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168 results on '"Sulé-Suso, Josep"'

2. Virtual Imaging for Patient Information on Radiotherapy Planning and Delivery for Prostate Cancer

Author

Martínez-Albaladejo, Miguel, Sulé-Suso, Josep, Lines, David, Bisson, James, Jassal, Simon, Edwards, Craig, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Papież, Bartłomiej W., editor, Yaqub, Mohammad, editor, Jiao, Jianbo, editor, Namburete, Ana I. L., editor, and Noble, J. Alison, editor

Published
2021
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4. Artificial Neural Network Analysis of Volatile Organic Compounds for the Detection of Lung Cancer

Author

Butcher, John B., Rutter, Abigail V., Wootton, Adam J., Day, Charles R., Sulé-Suso, Josep, Kacprzyk, Janusz, Series editor, Pal, Nikhil R., Advisory editor, Bello Perez, Rafael, Advisory editor, Corchado, Emilio S., Advisory editor, Hagras, Hani, Advisory editor, Kóczy, László T., Advisory editor, Kreinovich, Vladik, Advisory editor, Lin, Chin-Teng, Advisory editor, Lu, Jie, Advisory editor, Melin, Patricia, Advisory editor, Nedjah, Nadia, Advisory editor, Nguyen, Ngoc Thanh, Advisory editor, Wang, Jun, Advisory editor, Chao, Fei, editor, Schockaert, Steven, editor, and Zhang, Qingfu, editor

Published
2018
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10. Using Fourier transform IR spectroscopy to analyze biological materials

Author

Baker, Matthew J, Trevisan, Júlio, Bassan, Paul, Bhargava, Rohit, Butler, Holly J, Dorling, Konrad M, Fielden, Peter R, Fogarty, Simon W, Fullwood, Nigel J, Heys, Kelly A, Hughes, Caryn, Lasch, Peter, Martin-Hirsch, Pierre L, Obinaju, Blessing, Sockalingum, Ganesh D, Sulé-Suso, Josep, Strong, Rebecca J, Walsh, Michael J, Wood, Bayden R, Gardner, Peter, and Martin, Francis L

Published
2014
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13. Clinical applications of infrared and Raman spectroscopy in the fields of cancer and infectious diseases

Author

Santos Marfran, Tyagi Gunjan, Chakkumpulakkal P. V. Thulya, Adegoke A. John, Walsh Michael, Pebotuwa Savithri, Byrne J. Hugh, Crean StJohn, Matthew J. Baker, Wood Bayden, Christie Loren, Paraskevaidis Evangelos, Holly J. Butler, Kochan Kamila, Martin-Hirsch L. Pierre, Lima M. G. Kássio, Gassner Callum, Maria Paraskevaidi, Sulé-Suso Josep, Sala Alexandra, Kazarian G. Sergei, Kyrgiou Maria, and Gardner Peter

Subjects
Technology, medicine.medical_specialty, SPECTROCHEMICAL ANALYSIS, infectious disease, 0205 Optical Physics, Disease, VIBRATIONAL SPECTROSCOPY, clinical translation, Analytical Chemistry, RC0254, SPECTRAL HISTOPATHOLOGY, LABEL-FREE DETECTION, medicine, cancer, health economics, Medical physics, QD, Instruments & Instrumentation, Infrared spectroscopy, Instrumentation, IN-VIVO, Spectroscopy, Science & Technology, ATR-FTIR SPECTROSCOPY, B230, COLON-CANCER, HUMAN-PAPILLOMAVIRUS, Early disease, Cancer, Diagnostic test, R735, A300, medicine.disease, HUMAN BLOOD, R1, Infectious disease (medical specialty), Raman spectroscopy, disease diagnostics, DIFFERENTIAL-DIAGNOSIS
Abstract

