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7. Comparison of Outcomes in Bowel Resections by Gynecologic Oncologists Versus General Surgeons During Maximal Cytoreductive Surgery for Advanced Ovarian Cancer: Gynecologic Oncology Research Investigators Collaboration Study (GORILLA-3006)

Author

Kim, Myeong-Seon, Lee, A. Jin, Shim, Seung-Hyuk, Jang, Eun Bi, Kim, Nam Kyeong, Kim, Min Kyung, Suh, Dong Hoon, Kim, Jeeyeon, Son, Joo-Hyuk, Kong, Tae-Wook, Chang, Suk-Joon, Hwang, Dong Won, Park, Soo Jin, Kim, Hee Seung, Yoo, Ji Geun, Lee, Sung Jong, and Lee, Yoo-Young

Published
2024
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14. PM exposure during pregnancy affects childhood asthma via placental epigenetic changes: Neuronal differentiation and proliferation and Notch signaling pathways

Author

Kim, Hyo-Bin, Lee, Si Hyeon, Yang, Dae Yeol, Lee, Seung-Hwa, Kim, Jeong-Hyun, Kim, Hwan-Cheol, Choi, Kil Yong, Lee, So-Yeon, Yang, Song-I, Suh, Dong In, Shin, Youn Ho, Kim, Kyung Won, Ahn, Kangmo, Choi, Suk-Joo, Kwon, Ja-Young, Kim, Soo Hyun, Jun, Jong Kwan, Lee, Mi-Young, Won, Hye-Sung, Kim, Kwoneel, and Hong, Soo-Jong

Published
2025
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15. The evolving value assessment of cancer therapies: Results from a modified Delphi study

Author

Lee, Myrto, Larose, Hugo, Gräbeldinger, Martin, Williams, Jon, Baird, Anne-Marie, Brown, Susan, Bruns, Johannes, Clark, Russell, Cortes, Javier, Curigliano, Giuseppe, Ferris, Andrea, Garrison, Louis P., Gupta, Y.K., Kanesvaran, Ravindran, Lyman, Gary, Pani, Luca, Pemberton-Whiteley, Zack, Salmonson, Tomas, Sawicki, Peter, Stein, Barry, Suh, Dong-Churl, Velikova, Galina, and Grueger, Jens

Published
2024
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19. Atezolizumab and chemotherapy for advanced or recurrent endometrial cancer (AtTEnd): a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Zola, Paolo, Casanova, Claudia, Arcangeli, Valentina, Antonuzzo, Lorenzo, Gadducci, Angiolo, Cosio, Stefania, Clamp, Andrew, Persic, Mojca, McNeish, Ian, Tookman, Laura, Redondo Sanchez, Andrés, Choi, Chel Hun, Baldini, Editta, Palaia, Innocenza, Benedetti Panici, Pierluigi, Takahashi, Nobutaka, Lombard, Janine, Ardizzoia, Antonio, Bologna, Alessandra, Herrero Ibáñez, Ana Maria, Musolino, Antonino, Márquez Vázquez, Raúl, Pietzner, Klaus, Braicu, Elena, Heinzelmann-Schwarz, Viola A., Powell, Melanie, Yokoyama, Yoshihito, Baron-Hay, Sally, Abeni, Chiara, Martin Lorente, Cristina, Cueva, Juan Fernando, Trillsch, Fabian, Heitz, Florian, Ataseven, Beyhan, Petru, Edgar, Heubner, MartinLeonhard, Sadozye, Azmat Hassanq, Dubey, Sidharth, Tazbirkova, Andrea, Tiley, Susan, Chrystal, Kathryn, Kim, Sang Wun, Fehr, Mathias, Scatchard, Kate, Anand, Anjana, Taylor, Alexandra, Watary, Hidemichi, Enomoto, Takayuki, Yoshihara, Kosuke, Selva-Nayagam, Sudarsha, Karki, Bhaskar, Harrison, Michelle, Wilkinson, Kate, Goh, Jeffrey, Glasgow, Amanda, Chantrill, Lorraine, Lee, Chulmin, Bertolini, Alessandro, Narducci, Filomena, Bellotti, Giovanna, Fusco, Vittorio, Aebi, Stefan, Del Grande, Maria, Colombo, Ilaria, Tokunaga, Hideki, Shigeta, Shogo, Goss, Geraldine, Siow, Zhen Rong, Steer, Christopher, Lin, Hao, Lee, Kwang-Beom, Di Meglio, Giovanni, Massa, Elena, De Marino, Elvira, Tortora, Vincenzo, Palacio Vazquez, Isabel, Tsuji, Kosuke, Tominaga, Eiichiro, Black, Allison, So, Kyeong A, Suh, Dong Hoon, Lee, Keun Ho, Kim, Yong Man, Fossati, Roldano, Carlucci, Luciano, Barberis, Massimo, Torri, Valter, Santoni, Anna, Colombo, Nicoletta, Biagioli, Elena, Harano, Kenichi, Galli, Francesca, Hudson, Emma, Antill, Yoland, Rabaglio, Manuela, Marmé, Frederic, Marth, Christian, Parma, Gabriella, Fariñas-Madrid, Lorena, Nishio, Shin, Allan, Karen, Lee, Yeh Chen, Piovano, Elisa, Pardo, Beatriz, Nakagawa, Satoshi, McQueen, John, Zamagni, Claudio, Manso, Luis, Takehara, Kazuhiro, Tasca, Giulia, Ferrero, Annamaria, Tognon, Germana, Lissoni, Andrea Alberto, Petrella, Mariacristina, Laudani, Maria Elena, Rulli, Eliana, Uggeri, Sara, and Barretina Ginesta, M Pilar

