1. Conventional Therapy in Adults With X-Linked Hypophosphatemia: Effects on Enthesopathy and Dental Disease
- Author
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Jessica Connor, Lee Katz, Suher Baker, Raghbir Kaur, Thomas O. Carpenter, John Sterpka, Christine A. Simpson, Jane H. Zhang, Robert Dubrow, Elizabeth Olear, and Karl L. Insogna
- Subjects
medicine.medical_specialty ,Pediatrics ,business.industry ,Endocrinology, Diabetes and Metabolism ,Enthesopathy ,Biochemistry (medical) ,Clinical Biochemistry ,Psychological intervention ,Context (language use) ,X-linked hypophosphatemia ,medicine.disease ,Biochemistry ,Adult life ,Endocrinology ,Internal medicine ,Oral and maxillofacial pathology ,Physical therapy ,Medicine ,Observational study ,business ,Hypophosphatemia - Abstract
Context: Treatment of X-linked hypophosphatemia (XLH) with active vitamin D metabolites and phosphate can partially correct skeletal deformities. It is unclear whether therapy influences the occurrence of two major long-term morbidities in XLH: enthesopathy and dental disease. Objective: The objective of the study was to investigate the relationship between treatment and enthesopathy and dental disease in adult XLH patients. Design: The study was designed as observational and cross-sectional. Setting: The study was conducted at an academic medical center's hospital research unit. Participants: Fifty-two XLH patients aged 18 years or older at the time of the study participated in the study. Interventions: There were no interventions. Main Outcome Measures: The number of enthesopathy sites identified by radiographic skeletal survey and dental disease severity (more than five or five or fewer dental abscesses), identified historically, were measured. Methods: Associations between proportion of adult life and...
- Published
- 2015
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