Search

Because Systemic Lupus Erythematosus (SLE) is a rare disease, and due to the significant prognostic impact of early management, a diagnosis confirmed by a physician with experience in SLE is recommended, for example from an expert center. Once the diagnosis is confirmed, existing manifestations should be identified in particular, renal involvement by an assessment of proteinuria, disease activity and severity should be determined, potential complications anticipated, associated diseases searched for, and the patient's socioprofessional and family context noted. Therapeutic management of SLE includes patient education on recognizing symptoms, understanding disease progression as well as when they should seek medical advice. Patients are informed about routine checkups, treatment side effects, and the need for regular vaccinations, especially if they are receiving immunosuppressive treatment. They are also advised on lifestyle factors such as the risks of smoking, sun exposure, and dietary adjustments, especially when they are receiving corticosteroids. The importance of contraception, particularly when teratogenic medications are being used, and regular cancer screening are emphasized. Support networks can help relieve a patient's isolation. The first-line medical treatment of SLE is hydroxychloroquine (HCQ), possibly combined with an immunosuppressant and/or low-dose corticosteroid therapy. The treatment of flares depends on their severity, and typically involves HCQ and NSAIDs, but may be escalated to corticosteroid therapy with immunosuppressants or biologic therapies in moderate to severe cases. Because there is no curative treatment, the goals of therapy are patient comfort, preventing progression and flares, and preserving overall long-term health and fertility. The frequency of follow-up visits depends on disease severity and any new symptoms. Regular specialized assessments are necessary, especially when treatment changes, but a frequency of every 3 to 6 months is recommended during periods of remission and monthly during active or severe disease, especially in children. These assessments include both clinical and laboratory tests to monitor complications and disease activity, with specific attention to proteinuria. [ABSTRACT FROM AUTHOR]

Featuring data from a nationwide survey of English faculty in Canada, this study focuses on the reasons that faculty offered for choosing their respective doctoral programs. This analysis pays particular attention to gendered disparities in participants' responses and to disparities associated with parental educational level, two variables that sometimes intersect in striking ways. This investigation explains why some reasons that women and first-generation university students provided for their choice of doctoral program can increase a student's chances of entering a poorly ranked program. Employing previously unprocessed data from Statistics Canada, this article also presents information to help would-be PhD students who are women, first-generation university students, or both make more informed decisions about where to pursue doctoral study to be more competitive in the academic job market if they aspire to be professors. This article is simultaneously designed to increase faculty mentors' understanding of the problematic logic that women and first-generation university students may use when selecting their PhD programs so that such mentors can better address these students' misperceptions about doctoral studies and the profession. [ABSTRACT FROM AUTHOR]

Copyright of Forestry Chronicle is the property of Canadian Institute of Forestry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Naturaliste Canadien is the property of La Societe Provancher and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nouveau Praticien Vétérinaire Canine & Féline is the property of EDP Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Agroalimentaria is the property of Alejandro Antonio Gutierrez Socorro and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Contemporary Accounting Research is the property of Canadian Academic Accounting Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Forestry Chronicle is the property of Canadian Institute of Forestry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Monitoring in psychology courses has been a relevant experience for improving the quality of undergraduate teaching. The philosophical disciplines present in these courses could benefit from this kind of teaching program. The present study aims to analyze an experience of implementing monitoring in theoretical-philosophical curricular components in the psychology course. These components are present in the first year of the course, a phase marked by the adaptation of newcomers. Therefore, in the experience construction, the prediction was that students could present adversities when coming into contact with these themes, such as the complexity of debates and new academic language. Monitoring was used as a tool in educational practices to facilitate the communication process of students and teachers. The work was organized by two professors from a psychology course at the Federal University of Rio Grande do Norte (UFRN/FACISA), offering four voluntary scholarships over two years. The development of activities aimed to minimize students' difficulties, as well as incite and introduce historical and philosophical debates. During the intervention, autonomous teaching-learning was enabled for students, also providing teaching experience for monitors. With the conclusion of the activities, monitoring was consolidated as an effective mediation to achieve horizontality in academic relationships, with pedagogical gains for the participants, enabling the creation of subsequent initiatives in the study of psychology, epistemology, and other related areas. The current report demonstrates how similar practices can improve and improve the processes of student and professional training in Psychology courses. [ABSTRACT FROM AUTHOR]