Analytical technologies that can improve disease diagnosis are highly sought after. Current screening/diagnostic tests for several diseases are limited by their moderate diagnostic performance, invasiveness, costly and laborious methodologies or the need for multiple tests before a definitive diagnosis. Spectroscopic techniques, including infrared (IR) and Raman, have attracted great interest in the medical field, with applications expanding from early disease detection to monitoring and real-time diagnosis.\ud This review highlights applications of IR and Raman spectroscopy, with a focus on cancer and infectious diseases since 2015, and underscores the diverse sample types that can be analyzed, such as biofluids, cells and tissues. Studies involving more than 25 participants per group (disease and control group; if no control group >25 in disease group) were considered eligible, to retain the clinical focus of the paper. Following literature searches, we identified 94 spectroscopic studies on different cancers and 30 studies on infectious diseases. The review suggests that such technologies have the potential to develop into an objective, inexpensive, point-of-care test or facilitate disease diagnosis and monitoring. Up-to-date considerations for the implementation of spectroscopic techniques into a clinical setting, health economics and successful applications of vibrational spectroscopic tests in the clinical arena are also discussed.

Published
2021

19. Supplemental material for Identification of a Glass Substrate to Study Cells Using Fourier Transform Infrared Spectroscopy: Are We Closer to Spectral Pathology?

Author

Rutter, Abigail V., Crees, Jamie, Wright, Helen, Raseta, Marko, Pittius, Daniel G. Van, Roach, Paul, and Sulé-Suso, Josep

Subjects
FOS: Other engineering and technologies, 99999 Engineering not elsewhere classified
Abstract

Supplemental Material for Identification of a Glass Substrate to Study Cells Using Fourier Transform Infrared Spectroscopy: Are We Closer to Spectral Pathology? by Abigail V. Rutter, Jamie Crees, Helen Wright, Marko Raseta, Daniel G. van Pittius, Paul Roach and Josep Sulé-Suso in Applied Spectroscopy

Published
2019
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22. Correction: Clinical applications of infrared and Raman spectroscopy: state of play and future challenges

Author

Baker, Matthew J, Byrne, Hugh J, Chalmers, John, Gardner, Peter, Goodacre, Royston, Henderson, Alex, Kazarian, Sergei G, Martin, Francis L, Moger, Julian, Stone, Nick, Sulé-Suso, Josep, Baker, Matthew J, Byrne, Hugh J, Chalmers, John, Gardner, Peter, Goodacre, Royston, Henderson, Alex, Kazarian, Sergei G, Martin, Francis L, Moger, Julian, Stone, Nick, and Sulé-Suso, Josep

Abstract

Correction for 'Clinical applications of infrared and Raman spectroscopy: state of play and future challenges' by Matthew J. Baker, et al., Analyst, 2018, DOI: 10.1039/c7an01871a.

Published
2018

23. Clinical applications of infrared and Raman spectroscopy: state of play and future challenges

Author

Baker, Matthew J., Byrne, Hugh J., Chalmers, John, Gardner, Peter, Goodacre, Royston, Henderson, Alex, Kazarian, Sergei G., Martin, Francis L, Moger, Julian, Stone, Nick, Sulé-Suso, Josep, Baker, Matthew J., Byrne, Hugh J., Chalmers, John, Gardner, Peter, Goodacre, Royston, Henderson, Alex, Kazarian, Sergei G., Martin, Francis L, Moger, Julian, Stone, Nick, and Sulé-Suso, Josep

Abstract

Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have the potential to revolutionise our clinical systems leading to improved patient outcome, more efficient public services and significant economic savings. However, despite these strong drivers, there are many fundamental scientific and technological challenges which have limited the implementation of this technology in the clinical arena, although recent years have seen significant progress in addressing these challenges. This review examines (i) the state of the art of clinical applications of infrared absorption and Raman spectroscopy, and (ii) the outstanding challenges, and progress towards translation, highlighting specific examples in the areas of in vivo, ex vivo and in vitro applications. In addition, the requirements of instrumentation suitable for use in the clinic, strategies for pre-processing and statistical analysis in clinical spectroscopy and data sharing protocols, will be discussed. Emerging consensus recommendations are presented, and the future perspectives of the field are assessed, particularly in the context of national and international collaborative research initiatives, such as the UK EPSRC Clinical Infrared and Raman Spectroscopy Network, the EU COST Action Raman4Clinics, and the International Society for Clinical Spectroscopy.

