124 results on '"Sugiri D"'
Search Results
2. 173 Epidemiological evidence for a negative association between air pollution and basal cell carcinoma
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Schikowski, T., primary, Guo, Q., additional, Hüls, A., additional, Sugiri, D., additional, Seite, S., additional, and Krutmann, J., additional
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- 2019
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3. 231 Facial lentigines formation results from a complex interplay between solar ultraviolet radiation (sUVR) and ambient particulate matter (PM)
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Hüls, A., primary, Sugiri, D., additional, Fuks, K., additional, Krämer, U., additional, Krutmann, J., additional, and Schikowski, T., additional
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- 2018
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4. Residential greenness is differentially associated with childhood allergic rhinitis and aeroallergen sensitization in seven birth cohorts
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Fuertes, E, Markevych, I, Bowatte, G, Gruzieva, O, Gehring, U, Becker, A, Berdel, D, von Berg, A, Bergström, A, Brauer, M, Brunekreef, B, Brüske, I, Carlsten, C, Chan-Yeung, M, Dharmage, S C, Hoffmann, B, Klümper, C, Koppelman, G H, Kozyrskyj, A, Korek, M, Kull, I, Lodge, C, Lowe, A, MacIntyre, E, Pershagen, G, Standl, M, Sugiri, D, Wijga, A, Heinrich, J, dIRAS RA-2, Risk Assessment, dIRAS RA-2, Risk Assessment, and Groningen Research Institute for Asthma and COPD (GRIAC)
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Male ,Pediatrics ,Allergy ,greenness ,normalized difference vegetation index ,CHILDREN ,010501 environmental sciences ,Logistic regression ,01 natural sciences ,sensitization ,GINIPLUS ,Cohort Studies ,0302 clinical medicine ,DESIGN ,Residence Characteristics ,Risk Factors ,Immunology and Allergy ,030212 general & internal medicine ,Child ,Sensitization ,birth cohorts ,LISAPLUS ,Ndvi ,Allergic Rhinitis ,Birth Cohorts ,Greenness ,medicine.anatomical_structure ,ATOPIC SENSITIZATION ,1107 Immunology ,Female ,Birth cohort ,Life Sciences & Biomedicine ,Cohort study ,medicine.medical_specialty ,Immunology ,Environment ,03 medical and health sciences ,medicine ,Humans ,EXPOSURE ,METAANALYSIS ,0105 earth and related environmental sciences ,Asthma ,Science & Technology ,allergic rhinitis ,business.industry ,Odds ratio ,AIR-POLLUTION ,Allergens ,medicine.disease ,PREVENTION ,Rhinitis, Allergic ,Confidence interval ,Patient Outcome Assessment ,MACS ,ASTHMA ,Immunization ,business ,Demography - Abstract
Background: The prevalence of allergic rhinitis is high, but the role of environmental factors remains unclear. We examined cohort-specific and combined associations of residential greenness with allergic rhinitis and aeroallergen sensitization based on individual data from Swedish (BAMSE), Australian (MACS), Dutch (PIAMA), Canadian (CAPPS and SAGE), and German (GINI-plus and LISAplus) birth cohorts (n = 13 016).Methods: Allergic rhinitis (doctor diagnosis/symptoms) and aeroallergen sensitization were assessed in children aged 6-8 years in six cohorts and 10-12 years in five cohorts. Residential greenness was defined as the mean Normalized Difference Vegetation Index (NDVI) in a 500-m buffer around the home address at the time of health assessment. Cohort-specific associations per 0.2 unit increase in NDVI were assessed using logistic regression models and combined in a random-effects meta-analysis.Results: Greenness in a 500-m buffer was positively associated with allergic rhinitis at 6-8 years in BAMSE (odds ratio = 1.42, 95% confidence interval [1.13, 1.79]) and GINI/LISA South (1.69 [1.19, 2.41]) but inversely associated in GINI/LISA North (0.61 [0.36, 1.01]) and PIAMA (0.67 [0.47, 0.95]). Effect estimates in CAPPS and SAGE were also conflicting but not significant (0.63 [0.32, 1.24] and 1.31 [0.81, 2.12], respectively). All meta-analyses were nonsignificant. Results were similar for aeroallergen sensitization at 6-8 years and both outcomes at 10-12 years. Stratification by NO2 concentrations, population density, an urban vs rural marker, and moving did not reveal consistent trends within subgroups.Conclusion: Although residential greenness appears to be associated with childhood allergic rhinitis and aeroallergen sensitization, the effect direction varies by location.
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- 2016
5. Ozon, Feinstaub und Hautalterung in der Berliner Altersstudie II (BASE-II)
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Fuks, K, additional, Hüls, A, additional, Sugiri, D, additional, Goebel, J, additional, Demuth, I, additional, and Schikowski, T, additional
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- 2017
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6. 156 Air pollution and skin aging: Is there a mediator role for air pollution-induced lung inflammation?
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Vierkötter, A., primary, Hüls, A., additional, Sugiri, D., additional, Krämer, U., additional, Seite, S., additional, Yang, Y., additional, Jin, L., additional, Wang, S., additional, Krutmann, J., additional, and Schikowski, T., additional
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- 2017
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7. Effect modification of noise and air pollution on cognitive function
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Tzivian, L, Dlugaj, M, Winkler, A, Hennig, F, Fuks, K, Sugiri, D, Schikowski, T, Erbel, R, Jöckel, KH, Moebus, S, Weimar, C, and Hoffmann, B
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Introduction: Age-related cognitive decline is an important topic due to aging populations in developed countries and the resulting burden of disease on these aging societies. Thus, it is important to identify persons at risk for cognitive decline to preserve cognitive functioning. A possibility to [for full text, please go to the a.m. URL], GMDS 2015; 60. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)
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- 2015
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8. Natural-cause mortality and long-term exposure to particle components: An Analysis of 19 European cohorts within the multi-center ESCAPE project
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Beelen, R. Hoek, G. Raaschou-Nielsen, O. Stafoggia, M. Andersen, Z.J. Weinmayr, G. Hoffmann, B. Wolf, K. Samoli, E. Fischer, P.H. Nieuwenhuijsen, M.J. Xun, W.W. Katsouyanni, K. Dimakopoulou, K. Marcon, A. Vartiainen, E. Lanki, T. Yli-Tuomi, T. Oftedal, B. Schwarze, P.E. Nafstad, P. de Faire, U. Pedersen, N.L. Östenson, C.-G. Fratiglioni, L. Penell, J. Korek, M. Pershagen, G. Eriksen, K.T. Overvad, K. Sørensen, M. Eeftens, M. Peeters, P.H. Meliefste, K. Wang, M. Bas Bueno-De-Mesquita, H. Sugiri, D. Krämer, U. Heinrich, J. De Hoogh, K. Key, T. Peters, A. Hampel, R. Concin, H. Nagel, G. Jaensch, A. Ineichen, A. Tsai, M.-Y. Schaffner, E. Probst-Hensch, N.M. Schindler, C. Ragettli, M.S. Vilier, A. Clavel-Chapelon, F. Declercq, C. Ricceri, F. Sacerdote, C. Galassi, C. Migliore, E. Ranzi, A. Cesaroni, G. Badaloni, C. Forastiere, F. Katsoulis, M. Trichopoulou, A. Keuken, M. Jedynska, A. Kooter, I.M. Kukkonen, J. Sokhi, R.S. Vineis, P. Brunekreef, B.