Published
2024
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21. Ultrathin ferroic HfO2–ZrO2 superlattice gate stack for advanced transistors

Author

Cheema, Suraj S, Shanker, Nirmaan, Wang, Li-Chen, Hsu, Cheng-Hsiang, Hsu, Shang-Lin, Liao, Yu-Hung, San Jose, Matthew, Gomez, Jorge, Chakraborty, Wriddhi, Li, Wenshen, Bae, Jong-Ho, Volkman, Steve K, Kwon, Daewoong, Rho, Yoonsoo, Pinelli, Gianni, Rastogi, Ravi, Pipitone, Dominick, Stull, Corey, Cook, Matthew, Tyrrell, Brian, Stoica, Vladimir A, Zhang, Zhan, Freeland, John W, Tassone, Christopher J, Mehta, Apurva, Saheli, Ghazal, Thompson, David, Suh, Dong Ik, Koo, Won-Tae, Nam, Kab-Jin, Jung, Dong Jin, Song, Woo-Bin, Lin, Chung-Hsun, Nam, Seunggeol, Heo, Jinseong, Parihar, Narendra, Grigoropoulos, Costas P, Shafer, Padraic, Fay, Patrick, Ramesh, Ramamoorthy, Mahapatra, Souvik, Ciston, Jim, Datta, Suman, Mohamed, Mohamed, Hu, Chenming, and Salahuddin, Sayeef

Subjects
Engineering, Physical Sciences, Condensed Matter Physics, General Science & Technology
Abstract

With the scaling of lateral dimensions in advanced transistors, an increased gate capacitance is desirable both to retain the control of the gate electrode over the channel and to reduce the operating voltage1. This led to a fundamental change in the gate stack in 2008, the incorporation of high-dielectric-constant HfO2 (ref. 2), which remains the material of choice to date. Here we report HfO2-ZrO2 superlattice heterostructures as a gate stack, stabilized with mixed ferroelectric-antiferroelectric order, directly integrated onto Si transistors, and scaled down to approximately 20 ångströms, the same gate oxide thickness required for high-performance transistors. The overall equivalent oxide thickness in metal-oxide-semiconductor capacitors is equivalent to an effective SiO2 thickness of approximately 6.5 ångströms. Such a low effective oxide thickness and the resulting large capacitance cannot be achieved in conventional HfO2-based high-dielectric-constant gate stacks without scavenging the interfacial SiO2, which has adverse effects on the electron transport and gate leakage current3. Accordingly, our gate stacks, which do not require such scavenging, provide substantially lower leakage current and no mobility degradation. This work demonstrates that ultrathin ferroic HfO2-ZrO2 multilayers, stabilized with competing ferroelectric-antiferroelectric order in the two-nanometre-thickness regime, provide a path towards advanced gate oxide stacks in electronic devices beyond conventional HfO2-based high-dielectric-constant materials.