Published
2018

27. Probing single-tumor cell interactions with different-age type I collagen networks by synchrotron-based Fourier transform infrared microspectroscopy

Author

Guilbert, Marie, Eklouh-Molinier, Christophe, Wehbe, Katia, Sulé-Suso, Josep, Yang, Ying, Cinque, Gianfelice, Jeannesson, Pierre, Sockalingum, Ganesh, Unité MeDIAN, UFR Pharm, Université de Reims Champagne-Ardenne (URCA), Matrice extracellulaire et dynamique cellulaire - UMR 7369 (MEDyC), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), DIAMOND Light source, Institute for Science and Technology in Medicine, Keele University [Keele], Cancer Centre, University Hospital of North Staffordshire, and M.G. and C. E. are recipients of doctoral fellowships fromRégion Champagne-Ardenne. We acknowledge DiamondLight Source for time on B22-MIRIAM beamline, cell cultureand peripheral lab07 facilities under the proposals 8422-1 and8878-1. The research leading to these results has receivedfunding from the European Community’s Seventh FrameworkProgramme (FP7/2007–2013) under grant agreement n° 226716via the French Embassy in London, UK. This study wasalso supported by grants of the Centre National pour laRecherche Scientifique (CNRS), Cancéropôle Grand-Est andFEDER/CEPER Champagne-Ardenne.

Subjects
image clustering, collagen, aging, synchrotron-Fourier transform infrared microspectroscopy, cancer cells, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, cell/collagen interactions
Abstract

International audience; We report here on a first study using synchrotron radiation-based Fourier transform infrared microspectroscopy and imaging to investigate HT1080 human fibrosarcoma cells grown onto different-aged type I collagen networks. Spectral images were analyzed with k-means and fuzzy C-means (FCM) clustering algorithms. K-means delineated tumor cells from their surrounding collagen networks and the latter as a function of age mainly due to specific changes in the sugar absorption region. The FCM analysis gave a better nuance of the spectral images. A progression of the biochemical information was observed upon going from the cellular compartments to the pericellular contact regions and to the intact collagens of the different age groups. Two spectral markers based on sugar and protein bands via the intensity ratio (I 1032 ∕I 1655) and band area ratio (A sugar ∕A amide II), showed an increase in advanced glycation endproducts (AGEs) with age. A clear-separation of the three age groups was obtained for spectra originating from the peripheral contact areas mainly due to changes in protein band intensities. The above-described markers decreased to constant levels for the three conditions indicating a masking of the biochemical information. These results hold promises to better understand the impact of age on tumor progression processes while highlighting new markers of the tumor cell invasion front.

Published
2014
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30. Single cell analysis/data handling: general discussion

Author

Baker, Matthew J., primary, Goodacre, Royston, additional, Sammon, Christopher, additional, Marques, Maria Paula, additional, Gardner, Peter, additional, Tipping, William, additional, Sulé-Suso, Josep, additional, Wood, Bayden, additional, Byrne, Hugh J., additional, Hermes, Michael, additional, Matousek, Pavel, additional, Campbell, Colin J., additional, El-Mashtoly, Samir, additional, Frost, Jonathan, additional, Phillips, Christopher, additional, Diem, Max, additional, Kohler, Achim, additional, Lau, Katherine, additional, Kazarian, Sergei, additional, Petrich, Wolfgang, additional, Lloyd, Gavin, additional, Delfino, Ines, additional, Cinque, Gianfelice, additional, Isabelle, Martin, additional, Stone, Nick, additional, Kendall, Catherine, additional, Jamieson, Lauren, additional, Perez-Guaita, David, additional, Clark, Louise, additional, Gerwert, Klaus, additional, Notingher, Ioan, additional, Quaroni, Luca, additional, Bhargava, Rohit, additional, Meade, Aidan, additional, and Lyng, Fiona, additional

Published
2016
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31. Clinical Spectroscopy: general discussion