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complex mixtures - Abstract
Background: Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. oBjectives: Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter. Methods: Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis. results: The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced. conclusions: Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5. © 2015, Public Health Services, US Dept of Health and Human Services. All rights reserved.
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- 2015
9. Spatial variation of PM elemental composition between and within 20 European study areas - Results of the ESCAPE project
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Tsai, M.-Y. Hoek, G. Eeftens, M. de Hoogh, K. Beelen, R. Beregszászi, T. Cesaroni, G. Cirach, M. Cyrys, J. De Nazelle, A. de Vocht, F. Ducret-Stich, R. Eriksen, K. Galassi, C. Gražuleviciene, R. Gražulevicius, T. Grivas, G. Gryparis, A. Heinrich, J. Hoffmann, B. Iakovides, M. Keuken, M. Krämer, U. Künzli, N. Lanki, T. Madsen, C. Meliefste, K. Merritt, A.-S. Mölter, A. Mosler, G. Nieuwenhuijsen, M.J. Pershagen, G. Phuleria, H. Quass, U. Ranzi, A. Schaffner, E. Sokhi, R. Stempfelet, M. Stephanou, E. Sugiri, D. Taimisto, P. Tewis, M. Udvardy, O. Wang, M. Brunekreef, B.
- Abstract
An increasing number of epidemiological studies suggest that adverse health effects of air pollution may be related to particulate matter (PM) composition, particularly trace metals. However, we lack comprehensive data on the spatial distribution of these elements.We measured PM2.5 and PM10 in twenty study areas across Europe in three seasonal two-week periods over a year using Harvard impactors and standardized protocols. In each area, we selected street (ST), urban (UB) and regional background (RB) sites (totaling 20) to characterize local spatial variability. Elemental composition was determined by energy-dispersive X-ray fluorescence analysis of all PM2.5 and PM10 filters. We selected a priori eight (Cu, Fe, K, Ni, S, Si, V, Zn) well-detected elements of health interest, which also roughly represented different sources including traffic, industry, ports, and wood burning.PM elemental composition varied greatly across Europe, indicating different regional influences. Average street to urban background ratios ranged from 0.90 (V) to 1.60 (Cu) for PM2.5 and from 0.93 (V) to 2.28 (Cu) for PM10.Our selected PM elements were variably correlated with the main pollutants (PM2.5, PM10, PM2.5 absorbance, NO2 and NOx) across Europe: in general, Cu and Fe in all size fractions were highly correlated (Pearson correlations above 0.75); Si and Zn in the coarse fractions were modestly correlated (between 0.5 and 0.75); and the remaining elements in the various size fractions had lower correlations (around 0.5 or below). This variability in correlation demonstrated the distinctly different spatial distributions of most of the elements. Variability of PM10_Cu and Fe was mostly due to within-study area differences (67% and 64% of overall variance, respectively) versus between-study area and exceeded that of most other traffic-related pollutants, including NO2 and soot, signaling the importance of non-tailpipe (e.g., brake wear) emissions in PM. © 2015 Elsevier Ltd.
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- 2015
10. Performance of multi-city land use regression models for nitrogen dioxide and fine particles
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Wang, M. Beelen, R. Bellander, T. Birk, M. Cesaroni, G. Cirach, M. Cyrys, J. de Hoogh, K. Declercq, C. Dimakopoulou, K. Eeftens, M. Eriksen, K.T. Forastiere, F. Galassi, C. Grivas, G. Heinrich, J. Hoffmann, B. Ineichen, A. Korek, M. Lanki, T. Lindley, S. Modig, L. Mölter, A. Nafstad, P. Nieuwenhuijsen, M.J. Nystad, W. Olsson, D. Raaschou-Nielsen, O. Ragettli, M. Ranzi, A. Stempfelet, M. Sugiri, D. Tsai, M.-Y. Udvardy, O. Varró, M.J. Vienneau, D. Weinmayr, G. Wolf, K. Yli-Tuomi, T. Hoek, G. Brunekreef, B.
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Background: Land use regression (LUR) models have been developed mostly to explain intraurban variations in air pollution based on often small local monitoring campaigns. Transferability of LUR models from city to city has been investigated, but little is known about the performance of models based on large numbers of monitoring sites covering a large area. Objectives: We aimed to develop European and regional LUR models and to examine their transferability to areas not used for model development. Methods: We evaluated LUR models for nitrogen dioxide (NO2) and particulate matter (PM; PM2.5, PM2.5 absorbance) by combining standardized measurement data from 17 (PM) and 23 (NO2) ESCAPE (European Study of Cohorts for Air Pollution Effects) study areas across 14 European countries for PM and NO2. Models were evaluated with cross-validation (CV) and hold-out validation (HV). We investigated the transferability of the models by successively excluding each study area from model building. Results: The European model explained 56% of the concentration variability across all sites for NO2, 86% for PM2.5, and 70% for PM2.5 absorbance. The HV R2s were only slightly lower than the model R2 (NO2, 54%; PM2.5, 80%; PM2.5 absorbance, 70%). The European NO2, PM2.5, and PM2.5 absorbance models explained a median of 59%, 48%, and 70% of within-area variability in individual areas. The transferred models predicted a modest-to-large fraction of variability in areas that were excluded from model building (median R2: NO2, 59%; PM2.5, 42%; PM2.5 absorbance, 67%). Conclusions: Using a large data set from 23 European study areas, we were able to develop LUR models for NO2 and PM metrics that predicted measurements made at independent sites and areas reasonably well. This finding is useful for assessing exposure in health studies conducted in areas where no measurements were conducted.
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- 2014
11. Effects of long-term exposure to air pollution on natural-cause mortality: An analysis of 22 European cohorts within the multicentre ESCAPE project
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Beelen, R. Raaschou-Nielsen, O. Stafoggia, M. Andersen, Z.J. Weinmayr, G. Hoffmann, B. Wolf, K. Samoli, E. Fischer, P. Nieuwenhuijsen, M. Vineis, P. Xun, W.W. Katsouyanni, K. Dimakopoulou, K. Oudin, A. Forsberg, B. Modig, L. Havulinna, A.S. Lanki, T. Turunen, A. Oftedal, B. Nystad, W. Nafstad, P. De Faire, U. Pedersen, N.L. Östenson, C.-G. Fratiglioni, L. Penell, J. Korek, M. Pershagen, G. Eriksen, K.T. Overvad, K. Ellermann, T. Eeftens, M. Peeters, P.H. Meliefste, K. Wang, M. Bueno-De-Mesquita, B. Sugiri, D. Krämer, U. Heinrich, J. De Hoogh, K. Key, T. Peters, A. Hampel, R. Concin, H. Nagel, G. Ineichen, A. Schaffner, E. Probst-Hensch, N. Künzli, N. Schindler, C. Schikowski, T. Adam, M. Phuleria, H. Vilier, A. Clavel-Chapelon, F. Declercq, C. Grioni, S. Krogh, V. Tsai, M.-Y. Ricceri, F. Sacerdote, C. Galassi, C. Migliore, E. Ranzi, A. Cesaroni, G. Badaloni, C. Forastiere, F. Tamayo, I. Amiano, P. Dorronsoro, M. Katsoulis, M. Trichopoulou, A. Brunekreef, B. Hoek, G.