Kawasaki disease (KD) is an acute vasculitis with a particular tropism for the coronary arteries. KD mainly affects male children between 6 months and 5 years of age. The diagnosis is clinical, based on the international American Heart Association criteria. It should be systematically considered in children with a fever, either of 5 days or more, or of 3 days if all other criteria are present. It is important to note that most children present with marked irritability and may have digestive signs. Although the biological inflammatory response is not specific, it is of great value for the diagnosis. Because of the difficulty of recognising incomplete or atypical forms of KD, and the need for urgent treatment, the child should be referred to a paediatric hospital as soon as the diagnosis is suspected. In the event of signs of heart failure (pallor, tachycardia, polypnea, sweating, hepatomegaly, unstable blood pressure), medical transfer to an intensive care unit (ICU) is essential. The standard treatment is an infusion of IVIG combined with aspirin (before 10 days of fever, and for a minimum of 6 weeks), which reduces the risk of coronary aneurysms. In case of coronary involvement, antiplatelet therapy can be maintained for life. In case of a giant aneurysm, anticoagulant treatment is added to the antiplatelet agent. The prognosis of KD is generally good and most children recover without sequelae. The prognosis in children with initial coronary involvement depends on the progression of the cardiac anomalies, which are monitored during careful specialised cardiological follow-up. [ABSTRACT FROM AUTHOR]

Copyright of Nouveau Praticien Vétérinaire Canine & Féline is the property of EDP Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper collects and describes several clinical experiences with extremely pre-term born babies. They were nursed using different kind of settings: institutional, are NICU (Neonatal Intensive Care Unit) with the subsequent clinical follow-up and with the help of private therapies. Through these lengthwise efforts, some of the pre-term newborn's features, such as the complexity in psychosomatic integration, were identified and better understood. The cases described show how the sensorial intrusion achieved from the intensive cares, may influence the integration process as the newborn's development further up, entangling the parental interactions. [ABSTRACT FROM AUTHOR]

Copyright of Forestry Chronicle is the property of Canadian Institute of Forestry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Orthodontie Française is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Preterm premature rupture of membranes (PPROM) is the main cause of premature delivery, complicating 1-3% of all pregnancies. Conventional hospitalization (CH) is the most frequent mode of follow-up, but homecare (HC) seems to be an alternative., Objectives: Study of the impact of the monitoring mode on the duration of the latency period and on the latency ratio after PPROM, and analysis of the risk factors modifying this ratio., Methods: This was a bicentric retrospective cohort study here-abouts including patients who presented a PPROM between 24 and 36weeks of gestation from 2016 to 2018. Patients had a follow-up in HC at Lille University Hospital center (UHC) and in CH at Nantes UHC according to two different follow-up protocols. The latency ratio corresponded to the real latency period divided by the latency period to theoretical term., Results: We included 154 patients: 102 in HC and 52 in CH. The mean latency period was significantly higher in HC: 36.9±21.8 days, corresponding to an 85.5±23.7% latency ratio versus 20.2±12 days, corresponding to an 66.9±29.8% latency ratio in CH (P<0.001). The latency ratio in CH was correlated with term at PPROM (P=0.001)., Conclusions: The duration of the latency period seems prolonged for PPROM followed by HC management versus CH in selected populations. This study suggests a benefit to HC in stable patients., (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

This article aims to summarize the current knowledge on the evaluation and follow-up of urethral stricture (US) treatments through a comprehensive literature review and to propose a detailed follow-up protocol post-treatment. There is no consensus on how to assess US treatments. It must address both anatomical factors (evaluated by the urologist) and functional factors (evaluated by the patient). Anatomical assessment is guided by uroflowmetry, combined with a questionnaire validated in French, the IPSS or the USP, pending validation of a dedicated tool. If the IPSS is used, continence must also be assessed. Suspicion of recurrence on these criteria should lead to reassessment of urethral caliber (endoscopy and/or urethrography). The evaluation of areas other than miction (sexuality, pain, morbidity in the event of buccal harvesting) should not be neglected, particularly after urethroplasty. A follow-up protocol is proposed based on this literature review., (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

