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The crime of corruption in Indonesia is regulated by Law Number 31 Year 1999 on the Eradication of Corruption, which was later updated by Law Number 20 Year 2001. This research aims to legally discuss the application of death penalty and asset forfeiture in corruption cases, by considering the principle of justice. The research uses a normative juridical method, in which data is collected from various applicable legal regulations, and the results are presented descriptively-analytically. Although the death penalty is regulated in Indonesian positive law, until now its implementation in corruption cases has never been realized. As a result, the applicable law has not fully provided an adequate sense of justice for the state and the people harmed by acts of corruption. On the other hand, the Asset Forfeiture Bill (RUU) as an effort to recover state losses has been proposed. Asset forfeiture as an additional criminal offense is already regulated in Article 10 letter (b) of the Criminal Code. While the death penalty is the main punishment, both have different implementation procedures, but both aim to realize justice. Both the death penalty and asset forfeiture are expected to have a deterrent effect on perpetrators of corruption and reduce the number of corruption crimes in Indonesia.

Perumdam Tirta Siak Pekanbaru (PDAM) is a local government company responsible for the management and fulfillment of water needs. PDAM currently uses information technology to provide excellent service to customers. The Institute of Directors Report explains that a company has good IT governance if it focuses on risk management and resource management, value fulfillment, and strategic alignment. The level of IT capability in supporting the company's performance can be known through evaluation activities on the current IT implementation. Evaluation is important to determine the level of IT capability in supporting company performance in accordance with the objectives. Thus, this study aims to evaluate information technology governance through an analysis process using the COBIT 2019 framework and the ISO/IEC 27001 standard with process objectives APO14 - Managed Data and BAI06 - Managed IT Changes. The results showed that the current level of IT implementation capability in objective APO14 - Managed Data and BAI06 - Managed IT Changes is at level 2, namely the process has been running but there are still a number of activities that have not been carried out properly. There is a gap between the current capability level and the desired capability level of 1 level (APO14) and 2 levels (BAI06). Thus, 15 improvement recommendations are proposed that refer to the ISO / IEC 27001 standard to create IT governance that is effective, efficient and aligned with company goals.

Meatballs are a popular food in Indonesia. Vegetable meatballs (VM) are not as popular as meatballs. The utilization of soy protein isolate (SPI) in vegetable meatballs is expected to improve the functional quality of the meatballs. SPI is useful as a source of essential amino acids the body needs. SPI acts as a binder and gelling agent during processing and improves emulsion stability. This study aims to investigate the use of soy protein isolate in making vegetable meatballs (VM) and its effect on sensory and characteristic properties. The treatment material in this study was the use of SPI in meatball dough as a substitute for meat. The study used a completely randomized design (CRD) consisting of five treatments, namely the ratio of tapioca flour and SPI with treatments (VM0) 100:0%, (VM1) 80:20%, (VM2) 70:30%, (VM3) 60:40% and (VM4) 50:50% and analyzed triplicate. The investigated parameters of this investigation were: volume, weight, bulk density, cooking yield, water retention, proximate, and sensory evaluation. The results showed that using SPI 30% by weight of starch gave the best results. The value of the volume expansion ratio is 1.52 ml/ml, water reabsorption is 308.20%, bulk density is 0.64 g/ml, cooking yield is 218.84 %, and moisture retention is 227.54%. Crude protein content 29.417%. The preference score of vegetable meatballs is quite good, which is between 4 to 4.5 for color, aroma, and elasticity, while for taste and aroma, it is an average of 3.5. Although it is still lower than meatballs, vegetable meatballs provide a choice of healthy meatballs. It is expected that the results of this study will be able to produce VM that contains high vegetable protein and lower prices.

Abstract Background Typhoid fever is commonly found until today, especially in developing countries. It has fatal complications and measures must be taken to reduce the incidence of typhoid. Vaccinations are a key factor in prevention. This is a phase II randomized observer-blind clinical trial on a novel Vi-DT conjugate vaccine on 200 subjects 12 to 40 years of age. Methods Subjects were screened for eligibility after which a blood sample was taken and one dose of vaccine was administered. Investigational vaccine used was Vi-DT and control was Vi-PS. Twenty-eight days after vaccination, subjects visited for providing blood sample to assess immunogenicity and were asked about local and systemic adverse reactions that occurred in the first 28 days. Results Subjects had minor adverse reactions. Pain was the most common local reaction. Muscle pain was the most common systemic reaction. There were no serious adverse events up to 28 days post vaccination. Seroconversion rates were 100% in the Vi-DT group and 95.96% in the Vi-PS group. Post vaccination GMTs were increased in both groups but it was significantly higher in the Vi-DT group (p

Diseases in chili plants often cause farmers to experience crop failure. Diseases that are often encountered are leaf spot disease, wilt disease, and anthracnose disease caused by fungi. Therefore, farmers are trying to prevent and reduce the disease by using pesticides. The use of pesticides in agriculture plays a role in preventing and reducing diseases in chili plants. Pesticides for chili plants are quite widely spread on the market and have the advantages of each product offered to farmers, so farmers must be more careful and understanding in choosing pesticides to be used in preventing chili plant diseases. For that we need a decision support system (SPK). The purpose of this research is to apply the MAUT method in SPK which can help chili farmers in selecting pesticides. The data used in this study are 10 types of pesticides as an alternative. While the criteria consist of price, classification, number of diseases eradicated, method of action, shelf life, and formulation concentration. Data analysis uses the MAUT method with the steps of forming a decision matrix, normalizing the decision matrix, determining the utility matrix, calculating the final utility, and ranking. The research results obtained for the three best pesticides are Tridex 80 WP, Ziflo 76 WG, and Cabriotop 60 WG.

Crackers are a popular food consumed by Indonesian people as a side dish or as a snack. The quality of crackers is determined by their swelling power, crunchiness, taste and nutritional value. Crackers are generally made from tapioca flour, so the protein component is low. Therefore, this research utilized soy protein isolate which was added to tapioca and rice dough ingredients to increase the protein content of crackers. The aim of the research is to find the best formula for adding soy protein isolate and thick slices to produce crackers that contain high protein. The research method was experimental, the first treatment factor was the addition of soy protein isolate to the tapioca flour and rice mixture. The second factor is the thickness of the cracker slices. The treatment design was a Completely Randomized Design (CRD) with a 4 X 4 factorial pattern which was repeated 3 times. The research results showed that the interaction effect between the use of soy protein isolate in dough with various slice thicknesses resulted in significant differences in the swellability of crackers, frying time and oil absorption capacity. The average sensory properties of crackers added with soy protein isolate were favorable at a slice thickness of 1mm-1.5mm. The conclusion is that the best formula for making crackers made from tapioca flour and rice is to use 5% to 7.5% soy protein isolate, and the thickness of the cracker slices is 1mm – 1.5mm.

