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3. In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels

Author

Noshadi, Iman, Hong, Seonki, Sullivan, Kelly E, Shirzaei Sani, Ehsan, Portillo-Lara, Roberto, Tamayol, Ali, Shin, Su Ryon, Gao, Albert E, Stoppel, Whitney L, Black III, Lauren D, Khademhosseini, Ali, and Annabi, Nasim

Subjects
Heart Disease, Biotechnology, Cardiovascular, Regenerative Medicine, Bioengineering, Animals, Biocompatible Materials, Caprolactam, Cell Proliferation, Gelatin, Hydrogels, Light, Male, Materials Testing, Mechanical Phenomena, Mice, Myocytes, Cardiac, NIH 3T3 Cells, Photochemical Processes, Polymerization, Rats, Rats, Sprague-Dawley, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Medical Biotechnology
Abstract

Photocrosslinkable materials have been frequently used for constructing soft and biomimetic hydrogels for tissue engineering. Although ultraviolet (UV) light is commonly used for photocrosslinking such materials, its use has been associated with several biosafety concerns such as DNA damage, accelerated aging of tissues, and cancer. Here we report an injectable visible light crosslinked gelatin-based hydrogel for myocardium regeneration. Mechanical characterization revealed that the compressive moduli of the engineered hydrogels could be tuned in the range of 5-56 kPa by changing the concentrations of the initiator, co-initiator and co-monomer in the precursor formulation. In addition, the average pore sizes (26-103 μm) and swelling ratios (7-13%) were also shown to be tunable by varying the hydrogel formulation. In vitro studies showed that visible light crosslinked GelMA hydrogels supported the growth and function of primary cardiomyocytes (CMs). In addition, the engineered materials were shown to be biocompatible in vivo, and could be successfully delivered to the heart after myocardial infarction in an animal model to promote tissue healing. The developed visible light crosslinked hydrogel could be used for the repair of various soft tissues such as the myocardium and for the treatment of cardiovascular diseases with enhanced therapeutic functionality.

Published
2017

13. ALDH1A3 in CSCs

Author

Sullivan, Kelly E., primary, Cerione, Richard A., additional, and Wilson, Kristin F., additional

Published
2017
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21. In vitroand in vivoanalysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogelsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7bm00110j

Author

NoshadiThese authors contributed equally to this work., Iman, Hong, Seonki, Sullivan, Kelly E., Shirzaei Sani, Ehsan, Portillo-Lara, Roberto, Tamayol, Ali, Shin, Su Ryon, Gao, Albert E., Stoppel, Whitney L., Black III, Lauren D., Khademhosseini, Ali, and Annabi, Nasim

Abstract

Photocrosslinkable materials have been frequently used for constructing soft and biomimetic hydrogels for tissue engineering. Although ultraviolet (UV) light is commonly used for photocrosslinking such materials, its use has been associated with several biosafety concerns such as DNA damage, accelerated aging of tissues, and cancer. Here we report an injectable visible light crosslinked gelatin-based hydrogel for myocardium regeneration. Mechanical characterization revealed that the compressive moduli of the engineered hydrogels could be tuned in the range of 5–56 kPa by changing the concentrations of the initiator, co-initiator and co-monomer in the precursor formulation. In addition, the average pore sizes (26–103 μm) and swelling ratios (7–13%) were also shown to be tunable by varying the hydrogel formulation. In vitrostudies showed that visible light crosslinked GelMA hydrogels supported the growth and function of primary cardiomyocytes (CMs). In addition, the engineered materials were shown to be biocompatible in vivo, and could be successfully delivered to the heart after myocardial infarction in an animal model to promote tissue healing. The developed visible light crosslinked hydrogel could be used for the repair of various soft tissues such as the myocardium and for the treatment of cardiovascular diseases with enhanced therapeutic functionality.

Published
2017
Full Text
View/download PDF

23. Abstract 139.

Author

Sullivan, Kelly E, Sant, Sharada, Burns, Laura, and Black, Lauren D

Published
2014

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