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2. Elevated expression of N‐myc downstream regulated gene 1 protein in glioblastomas reflects tumor angiogenesis and poor patient prognosis.

Author

Sugita, Yasuo, Furuta, Takuya, Takahashi, Kenji, Higaki, Koichi, Murakami, Yuichi, Kuwano, Michihiko, Ono, Mayumi, Abe, Hideyuki, Akiba, Jun, and Morioka, Motohiro

Subjects
*GENE expression, *SURVIVAL rate, *IMMUNOSTAINING, *GLIOBLASTOMA multiforme, *GENETIC overexpression
Abstract

N‐myc downstream regulated gene 1 (NDRG1) is a member of the NDRG family, of which four members (NDRG1, NDRG2, NDRG3, and NDRG4) have been identified. NDRG1 is repressed by c‐MYC and N‐MYC proto‐oncogenes. NDRG1 is translated into a 43 kDa protein that is associated with the regulation of cellular stress responses, proliferation, and differentiation. In this study, we aimed to clarify the relationship between progression of glioblastoma (GB) IDH‐wildtype and NDRG1 expression in tumor cells. We assessed the expression of NDRG1 in 41 GBs using immunostaining and evaluated its prognostic significance. NDRG1 expression by GBs was evaluated using Histoscore, which showed high and low scores in 23 and 18 cases, respectively. NDRG1‐positive cells were strongly expressed in Ki‐67 labeled proliferating tumor cells and CD105 positive proliferating microvessels around the area of palisading necrosis. Statistical analyses showed lower survival rates in the high‐score group than the low‐score group (P < 0.01). This study indicated that overexpression of NDRG1 by GB reflects tumor angiogenesis and poor patient prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Increased expression of leucine‐rich α‐2 glycoprotein 1 as a predictive biomarker of favorable progression‐free survival in meningioma.

Author

Moritsubo, Mayuko, Furuta, Takuya, Miyoshi, Junko, Komaki, Satoru, Sakata, Kiyohiko, Miyoshi, Hiroaki, Morioka, Motohiro, Ohshima, Koichi, and Sugita, Yasuo

Subjects
PROGRESSION-free survival, LEUCINE, CENTRAL nervous system tumors, MENINGIOMA, BIOMARKERS, PROGNOSIS
Abstract

Most meningiomas, which are frequent central nervous system tumors, are classified as World Health Organization (WHO) grade 1 because of their slow‐growing nature. However, the recurrence rate varies and is difficult to predict using conventional histopathological diagnoses. Leucine‐rich α‐2 glycoprotein 1 (LRG1) is involved in cell signal transduction, cell adhesion, and DNA repair and is a predictive biomarker in different malignant tumors; however, such a relationship has not been reported in meningiomas. We examined tissue microarrays of histological samples from 117 patients with grade 1 and 2 meningiomas and assessed their clinical and pathological features, including expression of LRG1 protein. LRG1‐high meningiomas showed an increased number of vessels with CD3‐positive cell infiltration (P = 0.0328) as well as higher CD105‐positive vessels (P = 0.0084), as compared to LRG1‐low cases. They also demonstrated better progression‐free survival (hazard ratio [HR] 0.11, 95% confidence interval [CI] 0.016–0.841) compared to LRG1‐low patients (P = 0.033). Moreover, multivariate analysis indicated that high LRG1 expression was an independent prognostic factor (HR, 0.13; 95% CI, 0.018–0.991; P = 0.049). LRG1 immunohistochemistry may be a convenient tool for estimating the prognosis of meningiomas in routine practice. Further studies are required to elucidate the key role of LRG1 in meningioma progression. [ABSTRACT FROM AUTHOR]

Published
2024
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5. A case of a pilocytic astrocytoma with histological features of anaplasia and unprecedent genetic alterations.

Author

Moritsubo, Mayuko, Furuta, Takuya, Negoto, Tetsuya, Nakamura, Hideo, Uchiyama, Yusuke, Morioka, Motohiro, Oshima, Koichi, and Sugita, Yasuo

Subjects
ASTROCYTOMAS, DNA analysis, GLIOMAS, BRAIN tumors, KI-67 antigen
Abstract

We report a case of pediatric glioma with uncommon imaging, morphological, and genetic features. A one‐year‐old boy incidentally presented with a tumor in the fourth ventricle. The tumor was completely resected surgically and investigated pathologically. The mostly circumscribed tumor had piloid features but primitive and anaplastic histology, such as increasing cellularity and mitosis. The Ki‐67 staining index was 25% at the hotspot. KIAA1549::BRAF fusion and KIAA1549 partial deletions were detected by direct PCR, supported by Sanger sequencing. To the best of our knowledge, this is the first report of a glioma with both deletion of KIAA1549 p.P1771_P1899 and fusion of KIAA1549::BRAF. The tumor could not be classified using DNA methylome analysis. The present tumor fell into the category of pilocytic astrocytoma with histological features of anaplasia (aPA). Further studies are needed to establish pediatric aPA. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Data from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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10. Supplementary Figure 1A-B from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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11. Supplementary Figure 4A from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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12. Supplementary Table 2 from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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13. Supplementary Figure 2A-E from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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14. Supplementary Figure 5A-D from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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15. Supplementary Figure 4C-E from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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16. Supplementary Figure 3A from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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17. Supplementary Table 1 from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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18. Supplementary Figure 3C-D from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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19. Supplementary Figure 1C from YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth

Author

Fotovati, Abbas, primary, Abu-Ali, Samah, primary, Wang, Pei-Shan, primary, Deleyrolle, Loic P., primary, Lee, Cathy, primary, Triscott, Joanna, primary, Chen, James Y., primary, Franciosi, Sonia, primary, Nakamura, Yasuhiro, primary, Sugita, Yasuo, primary, Uchiumi, Takeshi, primary, Kuwano, Michihiko, primary, Leavitt, Blair R., primary, Singh, Sheila K., primary, Jury, Alexa, primary, Jones, Chris, primary, Wakimoto, Hiroaki, primary, Reynolds, Brent A., primary, Pallen, Catherine J., primary, and Dunn, Sandra E., primary

Published
2023
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26. Pediatric and elderly polymorphous low‐grade neuroepithelial tumor of the young: Typical and unusual case reports and literature review.

Author

Furuta, Takuya, Moritsubo, Mayuko, Muta, Hiroko, Shimamoto, Hotetsu, Ohshima, Koichi, and Sugita, Yasuo

Subjects
LITERATURE reviews, FIBROBLAST growth factors, MITOGEN-activated protein kinases, OLDER people, TEMPORAL lobe, ONCOGENES
Abstract

Polymorphous low‐grade neuroepithelial tumor of the young (PLNTY), one of the pediatric‐type diffuse low‐grade gliomas, is characterized by a diffuse infiltrating pattern of oligodendroglioma‐like tumor cells showing CD34 positivity and harbors mitogen‐activated protein kinase (MAPK) alteration, such as vRAF murine sarcoma viral oncogene homolog B1 (BRAF) p.V600E or fibroblast growth factor fusion genetically. It occurs mainly in pediatric and adolescents with seizures due to the dominant location of the temporal lobe. However, there have been a few cases of PLNTY in adult patients, suggesting the wide range of this tumor spectrum. Here, we describe two cases of PLNTY, one in a 14‐year‐old female and the other in a 66‐year‐old female. The pediatric tumor showed typical clinical course and histopathology with BRAF p.V600E mutation, whereas the elderly tumor was unusual because of non‐epileptic onset clinically and ependymal differentiation histopathologically harboring KIAA1549‐BRAF fusion. There might be unusual but possible PLNTY, as in our elderly case. We also compared typical pediatric and unusual elderly tumors by reviewing the literature. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Gliosarcoma with unusual glial components: Two case reports

Author

Otsu, Yusuke, primary, Matsumoto, Yoshihisa, additional, Higaki, Koichi, additional, Furuta, Takuya, additional, Moritsubo, Mayuko, additional, Yoshitake, Hidenobu, additional, Nagata, Yui, additional, Hashikawa, Takuro, additional, Sakai, Hideki, additional, Nakagawa, Setsuko, additional, Takahashi, Kenji, additional, and Sugita, Yasuo, additional

Published
2022
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38. Primary Nondural Central Nervous System Marginal ZoneB-Cell Lymphoma of the Mucosa-Associated Lymphoid Tissue Type Mimicking CNS Inflammatory Diseases

Author

Sugita, Yasuo, primary, Hashimoto, Go, additional, Fukuda, Kenji, additional, Takahashi, Kenji, additional, Shioga, Taro, additional, Furuta, Takuya, additional, Arakawa, Fumiko, additional, Ohshima, Koichi, additional, Nakamura, Hideo, additional, Miyata, Hajime, additional, Watanabe, Masashi, additional, and Kakita, Akiyoshi, additional

Published
2021
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39. Primary central nervous system lymphomas with massive intratumoral hemorrhage: Clinical, radiological, pathological, and molecular features of six cases

Author

Yamada, Seiji, primary, Muto, Jun, additional, Iba, Sachiko, additional, Shiogama, Kazuya, additional, Tsuyuki, Yuta, additional, Satou, Akira, additional, Ohba, Shigeo, additional, Murayama, Kazuhiro, additional, Sugita, Yasuo, additional, Nakamura, Shigeo, additional, Yokoo, Hideaki, additional, Tomita, Akihiro, additional, Hirose, Yuichi, additional, Tsukamoto, Tetsuya, additional, and Abe, Masato, additional

Published
2021
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