Introduction. Psychological disorders are closely associated with hormonal factors, including cortisol and serotonin. In patients with acute coronary syndrome (ACS), autonomic dysfunction and dysregulation of the hypothalamic-pituitaryadrenal (HPA) axis can occur, leading to an increase in cortisol levels that may worsen the prognosis of ACS patients. Therefore, it is important to understand the hormonal impact, namely cortisol and serotonin levels, on depressive symptoms, which will be examined in this study. Methods. This was a cross-sectional study to determine the impact of cortisol and serotonin in the incidence of depression in post-treatment ACS patients at the ICCU RSUPN dr. Cipto Mangunkusumo, Jakarta. Data collection from patients meeting the inclusion criteria was carried out 10-14 days post-treatment through interviews, HADS questionnaire completion, physical examinations, and laboratory tests. The Mann-Whitney test was used to examine the differences between serotonin and salivary cortisol levels in patients with and without depression. Results. Among the 73 ACS patients included in this study, the average age was 57.53 (9.97) years, with 68.5% was male. Posttreatment depression was observed in 15.1% of subjects. The median serotonin levels were lower in patients with depression [175 (147 – 227.64) ng/mL vs. 189.31 (152.87-235.44) ng/mL], while cortisol levels were higher in patients with depression [3.09 (1.46-6.26) ng/mL vs. 2.15 (0.92-3.91) ng/mL]. However, the statistical analysis showed no significant differences between plasma serotonin and depression (p=0.482) or saliva cortisol and depression (p=0.275). Conclusions. There were no significant differences in cortisol and serotonin levels concerning depressive symptoms among post-acute coronary syndrome patients. Nevertheless, this study holds clinical importance due to the observed lower plasma serotonin levels and higher saliva cortisol levels in ACS patients with depression.

Influenza is a prevalent health issue encountered in daily practice. Patients with diabetes mellitus face a higher risk of infections, including influenza, owing to the compromised immune system associated with diabetes. This susceptibility arises from the potential of diabetes mellitus to weaken the immune system. Moreover, elevated blood glucose levels can create a conducive environment for the growth of bacteria and viruses. This consensus is formulated by a multidisciplinary team to serve as practical guidance for the administration of influenza vaccinations to patients with diabetes mellitus in daily practice.

Perpustakaan sekolah harus diakreditasi dengan tujuan untuk meningkatkan kualitas perpustakaan. Dinas Perpustakaan dan Kearsipan Kota Pekanbaru (DISPUSIP) dalam menentukan suatu perpustakaan sekolah yang layak untuk diakreditasi masih dilakukan secara manual. Untuk itu diperlukan suatu sistem pendukung keputusan (SPK). Penelitian ini menggunakan metode SMART. Alternatif yang digunakan adalah sembilan (9) sekolah jenjang SMP baik negeri maupun swasta. Kriteria yang digunakan mengacu pada instrument akreditasi perpustakaan sekolah yang dikeluarkan oleh Perpustakaan Nasional (Perpusnas) terdiri dari enam (6) kriteria yaitu koleksi, sarana dan prasarana perpustakaan, pelayanan perpustakaan, tenaga perpustakaan, penyelenggaraan dan pengelolaan perpustakaan, serta penguat. Hasil penelitian yang diperoleh untuk perpustakaan SMP adalah Sek 4, Sek 5 dan Sek 3 yang layak untuk diakreditasi

The creative sector is one of the most rapidly growing sectors of the global economy. This sector can also play an important role in providing economic benefits for developing countries. Promoting the creative economy needs a better understanding of the underlying factors that account for its spatial distribution. One of the most important factors that may influence the development of creative industries is tolerance. This paper focuses on the spatial distribution of the creative economy across cities in Indonesia and examines its relationship with tolerance. The main data sources of this paper are the unique data produced by the Central Bureau of Statistics (Badan Pusat Statistik or BPS) and the Indonesian Agency for Creative Economy (Badan Ekonomi Kreatif or BEKRAF), in addition to the City Tolerance Index provided by the SETARA Institute. The study finds that the creative economy in Indonesia does not tend to have a high spatial concentration, indicating that cities in Indonesia have an opportunity to develop the creative economy. The analysis confirms that tolerance matters for the creation of the creative economy in Indonesia. Three components of the City Tolerance Index that influence the creative economy are the Mid-Term Regional Development Plan, discriminatory regional rules and incidents of abuses against the freedom of religion or belief. The size of the population, the Human Development Index, and the status of a city as the provincial capital play a significant role in explaining the distribution of creative economies across the cities in Indonesia.

School libraries should be accredited with the aim of improving the quality of libraries. Pekanbaru City Library and Archives Service (DISPUSIP) in determining a school library that deserves to be accredited is still done manually, namely DISPUSIP went directly to the field to monitoring the library in the school and the data collection still used manual entries. Meanwhile, a lot of data must be collected, causing the data to be inaccurate and take a long time. For this reason, a decision support system (DSS) is needed. The data used are nine junior high schools both public and private as an alternative. While the criteria refer to the school library accreditation instrument issued by the National Library (Perpusnas) consisting of six criteria, namely collections, library facilities and infrastructure, library services, library staff, library administration and management, and reinforcement. Data analysis using the TOPSIS method by steps of determining the decision matrix, normalization matrix, calculating both positive and negative ideal solutions, calculating the distance to the ideal solution, calculating preference values, and ranking. The results obtained for the SMP library are Sek 4, Sek 1 and Sek 5 which are eligible for accreditation.

Background: The COVID-19 pandemic has led to high mortality rates. There have been reports of hypersensitivity reactions with mild to severe symptoms. The COVID-19 vaccine provocation test is a vaccination protocol for individuals with a history of hypersensitivity. This study aims to determine the benefits of COVID-19 vaccine provocation tests in patients with a history of hypersensitivity reactions to COVID-19 vaccines and its influencing factors. Objective: To determine the incidence, severity, outcome of hypersensitivity reactions, and success of the COVID-19 vaccine provocation test. Methods: A retrospective cohort study was conducted, using subjects taken from medical record data at the RSCM who had received COVID-19 vaccination with a history of hypersensitivity. Data was taken from the COVID-19 vaccination records at the RSCM, BPJS Health Primary Care application. Results: From a total of 29,036 doses of the COVID-19 vaccine, 44 patients experienced hypersensitivity reactions. As many as 38.64% did not continue vaccination, 2.27% experienced mild hypersensitivity, and 59.44% were successfully vaccinated. Conclusions: People with a history of hypersensitivity reactions to COVID-19 vaccines can still receive subsequent COVID-19 vaccinations at healthcare facilities equipped with anaphylaxis kits and immunology allergists.

Background: COVID-19 is one of the most devastating pandemics of the 21st century. Vaccination is one of the most effective prevention methods in combating COVID-19, and one type of vaccine being developed was the protein subunit recombinant vaccine. We evaluated the efficacy of the CoV2-IB 0322 vaccine in Depok, Indonesia. Methods: This study aimed to assess the humoral and cellular immune response of the CoV2-IB 0322 vaccine compared to an active control vaccine (COVOVAX™ Vaccine). A total of 120 subjects were enrolled and randomized into two groups, with 60 subjects in each group. Participants received either two doses of the CoV2-IB 0322 vaccine or two doses of the control vaccine with a 28-day interval between doses. Safety assessments were conducted through onsite monitoring and participant-reported adverse events. Immunogenicity was evaluated by measuring IgG anti-RBD SARS-CoV-2 and IgG-neutralizing antibodies. Cellular immunity was assessed by specific T-cell responses. Whole blood samples were collected at baseline, 14 days, 6 months, and 12 months after the second dose for cellular immunity evaluation. Results: Both vaccines showed high seropositive rates, with neutralizing antibody and IgG titers peaking 14 days after the second dose and declining by 12 months. The seroconversion rate of anti-S IgG was 100% in both groups, but the rate of neutralizing antibody seroconversion was lower in the CoV2-IB 0322 vaccine group at 14 days after the second dose (p = 0.004). The CoV2-IB 0322 vaccine showed higher IgG GMT levels 6 and 12 months after the second dose (p < 0.001 and p = 0.01). T-cell responses, evaluated by IFN-γ, IL-2, and IL-4 production by CD4+ and CD8+ T-cells, showed similar results without significant differences between both groups, except for %IL-2/CD4+ cells 6 months after the second dose (p = 0.038). Conclusion: Both vaccines showed comparable B- and T-cell immunological response that diminish over time.