Published
2022

22. Non-Abelian operation of molecular topological superconductor by n-MOSFET

Author

Choi, Kyoung Hwan and Suh, Dong Hack

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

Braiding operations are challenging to create topological quantum computers. It is unclear whether braiding operations can be executed with any materials. Although various calculations based on Majorana fermions show braiding possibilities, a braiding operation with a Majorana fermion has not yet been experimentally proven. Herein, braiding operations are demonstrated using a molecular topological superconductor (MTSC) that utilizes the topological properties intrinsic in molecules. The braiding operations were implemented by controlling two MTSC modules made by pelletizing crystals of 4,5,9,10-tetrakis(dodecyloxy)pyrene, which is proposed as the first MTSC material through n-MOSFETs. It shows the elements of topological quantum computers that can be demonstrated without an external magnetic field at room temperature., Comment: 7 pages 4 figures

Published
2021

23. A Phase II Trial to Evaluate the Efficacy of Bortezomib and Liposomal Doxorubicin in Patients With BRCA Wild-type Platinum-resistant Recurrent Ovarian Cancer (KGOG 3044/EBLIN)

Author

Lee, Yong Jae, Seol, Aeran, Lee, Maria, Kim, Jae-Weon, Kim, Hee Seung, Kim, Kidong, Suh, Dong Hoon, Kim, Sunghoon, Kim, Sang Wun, and Lee, Jung-Yun

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Trials and Supportive Activities, Rare Diseases, Clinical Research, Genetics, Cancer, Ovarian Cancer, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Antineoplastic Combined Chemotherapy Protocols, Bortezomib, Carcinoma, Ovarian Epithelial, Doxorubicin, Female, Humans, Neoplasm Recurrence, Local, Ovarian Neoplasms, Platinum, Polyethylene Glycols, BRCA, antitumor activity, pegylated liposomal doxorubicin, platinum-resistant recurrent ovarian cancer, Oncology & Carcinogenesis, Clinical sciences, Dentistry, Oncology and carcinogenesis
Abstract

Background/aimThe majority of targeted therapies are focused on BRCA mutations, homologous recombination repair deficiency, and BRCA wild-type platinum-sensitive recurrent ovarian cancer. There is a growing need for platinum-resistant patients without BRCA mutations. Herein, we conducted a phase II multicenter study evaluated the efficacy and safety of bortezomib plus pegylated liposomal doxorubicin (PLD) in patients with BRCA wild-type platinum-resistant recurrent ovarian cancer (NCT03509246).Patients and methodsOvarian cancer patients with wild-type BRCA who experienced platinum-resistant recurrence after three or less prior treatment cycles from three Institutions were included. All patients received bortezomib, 1.3 mg/m2 subcutaneously (days 1, 4, 8, and 11), and PLD, 40 mg/m2 intravenously (day 4), every 4 weeks. The primary endpoint was best objective response rate (ORR), and secondary endpoints included disease control rate, progression-free survival (PFS), overall survival, and safety. Targeted sequencing was performed to evaluate biomarkers and their potential association with response to treatment.ResultsThe trial was terminated after 23 patients were recruited because of slow accrual. The median follow-up was 29.5 months. The overall ORR was 8.7% (2/23); partial response was observed in two patients. The median duration of response was 10.5 months, and median PFS was 2.9 months. Treatment-related adverse events (TRAEs) of grade 3/4 were reported in 43.5% of patients. One patient who exhibited TRAEs discontinued treatment. However, grade 4/5 TRAEs were not observed. Mutations in TP53 and CDK12 were detected in 67% (14/21) and 24% (12/21) of patients, respectively. Two patients with partial response harbored mutations in genes related to homologous recombination repair deficiency, including BRCA2, ATM, and CDK12.ConclusionThe combination of bortezomib and PLD was well tolerated; however, antitumor activity was not sufficient to warrant further investigation in ovarian cancer.

Published
2022

30. Meta-morphism: Exotic Polymorphism of Metamaterial Self-assembled by pyrene derivative

Author

Choi, Kyoung Hwan, Hwang, Da Young, and Suh, Dong Hack

Subjects
Condensed Matter - Materials Science, Condensed Matter - Soft Condensed Matter, Physics - Classical Physics
Abstract

