A., Vaudin, M., Wiegand, R., and Kaplan, H.B.

Subjects
Myxobacterales -- Genetic aspects, Cellular signal transduction -- Research, Bacterial genetics -- Research, Science and technology
Abstract

Myxobacteria are single-celled, but social, eubacterial predators. Upon starvation they build multicellular fruiting bodies using a developmental program that progressively changes the pattern of cell movement and the repertoire of genes expressed. Development terminates with spore differentiation and is coordinated by both diffusible and cell-bound signals. The growth and development of Myxococcus xanthus is regulated by the integration of multiple signals from outside the cells with physiological signals from within. A collection of M. xanthus cells behaves, in many respects, like a multicellular organism. For these reasons M, xanthus offers unparalleled access to a regulatory network that controls development and that organizes cell movement on surfaces. The genome of M, xanthus is large (9.14 Mb), considerably larger than the other sequenced [delta]-proteobacteria. We suggest that gene duplication and divergence were major contributors to genomic expansion from its progenitor. More than 1,500 duplications specific to the myxobacterial lineage were identified, representing > 15% of the total genes. Genes were not duplicated at random; rather, genes for cell--cell signaling, small molecule sensing, and integrative transcription control were amplified selectively. Families of genes encoding the production of secondary metabolites are overrepresented in the genome but may have been received by horizontal gene transfer and are likely to be important for predation. evolution of signaling | genome expansion | multicellular development

Published
2006

4. Autosomal dominant nanophthalmos (NNO1 (ital)) with high hyperopia and angle-closure glaucoma maps to chromosome 11

Author

Othman, M.I., Sullivan, S.A., Skuta, G.L., Cockrell, D.A., Stringham, H.M., Downs, C.A., Fornes, A., Mick, A., Boehnke, M., Vollrath, D., and Richards, J.E.

Subjects
Genetic disorders -- Research, Chromosome mapping -- Usage, Eye -- Abnormalities, Angle-closure glaucoma -- Genetic aspects, Biological sciences
Abstract

Mapping to chromosome 11 of autosomal dominant nanophthalmos (NNO1 (ital)) with high hyperopia and angle-closure glaucoma is discussed. This developmental ocular disorder, for which ocular examinations of 22 affected members of a large family were done, is uncommon and involves a small eye, in terms of axial length, high hyperopia, high incidence of angle-closure glaucoma and a high lens/eye volume ratio.

Published
1998

8. Genome of Geobacter sulfurreducens: metal reduction in subsurface environments

Author

Methe, B.A., Nelson, K.E., Eisen, J.A., Paulsen, I.T., Nelson, W., Heidelberg, J.F., Wu, D., Wu, M., Ward, N., Beanan, M.J., Dodson, R.J., Madupu, R., Brinkac, L.M., Daugherty, S.C., DeBoy, R.T., Durkin, A.S., Gwinn, M., Kolonay, J.F., Sullivan, S.A., Haft, D.H., Selengut, J., Davidsen, T.M., Zafar, N., White, O., Tran, B., Romero, C., Forberger, H.A, Weidman, J., Khouri, H., Feldblyum, T.V., Utterback, T.R., Van Aken, S.E., Lovley, D.R., and Fraser, C.M.

Subjects
Chemical properties, Usage, Properties, Environmental aspects, Metal ions -- Chemical properties -- Environmental aspects -- Usage, Electricity -- Environmental aspects -- Usage -- Chemical properties, Anaerobic bacteria -- Properties -- Environmental aspects -- Usage -- Chemical properties, Bioremediation -- Usage -- Chemical properties -- Environmental aspects, Aerobic bacteria -- Properties -- Environmental aspects -- Chemical properties -- Usage, Subsurface geological formations -- Usage -- Environmental aspects -- Chemical properties, Radioactive substances -- Environmental aspects -- Usage -- Chemical properties, Electricity (Physics) -- Environmental aspects -- Usage -- Chemical properties, Bacteria, Aerobic -- Properties -- Environmental aspects -- Chemical properties -- Usage
Abstract

G. sulfurreducens, a member of the δ-Proteobacteria and of the family Geobacteraceae, is an important component of subsurface biota. Geobacter spp. generate energy as adenosine triphosphate by using metal ion [...], The complete genome sequence of Geobacter sulfurreducens, a δ-proteobacterium, reveals unsuspected capabilities, including evidence of aerobic metabolism, one-carbon and complex carbon metabolism, motility, and chemotactic behavior. These characteristics, coupled with the possession of many two-component sensors and many c-type cytochromes, reveal an ability to create alternative, redundant, electron transport networks and offer insights into the process of metal ion reduction in subsurface environments. As well as playing roles in the global cycling of metals and carbon, this organism dearly has the potential for use in bioremediation of radioactive metals and in the generation of electricity.

Published
2003

14. Sentinel lymph node (SLN) isolated tumor cells (ITCs) in otherwise stage I/II endometrioid endometrial cancer: To treat or not to treat?