The World Health Organization recommends the use of the Integrated Care for Older People program to prevent the onset of dependency and enable seniors to age as they wish. In oncogeriatrics, it can be offered before or after the therapeutic project to any autonomous patient in order to monitor their intrinsic capacity. The experience of the Toulouse University Hospital shows the value of this follow-up in oncogeriatrics and the adherence of participants., (Copyright © 2024. Published by Elsevier Masson SAS.)

Retinopathy of prematurity (ROP, ORPHA: 90050) is the main cause of visual impairment in preterm infants and the leading preventable cause of childhood blindness in high- and middle-income countries. However, severe stages of the disease remain rare. While screening recommendations for the disease are well-established in France, management of ROP requiring treatment is less standardized, especially since new therapeutic options have been approval on this indication. The management of preterm infants requiring treatment for ROP is complex and involves a multidisciplinary team, including pediatric ophthalmologists, vitreoretinal surgeons, neonatologists, pediatric anesthetists, nurses, and orthoptists, within an adapted structure for premature infants care. There is a genuine need to unify national practices, with a strong demand from physicians involved in ROP care along the country. The objective of this National Diagnostic and Care Protocol (PNDS) is to provide guidelines for diagnostic and management for ROP, and to optimize and harmonize the management of this disease across the country. The main treatment indications, the different treatment modalities including laser photocoagulation, anti-VEGF injections, and vitreoretinal surgery as well as follow-up calendar, are reviewed to establish the best practice recommendations on ROP., (Copyright © 2024 Elsevier Masson SAS. All rights reserved.)

Au cours de la maladie de Sjögren ou syndrome de Sjögren primitif (SSp), les patients peuvent présenter des atteintes hétérogènes. La triade symptomatique caractéristique incluant sécheresse, fatigue et douleur est fréquente. Trente à 40 % des patients peuvent développer des atteintes systémiques. Ainsi, le suivi des patients atteints de SSp est personnalisé et doit être adapté au phénotype clinique et biologique du patient. Les modalités et la fréquence du suivi dépendent notamment de la présence ou non de complications systémiques, ou de leur risque de survenue. Le SSp étant une pathologie rare, il est recommandé d'organiser cette prise en charge en collaboration avec un centre de référence. La prise en charge est multidisciplinaire, impliquant différents professionnels de santé en fonction des atteintes initiales et de l'évolution. Le suivi a pour objectif de préciser l'activité et la sévérité de la maladie, ainsi que de dépister l'apparition d'atteintes systémiques. Il évalue l'efficacité et la tolérance des traitements et recherche des comorbidités. De plus, les facteurs de risque de lymphome doivent être régulièrement réévalués. Un suivi régulier de l'atteinte ophtalmologique et de l'état buccodentaire est nécessaire. Les recommandations récemment établies par l'EULAR portent sur la prise en charge de la triade sécheresse, fatigue et douleur, et détaillent la prise en charge des atteintes systémiques. De plus, le Protocole National de Diagnostic et de Soins (PNDS), établi récemment, propose une stratégie claire pour le suivi des patients. Enfin, l'éducation thérapeutique constitue un pilier de la prise en charge, permettant aux patients d'être actifs dans la gestion de leur maladie. In primary Sjögren's syndrome (pSS), patients may present with heterogeneous symptoms. The triad of characteristic symptoms is frequent and includes dryness, fatigue, and pain. Also, 30 to 40% of patients may develop systemic damage. Thus, pSS patients' follow-up is individualized and must be adapted to the patient clinical and biological phenotype. The modalities and the frequency of the follow-up depend on the presence or not of systemic complications, or their risk factors. As pSS is a rare disease, it is recommended to organize its management in collaboration with reference centers. pSS management is multidisciplinary and involves different health professionals depending on the initial damage characteristics and the evolution. The aim of the follow-up is to determine the activity and severity of the disease, as well as to detect occurrence of systemic complications. It assesses the efficacy and tolerance of treatments and includes the search for comorbidities. In addition, risk factors of lymphoma must be regularly reassessed. Regular monitoring of ophthalmologic and oral status is required. Recent EULAR guidelines address the management of the triad of dryness, fatigue and pain, and detail the management of systemic involvement. In addition, the "Protocole National de Diagnostic et de Soins" has been recently established and presents a clear strategy for patient management and follow-up. Finally, therapeutic education is a pillar of pSS management, allowing patients to be active in their disease follow-up. [ABSTRACT FROM AUTHOR]

