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222 results on '"Sugiura, Yoshimi"'

40. Multimodal Imaging Features and Clinical Relevance of Subretinal Lipid Globules

Author

Fernandez-Avellaneda, Pedro, Freund, K. Bailey, Wang, Reeking K., He, Qinghua, Zhang, Qinqin, Fragiotta, Serena, Xu, Xiaoyu, Ledesma-Gil, Gerardo, Sugiura, Yoshimi, Breazzano, Mark P., Yannuzzi, Lawrence A., Liakopoulos, Sandra, Sarraf, David, Dolz-Marco, Rosa, Fernandez-Avellaneda, Pedro, Freund, K. Bailey, Wang, Reeking K., He, Qinghua, Zhang, Qinqin, Fragiotta, Serena, Xu, Xiaoyu, Ledesma-Gil, Gerardo, Sugiura, Yoshimi, Breazzano, Mark P., Yannuzzi, Lawrence A., Liakopoulos, Sandra, Sarraf, David, and Dolz-Marco, Rosa

Abstract

PURPOSE: To describe the presence of subretinal lipid globules (SLG), analyze the multimodal imaging features inherent in their optical properties, and provide a means to distinguish them from other retinal structures and clinical signs. DESIGN: Retrospective cohort study. METHODS: The clinical data and multimodal imaging features of 39 patients (49 eyes) showing SLG were evaluated. Patients underwent color fundus photography, near-infrared reflectance (NIR), spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) and OCT angiography. In vitro phantom models were used to model OCT optical properties of water, mineral oil, and intralipid droplets and to investigate the optical mechanisms producing hypertransmission tails beneath SLG. RESULTS: The SLG were not visible in color fundus photographs or in NIR images. With both SD- and SS-OCT B-scans, SLG appeared as 31-157 pm, round, hyporeflective structures demonstrating a characteristic hypertransmission tail previously described with lipid globules found in the choroid and in neovascular membranes. Similarly, with en face OCT, SLG appeared as small, round, hyporeflective structures. SLG were encountered most often in eyes with neovascular age-related macular degeneration (AMD) that had type 1 macular neovascularization (MNV) (91.1%). Of those eyes, 93.3% were receiving intravitreal antivascular endothelial growth factor (VEGF) therapy (median of 15 injections) with a mean follow-up of 52.6 months. The number of prior injections positively correlated with the number of SLG. The detection of MNV preceded the presence of SLG in 66.7% of cases. En face OCT showed that, in many eyes (49%), SLG appeared in clusters of > 10. In 38.8% of eyes, SLG were found overlying type 1 MNV, and in 44.9% of eyes, often those with more numerous SLG, the SLG were located near the lesion border. In 2 eyes with AMD followed for nonexudative type 1 MNV, SLG were detected prior to the detection of other imaging signs of e

Published
2021

43. Contrast sensitivity and quality of life following intravitreal ranibizumab injection for central retinal vein occlusion

Author

Murakami, Tomoya, Okamoto, Fumiki, Sugiura, Yoshimi, Morikawa, Shohei, Okamoto, Yoshifumi, Hiraoka, Takahiro, and Oshika, Tetsuro

Abstract

Synopsis/precisWe investigated the relationship between contrast sensitivity (CS) and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion following ranibizumab intravitreal injection; CS showed a stronger association with VR-QOL than visual acuity.Background/aimsTo investigate the relationship between CS, VR-QOL and optical coherence tomography (OCT) findings in patients with cystoid macular oedema secondary to central retinal vein occlusion (CRVO-CMO) following intravitreal injection of ranibizumab.MethodsThis was a multicentre, open-label, single-arm, prospective study. The study included 23 patients with CRVO-CMO who were followed up for 12 months after treatment. The best-corrected visual acuity (BCVA), letter contrast sensitivity (LCS) and OCT images were obtained every month. For VR-QOL assessment, the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) was administered to the patients before treatment and at 3, 6 and 12 months following treatment.ResultsThe LCS and VFQ-25 composite score improved significantly from baseline to 12 months following treatment. The multiple regression analysis revealed that the LCS of the affected eye and BCVA of the fellow eye were related to the VFQ-25 composite score following treatment. The LCS improvement showed a significant correlation with the improvement in the VFQ-25 composite score, whereas the BCVA improvement was not correlated with the improvement in the VFQ-25 composite score. Stepwise multiple regression analyses revealed that, at the time of macular oedema resolution, the distance between the external limiting membrane and retinal pigment epithelium (ELM-RPE) and average ganglion cell-inner plexiform layer (GCIPL) thickness were associated with LCS.ConclusionCS had a stronger association with VR-QOL than with BCVA in patients with CRVO-CMO. With the resolution of macular oedema, CS was associated with ELM-RPE thickness and average GCIPL thickness.