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Background Few studies on long-term exposure to air pollution and mortality have been reported from Europe. Within the multicentre European Study of Cohorts for Air Pollution Effects (ESCAPE), we aimed to investigate the association between natural-cause mortality and long-term exposure to several air pollutants. Methods We used data from 22 European cohort studies, which created a total study population of 367 251 participants. All cohorts were general population samples, although some were restricted to one sex only. With a strictly standardised protocol, we assessed residential exposure to air pollutants as annual average concentrations of particulate matter (PM) with diameters of less than 2.5 μm (PM2.5), less than 10 μm (PM 10), and between 10 μm and 2.5 μm (PMcoarse), PM2.5 absorbance, and annual average concentrations of nitrogen oxides (NO2 and NOx) with land use regression models. We also investigated two traffic intensity variables-traffic intensity on the nearest road (vehicles per day) and total traffic load on all major roads within a 100 m buffer. We did cohort-specific statistical analyses using confounder models with increasing adjustment for confounder variables, and Cox proportional hazards models with a common protocol. We obtained pooled effect estimates through a random-effects metaanalysis. Findings The total study population consisted of 367 251 participants who contributed 5 118 039 person-years at risk (average follow-up 13.9 years), of whom 29 076 died from a natural cause during follow-up. A significantly increased hazard ratio (HR) for PM2.5 of 1.07 (95% CI 1.02-1.13) per 5 μg/m3 was recorded. No heterogeneity was noted between individual cohort effect estimates (I2 p value=0.95). HRs for PM2.5 remained significantly raised even when we included only participants exposed to pollutant concentrations lower than the European annual mean limit value of 25 μg/m3 (HR 1.06, 95% CI 1.00-1.12) or below 20 μg/m3 (1.07, 1.01-1.13). Interpretation Long-term exposure to fine particulate air pollution was associated with natural-cause mortality, even within concentration ranges well below the present European annual mean limit value.
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- 2014
12. Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects
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Wang, M. Beelen, R. Stafoggia, M. Raaschou-Nielsen, O. Andersen, Z.J. Hoffmann, B. Fischer, P. Houthuijs, D. Nieuwenhuijsen, M. Weinmayr, G. Vineis, P. Xun, W.W. Dimakopoulou, K. Samoli, E. Laatikainen, T. Lanki, T. Turunen, A.W. Oftedal, B. Schwarze, P. Aamodt, G. Penell, J. De Faire, U. Korek, M. Leander, K. Pershagen, G. Pedersen, N.L. Östenson, C.-G. Fratiglioni, L. Eriksen, K.T. Sørensen, M. Tjønneland, A. Bueno-de-Mesquita, B. Eeftens, M. Bots, M.L. Meliefste, K. Krämer, U. Heinrich, J. Sugiri, D. Key, T. De Hoogh, K. Wolf, K. Peters, A. Cyrys, J. Jaensch, A. Concin, H. Nagel, G. Tsai, M.-Y. Phuleria, H. Ineichen, A. Künzli, N. Probst-Hensch, N. Schaffner, E. Vilier, A. Clavel-Chapelon, F. Declerq, C. Ricceri, F. Sacerdote, C. Marcon, A. Galassi, C. Migliore, E. Ranzi, A. Cesaroni, G. Badaloni, C. Forastiere, F. Katsoulis, M. Trichopoulou, A. Keuken, M. Jedynska, A. Kooter, I.M. Kukkonen, J. Sokhi, R.S. Brunekreef, B. Katsouyanni, K. Hoek, G.
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Background: Associations between long-term exposure to ambient particulate matter (PM) and cardiovascular (CVD) mortality have been widely recognized. However, health effects of long-term exposure to constituents of PM on total CVD mortality have been explored in a single study only. Aims: The aim of this study was to examine the association of PM composition with cardiovascular mortality. Methods: We used data from 19 European ongoing cohorts within the framework of the ESCAPE (European Study of Cohorts for Air Pollution Effects) and TRANSPHORM (Transport related Air Pollution and Health impacts - Integrated Methodologies for Assessing Particulate Matter) projects. Residential annual average exposure to elemental constituents within particle matter smaller than 2.5 and 10μm (PM2.5 and PM10) was estimated using Land Use Regression models. Eight elements representing major sources were selected a priori (copper, iron, potassium, nickel, sulfur, silicon, vanadium and zinc). Cohort-specific analyses were conducted using Cox proportional hazards models with a standardized protocol. Random-effects meta-analysis was used to calculate combined effect estimates. Results: The total population consisted of 322,291 participants, with 9545 CVD deaths. We found no statistically significant associations between any of the elemental constituents in PM2.5 or PM10 and CVD mortality in the pooled analysis. Most of the hazard ratios (HRs) were close to unity, e.g. for PM10 Fe the combined HR was 0.96 (0.84-1.09). Elevated combined HRs were found for PM2.5 Si (1.17, 95% CI: 0.93-1.47), and S in PM2.5 (1.08, 95% CI: 0.95-1.22) and PM10 (1.09, 95% CI: 0.90-1.32). Conclusion: In a joint analysis of 19 European cohorts, we found no statistically significant association between long-term exposure to 8 elemental constituents of particles and total cardiovascular mortality. •Few studies explored long term effects of particle composition exposure to cardiovascular mortality.•We included a large population of 322,291 subjects from 19 cohorts in 12 countries of Europe.•Standardized cohort specific analyses were conducted individually and the results were pooled in meta-analysis.•We found no significant association between elemental constituents representing major sources and cardiovascular mortality.•Positive though non-significant associations were found for S and Si. © 2014 Elsevier Ltd.
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- 2014
13. Comparing land use regression and dispersion modelling to assess residential exposure to ambient air pollution for epidemiological studies
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de Hoogh, K. Korek, M. Vienneau, D. Keuken, M. Kukkonen, J. Nieuwenhuijsen, M.J. Badaloni, C. Beelen, R. Bolignano, A. Cesaroni, G. Pradas, M.C. Cyrys, J. Douros, J. Eeftens, M. Forastiere, F. Forsberg, B. Fuks, K. Gehring, U. Gryparis, A. Gulliver, J. Hansell, A.L. Hoffmann, B. Johansson, C. Jonkers, S. Kangas, L. Katsouyanni, K. Künzli, N. Lanki, T. Memmesheimer, M. Moussiopoulos, N. Modig, L. Pershagen, G. Probst-Hensch, N. Schindler, C. Schikowski, T. Sugiri, D. Teixidó, O. Tsai, M.-Y. Yli-Tuomi, T. Brunekreef, B. Hoek, G. Bellander, T.