Influenza is known to worsen cardiovascular events in patients with a history of coronary heart disease. However, the effectiveness of influenza vaccination in reducing hospitalization due to cardiovascular disease is not clearly known. We aim to determine the effect of influenza vaccination on hospitalization rates due to cardiovascular disease in patients with a history of coronary heart disease. Relevant literature was searched on four electronic databases: MEDLINE, EMBASE, SCOPUS, and Cochrane Library, using predetermined keywords. Critical review of the studies was done using the Center of Evidence Based Medicine (CEBM) University of Oxford assessment tool. The search yielded six articles, and critical review was done based on validity, importance, and applicability. Three studies showed that influenza vaccination in patients with coronary heart disease would reduce hospitalization rates due to cardiovascular disease within 12 months after vaccination. Three studies did not show any effect of influenza vaccination on hospitalization rates due to cardiovascular disease. The samples in the three studies that found a protective effect of the influenza vaccine were older and at higher risk of experiencing cardiovascular events. Based on our review, we conclude that influenza vaccination can be given to prevent hospitalization due to cardiovascular disease in patients with a history of coronary heart disease, especially in high-risk patients.

Newly emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are continuously posing high global public health concerns and panic resulting in waves of coronavirus disease 2019 (COVID-19) pandemic. Depending on the extent of genomic variations, mutations and adaptation, few of the variants gain the ability to spread quickly across many countries, acquire higher virulency and ability to cause severe disease, morbidity and mortality. These variants have been implicated in lessening the efficacy of the current COVID-19 vaccines and immunotherapies resulting in break-through viral infections in vaccinated individuals and recovered patients. Altogether, these could hinder the protective herd immunity to be achieved through the ongoing progressive COVID-19 vaccination. Currently, the only variant of interest of SARS-CoV-2 is Omicron that was first identified in South Africa. In this review, we present the overview on the emerging SARS-CoV-2 variants with a special focus on the Omicron variant, its lineages and hybrid variants. We discuss the hypotheses of the origin, genetic change and underlying molecular mechanism behind higher transmissibility and immune escape of Omicron variant. Major concerns related to Omicron including the efficacy of the current available immunotherapeutics and vaccines, transmissibility, disease severity, and mortality are discussed. In the last part, challenges and strategies to counter Omicron variant, its lineages and hybrid variants amid the ongoing COVID-19 pandemic are presented.

Penggunaan pestisida dalam bidang pertanian cukup berperan dalam mencegah dan mengurangi penyakit pada tanaman cabai. Pestisida untuk tanaman cabai cukup banyak tersebar di pasaran dan memiliki keunggulan masing-masing produk yang ditawarkan kepada petani, sehingga para petani harus lebih teliti dan memahami dalam memilih pestisida yang akan digunakan dalam mencegah penyakit tanaman cabai. Untuk itu diperlukan sistem pendukung keputusan (SPK). Data yang digunakan dalam penelitian in ada 10 jenis pestisida sebagai alternatif. Sedangkan kriteria ditentukan berdasarkan dari dinas pertanian dan pangan yaitu harga, klasifikasi, jumlah penyakit yang dibasmi, cara kerja, daya tahan simpan, dan konsentrasi formulasi. Analisa data menggunakan metode MOORA untuk mendukung pengambilan keputusan bagi petani dalam memberikan penilaian terhadap pestisida terbaik pada tanaman cabai. Hasil penelitian yang diperoleh untuk tiga pestisida terbaik adalah Tridex 80 WP, Lamzeb 85 WP, dan Ziflo 76 WG

Good pedagogical and professional competence of teachers will have implications for the graduates produced. The learning process of Islamic education that is in accordance with the standards and also taught by professional teachers will have implications for the quality of Islamic religious education learning itself. Currently, research on the learning process of Islamic religion that is in accordance with the standards, namely taught by professional teachers, has not been widely studied. Therefore, in this study, researchers were interested in discussing these issues precisely in the MTsN 3 East Aceh. The research method used was descriptive qualitative research. In collecting data, researchers conducted observations and interviews with five participants. The collected data were analyzed using interactive data analysis techniques. The results showed that Islamic education teachers at MTsN 3 East Aceh have met the criteria for pedagogical competence and are included in the category of professional teachers.

Penilaian kinerja karyawan di rumah sakit Permata Hati Duri dilakukan setiap bulan. Kriteria penilaian terdiri dari kompetensi, profesionalisme, komunikasi, manajemen, dan keramahan. Metode yang digunakan adalah metode VIKOR. Adapun data yang digunakan adalah 10 data karyawan sebagai alternatif. Hasil akhir adalah sistem memberikan rekomendasi penilaian karyawan untuk lima orang dengan urutan AJ, AD, AH, AI dan AA.

Introduction. Major depression criteria can be found in more than 20% of coronary heart patients and more than 30% acute coronary syndrome patients have significant depressive symptoms. Several studies have shown that reduction of hearth rate variability (HRV) and enhancement of neutrophil lymphocyte ratio (NLR) can cause enhancement of morbidity and mortality in myocardial infarction patients. On the other hand, depression can cause reduction of HRV, enhancement of NLR and reduction of quality of life. This study aimed to determine differences in HRV, NLR and quality of life between acute myocardial infarction (AMI) patients with depressive symptoms and AMI patients without depressive symptoms. Methods. A cross-sectional study was conducted among AMI patients who were treated during the period of March to July 2021 at the Intensive Cardiac Care Unit (ICCU) Cipto Mangunkusumo Hospital Jakarta. Samples were taken consecutively until the amount of sample is met. Data were analyzed using unp aired T test. Results. There was a total of 46 subjects AMI patients in this study, ten subjects with depressive symptoms and 36 subjects without depressive symptoms. From the analysis, it was found that AMI patients with depressive symptoms had lower standard deviation normal to normal (SDNN) average (p=0.447), lower low frequency/high frequency (LF/HF) (p=0.323), and higher NLR average (p=0.438) than AMI patients without depressive symptom, although it was not statistically significant. Analysis showed that the mean value of SF36 total scores (p

This study investigates a Wi-Fi-based indoor navigation system to determine building locations. The system was developed using the fingerprint method from the Received Signal Strength Indication (RSSI) of each Access Point (AP). The main components of a smartphone-based system use data from Wi-Fi and the Global Positioning System (GPS). The system developed for navigation is designed and implemented as an element of a dynamic, seamless mobility planning and building location route guidance application. Building map data is collected from Google Map data and enhanced by coloring the geographic location of buildings displayed on mobile devices. Navigational aids collected from sensors provide trip orientation and position updates. The approach of measuring the distance between known positions is compared to those displayed in the application with the haversine formula to measure the accuracy of the position displayed. A series of experiments were conducted in the Politeknik Negeri Semarang area, Indonesia. The experiment results showed that the Wi-Fi-based indoor positioning system was accurate within 7.050 meters of the error for that location, thus proving the system's usefulness for determining the location of buildings in the campus area. The measurement has not adopted the maximum APs placement for signal coverage and strength, only using the existing APs positions. The temperature nor humidity was neither measured in each area where the AP was installed, which is discussed later. This system can help visitors without asking, even though they have only visited once.