Published
2023
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46. Multimodal Imaging Features and Clinical Relevance of Subretinal Lipid Globules

Author

Fernández-Avellaneda, Pedro, primary, Freund, K. Bailey, additional, Wang, Reeking K., additional, He, Qinghua, additional, Zhang, Qinqin, additional, Fragiotta, Serena, additional, Xu, Xiaoyu, additional, Ledesma-Gil, Gerardo, additional, Sugiura, Yoshimi, additional, Breazzano, Mark P., additional, Yannuzzi, Lawrence A., additional, Liakopoulos, Sandra, additional, Sarraf, David, additional, and Dolz-Marco, Rosa, additional

Published
2021
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47. Non-neovascular age-related macular degeneration with subretinal fluid

Author

Hilely, Assaf, primary, Au, Adrian, additional, Freund, K Bailey, additional, Loewenstein, Anat, additional, Souied, Eric H, additional, Zur, Dinah, additional, Sacconi, Riccardo, additional, Borrelli, Enrico, additional, Peiretti, Enrico, additional, Iovino, Claudio, additional, Sugiura, Yoshimi, additional, Ellabban, Abdallah A, additional, Monés, Jordi, additional, Waheed, Nadia K., additional, Ozdek, Sengul, additional, Yalinbas, Duygu, additional, Thiele, Sarah, additional, de Moura Mendonça, Luísa Salles, additional, Lee, Mee Yon, additional, Lee, Won Ki, additional, Turcotte, Pierre, additional, Capuano, Vittorio, additional, Filali Ansary, Meryem, additional, Chakravarthy, Usha, additional, Lommatzsch, Albrecht, additional, Gunnemann, Frederic, additional, Pauleikhoff, Daniel, additional, Ip, Michael S, additional, Querques, Giuseppe, additional, Holz, Frank G, additional, Spaide, Richard F, additional, Sadda, SriniVas, additional, and Sarraf, David, additional

Published
2020
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49. Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion

Author

Au, Adrian, primary, Hilely, Assaf, additional, Scharf, Jackson, additional, Gunnemann, Frederic, additional, Wang, Derrick, additional, Chehaibou, Ismael, additional, Iovino, Claudio, additional, Grondin, Christelle, additional, Farecki, Marie-Louise, additional, Falavarjani, Khalil Ghasemi, additional, Phasukkijwatana, Nopasak, additional, Battista, Marco, additional, Borrelli, Enrico, additional, Sacconi, Riccardo, additional, Powell, Brittany, additional, Hom, Grant, additional, Greenlee, Tyler E., additional, Conti, Thais F., additional, Ledesma-Gil, Gerardo, additional, Teke, Mehmet Yasin, additional, Choudhry, Netan, additional, Fung, Adrian T., additional, Krivosic, Valerie, additional, Baek, Jiwon, additional, Lee, Mee Yon, additional, Sugiura, Yoshimi, additional, Querques, Giuseppe, additional, Peiretti, Enrico, additional, Rosen, Richard, additional, Lee, Won Ki, additional, Yannuzzi, Lawrence A., additional, Zur, Dinah, additional, Loewenstein, Anat, additional, Pauleikhoff, Daniel, additional, Singh, Rishi, additional, Modi, Yasha, additional, Hubschman, Jean Pierre, additional, Ip, Michael, additional, Sadda, SriniVas, additional, Freund, K. Bailey, additional, and Sarraf, David, additional

Published
2020
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