The purpose of this article is to describe the external irradiation process and updated recommendations of the French society for radiation oncology for patient follow-up. [ABSTRACT FROM AUTHOR]

There are two main arguments in favour of systematic reproductive monitoring in young women treated for cancer: 1) to assess follicular loss induced by chemotherapy or pelvic radiotherapy, as well as spontaneous fertility, in order to refine fertility preservation (FP) strategies prior to treatment, 2) to judge the interest of a second FP phase at a distance from the disease according to the degree of ovarian recovery. Longitudinal monitoring of anti-müllerian hormone, a realtime reflection of follicular loss and recovery during treatment, makes it possible to classify chemotherapy protocols according to their degree of ovarian toxicity, thus making it possible to develop decision trees for FP before and after the disease. [ABSTRACT FROM AUTHOR]

Copyright of Ecologia Mediterranea is the property of Ecologia Mediterranea and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ecoscience (Ecoscience) is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To inform the design of targeted, species-specific surveys of Prairie Warbler (Setophaga discolor) in Ontario, Canada, we used autonomous recording units (ARUs) to document patterns in male vocal activity. We deployed recorders within the territories of breeding males at coastal sites near Georgian Bay, and at inland sites near Kaladar, in June 2015 and 2016, respectively. Although coastal and inland sites are <250 km apart, we observed distinct differences in the patterns and frequency of male singing. Overall, the mean number of songs per minute of males at inland sites near Kaladar was nearly triple that of coastal sites near Georgian Bay. Daily singing activity peaked shortly after sunrise and declined throughout the day at both sites. Daily singing activity was uniformly high across the entire morning period at coastal sites, whereas at inland sites the highest rates of singing were during the post-dawn morning period. Singing activity varied by chronological day at inland sites, with distinct peaks at the beginning and end of June. Singing at coastal sites did not vary by chronological day and was consistently low throughout June. Although our sample sizes are small, with minimal replication, we discuss our results in the context of reduced pairing success and male-biased sex ratios in small, isolated populations. In addition to documenting singing activity patterns to optimize future surveys for species of conservation concern, ARUs may also signal potential demographic differences important for population persistence that warrant further exploration. [ABSTRACT FROM AUTHOR]

Standardized monitoring is critical for conservation because reliable survey data are used to inform the necessity, type, and effectiveness of conservation actions. Many of the avian monitoring data used for conservation are collected by "comprehensive" programs that survey for all species observed; however, there are some species that have low availability for detection during comprehensive surveys and are instead monitored with targeted programs. Unfortunately, those targeted programs are rarely evaluated relative to existing programs and management objectives to inform allocation of effort. We assessed the statistical performance of the comprehensive North American Breeding Bird Survey (BBS), the targeted Canadian Nightjar Survey (CNS), and the two programs combined for the Common Nighthawk (Chordeiles minor). First, we used parameters from the existing datasets to simulate population declines and determined the probability of detecting those declines. Analyses that combined both datasets resulted in higher probability of detecting a 30% population decline (BBS: 38%, CNS: 64%, combined: 69%). Next, we built probability of occurrence models and assessed the predictive performance of those models. Combined analyses had similar predictive performance to the CNS and moderated poor performance of the BBS in the north (mean Cohen's kappa; BBS: 0.40, CNS: 0.46, combined: 0.50). Our results suggest that data from targeted monitoring is important for evaluation of Common Nighthawk population trend and habitat relationships but is best combined with BBS data. Comprehensive and targeted monitoring programs may be better when considered together, and exploration of data combination should become the rule, not the exception. We suggest that the framework we present can be used as a starting point for evaluating targeted monitoring programs relative to defined objectives and existing programs, with the potential to explore hypothetical management scenarios. [ABSTRACT FROM AUTHOR]