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complex mixtures - Abstract
Background: Land-use regression (LUR) and dispersion models (DM) are commonly used for estimating individual air pollution exposure in population studies. Few comparisons have however been made of the performance of these methods. Objectives: Within the European Study of Cohorts for Air Pollution Effects (ESCAPE) we explored the differences between LUR and DM estimates for NO2, PM10 and PM2.5. Methods: The ESCAPE study developed LUR models for outdoor air pollution levels based on a harmonised monitoring campaign. In thirteen ESCAPE study areas we further applied dispersion models. We compared LUR and DM estimates at the residential addresses of participants in 13 cohorts for NO2; 7 for PM10 and 4 for PM2.5. Additionally, we compared the DM estimates with measured concentrations at the 20-40 ESCAPE monitoring sites in each area. Results: The median Pearson R (range) correlation coefficients between LUR and DM estimates for the annual average concentrations of NO2, PM10 and PM2.5 were 0.75 (0.19-0.89), 0.39 (0.23-0.66) and 0.29 (0.22-0.81) for 112,971 (13 study areas), 69,591 (7) and 28,519 (4) addresses respectively. The median Pearson R correlation coefficients (range) between DM estimates and ESCAPE measurements were of 0.74 (0.09-0.86) for NO2; 0.58 (0.36-0.88) for PM10 and 0.58 (0.39-0.66) for PM2.5. Conclusions: LUR and dispersion model estimates correlated on average well for NO2 but only moderately for PM10 and PM2.5, with large variability across areas. DM predicted a moderate to large proportion of the measured variation for NO2 but less for PM10 and PM2.5. © 2014 Elsevier Ltd.
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- 2014
14. Long-term exposure to air pollution and cardiovascular mortality: An analysis of 22 European cohorts
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Beelen, R. Stafoggia, M. Raaschou-Nielsen, O. Andersen, Z.J. Xun, W.W. Katsouyanni, K. Dimakopoulou, K. Brunekreef, B. Weinmayr, G. Hoffmann, B. Wolf, K. Samoli, E. Houthuijs, D. Nieuwenhuijsen, M. Oudin, A. Forsberg, B. Olsson, D. Salomaa, V. Lanki, T. Yli-Tuomi, T. Oftedal, B. Aamodt, G. Nafstad, P. De Faire, U. Pedersen, N.L. Östenson, C.-G. Fratiglioni, L. Penell, J. Korek, M. Pyko, A. Eriksen, K.T. Tjønneland, A. Becker, T. Eeftens, M. Bots, M. Meliefste, K. Wang, M. Bueno-De-Mesquita, B. Sugiri, D. Krämer, U. Heinrich, J. De Hoogh, K. Key, T. Peters, A. Cyrys, J. Concin, H. Nagel, G. Ineichen, A. Schaffner, E. Probst-Hensch, N. Dratva, J. Ducret-Stich, R. Vilier, A. Clavel-Chapelon, F. Stempfelet, M. Grioni, S. Krogh, V. Tsai, M.-Y. Marcon, A. Ricceri, F. Sacerdote, C. Galassi, C. Migliore, E. Ranzi, A. Cesaroni, G. Badaloni, C. Forastiere, F. Tamayo, I. Amiano, P. Dorronsoro, M. Katsoulis, M. Trichopoulou, A. Vineis, P. Hoek, G.
- Abstract
Background: Air pollution has been associated with cardiovascular mortality, but it remains unclear as to whether specific pollutants are related to specific cardiovascular causes of death. Within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE), we investigated the associations of long-term exposure to several air pollutants with all cardiovascular disease (CVD) mortality, as well as with specific cardiovascular causes of death. Methods: Data from 22 European cohort studies were used. Using a standardized protocol, study area-specific air pollution exposure at the residential address was characterized as annual average concentrations of the following: nitrogen oxides (NO2and NOx); particles with diameters of less than 2.5 μm (PM2.5), less than 10 μm (PM10), and 10 μm to 2.5 μm (PMcoarse); PM2.5absorbance estimated by land-use regression models; and traffic indicators. We applied cohort-specific Cox proportional hazards models using a standardized protocol. Random-effects meta-analysis was used to obtain pooled effect estimates. Results: The total study population consisted of 367,383 participants, with 9994 deaths from CVD (including 4,992 from ischemic heart disease, 2264 from myocardial infarction, and 2484 from cerebrovascular disease). All hazard ratios were approximately 1.0, except for particle mass and cerebrovascular disease mortality; for PM2.5, the hazard ratio was 1.21 (95% confidence interval = 0.87-1.69) per 5 μg/m and for PM10, 1.22 (0.91-1.63) per 10 μg/m. Conclusion: In a joint analysis of data from 22 European cohorts, most hazard ratios for the association of air pollutants with mortality from overall CVD and with specific CVDs were approximately 1.0, with the exception of particulate mass and cerebrovascular disease mortality for which there was suggestive evidence for an association. Copyright © 2014 by Lippincott Williams & Wilkins.
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- 2014
15. Air pollution modelling in the Ruhr Area: Land-Use Regression vs. Dispersion Chemistry Transport
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Hennig, F, primary, Sugiri, D, additional, Tzivian, L, additional, Fuks, K, additional, Moebus, S, additional, Jöckel, KH, additional, Vienneau, D, additional, Kuhlbusch, T, additional, de Hoogh, K, additional, Memmesheimer, M, additional, Jakobs, H, additional, Quass, U, additional, and Hoffmann, B, additional
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- 2016
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16. Elemental composition of fine particulate matter and arterial blood pressure in a population-based German cohort
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Fuks, K, primary, Hennig, F, additional, Sugiri, D, additional, Kuhlbusch, T, additional, Moebus, S, additional, Erbel, R, additional, Jöckel, KH, additional, and Hoffmann, B, additional
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- 2016
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17. Development of land use regression models for particle composition in twenty study areas in Europe
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De Hoogh, K. Wang, M. Adam, M. Badaloni, C. Beelen, R. Birk, M. Cesaroni, G. Cirach, M. Declercq, C. Dědelě, A. Dons, E. De Nazelle, A. Eeftens, M. Eriksen, K. Eriksson, C. Fischer, P. Gražulevičieně, R. Gryparis, A. Hoffmann, B. Jerrett, M. Katsouyanni, K. Iakovides, M. Lanki, T. Lindley, S. Madsen, C. Mölter, A. Mosler, G. Nádor, G. Nieuwenhuijsen, M. Pershagen, G. Peters, A. Phuleria, H. Probst-Hensch, N. Raaschou-Nielsen, O. Quass, U. Ranzi, A. Stephanou, E. Sugiri, D. Schwarze, P. Tsai, M.-Y. Yli-Tuomi, T. Varró, M.J. Vienneau, D. Weinmayr, G. Brunekreef, B. Hoek, G.