Polymorphism, which describes the occurrence of different lattice structures in a crystalline material, is a critical phenomenon in material science and condensed matter physics. It has emerged as a major focus for industry and regulatory agencies respectively. Thermomicroscopy, infrared spectroscopy and thermal analysis, especially differential scanning calorimetry (DSC) is used to characterize polymorphism to provide a powerful to isolate and identify of crystalline modification. Enantiotropic and monotropic with reversible endothermic and irreversible exothermic phase transition is representative classifications of polymorphism. Recently, Dirac metamaterial based on pyrene derivatives is attracting great attention. It succeeded in forming a periodic and regular structure using the unique {\pi}-{\pi} interaction of the pyrene derivative, namely HYLION-12. The phase transition between modifications is not classified into the existing polymorphism system. Here, we propose a new kind of polymorphism by identifying and analyzing thermodynamic functions such as heat capacity, enthalpy, entropy and, Gibbs free energy between modifications from DSC. This not only allows us to better understand the formation of Dirac materials at the molecular level, but also to think about the condition for new types of polymorphism., Comment: 8 pages, 3 figures

Published
2021

31. The Origin of Aromaticity: Aromatic Compounds as Intrinsic Topological Superconductors with Majorana Fermion

Author

Choi, Kyoung Hwan and Suh, Dong Hack

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Soft Condensed Matter, Condensed Matter - Strongly Correlated Electrons
Abstract

Topological superconductors have been discovered with recent advances in understanding the topological properties of condensed matters. These states have a full pairing gap in the bulk and gapless counter-propagating Majorana states at the boundary. A pair of Majorana zero modes is associated with each vortex. This understanding had a great influence on the theory of superconductivity and their following experiments, but its relevantce to organic compounds was not closely observed. Here, we analyze the topological states of various polyaromatic hydrocarbons (PAHs), including benzene, and reveal that they are topological superconductors. We have analyzed the momentum vectors of benzene and other PAHs through a semi-classical approach to confirm their non-trivial state. Their unique properties might be originated from the odd number of Kramers doublets in PAHs. The H\"uckel rule describing aromaticity can be reinterpreted with a topological viewpoint. It suggests that the (4n+2) rule can be split into two pairs of (2n+1) electrons each, namely, electrons and holes with spin up and down. Therefore, it always forms an odd number of Kramers` doublet. Moreover, n in the H\"uckel rule can be interpreted as the winding number in global next-nearest-neighbor(NNN) hopping. This work will re-establish the definition of aromaticity that has been known so far and extend the use of aromatic compounds as topological superconductors to quantum computers., Comment: 9 pages, 5 figures

Published
2021

32. Growth of metamaterial from Isolated nuclei with anisotropic building block

Author

Choi, Kyoung Hwan, Hwang, Da Young, and Suh, Dong Hack

Subjects
Condensed Matter - Materials Science
Abstract

Crystallization has long been the subject of research as one of the basic ways in which solid materials are constructed. In particular, the nucleation stage has not been isolated, thus has been predicted through many calculations and achieved theoretical completion through the nucleation rate(J). Si nce most of these results were obtained through isotropic building blocks in three-dimensional space, it was difficult to interpret nuclei formed by anisotropic building block in 2D or 1D structure. Recently, a lot of studies related to amyloid fibril have shown nucleation of anisotropic building block. However, due to the complexity of the amyloid fibrils, there is no unified explanation of the thermodynamic method of classical nucleation theory which is the energy loss from surface and energy gain from volume. We have experimentally demonstrated the isolation of nuclei of the orthorhombic phase of HYLION-12 which is a Dirac metamaterial and provide the effect of anisotropy of the molecules on nucleation The thermal behavior of nuclei of Dirac metamaterial through DSC has demonstrated that it can be crystallized to a Dirac metamaterial through the first order phase transition. The growth process is verified at low temperature where no phase transition occurs. The calculation of surface and bulk energy of the Dirac metamaterial was conducted. It could explain the isolation of nuclei of the Dirac metamaterial by enlarging the thermodynamic classical nucleation theory., Comment: 10 pages, 5 figures

Published
2021

33. Meta-separation: complete separation of organic-water mixtures by structural property of metamaterial

Author

Choi, Kyoung Hwan, Hwang, Da Young, Park, Jeong Eon, and Suh, Dong Hack

Subjects
Condensed Matter - Materials Science
Abstract

The separation of liquid mixture has been studied for a long time. Separation proceeds based on the difference in physical properties including pore size and electrostatic interaction. Therefore, there are many difficulties in separation of materials having similar size or polarities in physical properties such as ethanol-water and 1,4-dioxane-water mixtures. While we still lack a universal generalization of these ideas to the separation, pervaporation based on a difference in transport rates by permeability through a membrane by the permeate was early suggested. Yet there is an existing technical gap to remove trace amounts of organics dissolved in water. Here, we report a novel separation strategy employing a metamaterial, called meta-separation using the exotic structural property of metamateirals rather than electrostatic characteristics. The structural properties of metamaterials provide various functions of super-hydrophobicity based on roughness of surface, the strong capillary effect based on nanopore, and huge void for great absorption of organics. It exhibited a water contact angle of 151.3{\deg} and high adhesive property from nanopore. On the other hands, ethanol was immediately absorbed up to 93 wt%. This differences made it possible to quickly and easily eliminate organics dissolved in water. Furthermore, their applications are expected to achieve functions in environmental remediation, biofuel separation process, etc., without large scale facilities., Comment: 7 pages, 5figures

