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2. Kisspeptin administration does not alter anxiety or circulating cortisol levels in humans

Author

Mills, Edouard G, primary, Thurston, Layla, additional, Yang, Lisa, additional, Suladze, Sofiya, additional, Hunjan, Tia, additional, Phylactou, Maria, additional, Patel, Bijal, additional, Clarke, Sophie A., additional, Shah, Amar J., additional, Izzi-Engbeaya, Chioma, additional, Tsoutsouki, Jovanna, additional, Bech, Paul, additional, Ertl, Natalie, additional, Demetriou, Lysia, additional, Wall, Matthew B., additional, Goldmeier, David, additional, Abbara, Ali, additional, Comninos, Alexander N., additional, and Dhillo, Waljit S., additional

Published
2024
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3. Melanocortin 4 receptor agonism enhances sexual brain processing in women with hypoactive sexual desire disorder

Author

Thurston, Layla, Hunjan, Tia, Mills, Edouard G., Wall, Matthew B., Ertl, Natalie, Phylactou, Maria, Muzi, Beatrice, Patel, Bijal, Alexander, Emma C., Suladze, Sofiya, Modi, Manish, Eng, Pei C., Bassett, Paul A., Abbara, Ali, Goldmeier, David, Comninos, Alexander N., and Dhillo, Waljit S.

Subjects
Women -- Health aspects, Sexual excitement -- Analysis, Frigidity (Psychology) -- Diagnosis -- Care and treatment, Health care industry
Abstract

BACKGROUND. Hypoactive sexual desire disorder (HSDD) is characterized by a persistent deficiency of sexual fantasies and desire for sexual activity, causing marked distress and interpersonal difficulty. It is the most prevalent female sexual health problem globally, affecting approximately 10% of women, but has limited treatment options. Melanocortin 4 receptor (MC4R) agonists have emerged as a promising therapy for women with HSDD, through unknown mechanisms. Studying the pathways involved is crucial for our understanding of normal and abnormal sexual behavior. METHODS. Using psychometric, functional neuroimaging, and hormonal analyses, we conducted a randomized, double-blinded, placebo-controlled, crossover clinical study to assess the effects of MC4R agonism compared with placebo on sexual brain processing in 31 premenopausal heterosexual women with HSDD. RESULTS. MC4R agonism significantly increased sexual desire for up to 24 hours after administration compared with placebo. During functional neuroimaging, MC4R agonism enhanced cerebellar and supplementary motor area activity and deactivated the secondary somatosensory cortex, specifically in response to visual erotic stimuli, compared with placebo. In addition, MC4R agonism enhanced functional connectivity between the amygdala and the insula during visual erotic stimuli compared with placebo. CONCLUSION. These data suggest that MC4R agonism enhanced sexual brain processing by reducing self-consciousness, increasing sexual imagery, and sensitizing women with HSDD to erotic stimuli. These findings provide mechanistic insight into the action of MC4R agonism in sexual behavior and are relevant to the ongoing development of HSDD therapies and MC4R agonist development more widely. TRIAL REGISTRATION. ClinicalTrials.gov NCT04179734. FUNDING. This is an investigator-sponsored study funded by AMAG Pharmaceuticals Inc., the Medical Research Council (MRC) (MR/T006242/1), and the National Institute for Health Research (NIHR) (CS-2018-18-ST2-002 and RP-2014-05-001)., Introduction Sexual arousal and desire are fundamental physiological processes in humans and are designed to drive sexual activity and ultimately reproduction at a population level. The presence of sexual arousal [...]

Published
2022
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4. Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder

Author

Mills, Edouard G., primary, Ertl, Natalie, additional, Wall, Matthew B., additional, Thurston, Layla, additional, Yang, Lisa, additional, Suladze, Sofiya, additional, Hunjan, Tia, additional, Phylactou, Maria, additional, Patel, Bijal, additional, Muzi, Beatrice, additional, Ettehad, Dena, additional, Bassett, Paul A., additional, Howard, Jonathan, additional, Rabiner, Eugenii A., additional, Bech, Paul, additional, Abbara, Ali, additional, Goldmeier, David, additional, Comninos, Alexander N., additional, and Dhillo, Waljit S., additional

Published
2023
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5. OR17-5 Kisspeptin Increases Penile Tumescence and Sexual Brain Processing in Men with Hypoactive Sexual Desire Disorder

Author

Abbara, Ali, primary, Bech, Paul, additional, Comninos, Alexander N, additional, Dhillo, Waljit S, additional, Ertl, Natalie, additional, Ettehad, Dena, additional, Goldmeier, David, additional, Howard, Jonathan, additional, Hunjan, Tia, additional, Muzi, Beatrice, additional, Patel, Bijal, additional, Phylactou, Maria, additional, Rabiner, Eugenii A, additional, Suladze, Sofiya, additional, Thurston, Layla, additional, Wall, Matt B, additional, Yang, Lisa, additional, and Mills, Edouard G, additional

Published
2022
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6. PMON214 Kisspeptin Restores Sexual and Attraction Brain Processing in Women with Hypoactive Sexual Desire Disorder