After neonatal hospitalization, our healthcare system offers multidisciplinary care for premature babies and their families during the first years of life. However, there are disparities and gaps, particularly in the case of medium prematurity. Maternal and child protection, a major player in early prevention and family follow-up, is a partner likely to be able to deploy post-hospital support perspectives in favor of child development and parenting support., (Copyright © 2024 Elsevier Masson SAS. All rights reserved.)

To date, physical activity (PA) programs for overweight and obese people are built around recommendations established for the general population. However, these people have special characteristics that require adapted coaching. In order to begin this work of recommendations, the objective of this article was to list the criteria usually used to describe and study PA programs for overweight and obese people and its associated postprogram follow-up. A systematic review of both meta-analyses and systematic reviews related to PA programs in the management of overweight and obesity has highlighted that few descriptive elements of programs are systematically reported, and that PA programs are rarely sufficiently detailed to be able to calculate a PA dose or to compare the different programs. These convergences, disparities or gaps in the description of PA programs, led us to initiate a reflection on the interest of these criteria as well as on the interest of their systematization in weight management program design, including PA. We hope that will be a first step towards facilitating the development of recommendations for PA management of overweight and obesity. Novelty Objective: to identify criteria used to describe PA programs in the management of overweight and obesity. Criteria to systematize: data to calculate PA dose; description of program individualization strategy. Criteria to develop: drop-out rate as an indicator of program adaptation; description of fatigue management strategy. [ABSTRACT FROM AUTHOR]

Bourneville's tuberous sclerosis (STB) is a rare autosomal dominant genetic disorder. It is characterized by the multisystem development of hamartomas. The association of brain, heart, and skin lesions is strongly suggestive of the diagnosis, especially in the neonatal period. The cognitive and behavioral prognosis is improved by controlling spasms. We report the case of a newborn admitted for the management of prematurity, the diagnosis of STB was made secondarily on the discovery of cutaneous and cerebral lesions, complicated by epilepsy. The evolution was favorable under treatment. [ABSTRACT FROM AUTHOR]

The assessment of tumour response during and after radiotherapy determines the subsequent management of patients (adaptation of treatment plan, monitoring, adjuvant treatment, rescue treatment or palliative care). In addition to its role in extension assessment and therapeutic planning, positron emission tomography combined with computed tomography provides useful functional information for the evaluation of tumour response. The objective of this article is to review published data on positron emission tomography combined with computed tomography as a tool for evaluating external radiotherapy for cancers. Data on positron emission tomography combined with computed tomography scans acquired at different times (during, after initial and after definitive [chemo-]radiotherapy, during post-treatment follow-up) in solid tumours (lung, head and neck, cervix, oesophagus, prostate and rectum) were collected and analysed. Recent recommendations of the National Comprehensive Cancer Network are also reported. Positron emission tomography combined with computed tomography with (18F)-labelled fluorodeoxyglucose has a well-established role in clinical routine after chemoradiotherapy for locally advanced head and neck cancers, particularly to limit the number of neck lymph node dissection. This imaging modality also has a place for the evaluation of initial chemoradiotherapy of oesophageal cancer, including the detection of distant metastases, and for the post-therapeutic evaluation of cervical cancer. Several radiotracers for positron emission tomography combined with computed tomography, such as choline, are also recommended for patients with prostate cancer with biochemical failure. (18F)-fluorodeoxyglucose positron emission tomography combined with computed tomography is optional in many other circumstances and its clinical benefits, possibly in combination with MRI, to assess response to radiotherapy remain a very active area of research. [ABSTRACT FROM AUTHOR]