Published
2021

34. Observation of Majorana Plasmon by Molecular Topological Superconductor and Its Topological SPASER

Author

Choi, Kyoung Hwan and Suh, Dong Hack

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science, Physics - Optics, Physics - Plasma Physics
Abstract

Plasmons, quantized collective oscillations of electrons, have been observed in metals and semiconductors. Such massive electrons have been the basic ingredients of research in plasmonics and optical metamaterials.1 Also, Dirac plasmons have been observed in graphene, two-dimensional electron systems and topological insulators (TIs). A nontrivial Z2 topology of the bulk valence band leads to the emergence of massless Dirac fermions on the surface in TIs.2,3 Although Dirac plasmons can be formed through additional grating or patterning, their characteristics promise novel plasmonic metamaterials that are tunable in the terahertz and mid-infrared frequency ranges.4 Recently, the Majorana fermions have been verified through various kinds of topological superconductors(TSCs). In particular, the quantized and paired spin waves have been discovered in polyaromatic hydrocarbons(PAHs)5 and Majorana hinge and corner modes have been identified in the organic crystal of PAHs. Interestingly, regularity and periodicity can serve in the xy-plane of the crystal as the patterning of TSC resonators. Here, first we report experimental evidence of Majorana plasmonic excitations in a molecular topological superconductor (MTSC). It was prepared from MTSC resonators with different stacked numbers of HYLION-12. Distributing carriers into multiple MTSC resonators enhance the plasmonic resonance frequency and magnitude, which is different from the effects in a conventional semiconductor superlattice.6,7 The direct results of the unique carrier density scaling law of the resonance of massless Majorana fermions is demonstrated. Moreover, topological surface plasmon amplification by stimulated emission of radiation (SPASER) is also firstly created from the MTSC resonator. It has two mutually time-reversed chiral surface plasmon modes carrying the opposite topological charges., Comment: 8 pages, 4 figures

Published
2021

35. Experimental realization of Majorana hinge and corner modes in intrinsic organic topological superconductor without magnetic field at room temperature

Author

Choi, Kyoung Hwan and Suh, Dong Hack

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Superconductivity
Abstract

Exotic states of topological materials are challenging or impossible to create under ambient conditions.1-4 Moreover, it is unclear whether topological superconductivity, as a critical element for topological quantum computing, exists in any naturally occurring materials.5-7 Although these problems can be overcome through the combination of materials in heterostructures, there are still many requisites, such as low temperatures and specific magnetic fields.8,9 Herein, an intrinsic topological superconductor that does not depend on particular external conditions is demonstrated. It is accomplished utilizing the unique properties of polyaromatic hydrocarbons (PAHs), which have been proposed to have persistent ring current.10-12 According to the Su-Schrieffer-Heeger(SSH)13 and Kitaev14 models, PAHs can have a non-trivial edge mode, so that perpendicularly stacked PAHs are expected to have Majorana hinge and corner modes.15 Intrinsic persistent ring current of HYLION-12 is demonstrated by MPMS.16 Coherent Quantum Phase Slip(CQPS), the Constant Conductance Plateau (CCP) and the zero bias conductance peak(ZBP) which is signatures of hinge modes are confirmed through the Josephson junction device of pelletized orthorhombic phase organic crystals of HYLION-12 by transport spectroscopy.17,18 They are signatures of Majorana hinge and corner modes. In addition, the braidinglike operation by transport spectroscopy shows the emergence of the most important and critical elements of quantum computers that can be realized without an external magnetic field at room temperature., Comment: 11 pages, 5 figures

Published
2021

36. Dirac Metamaterial Assembled by Pyrene Derivative and its Topological Photonics

Author

Choi, Kyoung Hwan, Hwang, Da Young, and Suh, Dong Hack

Subjects
Physics - Optics, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science, Condensed Matter - Other Condensed Matter
Abstract