- Abstract
Land Use Regression (LUR) models have been used to describe and model spatial variability of annual mean concentrations of traffic related pollutants such as nitrogen dioxide (NO2), nitrogen oxides (NOx) and particulate matter (PM). No models have yet been published of elemental composition. As part of the ESCAPE project, we measured the elemental composition in both the PM10 and PM2.5 fraction sizes at 20 sites in each of 20 study areas across Europe. LUR models for eight a priori selected elements (copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V), and zinc (Zn)) were developed. Good models were developed for Cu, Fe, and Zn in both fractions (PM10 and PM 2.5) explaining on average between 67 and 79% of the concentration variance (R2) with a large variability between areas. Traffic variables were the dominant predictors, reflecting nontailpipe emissions. Models for V and S in the PM10 and PM2.5 fractions and Si, Ni, and K in the PM10 fraction performed moderately with R2 ranging from 50 to 61%. Si, NI, and K models for PM2.5 performed poorest with R2 under 50%. The LUR models are used to estimate exposures to elemental composition in the health studies involved in ESCAPE. © 2013 American Chemical Society.
- Published
- 2013
18. Evaluation of land use regression models for NO2 and particulate matter in 20 European study areas: The ESCAPE project
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Wang, M. Beelen, R. Basagana, X. Becker, T. Cesaroni, G. De Hoogh, K. Dedele, A. Declercq, C. Dimakopoulou, K. Eeftens, M. Forastiere, F. Galassi, C. Gražulevičiene, R. Hoffmann, B. Heinrich, J. Iakovides, M. Künzli, N. Korek, M. Lindley, S. Mölter, A. Mosler, G. Madsen, C. Nieuwenhuijsen, M. Phuleria, H. Pedeli, X. Raaschou-Nielsen, O. Ranzi, A. Stephanou, E. Sugiri, D. Stempfelet, M. Tsai, M.-Y. Lanki, T. Udvardy, O. Varró, M.J. Wolf, K. Weinmayr, G. Yli-Tuomi, T. Hoek, G. Brunekreef, B.
- Abstract
Land use regression models (LUR) frequently use leave-one-out-cross- validation (LOOCV) to assess model fit, but recent studies suggested that this may overestimate predictive ability in independent data sets. Our aim was to evaluate LUR models for nitrogen dioxide (NO2) and particulate matter (PM) components exploiting the high correlation between concentrations of PM metrics and NO2. LUR models have been developed for NO2, PM2.5 absorbance, and copper (Cu) in PM10 based on 20 sites in each of the 20 study areas of the ESCAPE project. Models were evaluated with LOOCV and "hold-out evaluation (HEV)" using the correlation of predicted NO2 or PM concentrations with measured NO2 concentrations at the 20 additional NO2 sites in each area. For NO2, PM2.5 absorbance and PM10 Cu, the median LOOCV R2s were 0.83, 0.81, and 0.76 whereas the median HEV R 2 were 0.52, 0.44, and 0.40. There was a positive association between the LOOCV R2 and HEV R2 for PM2.5 absorbance and PM10 Cu. Our results confirm that the predictive ability of LUR models based on relatively small training sets is overestimated by the LOOCV R2s. Nevertheless, in most areas LUR models still explained a substantial fraction of the variation of concentrations measured at independent sites. © 2013 American Chemical Society.
- Published
- 2013
19. Development of land use regression models for PM2.5, PM 2.5 absorbance, PM10 and PMcoarse in 20 European study areas; Results of the ESCAPE project
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Eeftens, M. Beelen, R. De Hoogh, K. Bellander, T. Cesaroni, G. Cirach, M. Declercq, C. Dedele, A. Dons, E. De Nazelle, A. Dimakopoulou, K. Eriksen, K. Falq, G. Fischer, P. Galassi, C. Gražulevičiene, R. Heinrich, J. Hoffmann, B. Jerrett, M. Keidel, D. Korek, M. Lanki, T. Lindley, S. Madsen, C. Mölter, A. Nádor, G. Nieuwenhuijsen, M. Nonnemacher, M. Pedeli, X. Raaschou-Nielsen, O. Patelarou, E. Quass, U. Ranzi, A. Schindler, C. Stempfelet, M. Stephanou, E. Sugiri, D. Tsai, M.-Y. Yli-Tuomi, T. Varró, M.J. Vienneau, D. Klot, S.V. Wolf, K. Brunekreef, B. Hoek, G.
- Abstract
Land Use Regression (LUR) models have been used increasingly for modeling small-scale spatial variation in air pollution concentrations and estimating individual exposure for participants of cohort studies. Within the ESCAPE project, concentrations of PM2.5, PM2.5 absorbance, PM10, and PMcoarse were measured in 20 European study areas at 20 sites per area. GIS-derived predictor variables (e.g., traffic intensity, population, and land-use) were evaluated to model spatial variation of annual average concentrations for each study area. The median model explained variance (R2) was 71% for PM2.5 (range across study areas 35-94%). Model R2 was higher for PM2.5 absorbance (median 89%, range 56-97%) and lower for PMcoarse (median 68%, range 32- 81%). Models included between two and five predictor variables, with various traffic indicators as the most common predictors. Lower R2 was related to small concentration variability or limited availability of predictor variables, especially traffic intensity. Cross validation R2 results were on average 8-11% lower than model R2. Careful selection of monitoring sites, examination of influential observations and skewed variable distributions were essential for developing stable LUR models. The final LUR models are used to estimate air pollution concentrations at the home addresses of participants in the health studies involved in ESCAPE. © 2012 American Chemical Society.
- Published
- 2012
20. Spatial variation of PM2.5, PM10, PM2.5 absorbance and PMcoarse concentrations between and within 20 European study areas and the relationship with NO2 - Results of the ESCAPE project
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Eeftens, M. Tsai, M.-Y. Ampe, C. Anwander, B. Beelen, R. Bellander, T. Cesaroni, G. Cirach, M. Cyrys, J. de Hoogh, K. De Nazelle, A. de Vocht, F. Declercq, C. Dedele, A. Eriksen, K. Galassi, C. Gražulevičiene, R. Grivas, G. Heinrich, J. Hoffmann, B. Iakovides, M. Ineichen, A. Katsouyanni, K. Korek, M. Krämer, U. Kuhlbusch, T. Lanki, T. Madsen, C. Meliefste, K. Mölter, A. Mosler, G. Nieuwenhuijsen, M. Oldenwening, M. Pennanen, A. Probst-Hensch, N. Quass, U. Raaschou-Nielsen, O. Ranzi, A. Stephanou, E. Sugiri, D. Udvardy, O. Vaskövi, É. Weinmayr, G. Brunekreef, B. Hoek, G.