Author

Goodacre, Royston, primary, Sergo, Valter, additional, Barr, Hugh, additional, Sammon, Christopher, additional, Schultz, Zachary D., additional, Baker, Matthew J., additional, Graham, Duncan, additional, Marques, Maria Paula, additional, Sulé-Suso, Josep, additional, Livermore, James, additional, Faulds, Karen, additional, Sinjab, Faris, additional, Matousek, Pavel, additional, Campbell, Colin J., additional, Dluhy, Richard, additional, Gardner, Peter, additional, Phillips, Christopher, additional, Diem, Max, additional, Wood, Bayden, additional, Apolonskiy, Alexander, additional, Kazarian, Sergei, additional, Fullwood, Leanne, additional, Gough, Kathleen, additional, Petrich, Wolfgang, additional, Lloyd, Gavin, additional, Ibrahim, Ola, additional, Cinque, Gianfelice, additional, Sockalingum, Ganesh Dhruvananda, additional, Stone, Nick, additional, Kendall, Catherine, additional, McAughtrie, Sarah, additional, Perez-Guaita, David, additional, Clark, Louise, additional, Gerwert, Klaus, additional, Bonifacio, Alois, additional, Notingher, Ioan, additional, Lasch, Peter, additional, Bhargava, Rohit, additional, Lepert, Guillaume, additional, Mader, Kerstin, additional, and Paterson, Carl, additional

Published
2016
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32. Biofluids and other techniques: general discussion

Author

Goodacre, Royston, primary, Baker, Matthew J., additional, Graham, Duncan, additional, Schultz, Zachary D., additional, Diem, Max, additional, Marques, Maria Paula, additional, Cinque, Gianfelice, additional, Vernooij, Robbin, additional, Sulé-Suso, Josep, additional, Byrne, Hugh J., additional, Faulds, Karen, additional, Hermes, Michael, additional, Fleming, Holly, additional, Bonifacio, Alois, additional, Dluhy, Richard, additional, Gardner, Peter, additional, El-Mashtoly, Samir, additional, Wood, Bayden, additional, Gough, Kathleen, additional, Fornasaro, Stefano, additional, Kazarian, Sergei, additional, Jamieson, Lauren, additional, Petrich, Wolfgang, additional, Sockalingum, Ganesh Dhruvananda, additional, Stone, Nick, additional, Kendall, Catherine, additional, Sinjab, Faris, additional, Haris, Parvez, additional, Subaihi, Abdu, additional, Remiszewski, Stan, additional, Hellwig, Petra, additional, Sergo, Valter, additional, Gerwert, Klaus, additional, Phillips, Christopher, additional, and Campbell, Colin J., additional

Published
2016
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33. Evaluation of peroxidative stress of cancer cells in vitro by real-time quantification of volatile aldehydes in culture headspace.

Author

Shestivska, Violetta, Rutter, Abigail V., Sulé‐Suso, Josep, Smith, David, and Španěl, Patrik

Subjects
CANCER cells, OXIDATIVE stress, PEROXIDATION, ALDEHYDES, VOLATILE organic compounds, CELL membranes
Abstract

Rationale Peroxidation of lipids in cellular membranes results in the release of volatile organic compounds (VOCs), including saturated aldehydes. The real-time quantification of trace VOCs produced by cancer cells during peroxidative stress presents a new challenge to non-invasive clinical diagnostics, which as described here, we have met with some success. Methods A combination of selected ion flow tube mass spectrometry (SIFT-MS), a technique that allows rapid, reliable quantification of VOCs in humid air and liquid headspace, and electrochemistry to generate reactive oxygen species (ROS) in vitro has been used. Thus, VOCs present in the headspace of CALU-1 cancer cell line cultures exposed to ROS have been monitored and quantified in real time using SIFT-MS. Results The CALU-1 lung cancer cells were cultured in 3D collagen to mimic in vivo tissue. Real-time SIFT-MS analyses focused on the volatile aldehydes: propanal, butanal, pentanal, hexanal, heptanal and malondialdehyde (propanedial), that are expected to be products of cellular membrane peroxidation. All six aldehydes were identified in the culture headspace, each reaching peak concentrations during the time of exposure to ROS and eventually reducing as the reactants were depleted in the culture. Pentanal and hexanal were the most abundant, reaching concentrations of a few hundred parts-per-billion by volume, ppbv, in the culture headspace. Conclusions The results of these experiments demonstrate that peroxidation of cancer cells in vitro can be monitored and evaluated by direct real-time analysis of the volatile aldehydes produced. The combination of adopted methodology potentially has value for the study of other types of VOCs that may be produced by cellular damage. [ABSTRACT FROM AUTHOR]

Published
2017
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34. Spectropathology for the next generation: Quo vadis?