Over the past decade, topology has garnered great attention in a wide area of physics. In particular, it has exerted influence on photonics because carefully engineered photonic crystals and metamaterials can help explore the non-trivial state of materials. In this regard, all dielectric metamaterials with large anisotropy, and dipole and multipole Mie resonators have played an increasingly important role in topological photonics. Advantages of Mie resonators make it possible to quest for non-trivial states in three dimensions and theoretical calculation supports its potential. However, it is very difficult to demonstrate this experimentally because it is hard to make the metacrystal by anisotropic meta-atoms despite much effort. Here we report a Dirac metamaterial for 3D topological photonics. It is implemented by a metacrystal self-assembled by a molecule, HYLION-12 which has both anisotropic polarizability and ring current. As its peculiar properties, it has an exotic optical constant that can be used for the electric and magnetic hyperbolic metamaterial, and the double hyperbolic metamaterial in the ultraviolet region. It also showed 142% of reflectance at 242nm as an amplified reflector and asymmetric transmittance up to 30% through the opaque substrate as a Huygens source under 300nm. Furthermore, it demonstrated various phenomena of topological photonics such as Pancharatnam-Berry and waveguide phase merging, wavefront shaping and waveguide on edges as a 3D topological photonic material. The new strategy using polyaromatic hydrocarbons (PAHs) is expected to be an effective way to realize 3D topological photonics., Comment: 10 pages, 5 figures