Author

Backes, F.J., primary, Felix, A.S., additional, Grégoire, J., additional, Plante, M., additional, Sullivan, S.A., additional, Rossi, E.C., additional, Tanner, E.J., additional, Stewart, K.I., additional, Soliman, P.T., additional, Cohen, D., additional, Holloway, R.W., additional, Abu-Rustum, N.R., additional, and Leitao, M.M., additional

Published
2018
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39. Gas phase photodissociation spectrum of Cl−2

Author

Sullivan, S.A., Freiser, B.S., and Beauchamp, J.L.

Abstract

Photoinduced reactions of Cl−2have been examined in the gas phase using ion cyclotron resonance techniques. The molecular ion is observed to undergo photodissociation in preference to photodetachment. The photodissociation spectrum exhibits one broad peak in the wavelength region 220–700 nm, with a maximum λmax= 350 ± 10 nm, which can be attributed to the 2Σ+u→ 2Σ+gtransition. This spectrum is compared to absorption spectra of Cl−2obtained in solid state environments.

Published
1977
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43. Correction: A goldfish <TOGGLE>Notch-3</TOGGLE> homologue is expressed in neurogenic regions of embryonic, adult, and regenerating brain and retina. Dev. Genet. 20:208–223, 1997.

Author

Sullivan, S.A., Barthel, L.K., Largent, B.L., and Raymond, P.A.

Abstract

The following paragraphs replace text on pages 213 and 218 of the article referenced above. p. 213, column 1, 3rd paragraph: An initial screen of a goldfish retinal cDNA library using Xenopus Notch-1 (X-Notch-1) probes yielded a ~2-kb clone (GotchCDC) encoding a peptide with extensive homology to the intracellular region of Notch proteins. The 5' end of GotchCDC encoded a region poorly conserved between mammalian Notch paralogues. p. 218, column 2, 3rd paragraph: The question of to which Notch class G-Notch belongs is probably not trivial, since it has been shown in mice that neither the expression patterns nor the functions of Notch paralogues are redundant. [Swiatek et al., 1994; Williams et al., 1995]. G-Notch most likely encodes a member of the Notch-3 class previously represented solely by a murine cDNA [Lardelli et al., 1994]. Although specific functions of the Notch paralogues remain uncertain, mutations in the human Notch-3 gene recently have been identified in a familial syndrome known as CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukemoencephalopathy) causing dementia and stroke with adult onset [Joutel et al., 1996]. Sequence analysis of Notch-1 and Notch-2 proteins [Maine et al., 1995] has shown that Notch orthologues (e.g., M-Notch-1 vs X-Notch-1) are less divergent than Notch paralogues (e.g., M-Notch-1 vs. M-Notch-2). Thus we would predict that a goldfish Notch-3 would be more homologous to a mammalian Notch-3 than to a member of a different Notch class in goldfish or a closely related species. Inagreement with this inference, G-Notch is more homologous to M-Notch-3 than to zebrafish Z-Notch, which our sequence analysis shows is in the Notch-1 class. As only a single Notch gene is present in Drosophila, it has been previously proposed that the evolution of Notch paralogues occurred between the divergence of arthropods and amphibians from the mammalian lineage [Lardelli and Lendahl, 1993; Lardelli et al., 1994]; our analysis further localizes this event in time to before the evolution of teleosts. Our expression data also support the identification of G-Notch as a Notch gene, particularly its expression in proliferative neuroepithelia. For example, expression in the proliferating ventricular zone of the embryonic murine neural tube is characteristic of Notch-1, -2, and -3 [Lardelli et al., 1994; Higuchi et al., 1995]. However, assignment of G-Notch to a specific Notch class based on expression data is complicated by the paucity of such data for lower vertebrates, where only Notch-1 expression patterns have been documented [Coffman et al., 1990; Bierkamp and Campos-Ortega, 1993], and by inconsistencies in descriptions of rodent Notch paralogue expression patterns [Weinmaster et al., 1992; Lardelli et al., 1994; Higuchi et al., 1995; Williams et al., 1995]. G-Notch expression accords with that of M-Notch-3 in that both (1) occur in the ectoderm and mesoderm of gastrulating embryos, (2) are absent in notochord and floor plate, (3) are strong in the embryonic periventricular neuroepithelium and the otic vesicles, and (4) occur in adult brain [Lardelli et al., 1994; Williams et al., 1995; Lindsell et al., 1995]. However, expression patterns of M-Notch-3 and G-Notch are not completely analogous. For example, M-Notch-3 expression was detected in embryonic rodent epidermis and adult skeletal muscle, and not in the mostly undifferentiated E10.5 retina [Lardelli et al., 1994; Williams et al., 1995]. These discrepancies may reflect differences in probe sensitivities, species-specific adaptations of Notch-3 function, or alternatively, G-Notch might represent a novel class of Notch. The existence of zebrafish Notch-1 and of multiple Notch paralogues in mammalian species suggests that additional goldfish paralogues of G-Notch await discovery.

Published
1997
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44. Infant dietary experience and acceptance of solid foods.

Author

Sullivan, S.A. and Birch, L.L.

Subjects
*NEWBORN infant nutrition, *BREASTFEEDING
Abstract

Reports on the study about infant acceptance of solid foods. Formula-feeding and breast-feeding as facilitators for infants acceptance of solid foods.

Published
1994

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