Our work aimed to investigate the illnesses unrelated to systemic sclerosis (IUSS), diagnosed among patients with systemic sclerosis (SSc) throughout their follow-up in a referral tertiary care center. All the patients with SSc followed in the Internal Medicine Department of the University Hospital between October, 2014 and December, 2015, were included. We specifically reviewed the medical records of the patients who exhibited IUSS, defined as an illness that could not be considered as a typical clinical manifestation or as a usual complication of the disease. Two hundred patients were included, and 38 IUSS were diagnosed among 31 SSc patients, over a 4 years median follow-up period. These diagnoses included vascular diseases (26%), heart diseases (21%), neoplasia (8%), infectious diseases (6%), autoimmune diseases (5%), endocrinopathies (5%), and others (24%). The median follow-up time before IUSS diagnosis was two years. Seventeen (45%) of these diagnoses were considered in patients showing suggestive clinical signs. A specific therapy was delivered in 25 cases (66%). Group comparisons revealed that dyslipidemia was more frequent in patients with IUSS (OR = 2.6 [1.1–1.5]; p = 0.014), while no differences were found for the other characteristics. Especially, no association between auto-antibodies specificity and the occurrence of IUSS was found. This study focused on IUSS in SSc patients and highlights the need for a polyvalent clinical approach all along the follow up of SSc patients. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Social Work Review / Revue Canadienne de Service Social is the property of Canadian Association for Social Work Education and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Résumé: En 2015 un consensus international (STRIDE) a été publié par un groupe de gastroentérologues, et présentait le choix d'objectifs cliniques et thérapeutiques à atteindre et à suivre chez des patients atteints de rectocolite hémorragique (RCH) et de maladie de Crohn (MC). En 2019, au regard des connaissances actuelles et de nouveaux critères d'évaluation, des experts français ont souhaité rendre compte de leurs pratiques et de leur avis pragmatique, pour apporter des outils pour le suivi des patients atteints de MICI selon une approche treat-to-taget (T2T) : Quels objectifs cibler ? Comment et quand les atteindre ? Méthodes : Une méthodologie de consensus de type groupe nominal a été adoptée pour définir les objectifs thérapeutiques à rechercher et atteindre, les seuils et les délais pour les atteindre, chez les patients présentant une MC et une RCH. Résultats : Pour les deux maladies, les cibles à atteindre étaient les suivantes : le ressenti des patients sur leur expérience globale de la maladie (PRO-1), le ressenti des patients sur les troubles gastro-intestinaux (PRO-2), la cicatrisation endoscopique et le niveau des marqueurs biologiques de l'inflammation. L'état nutritionnel n'a été retenu que pour la MC. La cicatrisation histologique et la cicatrisation transmurale n'ont pas été retenues. Les délais pour atteindre les cibles et la fréquence de surveillance ont également été abordés. Conclusions : Selon une approche T2T, ce travail apporte aux praticiens les outils pour l'évaluation et le suivi des patients atteints de MC et de RCH. In 2015 an international consensus (STRIDE) has been published by gastroenterologists, whom developed recommendations upon clinical and therapeutic targets for ulcerative colitis (UC) and Crohn Disease (CD). In 2019, regarding the current knowledges and evaluation criteria, a French experts group reported their practices and their opinion, to bring tools for IBD patients monitoring, based on the Treat-to-Target approach. What are the targets? How and when to reach them? Methods : A nominal group consensus methodology has been used to define therapeutic targets, threshold and deadlines, for evaluation and monitoring of patients with CD and UC. Results: For both diseases, the agreed targets were: patient related outcomes on disease (PRO-1), patient related outcomes on gastrointestinal symptoms (PRO-2), endoscopic healing and biomarkers of inflammation. Nutritional status has been defined as a target for CD only. Histological healing and transmural healing were not defined as targets. Deadlines to achieve targets and monitoring frequency have been agreed as well. Conclusion: Focused on the Treat-to-Target approach, this work gave to practitioners' evaluation and monitoring tools for patients with CD and UC. [ABSTRACT FROM AUTHOR]