Kantor Wali Nagari Simpang memiliki proposal kegiatan desa. Penilaian proposal dilakukan secara langsung ke lapangan dan dilakukan secara manual, sehingga menungkinkan terjadinya kesalahan. Untuk itu diperlukan sistem pendukung keputusan menggunakan metode VIKOR. Hasil akhir dari lima proposal yang diajukan dengan kriteria yang ditentukan, memberikan rekomendasi bahwa proposal Jembatan Kp. Batuang - Bukik Putuih merupakan proposal terbaik dan layak untuk didanai

This study aims to analyze the substance of the Covid-19 vaccine certificate policy as an administrative requirement in Jambi City and the regional government’s authority in enforcing the Covid-19 vaccine certificate policy in Jambi City. This study uses an empirical legal approach with a descriptive research type. Data collection techniques using interviews, observation, and documentation. Source of data used in the form of primary data and secondary data. The data that has been obtained is analyzed systematically. The results of the study show that the Covid-19 vaccine certificate policy as an administrative requirement for entering public places regulated through the Mayor of Jambi Circular Letter Number PW.01/441/DPK/2021 must be pursued into a Regional Regulation so that the substance has strong binding power. The Regional Government of Jambi City in enforcing the Covid-19 vaccine certificate policy has the authority to disseminate information to the community and carry out a real monitoring function as a means to evaluate the performance of implementing the Covid-19 vaccine certificate in public places or public spaces.

Abstract Background People living with HIV (PLHIV) have higher risk of COVID-19 infection and mortality due to COVID-19. Health professionals should be able to assess PLHIV who are more likely to develop severe COVID-19 and provide appropriate medical treatment. This study aimed to assess clinical factors associated with COVID-19 severity and developed a scoring system to predict severe COVID-19 infection among PLHIV. Methods This retrospective cohort study evaluated PLHIV at four hospitals diagnosed with COVID-19 during the first and second wave COVID-19 pandemic in Indonesia. The independent risk factors related to the severity of COVID-19 were identified with multivariate logistic regression. Results 342 PLHIV were diagnosed with COVID-19, including 23 with severe-critical diseases. The cumulative incidence up to December 2021 was 0.083 (95% CI 0.074–0.092). Twenty-three patients developed severe-critical COVID-19, and the mortality rate was 3.2% (95% CI 1.61%–5.76%). Having any comorbidity, CD4 count of

Background and purpose: Flavonoids are a group of phytochemicals found abundantly in various plants. Scientific evidence has revealed that flavonoids display potential biological activities, including their ability to alleviate inflammation. This activity is closely related to their action in blocking the inflammatory cascade and inhibiting the production of pro-inflammatory factors. However, as flavonoids typically have poor bioavailability and pharmacokinetic profile, it is quite challenging to establish these compounds as a drug. Nevertheless, progressive advancements in drug delivery systems, particularly in nanotechnology, have shown promising approaches to overcome such challenges. Review approach: This narrative review provides an overview of scientific knowledge about the mechanism of action of flavonoids in the mitigation of inflammatory reaction prior to delivering a comprehensive discussion about the opportunity of the nanotechnology-based delivery system in the preparation of the flavonoid-based drug. Key results: Various studies conducted in silico, in vitro, in vivo, and clinical trials have deciphered that the anti-inflammatory activities of flavonoids are closely linked to their ability to modulate various biochemical mediators, enzymes, and signalling pathways involved in the inflammatory processes. This compound could be encapsulated in nanotechnology platforms to increase the solubility, bioavailability, and pharmacological activity of flavonoids as well as reduce the toxic effects of these compounds. Conclusion: in Summary, we conclude that flavonoids and their derivates have given promising results in their development as new anti-inflammatory drug candidates, especially if they formulate in nanoparticles.

Patchouli growers in Indonesia were constrained by detrimentally systemic diseases caused by viruses. Potyvirus and Fabavirus were pathogenic viruses that commonly found in several production centers. Virus elimination for retaining healthy protocols was investigated and one of the promising methods through mersitem culture and antiviral treatments. The research was conducted to find out the effects of ribavirin treatments following meristem culture on the existence of Potyvirus and Fabavirus on the infected patchouli plants. The research was conducted at The Indonesian Spices and Medicinal Research Institute from September 2018 to August 2019. A factorial experiment with 10 replications established to facilitate the combination of two factors. The first factor was two commercial patchouli cultivars, namely Patchoulina 1 and Patchoulina 2. While the second factor dealt with the concentration of ribavirin i.e. 0, 5, 10, 15 and 20 ppm. The results showed that the potyvirus was still detected based on ELISA analysis after the treatments of meristem culture and ribavirin in any concentrations. However, the application ribavirin at 20 ppm following meristem culture effectively eliminated fabavirus form both the tested patchouli cultivars. These partial virus elimination within the plantlet gave significant growth improvement on plantlet height, number of leaves and number of auxiliary shoots after 8 weeks subculture.

An infectious respiratory disease called Covid-19 is brought on by the SARS-CoV-2 virus. It is thought that the rare Covid-19 Omicron variant is a global epidemic since it is disseminating so swiftly and broadly. It is essential that the community receives timely and accurate information on Covid -19. Because handwritten reports in Excel format are still used for Covid-19 patient data collection, it is difficult to reliably and effectively gather data. Comprehensive and in-depth Covid-19 data will be provided for the Cileungsi sub-district in the Bogor Regency as part of this project. The prototype approach was chosen for this study because it provides a method for quickly and gradually developing apps and allows user-direct evaluation. Since Leaflet can be trusted to display data in the form of a spatial map and its attributes, it will be utilized to build the application. The use of the MySQL database will significantly aid in the storage of map data in the form of spatial and other general data. The software will be simpler to use for the general public if data is displayed in a user-friendly, interactive, real-time GIS map format.