Published
2021

43. A syndromic neurodevelopmental disorder caused by rare variants in PPFIA3

Author

Acosta, Maria T., Adam, Margaret, Adams, David R., Alvarez, Raquel L., Alvey, Justin, Amendola, Laura, Andrews, Ashley, Ashley, Euan A., Bacino, Carlos A., Bademci, Guney, Balasubramanyam, Ashok, Baldridge, Dustin, Bale, Jim, Bamshad, Michael, Barbouth, Deborah, Bayrak-Toydemir, Pinar, Beck, Anita, Beggs, Alan H., Behrens, Edward, Bejerano, Gill, Bellen, Hugo J., Bennett, Jimmy, Berg-Rood, Beverly, Bernstein, Jonathan A., Berry, Gerard T., Bican, Anna, Bivona, Stephanie, Blue, Elizabeth, Bohnsack, John, Bonner, Devon, Botto, Lorenzo, Boyd, Brenna, Briere, Lauren C., Brown, Gabrielle, Burke, Elizabeth A., Burrage, Lindsay C., Butte, Manish J., Byers, Peter, Byrd, William E., Carey, John, Carrasquillo, Olveen, Cassini, Thomas, Chang, Ta Chen Peter, Chanprasert, Sirisak, Chao, Hsiao-Tuan, Chinn, Ivan, Clark, Gary D., Coakley, Terra R., Cobban, Laurel A., Cogan, Joy D., Coggins, Matthew, Cole, F. Sessions, Colley, Heather A., Cope, Heidi, Corona, Rosario, Craigen, William J., Crouse, Andrew B., Cunningham, Michael, D’Souza, Precilla, Dai, Hongzheng, Dasari, Surendra, Davis, Joie, Dayal, Jyoti G., Dell'Angelica, Esteban C., Dipple, Katrina, Doherty, Daniel, Dorrani, Naghmeh, Doss, Argenia L., Douine, Emilie D., Earl, Dawn, Eckstein, David J., Emrick, Lisa T., Eng, Christine M., Falk, Marni, Fieg, Elizabeth L., Fisher, Paul G., Fogel, Brent L., Forghani, Irman, Gahl, William A., Glass, Ian, Gochuico, Bernadette, Goddard, Page C., Godfrey, Rena A., Golden-Grant, Katie, Grajewski, Alana, Hadley, Don, Hahn, Sihoun, Halley, Meghan C., Hamid, Rizwan, Hassey, Kelly, Hayes, Nichole, High, Frances, Hing, Anne, Hisama, Fuki M., Holm, Ingrid A., Hom, Jason, Horike-Pyne, Martha, Huang, Alden, Hutchison, Sarah, Introne, Wendy, Isasi, Rosario, Izumi, Kosuke, Jamal, Fariha, Jarvik, Gail P., Jarvik, Jeffrey, Jayadev, Suman, Jean-Marie, Orpa, Jobanputra, Vaidehi, Karaviti, Lefkothea, Ketkar, Shamika, Kiley, Dana, Kilich, Gonench, Kobren, Shilpa N., Kohane, Isaac S., Kohler, Jennefer N., Korrick, Susan, Kozuira, Mary, Krakow, Deborah, Krasnewich, Donna M., Kravets, Elijah, Lalani, Seema R., Lam, Byron, Lam, Christina, Lanpher, Brendan C., Lanza, Ian R., LeBlanc, Kimberly, Lee, Brendan H., Levitt, Roy, Lewis, Richard A., Liu, Pengfei, Liu, Xue Zhong, Longo, Nicola, Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., Macnamara, Ellen F., MacRae, Calum A., Maduro, Valerie V., Maghiro, Audrey Stephannie, Mahoney, Rachel, Malicdan, May Christine V., Mamounas, Laura A., Manolio, Teri A., Mao, Rong, Maravilla, Kenneth, Marom, Ronit, Marth, Gabor, Martin, Beth A., Martin, Martin G., Martínez-Agosto, Julian A., Marwaha, Shruti, McCauley, Jacob, McConkie-Rosell, Allyn, McCray, Alexa T., McGee, Elisabeth, Mefford, Heather, Merritt, J. Lawrence, Might, Matthew, Mirzaa, Ghayda, Morava, Eva, Moretti, Paolo, Mulvihill, John, Nakano-Okuno, Mariko, Nelson, Stanley F., Newman, John H., Nicholas, Sarah K., Nickerson, Deborah, Nieves-Rodriguez, Shirley, Novacic, Donna, Oglesbee, Devin, Orengo, James P., Pace, Laura, Pak, Stephen, Pallais, J. Carl, Palmer, Christina G.S., Papp, Jeanette C., Parker, Neil H., Phillips III, John A., Posey, Jennifer E., Potocki, Lorraine, Pusey Swerdzewski, Barbara N., Quinlan, Aaron, Rao, Deepak A., Raper, Anna, Raskind, Wendy, Renteria, Genecee, Reuter, Chloe M., Rives, Lynette, Robertson, Amy K., Rodan, Lance H., Rosenfeld, Jill A., Rosenwasser, Natalie, Rossignol, Francis, Ruzhnikov, Maura, Sacco, Ralph, Sampson, Jacinda B., Saporta, Mario, Schaechter, Judy, Schedl, Timothy, Schoch, Kelly, Scott, Daryl A., Scott, C. Ron, Seto, Elaine, Shashi, Vandana, Shin, Jimann, Silverman, Edwin K., Sinsheimer, Janet S., Sisco, Kathy, Smith, Edward C., Smith, Kevin S., Solnica-Krezel, Lilianna, Solomon, Ben, Spillmann, Rebecca C., Stoler, Joan M., Sullivan, Kathleen, Sullivan, Jennifer A., Sun, Angela, Sutton, Shirley, Sweetser, David A., Sybert, Virginia, Tabor, Holly K., Tan, Queenie K.-G., Tan, Amelia L.M., Tarakad, Arjun, Tekin, Mustafa, Telischi, Fred, Thorson, Willa, Tifft, Cynthia J., Toro, Camilo, Tran, Alyssa A., Ungar, Rachel A., Urv, Tiina K., Vanderver, Adeline, Velinder, Matt, Viskochil, Dave, Vogel, Tiphanie P., Wahl, Colleen E., Walker, Melissa, Wallace, Stephanie, Walley, Nicole M., Wambach, Jennifer, Wan, Jijun, Wang, Lee-kai, Wangler, Michael F., Ward, Patricia A., Wegner, Daniel, Weisz Hubshman, Monika, Wener, Mark, Wenger, Tara, Westerfield, Monte, Wheeler, Matthew T., Whitlock, Jordan, Wolfe, Lynne A., Worley, Kim, Xiao, Changrui, Yamamoto, Shinya, Yang, John, Zhang, Zhe, Zuchner, Stephan, Paul, Maimuna S., Michener, Sydney L., Pan, Hongling, Chan, Hiuling, Pfliger, Jessica M., Lerma, Vanesa C., Tran, Alyssa, Longley, Megan A., Weisz-Hubshman, Monika, Bekheirnia, Mir Reza, Bekheirnia, Nasim, Massingham, Lauren, Zech, Michael, Wagner, Matias, Engels, Hartmut, Cremer, Kirsten, Mangold, Elisabeth, Peters, Sophia, Trautmann, Jessica, Perne, Claudia, Mester, Jessica L., Guillen Sacoto, Maria J., Person, Richard, McDonnell, Pamela P., Cohen, Stacey R., Lusk, Laina, Cohen, Ana S.A., Le Pichon, Jean-Baptiste, Pastinen, Tomi, Zhou, Dihong, Engleman, Kendra, Racine, Caroline, Faivre, Laurence, Moutton, Sébastien, Denommé-Pichon, Anne-Sophie, Koh, Hyun Yong, Poduri, Annapurna, Bolton, Jeffrey, Knopp, Cordula, Julia Suh, Dong Sun, Maier, Andrea, Toosi, Mehran Beiraghi, Karimiani, Ehsan Ghayoor, Maroofian, Reza, Schaefer, Gerald Bradley, Ramakumaran, Vijayalakshmi, Vasudevan, Pradeep, Banos-Pinero, Benito, Pagnamenta, Alistair T., Prasad, Chitra, Osmond, Matthew, Schuhmann, Sarah, Vasileiou, Georgia, Russ-Hall, Sophie, Scheffer, Ingrid E., and Carvill, Gemma L.