Copyright of Sante Mentale au Quebec is the property of Revue Sante Mentale au Quebec and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

• Our study confirmed the major role of loss to follow-up in the low proportion of successful TB treatment in northern France. • Previous history of TB treatment was independently associated with an increased risk of loss to follow-up, while HIV infection was associated with a reduced risk. • The reduced risk of loss to follow-up in case of HIV infection could be explained by specific measures targeting HIV-infected patients to improve compliance. • The implementation of similar supportive measures for patients at risk of loss to follow-up, especially patients with a history of TB treatment, should be evaluated. The proportion of successfully treated tuberculosis (TB) patients remains below the WHO target in France, because of a high proportion of loss to follow-up. We aimed to identify factors associated with loss to follow-up in northern France, a low-incidence area. Between 1997 and 2017, all consecutive patients diagnosed with TB at the Tourcoing Hospital, except those infected with multidrug-resistant or extensively drug-resistant strains, were included in a retrospective cohort study. A logistic regression analysis was performed to determine factors associated with loss to follow-up. One hundred and ninety patients were included. Previous TB treatment was reported in 32 patients (17%), extrapulmonary TB in 107 (56%), and HIV infection in 44 (23%). The proportion of loss to follow-up was 15%. In multivariate analysis, the risk of loss to follow-up decreased in case of first TB treatment (OR 0.36; 95% CI: 0.14–0.92, P = 0.03) and increased in non-HIV-infected patients (OR 7.67; 95% CI: 1.00–59.0, p = 0.05). Support for compliance was more frequent in HIV-infected patients (23% vs. 7%, p = 0.005). The proportion of loss to follow-up was high. HIV infection was associated with a lower risk of loss to follow-up, likely to be due to more frequent support for compliance. [ABSTRACT FROM AUTHOR]

Background: Many of the adverse outcomes of gestational diabetes mellitus (GDM) are linked to excessive fetal growth, which is strongly mediated by the adequacy of maternal glycemic management. The COVID-19 pandemic led to a rapid adoption of virtual care models. We aimed to compare glycemic management, fetal growth, and perinatal outcomes before and during the COVID-19 pandemic., Methods: A retrospective cohort study was conducted between 2017 and 2020. Singleton pregnancies complicated by GDM were included in the study. The cohort was stratified into "before" and "during" COVID-19 subgroups, using March 11, 2020, as the demarcation time point. Women who began their GDM follow-up starting March 11, 2020, and thereafter were allocated to the COVID-19 era, whereas women who delivered before the demarcation point served as the pre-COVID-19 era. The primary outcome was the rate of large-for-gestational-age (LGA) neonates. Secondary outcomes included select maternal and neonatal adverse outcomes., Results: Seven hundred seventy-five women were included in the analysis, of which 187 (24.13%) were followed during the COVID-19 era and 588 (75.87%) before the COVID-19 era. One hundred seventy-one of the 187 women (91.44%) followed during COVID-19 had at least 1 virtual follow-up visit. No virtual follow-up visits occurred before the COVID-19 era. There was no difference in the rate of LGA neonates between groups on both univariate (5.90% vs 7.30%, p=0.5) and multivariate analyses, controlling for age, ethnicity, parity, body mass index, gestational weight gain, chronic hypertension, smoking, and hypertensive disorders in pregnancy (adjusted odds ratio [aOR] 1.11, 95% confidence interval [CI] 0.49 to 2.51, p=0.80). In the multivariate analysis, there was no difference in composite neonatal outcome between groups (GDM diet: aOR 1.40, 95% CI 0.81 to 2.43, p=0.23; GDM medical treatment: aOR 1.20, 95% CI 0.63 to 2.43, p=0.5)., Conclusions: After adjusting for differences in baseline variables, the combined virtual mode of care was not associated with a higher rate of LGA neonates or other adverse perinatal outcomes in women with GDM. Larger studies are needed to better understand the specific impact of virtual care on less common outcomes in pregnancies with GDM., (Copyright © 2023 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.)