Perpustakaan sekolah harus diakreditasi dengan tujuan untuk meningkatkan kualitas perpustakaan. Dinas Perpustakaan dan Kearsipan Kota Pekanbaru (DISPUSIP) dalam menentukan suatu perpustakaan sekolah yang layak untuk diakreditasi masih dilakukan secara manual, yaitu DISPUSIP turun langsung ke lapangan melakukan memonitoring terhadap perpustakaan yang ada di sekolah dan pendataannya masih menggunakan isian manual. Sementara data yang harus dikumpulkan banyak, sehingga menyebabkan datanya kurang akurat serta memerlukan waktu yang lama. Untuk itu diperlukan suatu sistem pendukung keputusan (SPK). Data yang digunakan adalah sembilan sekolah jenjang SMP baik negeri maupun swasta sebagai alternatif. Sedangkan kriteria mengacu pada instrument akreditasi perpustakaan sekolah yang dikeluarkan oleh Perpustakaan Nasional (Perpusnas) terdiri dari enam kriteria yaitu koleksi, sarana dan prasarana perpustakaan, pelayanan perpustakaan, tenaga perpustakaan, penyelenggaraan dan pengelolaan perpustakaan, serta penguat. Analisa data menggunakan metode ARAS. Hasil penelitian adalah Sek 4, Sek 5 dan Sek 2 merupakan perpustakaan sekolah yang layak untuk diakreditasi

Currently, the incidence of metabolic disorders is increasing, setting a challenge to global health. With major advancement in the diagnostic tools and clinical procedures, much has been known in the etiology of metabolic disorders and their corresponding pathophysiologies. In addition, the use of in vitro and in vivo experimental models prior to clinical studies has promoted numerous biomedical breakthroughs, including in the discovery and development of drug candidates to treat metabolic disorders. Indeed, chemicals isolated from natural products have been extensively studied as prospective drug candidates to manage diabetes, obesity, heart-related diseases, and cancer, partly due to their antioxidant and anti-inflammatory properties. Continuous efforts have been made in parallel to improve their bioactivity and bioavailability using selected drug delivery approaches. Here, we provide insights on recent progress in the role of inflammatory-mediated responses on the initiation of metabolic disorders, with particular reference to diabetes mellitus, obesity, heart-related diseases, and cancer. In addition, we discussed the prospective role of natural products in the management of diabetes, obesity, heart-related diseases, and cancers and provide lists of potential biological targets for high throughput screening in drug discovery and development. Lastly, we discussed findings observed in the preclinical and clinical studies prior to identifying suitable approaches on the phytochemical drug delivery systems that are potential to be used in the treatment of metabolic disorders.

Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder which causes bradykinin mediated angioedema. Although it can be life threatening, HAE may be underdiagnosed due to a lack of awareness of the disease and limited access to laboratory testing. Here, we report a case of HAE which was diagnosed only after the patient was referred for COVID-19 vaccination even though he had been experiencing recurrent angioedema for the past 30 years.

Laporan keuangan utama yang dihasilkan dari proses akuntansi adalah neraca, laporan rugi-laba, dan juga laporan aliran kas. Neraca dibuat dengan maksud untuk menggambarkan posisi keuangan suatu organisasi pada suatu saat tertentu. Pembiayaan adalah sumber pendapatan bank syariah yang terbesar, namun sekaligus merupakan sumber risiko operasi bisnis yang terbesar, yaitu timbulnya Pembiayaan bermasalah, karena dengan adanya pembiayaan bermasalah bukan saja menurunkan pendapatan bagi bank syariah tetapi juga akan berdampak pada kesehatan bank syariah dan pada akhirnya akan merugikan nasabah penyimpan. profitabilitas bank merupakan kemampuan bank dalam mendapatkan keuntungan dalam suatu periode. rasio “Return On Assets“(ROA) yang dipakai guna mengukur kemampuan bank dalam memperoleh laba dan melakukannya secara efisien secara keseluruhan. Rasio likuiditas sering digunakan dalam dunia perbankan diperoleh dari “Loan to Deposit Ratio” (LDR). Namun “Loan to Deposit Ratio” (LDR) itu sendiri digunakan untuk objek penelitian pada bank konvensional, sedangkan jika bank syariah menggunakan istilah berbeda yaitu “Financing to Deposit Ratio “(FDR).””Non Performing Financing” (NPF) pada bank syariah atau pada bank konvensional disebut “Non Performing Loan (NPL) merupakan rasio keuangan yang berkaitan dengan resiko kredit. Non Performing Financing” (NPF) menunjukan risiko pembiayaan yang akan dihadapi bank akibat dari penyaluran pembiayaan dan investasi dana bank. Capital adequacy ratio digunakan untuk mengukur kemampuan permodalan yang ada untuk menutup kemungkinan kerugian di dalam kegiatan perkreditan dan perdagangan surat-surat berharga.

Abstract Background Saline hydration with addition of mannitol have commonly been the strategy to avoid cisplatin induced acute kidney injury (AKI). While the initial reports demonstrated that mannitol diuresis decreased cisplatin induced renal injury, others have shown renal injury to be worsened. Objective To compare the risk of AKI in cancer patients receiving high dose cisplatin with and without addition of mannitol. Method This was an ambispective cohort study based on consecutive sampling at Cipto Mangunkusumo General Hospital (CMGH) and Mochtar Riady Comprehensive Cancer Centre (MRCCC) Siloam Hospitals. The data was obtained from September 2017 to February 2018. The choice of mannitol administration based on attending physician clinical judgement. The primary outcome was increase of serum creatinine more than 0.3 mg/dL or 1.5 times from baseline. Analysis was done by using univariate, bivariate and multivariate logistic regression to obtain crude risk ratio and adjusted risk ratio of cisplatin induced AKI probability caused by mannitol addition on top of usual saline hydration protocol. Result Data from 110 patients (57.3% male) with a median age of 44.5 years (range 19 to 60 years) were collected; 63 received saline with the addition of mannitol and 47 received saline only. Incidence of AKI were higher in mannitol vs saline only group. Bivariate analysis showed higher probability of post chemotherapy AKI in mannitol group, however it was statistically insignificant (RR 2.168; 95% CI 0.839–5.6; p = 0.094). On multivariate analysis the age adjusted RR was 2.852 (95% CI 0.68–11.96; p = 0.152). Conclusion The addition of mannitol to hydration did not reduce the risk of cisplatin induced AKI as compared with saline hydration only. It was also found that risk for acute kidney injury were higher in population ≥ 40 years old.

Background: High COVID-19 vaccine coverage is essential. Patients who are considered high risk for hypersensitivity reactions and have had an allergic reaction to the COVID-19 vaccine are usually referred to an allergist for assessment of vaccination. Administration of a vaccine graded challenge (also known as a provocation test) is an option that can be considered in this population. This primary objective of this study is to describe the outcome of the COVID-19 vaccine provocation test and to understand the predicting factors associated with hypersensitivity reaction after the provocation test as the secondary objective. Methods: Adult patients with a history of hypersensitivity reaction to the first COVID-19 vaccine and high-allergic patients who underwent COVID-19 vaccine provocation test up until May 2022 were included. A protocol using skin prick test (SPT), intradermal test (IDT), followed by graded challenge was developed for the determined vaccine used. Results: A total of 232 patients were included in the analysis. Twenty-eight had hypersensitivity to their first COVID-19 vaccine dose and 204 were high risk for allergic reaction. Hypersensitivity reactions occurred in 20 patients (8.6%, 95% CI: 5–12.2%), consisting of 4 reactions after SPT, 9 after IDT, 7 during or after titrated challenge. Half of the reactions were mild; however, 3 patients developed severe reactions. Patients with history of anaphylaxis were more likely to experience hypersensitivity reaction after provocation test (aRR = 2.79, 95% CI: 1.05–7.42). Conclusion: Provocation test in COVID-19 vaccination has a high success rate in patients with a history of hypersensitivity to the first COVID-19 vaccine and in high allergic patients. History of anaphylaxis is associated with hypersensitivity reaction after a COVID-19 vaccine provocation test.