Author

Byrne, Hugh J., primary, Baranska, Malgorzata, additional, Puppels, Gerwin J., additional, Stone, Nick, additional, Wood, Bayden, additional, Gough, Kathleen M., additional, Lasch, Peter, additional, Heraud, Phil, additional, Sulé-Suso, Josep, additional, and Sockalingum, Ganesh D., additional

Published
2015
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35. Using Fourier transform IR spectroscopy to analyze biological materials

Author

Baker, Matthew J., Trevisan, Júlio, Bassan, Paul, Bhargava, Rohit, Butler, Holly J., Dorling, Konrad M., Fielden, Peter R., Fogarty, Simon W., Fullwood, Nigel J., Heys, Kelly A., Hughes, Caryn, Lasch, Peter, Martin-Hirsch, Pierre L., Obinaju, Blessing, Sockalingum, Ganesh D., Sulé-Suso, Josep, Strong, Rebecca, Walsh, Michael J., Wood, Bayden R., Gardner, Peter, Martin, Francis L., Baker, Matthew J., Trevisan, Júlio, Bassan, Paul, Bhargava, Rohit, Butler, Holly J., Dorling, Konrad M., Fielden, Peter R., Fogarty, Simon W., Fullwood, Nigel J., Heys, Kelly A., Hughes, Caryn, Lasch, Peter, Martin-Hirsch, Pierre L., Obinaju, Blessing, Sockalingum, Ganesh D., Sulé-Suso, Josep, Strong, Rebecca, Walsh, Michael J., Wood, Bayden R., Gardner, Peter, and Martin, Francis L.

Abstract

IR spectroscopy is an excellent method for biological analyses. It enables the nonperturbative, label-free extraction of biochemical information and images toward diagnosis and the assessment of cell functionality. Although not strictly microscopy in the conventional sense, it allows the construction of images of tissue or cell architecture by the passing of spectral data through a variety of computational algorithms. Because such images are constructed from fingerprint spectra, the notion is that they can be an objective reflection of the underlying health status of the analyzed sample. One of the major difficulties in the field has been determining a consensus on spectral pre-processing and data analysis. This manuscript brings together as coauthors some of the leaders in this field to allow the standardization of methods and procedures for adapting a multistage approach to a methodology that can be applied to a variety of cell biological questions or used within a clinical setting for disease screening or diagnosis. We describe a protocol for collecting IR spectra and images from biological samples (e.g., fixed cytology and tissue sections, live cells or biofluids) that assesses the instrumental options available, appropriate sample preparation, different sampling modes as well as important advances in spectral data acquisition. After acquisition, data processing consists of a sequence of steps including quality control, spectral pre-processing, feature extraction and classification of the supervised or unsupervised type. A typical experiment can be completed and analyzed within hours. Example results are presented on the use of IR spectra combined with multivariate data processing.

Published
2014

46. Vibrational spectroscopy differentiates between multipotent and pluripotent stem cells

Author

Pijanka, Jacek Klaudiusz, primary, Kumar, Deepak, additional, Dale, Tina, additional, Yousef, Ibraheem, additional, Parkes, Gary, additional, Untereiner, Valérie, additional, Yang, Ying, additional, Dumas, Paul, additional, Collins, David, additional, Manfait, Michel, additional, Sockalingum, Ganesh Dhruvananda, additional, Forsyth, Nicholas Robert, additional, and Sulé-Suso, Josep, additional

Published
2010
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47. FTIR microspectroscopy of stained cells and tissues. Application in cancer diagnosis

Author

Pijanka, Jacek K., primary, Stone, Nicholas, additional, Cinque, Gianfelice, additional, Yang, Ying, additional, Kohler, Achim, additional, Wehbe, Katia, additional, Frogley, Mark, additional, Parkes, Gary, additional, Parkes, Joanne, additional, Dumas, Paul, additional, Sandt, Christophe, additional, Pittius, Daniel G. van, additional, Douce, Gillian, additional, Sockalingum, Ganesh D., additional, and Sulé-Suso, Josep, additional

Published
2010
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