- Subjects
complex mixtures - Abstract
The ESCAPE study (European Study of Cohorts for Air Pollution Effects) investigates relationships between long-term exposure to outdoor air pollution and health using cohort studies across Europe. This paper analyses the spatial variation of PM2.5, PM2.5 absorbance, PM10 and PMcoarse concentrations between and within 20 study areas across Europe.We measured NO2, NOx, PM2.5, PM2.5 absorbance and PM10 between October 2008 and April 2011 using standardized methods. PMcoarse was determined as the difference between PM10 and PM2.5. In each of the twenty study areas, we selected twenty PM monitoring sites to represent the variability in important air quality predictors, including population density, traffic intensity and altitude. Each site was monitored over three 14-day periods spread over a year, using Harvard impactors. Results for each site were averaged after correcting for temporal variation using data obtained from a reference site, which was operated year-round.Substantial concentration differences were observed between and within study areas. Concentrations for all components were higher in Southern Europe than in Western and Northern Europe, but the pattern differed per component with the highest average PM2.5 concentrations found in Turin and the highest PMcoarse in Heraklion. Street/urban background concentration ratios for PMcoarse (mean ratio 1.42) were as large as for PM2.5 absorbance (mean ratio 1.38) and higher than those for PM2.5 (1.14) and PM10 (1.23), documenting the importance of non-tailpipe emissions. Correlations between components varied between areas, but were generally high between NO2 and PM2.5 absorbance (average R2 = 0.80). Correlations between PM2.5 and PMcoarse were lower (average R2 = 0.39). Despite high correlations, concentration ratios between components varied, e.g. the NO2/PM2.5 ratio varied between 0.67 and 3.06.In conclusion, substantial variability was found in spatial patterns of PM2.5, PM2.5 absorbance, PM10 and PMcoarse. The highly standardized measurement of particle concentrations across Europe will contribute to a consistent assessment of health effects across Europe. © 2012 Elsevier Ltd.
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- 2012
21. Variation of NO2 and NOx concentrations between and within 36 European study areas: Results from the ESCAPE study
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Cyrys, J. Eeftens, M. Heinrich, J. Ampe, C. Armengaud, A. Beelen, R. Bellander, T. Beregszaszi, T. Birk, M. Cesaroni, G. Cirach, M. de Hoogh, K. De Nazelle, A. de Vocht, F. Declercq, C. Dedele, A. Dimakopoulou, K. Eriksen, K. Galassi, C. Graulevičiene, R. Grivas, G. Gruzieva, O. Gustafsson, A.H. Hoffmann, B. Iakovides, M. Ineichen, A. Krämer, U. Lanki, T. Lozano, P. Madsen, C. Meliefste, K. Modig, L. Mölter, A. Mosler, G. Nieuwenhuijsen, M. Nonnemacher, M. Oldenwening, M. Peters, A. Pontet, S. Probst-Hensch, N. Quass, U. Raaschou-Nielsen, O. Ranzi, A. Sugiri, D. Stephanou, E.G. Taimisto, P. Tsai, M.-Y. Vaskövi, É. Villani, S. Wang, M. Brunekreef, B. Hoek, G.
- Subjects
inorganic chemicals ,respiratory system - Abstract
The ESCAPE study (European Study of Cohorts for Air Pollution Effects) investigates long-term effects of exposure to air pollution on human health in Europe. This paper documents the spatial variation of measured NO2 and NOx concentrations between and within 36 ESCAPE study areas across Europe.In all study areas NO2 and NOx were measured using standardized methods between October 2008 and April 2011. On average, 41 sites were selected per study area, including regional and urban background as well as street sites. The measurements were conducted in three different seasons, using Ogawa badges. Average concentrations for each site were calculated after adjustment for temporal variation using data obtained from a routine monitor background site.Substantial spatial variability was found in NO2 and NOx concentrations between and within study areas; 40% of the overall NO2 variance was attributable to the variability between study areas and 60% to variability within study areas. The corresponding values for NOx were 30% and 70%. The within-area spatial variability was mostly determined by differences between street and urban background concentrations. The street/urban background concentration ratio for NO2 varied between 1.09 and 3.16 across areas. The highest median concentrations were observed in Southern Europe, the lowest in Northern Europe.In conclusion, we found significant contrasts in annual average NO2 and NOx concentrations between and especially within 36 study areas across Europe. Epidemiological long-term studies should therefore consider different approaches for better characterization of the intra-urban contrasts, either by increasing of the number of monitors or by modelling. © 2012 Elsevier Ltd.
- Published
- 2012
22. Inzidenz von Typ 2 Diabetes und Luftverunreinigungen aus dem Straßenverkehr in einer Kohorte älterer Frauen aus dem Ruhrgebiet (SALIA-Studie)
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Krämer, U, Sugiri, D, Schikowski, T, Ranft, U, Strassburger, K, Herder, C, and Rathmann, W
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ddc: 610 ,Luftverunreinigung ,Ruhrgebiet ,Diabetes ,Kohortenstudie ,610 Medical sciences ,Medicine - Abstract
Chronische Exposition mit Luftverunreinigungen aus dem Straßenverkehr führen zu einer Verschlechterung der Atemwegsgesundheit und zu einer erhöhten Herz-Kreislaufmortalität, wie wir für die Frauen der SALIA Studie nachweisen konnten [ref:1], [ref:2]. Ob ebenfalls[for full text, please go to the a.m. URL], 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds)
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- 2009
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23. Expositionen aus dem Straßenverkehr und Entwicklung von Allergien bei Kindern der GINIplus Geburtskohorte aus dem Raum Wesel
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Krämer, U, Link, E, Sugiri, D, Heinrich, J, Wichmann, HE, Behrendt, H, Kuhlbusch, T, Hochadel, M, Bollrath, C, and von Berg, A
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Straßenverkehr ,Allergie ,ddc: 610 ,Geburtskohorte - Published
- 2007
24. Advanced Glycation Endproducts im Plasma von Frauen ohne und mit gestörter Nüchternglukose: Ergebnisse aus der SALIA-Studie
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Teichert, T, primary, Hellwig, A, additional, Peßler, A, additional, Hellwig, M, additional, Vossoughi, M, additional, Sugiri, D, additional, Vierkötter, A, additional, Schulte, T, additional, Roden, M, additional, Hoffmann, B, additional, Schikowski, T, additional, Luckhaus, C, additional, Krämer, U, additional, Henle, T, additional, and Herder, C, additional
- Published
- 2014
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25. Advanced glycation endproducts in plasma of women without and with impaired glucose metabolism: Results from the SALIA-study
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Teichert, T, primary, Hellwig, A, additional, Peßler, A, additional, Hellwig, M, additional, Vossoughi, M, additional, Sugiri, D, additional, Vierkötter, A, additional, Schulte, T, additional, Roden, M, additional, Hoffmann, B, additional, Schikowski, T, additional, Luckhaus, C, additional, Krämer, U, additional, Henle, T, additional, and Herder, C, additional
- Published
- 2014
- Full Text
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26. Indoor pyrethroid exposure in homes with woollen textile floor coverings
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Berger-Preiß, E., Levsen, K., Leng, G., Idel, H., Sugiri, D., Ranft, U., and Publica
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permethrin ,health effect ,biological monitoring ,woollen textile floor covering ,Indoor monitoring - Abstract
In order to investigate human's exposure to permethrin from treated woollen textile floor coverings and possible adverse health effects, a study was carried out in 80 private homes in Hannover (Germany) equipped with woollen textile floor coverings (wool wall-to-wall carpets or woven or knotted rugs). For indoor monitoring, permethrin was determined both in house dust and on suspended particles. While permethrin concentrations in house dust (< 2 mm) were high (arithmetic mean: 53.7 mg/kg, 90th percentile 129.1 mg/kg), the permethrin concentrations in the air (suspended particles) were very low (arithmetic mean 2.8 ng/m3, 90th percentile 5.8 ng/m3, first sampling). Additional experiments demonstrate that permethrin on suspended particles result from carpet fiber abrasion (and not from an evaporation/re-condensation process). The internal exposure of the 145 inhabitants participating in the study was determined by biological monitoring (permethrin metabolites in urine). In a first sampling period almost 14% of the samples showed concentrations of the metabolite DCCA and almost 23% of the metabolite 3-PBA above the limit of detection (0.2 microgram/l). A model was developed which allows the calculation of the metabolite concentration in urine due to inhalative uptake of permethrin. Even for the worst case situation the calculated metabolite concentrations were ca. 30 times lower than the experimental results. The observed concentrations of metabolites are comparable to those of the background concentrations of the general population in Germany, suggesting that they must origin from other sources than woollen textile floor coverings. The indoor and biological monitoring data as well as the evaluation of the reported symptoms give no indication of an adverse health effect due to carpet treatment by permethrin.