Copyright of Forestry Chronicle is the property of Canadian Institute of Forestry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

La calcification de cristaux d'hydroxyapatite (HA) intra- ou péri-articulaires peut provoquer des poussées aiguës hyperalgiques. Une étude pilote a suggéré que l'inhibiteur de l'interleukine-1β (IL-1β) anakinra était un traitement efficace. L'objectif de cette étude observationnelle était de confirmer ce résultat dans un plus grand groupe de patients et de décrire le suivi à long terme. Une poussée a été définie comme des douleurs aiguës pendant moins de 10 jours. Une calcification intra- ou péri-articulaire (coiffe des rotateurs : 15/23 patients) a été confirmée par radiographie classique et/ou échographie. Une dose quotidienne de 100 mg d'anakinra a été administrée par voie sous-cutanée pendant un à trois jours consécutifs. Les données cliniques collectées avant l'injection et aux jours 3 et 21 comprenaient le score de douleur sur une échelle visuelle analogique (EVA, 0-10 cm) et le taux de protéine réactive C (CRP). Lorsqu'ils étaient disponibles, les résultats de l'échographie à l'inclusion et pendant le suivi ont été comparés. Les données de suivi à long terme ont été collectées dans les dossiers des patients et/ou par téléphone. Vingt trois patients (15 hommes, âge moyen [ET] 58 [11] ans) ont été inclus. Le score de douleur EVA moyen (ET) à l'inclusion était de 7,7 (1) cm et la moitié des patients avaient un taux de CRP élevé. Après traitement, le score de douleur EVA moyen (ET) a diminué rapidement pendant les trois premiers jours pour atteindre 1,6 (1,4) cm (p < 0,001), puis est resté stable pendant 3 semaines à 1,8 (2,1) cm. L'évaluation échographique a révélé une intensité Doppler réduite mais aucun changement significatif dans la taille des calcifications. Aucun effet indésirable notable n'a été observé. Après un suivi à long terme (durée médiane 24 mois), la moitié des patients présentaient encore des douleurs chroniques, mais quatre seulement ont subi une rechute aiguë. Cette étude suggère que l'inhibition de l'IL-1β peut constituer une approche thérapeutique efficace et d'un bon profil de sécurité pour les poussées d'HA aiguës. [ABSTRACT FROM AUTHOR]

Copyright of Bulletin de la Société de Pathologie Exotique is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of International Annals of Criminology is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Archives of Cardiovascular Diseases is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Summary In primary male to female (MTF) sex reassignment surgery (SRS), the most frequent postoperative functional complications using the penoscrotal skin technique remain neovaginal stenosis, urinary meatal stenosis and secondary revision surgery. We aimed to retrospectively analyze postoperative functional and anatomical complications, as well as secondary procedures required after MTF SRS by penile skin inversion. All patients operated on for MTF SRS, using the inverted technique, from June 2006 to July 2016, were retrospectively reviewed. The minimum follow-up was one year (five-years maximum follow-up). Soft postoperative dilationprotocol was prescribed until complete healing of the vagina. We did not prescribe long-term hard dilation systematically. Possible short-depth neovaginas were primarily treated with further temporary dilation using a hard bougie. Among the 189 included patients, we reported a 2.6% of rectovaginal wall perforations. In 37% of patients we had repeated compressive dressings and 15% of them required blood transfusions. Eighteen percent of patients presented with hematoma and 27% with early infectious complications. Delayed short-depth neovagina occurred in 21% of patients, requiring additional hard dilatation, with a 95.5% success rate. Total secondary vaginoplasty rate was 6.3% (4.7% skin graft and 3.7% bowel plasty). Secondary functional meatoplasty occurred in 1% of cases. Other secondary cosmetic surgery rates ranged between 3 to 20%. A low rate of secondary functional meatoplasty was showed after MTF SRS by penile skin inversion. Hard dilation was prescribed in case of healed short-depth vagina, with good efficiency in most of cases. Secondary vaginoplasty was required in cases of neovagina stenosis or persisting short-depth neovagina after failure of hard dilation protocol. [ABSTRACT FROM AUTHOR]