Abstract Background Acute myocardial infarction (AMI) is major cardiovascular disease that causes high morbidity and mortality. In AMI, ischemia and necrosis affected some cardiomyocytes leading to a decrease in myocardial contractility which is followed by an acute proinflammation reaction and increased sympathetic tone. Meanwhile, high blood pressure variability (BPV) causing an increased left ventricular workload, heart rate, myocardial oxygen demand and induces proinflamations and endothelial dysfunction. Therefore a high BPV and its associated pathological effects are likely to aggravate the physiological function of the heart and affect the emergence of acute cardiac complications in AMI patients. This study aims to investigate the association’s between short-term BPV and major adverse cardiac events (MACE) in AMI patients. This retrospective cohort study used simple random sampling to identify AMI patients who were hospitalized at Cipto Mangunkusumo National Hospital between January 2018 and December 2019. Mann Withney was performed to investigate the association between BPV and MACE. Results The average systolic BPV value which was calculated as standard deviation (SD) and average real variability (ARV) was higher in the MACE group than in the non-MACE group. Systolic SD and systolic ARV in the MACE group were 13.28 ± 5.41 mmHg and 9.88 ± 3.81 mmHg respectively. In the non-MACE group, systolic SD and systolic ARV were 10.76 (4.59–26.17) mmHg and 8.65 (3.22–19.35) mmHg respectively. There was no significant association between BPV and MACE. However, there were significant differences between systolic SD and systolic ARV in patients with hypertension who experienced MACE and patients without hypertension who experienced MACE. Conclusions The BPV of AMI patients who experience MACE was higher than that of non-MACE AMI patients. There was no significant association between BPV ​​and MACE during the acute phase of AMI.

BackgroundCurrent evidence of interprofessional collaboration suggests the importance of measuring and identifying the current state of the health professions’ interprofessional competencies. Therefore, this study was aimed at measuring the interprofessional competencies of health professionals in the Global South context using the validated CICS29.Materials and methodsThis was a cross-sectional study involving 300 healthcare professionals of a newly established teaching hospital. Prior to the measurement of interprofessional competencies, the 29-items CICS29, which has been translated into Indonesian language, was revalidated using a confirmatory factor analysis (CFA). The 29 items of CICS29 were grouped into six subscales and each item was measured using a 5-point Likert scale. Data on gender, age, type of profession, and the length of working experience was also collected to identify whether discernible differences between grouping variables exists.ResultsPrior to measuring the interprofessional competencies, the validity of the instrument was established. Based on the CFA, the same six-factor model was found in the current study. The Indonesian CICS29 was reliable, with Cronbach alpha values of 0.921 for the whole instrument and that of each subscale ranged between 0.656 and 0.726. The mean total score of CICS29 was 128.53 (out of 145), ranged from 123 to 133.40 obtained by pharmacists and dentists respectively. No significant differences of CICS29 scores were found between grouping variables.ConclusionThe current study has revealed relatively good interprofessional competencies of healthcare professionals working in a newly established teaching hospital in the Global South healthcare context. Measuring the interprofessional competencies serves as baseline for further intervention to nurture and maintain collaborative practice. In addition, the current study has further proven the cross-cultural validity of CICS29, thus appropriate to be utilized in different setting and context.

The focus of this research was to determine the implementation of Pioneer Teaching Campus (PTC) 2020 activities as a forerunner to driving literacy and numeracy learning at elementary schools. The type of this research was qualitative research with a narrative approach. The stages in this narrative research included (1) identification of phenomena to be studied, (2) determining participants allowing researchers to study the phenomena, (3) gathering information (experiences) from participants, (4) retelling information (experiences) from participants, (5) collaborating with participants, and (6) writing narratives based on information (experiences) from participants. The results showed that the implementation of PTC 2020 was very helpful for teachers in target schools, especially in literacy and numeracy learning since it was common for many teachers to be reluctant to carry out literacy and numeracy learning in their classes, even though literacy and numeracy programs had been promoted for a long time. Many factors caused this condition, ranging from age that affected motivation, teachers' understanding of literacy and numeracy learning, to the limited ability of teachers to use technology.

Patients with autoimmune diseases are among the susceptible groups to COVID-19 infection because of the complexity of their conditions and the side effects of the immunosuppressive drugs used to treat them. They might show impaired immunogenicity to COVID-19 vaccines and have a higher risk of developing COVID-19. Using a systematic review and meta-analysis, this research sought to summarize the evidence on COVID-19 vaccine efficacy, immunogenicity, and safety in patients with autoimmune diseases following predefined eligibility criteria. Research articles were obtained from an initial search up to 26 September 2022 from PubMed, Embase, EBSCOhost, ProQuest, MedRxiv, bioRxiv, SSRN, EuroPMC, and the Cochrane Center of Randomized Controlled Trials (CCRCT). Of 76 eligible studies obtained, 29, 54, and 38 studies were included in systematic reviews of efficacy, immunogenicity, and safety, respectively, and 6, 18, and 4 studies were included in meta-analyses for efficacy, immunogenicity, and safety, respectively. From the meta-analyses, patients with autoimmune diseases showed more frequent breakthrough COVID-19 infections and lower total antibody (TAb) titers, IgG seroconversion, and neutralizing antibodies after inactivated COVID-19 vaccination compared with healthy controls. They also had more local and systemic adverse events after the first dose of inactivated vaccination compared with healthy controls. After COVID-19 mRNA vaccination, patients with autoimmune diseases had lower TAb titers and IgG seroconversion compared with healthy controls.

Introduction: Roselle (Hibiscus sabdariffa L.) calyces possess natural antioxidants that may provide therapeutic benefits. This study aimed to investigate the protective effects of Roselle calyx water extract against isoniazid (INH) and rifampicin (RIF) induced liver and renal toxicities.Methods: Male Wistar rats (150-250 g) were designated into five groups: control group, INH-RIF group that was treated with INH-RIF at the toxic doses (50-100 mg/kg for 4 weeks, followed by 100-200 mg/kg for 2 weeks), and Roselle groups that were treated daily with Roselle extract at the doses 62.5, 125, and 250 mg/kg, respectively prior to INH-RIF administration. Blood samples were withdrawn weekly for 6 weeks before removing rats’ livers and kidneys for tissue malondialdehyde (MDA) and histopathological analysis.Results: The results showed all rats in the INH-RIF group experienced marked elevations of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, creatinine, and tissue MDA levels compared to the controls (P

This research aimed to fulfill the rights of persons with disabilities to get jobs according to their fields without reducing their rights. One of them was the recruitment of civil servant candidates. The research method used was normative juridical with literature study. Decent work is a right for every human being without exception. Various racial, ethnic, and religious backgrounds that are part of human identity do not prevent him from getting his rights, likewise with the physical or non-physical conditions that underlie a human being. Every human being who has a certain physical or non-physical background also has the same right to get a decent job, including people with disabilities. The State of Indonesia has ratified the Convention on the Rights of Persons with Disabilities into Law Number 19 of 2011. In the preamble to the law, it is explained that countries that sign the Convention should promote and protect the rights and dignity of persons with disabilities and increase the participation of persons with disabilities in the civil, political fields, economic, social, and cultural-based on an equal opportunity. It means that the Indonesian government is legally obliged to fulfill the rights of persons with disabilities, especially regarding the right to work in Indonesia.