- Published
- 2002
27. Zusammenhang zwischen Luftverschmutzung, subklinischer Inflammation und gestörter Glukoseregulation - Ergebnisse aus der SALIA-Studie
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Teichert, T, primary, Vossoughi, M, additional, Vierkötter, A, additional, Sugiri, D, additional, Schulte, T, additional, Roden, M, additional, Luckhaus, C, additional, Herder, C, additional, and Krämer, U, additional
- Published
- 2013
- Full Text
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28. Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: Results from the SALIA study
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Teichert, T, primary, Vossoughi, M, additional, Vierkötter, A, additional, Sugiri, D, additional, Schulte, T, additional, Roden, M, additional, Luckhaus, C, additional, Herder, C, additional, and Krämer, U, additional
- Published
- 2013
- Full Text
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29. Prävalenz und Inzidenz allergischer Erkrankungen bei Älteren – Ergebnisse der Kohortenstudie SALIA
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Krämer, U., primary, Vierkötter, A., additional, Schikowski, T., additional, Sugiri, D., additional, Brüning, T., additional, and Raulf-Heimsoth, M., additional
- Published
- 2012
- Full Text
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30. Temporal-Spatial Trends of Health Indicators in Children in a Highly-Exposed Industrial City in Germany
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Ranft, U, primary, Sugiri, D, additional, Gladtke, D, additional, Eberwein, G, additional, Krämer, U, additional, and Wilhelm, M, additional
- Published
- 2007
- Full Text
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31. Lead Concentration in the Blood of Children and Its Association With Lead in Soil and Ambient Air: Trends Between 1983 and 2000 in a German Industrial City
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Ranft, U, primary, Delschen, T, additional, Machtolf, M, additional, Sugiri, D, additional, and Wilhelm, M, additional
- Published
- 2006
- Full Text
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32. Variation of NO2 and NOx concentrations between and within 36 European study areas : results from the ESCAPE study
- Author
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Cyrys, J., Eeftens, M., Heinrich, J., Ampe, C., Armengaud, A., Beelen, R., Bellander, T., Beregszaszai, T., Birk, M., Cesaroni, G., Cirach, M., de Hoogh, K., de Nazelle, A., de Vocht, F., Declercq, C., Dedele, A., Dimakopoulou, K., Eriksen, K., Galassi, C., Grazuleviciene, R., Grivas, G., Gruzieva, O., Hagenbjörk, Gustafsson, Hoffmann, B., Iakovides, M., Ineichen, A., Krämer, U., Lanki, T., Lozano, P., Madsen, C., Meliefste, K., Modig, L., Mölter, A., Mosler, G., Nieuwenhuijsen, M., Nonnemacher, M., Oldenwening, M., Peters, A., Pontet, S., Probst-Hensch, N., Quass, U., Raaschou-Nielsen, O., Ranzi, A., Sugiri, D., Stephanou, E. G., Taimisto, P., Tsai, M. Y., Vaskövi, E., Villani, S., Wang, M., Brunekreef, B., and Hoek, G.
- Subjects
13. Climate action
33. Spatial variation of PM2.5, PM10, PM2.5 absorbance and PMcoarse concentrations between and within 20 European study areas and the relationship with NO2 : results of the ESCAPE project
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Eeftens, M., Tsai, M. Y., Ampe, C., Anwander, B., Beelen, R., Bellander, T., Cesaroni, G., Cirach, M., Cyrys, J., de Hoogh, K., de Nazelle, A., de Vocht, F., Declercq, C., Dedele, A., Eriksen, K., Galassi, C., Grauleviciene, R., Grivas, G., Heinrich, J., Hoffmann, B., Iakovides, M., Ineichen, A., Katsouyanni, K., Korek, M., Krämer, U., Kuhlbusch, T., Lanki, T., Madsen, C., Meliefste, K., Mölter, A., Mosler, G., Nieuwenhuijsen, M., Oldenwening, M., Pennanen, A., Probst-Hensch, N., Quass, U., Raaschou-Nielsen, O., Ranzi, A., Stephanou, E., Sugiri, D., Udvardy, O., Vaskövi, E., Weinmayr, G., Brunekreef, B., and Hoek, G.
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13. Climate action ,11. Sustainability
34. Decline in air pollution and change in prevalence in respiratory symptoms and chronic obstructive pulmonary disease in elderly women
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Schikowski Tamara, Ranft Ulrich, Sugiri Dorothee, Vierkötter Andrea, Brüning Thomas, Harth Volker, and Krämer Ursula
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Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background While adverse effects of exposure to air pollutants on respiratory health are well studied, little is known about the effect of a reduction in air pollutants on chronic respiratory symptoms and diseases. We investigated whether different declines in air pollution levels in industrialised and rural areas in Germany were associated with changes in respiratory health over a period of about 20 years. Methods We used data from the SALIA cohort study in Germany (Study on the influence of Air pollution on Lung function, Inflammation and Aging) to assess the association between the prevalence of chronic obstructive pulmonary disease (COPD) and chronic respiratory symptoms and the decline in air pollution exposure. In 1985-1994, 4874 women aged 55-years took part in the baseline investigation. Of these, 2116 participated in a questionnaire follow-up in 2006 and in a subgroup of 402 women lung function was tested in 2008-2009. Generalized estimating equation (GEE) models were used to estimate the effect of a reduction in air pollution on respiratory symptoms and diseases. Results Ambient air concentrations of particulate matter with aerodynamic size < 10 μm (PM10) declined in average by 20 μg/m3. Prevalence of chronic cough with phlegm production and mild COPD at baseline investigation compared to follow-up was 9.5% vs. 13.3% and 8.6% vs. 18.2%, respectively. A steeper decline of PM10 was observed in the industrialized areas in comparison to the rural area, this was associated with a weaker increase in prevalence of respiratory symptoms and COPD. Among women who never smoked, the prevalence of chronic cough with phlegm and mild COPD was estimated at 21.4% and 39.5%, respectively, if no air pollution reduction was assumed, and at 13.3% and 17.5%, respectively, if air pollution reduction was assumed. Conclusion We concluded that parallel to the decline of ambient air pollution over the last 20 years in the Ruhr area the age-related increase in chronic respiratory diseases and symptoms appears to attenuate in the population of elderly women.
