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In view of the increasing demand on ground water supplies in the northeastern United States, it is imperative to develop appropriate methods to geophysically characterize the most widely used sources of ground water in the region: shallow unconfined aquifers consisting of well-sorted, stratified glacial deposits laid down in bedrock valleys and channels. The gravity method, despite its proven value in delineating buried bedrock valleys elsewhere, is seldom used by geophysical contractors in this region. To demonstrate the method's effectiveness for evaluating such aquifers, a pilot study was undertaken in the Palmer River Basin in southeastern Massachusetts. Because bedrock is so shallow beneath this aquifer (maximum depth is 30 in), the depth-integrated mass deficiency of the overlying unconsolidated material was small, so that the observed gravity anomaly was on the order of 1 milligal (mGal) or less. Thus data uncertainties were significant. Moreover, unlike previous gravity studies elsewhere, we had no a priori information on the density of the sediment. Under such circumstances, it is essential to include model constraints and weighted least-squares in the inversion procedure. Among the model constraints were water table configuration, bedrock outcrops, and depth to bedrock from five water wells. Our procedure allowed us to delineate depth to bedrock along a 3.5 km profile with a confidence interval of 1.8 m at a nominal depth of 17 m. Moreover, we obtained a porosity estimate in the range of 39% to 44%. Thus the gravity method, with appropriate refinements, is an effective tool for the reconnaissance of shallow unconfined aquifers., Rabi N. Bohidar (1), Jeffrey P. Sullivan (1,2), and John F. Hermance (1,3) Introduction The most commonly used aquifers for potable ground water supplies in the northeastern United States are [...]

Abstract Background In order to establish a consistent method for brachial artery reactivity assessment, we analyzed commonly used approaches to the test and their effects on the magnitude and time-course of flow mediated dilation (FMD), and on test variability and repeatability. As a popular and noninvasive assessment of endothelial function, several different approaches have been employed to measure brachial artery reactivity with B-mode ultrasound. Despite some efforts, there remains a lack of defined normal values and large variability in measurement technique. Methods Twenty-six healthy volunteers underwent repeated brachial artery diameter measurements by B-mode ultrasound. Following baseline diameter recordings we assessed endothelium-dependent flow mediated dilation by inflating a blood pressure cuff either on the upper arm (proximal) or on the forearm (distal). Results Thirty-seven measures were performed using proximal occlusion and 25 with distal occlusion. Following proximal occlusion relative to distal occlusion, FMD was larger (16.2 ± 1.2% vs. 7.3 ± 0.9%, p < 0.0001) and elongated (107.2 s vs. 67.8 s, p = 0.0001). Measurement of the test repeatability showed that differences between the repeated measures were greater on average when the measurements were done using the proximal method as compared to the distal method (2.4%; 95% CI 0.5–4.3; p = 0.013). Conclusion These findings suggest that forearm compression holds statistical advantages over upper arm compression. Added to documented physiological and practical reasons, we propose that future studies should use forearm compression in the assessment of endothelial function.

Abstract Background The mechanism behind the triggering effect of fine particulate matter (PM) air pollution on cardiovascular events remains elusive. We postulated that elevated levels of PM would be associated with increased blood levels of inflammatory and thrombotic markers in elderly individuals. We also hypothesized that elevated PM would increase levels of cytokines in individuals with heart disease. Methods We measured these blood markers in 47 elderly individuals with (23) and without (16 COPD and 8 healthy) cardiovascular disease (CVD) on 2 or 3 mornings over a 5 or 10-day period between February 2000 and March 2002. Blood measures were paired with residence level outdoor PM measured by nephelometry. Analyses determined the within-individual effect of 24-hour averaged outdoor PM on blood measures. Results Analyses found no statistically significant effect of a same day 10 ug/m3 increase in fine PM on log transformed levels of CRP 1.21 fold-rise [95% CI: 0.86, 1.70], fibrinogen 1.02 fold-rise [95% CI: 0.98, 1.06], or D-dimer 1.02 fold-rise [95% CI: 0.88, 1.17] in individuals with CVD. One-day lagged analyses in the CVD subgroup found similar null results. These same models found no change in these blood markers at the same-day or 1-day lag in the group without CVD. In 21 individuals with CVD, a 10 μg/m3 increase in same-day PM was associated with a 1.3 fold-rise [95% CI: 1.1, 1.7] in the level of monocyte chemoattractant protein-1. Conclusion We did not find consistent effects of low ambient levels of PM on blood measures of inflammation or thrombosis in elderly individuals.