In the past few years, phytochemicals from natural products have gotten the boundless praise in treating cancer. The promising role of cruciferous vegetables and active components contained in these vegetables, such as isothiocyanates, indole-3-carbinol, and isothiocyanates, has been widely researched in experimental in vitro and in vivo carcinogenesis models. The chemopreventive agents produced from the cruciferous vegetables were recurrently proven to affect carcinogenesis throughout the onset and developmental phases of cancer formation. Likewise, findings from clinical investigations and epidemiological research supported this statement. The anticancer activities of these functional foods bioactive compounds are closely related to their ability to upregulate p53 and its related target genes, e.g., p21. As the “guardian of the genome,” the p53 family (p53, p63, and p73) plays a pivotal role in preventing the cancer progression associated with DNA damage. This review discusses the functional foods bioactive compounds derived from several cruciferous vegetables and their use in altering the tumor-suppressive effect of p53 proteins. The association between the mutation of p53 and the incidence of gastrointestinal malignancies (gastric, small intestine, colon, liver, and pancreatic cancers) is also discussed. This review contains crucial information about the use of cruciferous vegetables in the treatment of gastrointestinal tract malignancies.

In 2020, a new type of coronavirus (SARS-CoV-2) whose disease is called Coronavirus disease 2019 (COVID-19) has been reported. This virus was first discovered in Wuhan, China and has infected 90,308 people per March 2, 2020. As of the end of October 2020, more than 40 million people have been infected, with the death toll reaching 1,150,000 worldwide. Apart from respiratory tract infections, patients infected with this virus may exhibit other symptoms, such as diarrhea, abdominal pain, nausea, or vomiting. This means that the virus can be found in feces and anus, hence the anal swab can be used as a diagnostic tool for COVID-19 infection. The results of the specimen test show that the sensitivity of the nasopharyngeal swab positive detection rate is the highest and remains the gold standard for diagnosis. This sensitivity can also be influenced by the course of the disease that can infect the gastrointestinal tract so that anal PCR is performed for the diagnosis to detect the COVID-19 virus in patients.

Mathematical problem solving is a method used to solve knowledge and ability problems related to calculation problems, both personal problems and group problems in everyday life. This research was conducted to determine how the ability of students in solving math problems in elementary schools on discharge material using tests. This research was a type of research that uses qualitative methods with descriptive types, where each result of this analysis will be more accurately and clearly expressed about the problem-solving abilities of students in solving problems. The subjects were 5 students of fifth grade of elementary school. Data collection was carried out through questionnaires, observation, documentation, and tests of mathematical problem-solving abilities as well as interview guides. This research showed that 0% of students experience errors at the question reading stage. 20% of students indicate the error lies in understanding the problem. 16% of students indicated the location of the error in the transformation problem. 24% of students showed the location of the error in the numeracy process skills and the biggest error was writing the final answer by 80%. From this study, there were 1 student who scored below the minimum score, 4 students had exceeded the predetermined standard limit for mathematics lessons. Based on this research, it can find out the locations of the students' mistakes so that it provides instructions for the teacher where the teacher can deploy effective teaching strategies to overcome them.

The use of vegetable protein has been developed to increase the protein content of instant noodles. Indonesia is one of the countries that consumes noodles in second place after China. These conditions led to an increase in wheat imports. In an effort to increase the protein content in instant noodles and also reduce the need for wheat, alternative local raw materials are needed to substitute wheat flour. The aim of the study was to utilize tapioca and corn flour as a substitute for wheat flour in the manufacture of instant noodles, which added soybean protein isolate (SPI) and Na-alginate to increase protein content and physical properties. Factorial randomized block design (RBD) was used in this research, factor I was SPI and factor II Na-alginate. The treatment was repeated 3 times. The observational variations were analyzed for variance and continued with the tukey test with α≤ 5% if there was significant. The results showed that the addition of SPI 30% and Na-alginate up to 0.2% increased the protein content of instant noodles to 31.36 ± 0.39% - 34.44 ± 0.34%, water absorption for 5 minutes of cooking was 147 %, cooking time 6.16 ± 0.22 minutes. Overall, the instant noodle is in the category of rather like to like the taste, aroma, color, and texture. Composite flour (corn flour and tapioca) can substitute 50% of wheat flour to produce the instant noodles. The protein contain is 34.44 %, with a contribution of 30% SPI and Na-alginate 0.2%.

Perkembangan teknologi dewasa ini telah mengalami banyak perubahan yang sangat pesat yang mampu membantu cara berpikir manusia yang dikenal dengan istilah kecerdasan buatan. Salah satu aplikasi dari kecerdasan buatan adalah sistem pakar. Tanaman jambu madu merupakan jenis tanaman jambu air varietas baru yang menjadi salah satu buah unggulan Indonesia yang banyak diminati konsumen. Penanganan tanaman jambu madu itu selalu menemui hambatan, salah satunya adalah serangan hama. Serangan hama tersebut memerlukan penanganan yang cepat dan benar, karena hal ini dapat merugikan para petani jambu dan dapat memberikan pengaruh pada hasil panen yang kurang maksimal. Adapun tujuan penelitian ini adalah membangun sistem pakar yang dapat mendiagnosa hama pada tanaman jambu madu menggunakan metode Dempster-Shafer. Cara kerja metode ini adalah membandingkan beberapa kemungkinan dari gejala-gejala yang dipilih. Hasil dari penelitian ini adalah pengujian dengan 9 jenis hama dan 32 jenis gejala yang memberikan rekomendasi bahwa hama yang menyerang tanaman jambu madu adalah hama lalat buah dan hama ulat buah dengan tingkat keyakinan sebesar 99,88%. Adapun solusi penanganannya adalah membungkus buah yang masih ada di pohon dengan plastik sewaktu masih pecah bunga, melakukan penyemprotan pestisida (Petrogenol, Alika), membuat perangkap dari botol bekas untuk memancing dan menangkap lalat buah masuk yang berisi cairan Metil Eugenol, dan memasang perangkap menggunakan lem.

Matakuliah pilihan juga merupakan matakuliah yang penting, karena pengetahuan dari matakuliah pilihan dapat membantu mahasiswa dalam matakuliah lainnya, skripsi bahkan dalam pekerjaan kedepannya. Maka dari itu, penentuan matakuliah pilihan tidak boleh sembarangan. Tujuan penelitian ini adalah untuk membuat suatu sistem pendukung keputusan berbasis Web untuk membantu mahasiswa Sistem Informasi FMIPA Universitas Riau dalam menentukan matakuliah pilihan yang akan dipilih menggunakan metode Technique for Order Performance of Similarity to Ideal Solution (TOPSIS). TOPSIS mempunyai prinsip bahwa alternatif yang terpilih harus mempunyai jarak terdekat dari solusi ideal positif dan mempunyai jarak terjauh dari solusi ideal negatif. Sistem yang dihasilkan dapat membantu mahasiswa dalam memilih matakuliah pilihan dengan menggunakan kriteria seperti tingkat kesulitan, referensi, lapangan pekerjaan, minat dan bakat. Hasil akhir dari sistem ini adalah lembar hasil perhitungan yang nilai preferensinya telah diurutkan dari yang tertinggi ke terendah. Alternatif dengan nilai tertinggi adalah matakuliah yang direkomendasikan untuk dipilih. Untuk kasus mahasiswa semester IV matakuliah pilihan berdasarkan rangking adalah Data Mining, Perancangan Sumber Daya Perusahaan, dan Pengolahan Citra Digital