Published
2024
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47. Designing a Strategy Trial for the Management of Gout: The Use of a Modified Delphi Panel

Author

Solomon, Daniel H, Weissman, Joel S, Choi, Hyon, Atlas, Steven J, Berardinelli, Cesar, Dedier, Julien, Fischer, Michael A, Fitzgerald, John, Hinteregger, Erica, Johnsen, Brianne, Marini, Diana D, McLean, Robert, Murray, Fred, Neogi, Tuhina, Oertel, Lynn B, Pillinger, Michael H, Riggs, Kevin R, Saag, Ken, Suh, Dong, Watkins, James, and Barry, Michael J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Clinical sciences
Abstract

ObjectiveDisagreement exists between rheumatology and primary care societies regarding gout management. This paper describes a formal process for gathering input from stakeholders in the planning of a trial to compare gout management strategies.MethodsWe recruited patients, nurses, physician assistants, primary care clinicians, and rheumatologists to participate in a modified Delphi panel (mDP) to provide input on design of a trial focused on optimal management for primary care patients with gout. The 16 panelists received a plain-language briefing document that discussed the rationale for the trial, key clinical issues in gout, and aspects of trial design. The panelists also received information and considerations on nine voting questions (VQs), judged to be the key design questions. Cognitive interviews with panelists ensured that the VQs were understood by the range of panelists involved in the mDP. Panelists were asked to score all VQs from 1 (definitely no) to 9 (definitely yes). Two voting rounds were conducted-round 1 by email and round 2 by video conference.ResultsThe VQs were modified through the cognitive interviews. The round 1 voting resulted in consensus on eight items, with consensus defined as median voting score in the same tercile (1-3, 4-6 or 7-9). Re-voting at the meeting (round 2) reached consensus on the remaining item.ConclusionAn mDP with various stakeholders facilitated consensus on the design of a trial of different management strategies for chronic gout. This method may be useful for designing trials of clinical questions with substantial disagreement across stakeholders.

Published
2021

49. Frequency of exacerbation and degree of required asthma medication can characterize childhood longitudinal asthma trajectories

Author

Lee, Eun, Rhee, Eun Hee, Kim, Kyunghoon, Kim, Hwan Soo, Kim, Woo Kyung, Song, Dae Jin, Park, Ji Soo, Yoo, Young, Suh, Dong In, Jung, Sungsu, Yoon, Ji-Sun, Lee, Seung Won, Kim, Jin Tack, Lim, Dae Hyun, Baek, Hey Sung, Shin, Meeyong, Kwon, Ji Won, Jang, Gwang Cheon, Seo, Ju Hee, Woo, Sung Il, Kim, Hyung Young, Shin, Youn Ho, Lee, Ju Suk, Yang, Hyeon-Jong, and Yu, Jinho

Published
2023
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50. Equivariant cobordism of torus orbifolds

Author

Sarkar, Soumen and Suh, Dong Youp

Subjects
Mathematics - Algebraic Topology
Abstract

Torus orbifolds are topological generalization of symplectic toric orbifolds. We give a construction of smooth orbifolds with torus actions whose boundary is a disjoint union of torus orbifolds using toric topological method. As a result, we show that any orientable locally standard torus orbifold is equivariantly cobordant to some copies of orbifold complex projective spaces. We also discuss some further equivariant cobordism results including the cases when torus orbifolds are actually torus manifolds., Comment: 27 pages, 7 figures, Comments are welcome!

Published
2019

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