Author

Thurston, Layla, primary, Hunjan, Tia, additional, Ertl, Natalie, additional, Wall, Matt, additional, Mills, Edouard, additional, Suladze, Sofiya, additional, Alexander, Emma, additional, Muzi, Beatrice, additional, Patel, Bijal, additional, Bech, Paul, additional, Goldmeier, David, additional, Rabiner, Eugenii, additional, Abbara, Ali, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2022
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7. RF01 | PMON43 Melanocortin-4 Receptor Agonism Enhances Sexual Brain Processing in Women with Hypoactive Sexual Desire Disorder

Author

Thurston, Layla, primary, Hunjan, Tia, additional, Mills, Edouard, additional, Wall, Matthew, additional, Ertl, Natalie, additional, Phylactou, Maria, additional, Muzi, Beatrice, additional, Patel, Bijal, additional, Alexander, Emma, additional, Suladze, Sofiya, additional, Modi, Manish, additional, Eng, Pei Chia, additional, Bassett, Paul, additional, Abbara, Ali, additional, Goldmeier, David, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2022
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8. Kisspeptin enhances sexual and attraction brain processing in women with low sexual desire

Author

Thurston, Layla, primary, Hunjan, Tia, additional, Ertl, Natalie, additional, Wall, Matthew, additional, Mills, Edouard, additional, Suladze, Sofiya, additional, Patel, Bijal, additional, Alexander, Emma, additional, Muzi, Beatrice, additional, Bassett, Paul, additional, Rabiner, Eugenii, additional, Bech, Paul, additional, Goldmeier, David, additional, Abbara, Ali, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2022
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9. Kisspeptin enhances penile tumescence and sexual brain processing in men with low sexual desire

Author

Mills, Edouard G, primary, Ertl, Natalie, additional, Wall, Matt B, additional, Thurston, Layla, additional, Yang, Lisa, additional, Suladze, Sofiya, additional, Hunjan, Tia, additional, Phylactou, Maria, additional, Patel, Bijal, additional, Muzi, Beatrice, additional, Ettehad, Dena, additional, Bassett, Paul A, additional, Howard, Jonathan, additional, Rabiner, Eugenii A, additional, Bech, Paul, additional, Abbara, Ali, additional, Goldmeier, David, additional, Comninos, Alexander N, additional, and Dhillo, Waljit S, additional

Published
2022
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10. Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder

Author

Thurston, Layla, primary, Hunjan, Tia, additional, Ertl, Natalie, additional, Wall, Matthew B., additional, Mills, Edouard G., additional, Suladze, Sofiya, additional, Patel, Bjial, additional, Alexander, Emma C., additional, Muzi, Beatrice, additional, Bassett, Paul A., additional, Rabiner, Eugenii A., additional, Bech, Paul, additional, Goldmeier, David, additional, Abbara, Ali, additional, Comninos, Alexander N., additional, and Dhillo, Waljit S., additional

Published
2022
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11. Kisspeptin improves sexual brain processing in women with low sexual desire

Author

Thurston, Layla, primary, Hunjan, Tia, additional, Ertl, Natalie, additional, B, Wall Matt, additional, Mills, Edouard, additional, Suladze, Sofiya, additional, Patel, Bijal, additional, Alexander, Emma, additional, Muzi, Beatrice, additional, A, Rabiner Eugenii, additional, Bech, Paul, additional, Goldmeier, David, additional, Abbara, Ali, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2022
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12. Sexual brain processing is enhanced by melanocortin-4 receptor agonism

Author

Thurston, Layla, primary, Hunjan, Tia, additional, Mills, Edouard, additional, Wall, Matt B, additional, Ertl, Natalie, additional, Phylactou, Maria, additional, Muzi, Beatrice, additional, Patel, Bijal, additional, Alexander, Emma, additional, Suladze, Sofiya, additional, Modi, Manish, additional, Eng, Pei, additional, Bassett, Paul, additional, Abbara, Ali, additional, Goldmeier, David, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2022
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13. Kisspeptin administration has therapeutic potential for men with low sexual desire by increasing penile tumescence and sexual brain processing

Author

Mills, Edouard, primary, Ertl, Natalie, additional, Wall, Matt B, additional, Thurston, Layla, additional, Yang, Lisa, additional, Suladze, Sofiya, additional, Hunjan, Tia, additional, Phylactou, Maria, additional, Patel, Bijal, additional, Muzi, Beatrice, additional, Ettehad, Dena, additional, Howard, Jonathan, additional, Rabiner, Eugenii A, additional, Bech, Paul, additional, Abbara, Ali, additional, Goldmeier, David, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2022
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14. Melanocortin-4 receptor agonism improves sexual brain processing in women with low sexual desire

Author

Thurston, Layla, primary, Hunjan, Tia, additional, Mills, Edouard, additional, Wall, Matthew, additional, Ertl, Natalie, additional, Phylactou, Maria, additional, Muzi, Beatrice, additional, Patel, Bijal, additional, Alexander, Emma, additional, Suladze, Sofiya, additional, Modi, Manish, additional, Eng, Pei, additional, Bassett, Paul, additional, Abbara, Ali, additional, Goldmeier, David, additional, Comninos, Alexander, additional, and Dhillo, Waljit, additional

Published
2021
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