Penelitian ini bertujuan untuk memprediksi UKT yang akan dibayarkan oleh calon mahasiswa khususnya program studi S1 Sistem Informasi FMIPA Universitas Riau dengan menggunakan metode K-Nearest Neighbor (K-NN). Kriteria yang digunakan yaitu penghasilan kotor, penanggung uang kuliah, jumlah tanggungan yang tercantum dalam kartu keluaga, status tempat tinggal, keadaan dinding tempat tinggal, keadaan atap tempat tinggal, total luas kepemilikan lahan dan biaya pemakaian listrik sebulan. Adapun kelompok UKTnya adalah UKT1, UKT2, UKT3, UKT4, UKT5 dan UKT6. Data yang digunakan adalah mahasiswa S1 FMIPA Universitas Riau tahun angkatan 2016, 2017, dan 2018. Perbandingan untuk data latih dan data uji adalah 90% : 10%. Tingkat keakuratan dari klasifikasi yang didapat sebesar 84,21%. Kata-kata kunci: Klasifikasi, K-Nearest Neighbor, UKT

Artikel ini meneliti sikap Kristen Calvinis terhadap agama-agama yang ada di Batavia pada abad ke-XVII. Dengan menggunakan Metode Sejarah, didapat beberapa kesimpulan: (1) VOC hanya mengakui satu agama yang sah (publieke kerk) yaitu Kristen Calvinis, (2) Dengan menggunakan VOC, sikap Kristen Calvinis terhadap komunitas Katolik Roma sangat tegas, banyak pastor Katolik Roma yang dipenjara. Untuk membatasi perpindahan penduduk Batavia ke Gereja Katolik Roma, dibuat peraturan bahwa sakramen Katolik Roma (Baptisan) dianggap tidak sah secara hukum dan tidak bisa dijadikan sebagai syarat pernikahan, (3) Islam dan Kong Hu Cu di Batavia tidak diakui sebagai agama resmi, namun karena secara politik dan ekonomi mereka kuat, VOC menjadi sangat berhati-hati dalam membuat kebijakan-kebijakan, khususnya yang berkaitan dengan hidup keagamaan mereka. The article presents the findings of the research of Calvinistic Christianity’s attitude towards the other religion groups in Batavia during the 17th century. By using the Historical Method, the conclusions are obtained as follows: (1) The VOC recognized exclusively the Calvinistic Christianity as the only legitimate religion (publieke kerk), (2) The Calvinistic Christianity manipulated the VOC to behave strict towards the Roman Catholics so that many Roman Catholic priests were consequently imprisoned. To prevent the Batavia citizens from embracing the Roman Catholics, the Calvinistic Christianity had the Roman Catholic's sacrament of Baptism considered as as not legally valid by the VOC so that it could not fulfill the marriage requirements, (3) Meanwhile, Islam and Confucianism in Batavia remained unrecognized as official religions. However, their political and economic influence forced the VOC to be very careful in decision-making, especially concerning their religious lives.

Patients with an autoimmune disease could be at higher risk of a poor outcome when contracting COVID-19 infection due to aberrant immune responses and use of immunosuppressant therapies for chronic autoimmune treatment. Here, we conducted a retrospective study to identify the factors related to severity, hospitalization, and mortality among patients with autoimmune diseases. We found 165 cases of patients with pre-existing autoimmune diseases who had contracted COVID-19 between March 2020 and September 2022. Data on demographical characteristics; autoimmune diagnosis and treatment; COVID-19 vaccination status; and time, severity, and outcome of COVID-19 infection were collected. Most of the subjects were female (93.3%) and autoimmune diagnoses included systemic lupus erythematosus (54.5%), Sjogren’s syndrome (33.5%), antiphospholipid syndrome (23%), vasculitis (5.5%), autoimmune thyroid disease (3.6%), rheumatoid arthritis (3.03%), and inflammatory bowel disease (3.03%) among other autoimmune diseases. There were four COVID-19-related deaths in this study. Factors associated with moderate to severe COVID-19 infection in patients with autoimmune diseases included not being vaccinated against COVID-19, taking a steroid of ≥10 mg prednisone-equivalent per day, and having a cardiovascular disease. Taking a steroid of ≥10 mg prednisone-equivalent per day was also associated with hospitalization in the event of COVID-19 infection, while cardiovascular diseases also showed a significant correlation to mortality in patients with autoimmune diseases who had been hospitalized with COVID-19 infection.

Preeclampsia detection research has started exploring some methods to diagnose and predict preeclampsia. Machine learning (ML) methods and the Internet of Things (IoT) have been successfully implemented in medical research to improve the diagnosis and prevention of complex diseases and syndromes. The goal of this work is to undertake a review of the most recent work on preeclampsia detection. The research focused on articles related to the keywords 'machine learning, 'Internet of Things, 'IoT', 'medical', and preeclampsia in five main databases, namely IEEEXplore, ScienceDirect, SpringerLink, ResearchGate, and ACM Digital Library, etc. We selected and reviewed 90 articles in the end. The final discussion highlights research gaps that remain to be investigated in the cognitive approach to IoT. The study found that preeclampsia detection based on the internet of Medical things (IoMT) was not found, so it became a big opportunity to develop this research in the future.

In the global competition era and in Covid 19 pandemic period, the innovative competence of emerging entrepreneurs relies on the positive characters they should have. The present study was aimed to formulate a reinforcement model of innovative behavior through the identification of dominant determinant factors. The study employed survey methods and involved variables of innovative behavior (Y), creativity (X1), technology literacy (X2), and risk-taking behavior (X3). The respondents were 86 final year students of Faculty of Business Economics (emerging entrepreneur candidates) as the samples, and the data were further analyzed by multiple regression. The creativity (X1), technology literacy (X2), and risk-taking behavior (X3) contribute simultaneously at 45.70 percent to the development of innovative behavior (Y); b) the applicable prediction model of innovative behavior is Y=1.171+0.622X1+0.170X2 -0.080X3; meanwhile, the creativity yielded the most significant sensitivity in developing the innovative behavior variable compared to the technology literacy and risk-taking behavior variables; c) it is worth noting that risk-taking behavior is not among the contributing factors; in fact, this variable constrains an individual to be innovative (if it is too high); e) the variable of creativity is in line with innovation.

One of the environmentally friendly ways to increase soybean production was to use organic fertilizers and mycorrhiza. This study aimed to determine the effect of cow manure dose and a dose of mycorrhiza on the growth and yield of soybean varieties Devon I. The study was conducted in April to September 2019 in Teguhan village, Sragen Regency, altitude 86 masl, with the grumosol soil type. This study used a randomized block design Complete by a factor of two treatments, the first factor dose of cow manure consists of four levels ie K0 = 0 tonnes / ha, K1 = 5 tonnes / ha, K2 = 10 tonnes / ha, K3 = 15 ton / ha and a dose of mycorrhiza consists of three levels ie M0 = 0 g, M1 = 3 g, M2 = 6 g per plant. The use of fertilizer was reduced by half a dose recommendation. The results showed that the dose of cow manure significantly affected the growth and yield of soybean, the mycorrhiza dose had no significant effect on the growth and yield of soybean. The lowest productivity in this study in the treatment without cow manure (1.158 tonnes/ha) and the highest productivity in the treatment of cow manure is 15 tonnes/ha (1, 46 tonnes/ha).