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- 2010
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35. Contribution of smoking and air pollution exposure in urban areas to social differences in respiratory health
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Ranft Ulrich, Pesch Beate, Reimann Verena, Sugiri Dorothee, Schikowski Tamara, and Krämer Ursula
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Socio-economic status, smoking, and exposure to increased levels of environmental air pollution are associated with adverse effects on respiratory health. We assessed the contribution of occupational exposures, smoking and outdoor air pollution as competing factors for the association between socio-economic status and respiratory health indicators in a cohort of women from the Ruhr area aged 55 at the time of investigation between 1985 and 1990. Methods Data of 1251 women with spirometry and complete questionnaire information about respiratory diseases, smoking and potential confounders were used in the analyses. Exposure to large-scale air pollution was assessed with data from monitoring stations. Exposure to small-scale air pollution was assessed as traffic-related exposure by distance to the nearest major road. Socio-economic status was defined by educational level. Multiple regression models were used to estimate the contribution of occupational exposures, smoking and outdoor air pollution to social differences in respiratory health. Results Women with less than 10 years of school education in comparison to more than 10 years of school education were more often occupationally exposed (16.4% vs. 10.1%), smoked more often (20.3% vs. 13.9%), and lived more often close to major roads (26.0% vs. 22.9%). Long-term exposure to increased levels of PM10 was significantly associated with lower school education. Women with low school education were more likely to suffer from respiratory symptoms and had reduced lung function. In the multivariate analysis the associations between education and respiratory health attenuated after adjusting for occupational exposure, smoking and outdoor air pollution. The crude odds ratio for the association between the lung function indicator FEV1 less than 80% of predicted value and educational level (10 years of school education) was 1.83 (95% CI: 1.22–2.74). This changed to 1.56 (95% CI: 1.03–2.37) after adjusting for occupational exposure, smoking and outdoor air pollution. Conclusion We found an association between socio-economic status and respiratory health. This can partly be explained by living conditions indicated by occupational exposure, smoking behaviour and ambient air pollution. A relevant part of the social differences in respiratory health, however, remained unexplained.
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- 2008
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36. Does respiratory health contribute to the effects of long-term air pollution exposure on cardiovascular mortality?
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Heinrich Joachim, Gehring Ulrike, Ranft Ulrich, Sugiri Dorothea, Schikowski Tamara, Wichmann H-Erich, and Krämer Ursula
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Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background There is growing epidemiological evidence that short-term and long-term exposure to high levels of air pollution may increase cardiovascular morbidity and mortality. In addition, epidemiological studies have shown an association between air pollution exposure and respiratory health. To what extent the association between cardiovascular mortality and air pollution is driven by the impact of air pollution on respiratory health is unknown. The aim of this study was to investigate whether respiratory health at baseline contributes to the effects of long-term exposure to high levels of air pollution on cardiovascular mortality in a cohort of elderly women. Method We analyzed data from 4750 women, aged 55 at the baseline investigation in the years 1985–1994. 2593 of these women had their lung function tested by spirometry. Respiratory diseases and symptoms were asked by questionnaire. Ambient air pollution exposure was assessed by the concentrations of NO2 and total suspended particles at fixed monitoring sites and by the distance of residency to a major road. A mortality follow-up of these women was conducted between 2001 and 2003. For the statistical analysis, Cox' regression was used. Results Women with impaired lung function or pre-existing respiratory diseases had a higher risk of dying from cardiovascular causes. The impact of impaired lung function declined over time. The risk ratio (RR) of women with forced expiratory volume in one second (FEV1) of less than 80% predicted to die from cardiovascular causes was RR = 3.79 (95%CI: 1.64–8.74) at 5 years survival time and RR = 1.35 (95%CI: 0.66–2.77) at 12 years. The association between air pollution levels and cardiovascular death rate was strong and statistically significant. However, this association did only change marginally when including indicators of respiratory health into the regression analysis. Furthermore, no interaction between air pollution and respiratory health on cardiovascular mortality indicating a higher risk of those with impaired respiratory health could be detected. Conclusion Respiratory health is a predictor for cardiovascular mortality. In women followed about 15 years after the baseline investigation at age 55 years long-term air pollution exposure and impaired respiratory health were independently associated with increased cardiovascular mortality.
- Published
- 2007
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37. Long-term air pollution exposure and living close to busy roads are associated with COPD in women
- Author
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Gehring Ulrike, Ranft Ulrich, Sugiri Dorothea, Schikowski Tamara, Heinrich Joachim, Wichmann H-Erich, and Krämer Ursula
- Subjects
Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Lung function and exacerbations of chronic obstructive pulmonary disease (COPD) have been associated with short-term exposure to air pollution. However, the effect of long-term exposure to particulate matter from industry and traffic on COPD as defined by lung function has not been evaluated so far. Our study was designed to investigate the influence of long-term exposure to air pollution on respiratory symptoms and pulmonary function in 55-year-old women. We especially focused on COPD as defined by GOLD criteria and additionally compared the effects of air pollution on respiratory symptoms by questionnaire data and by lung function measurements. Methods In consecutive cross sectional studies conducted between 1985–1994, we investigated 4757 women living in the Rhine-Ruhr Basin of Germany. NO2 and PM10 exposure was assessed by measurements done in an 8 km grid, and traffic exposure by distance from the residential address to the nearest major road using Geographic Information System data. Lung function was determined and COPD was defined by using the GOLD criteria. Chronic respiratory symptoms and possible confounders were defined by questionnaire data. Linear and logistic regressions, including random effects were used to account for confounding and clustering on city level. Results The prevalence of COPD (GOLD stages 1–4) was 4.5%. COPD and pulmonary function were strongest affected by PM10 and traffic related exposure. A 7 μg/m3 increase in five year means of PM10 (interquartile range) was associated with a 5.1% (95% CI 2.5%–7.7%) decrease in FEV1, a 3.7% (95% CI 1.8%–5.5%) decrease in FVC and an odds ratio (OR) of 1.33 (95% CI 1.03–1.72) for COPD. Women living less than 100 m from a busy road also had a significantly decreased lung function and COPD was 1.79 times more likely (95% CI 1.06–3.02) than for those living farther away. Chronic symptoms as based on questionnaire information showed effects in the same direction, but less pronounced. Conclusion Chronic exposure to PM10, NO2 and living near a major road might increase the risk of developing COPD and can have a detrimental effect on lung function.
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- 2005
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38. CHILDREN'S HEALTH AND AIR POLLUTION AROUND INDUSTRIAL HOT SPOTS IN NORTH RHINE-WESTPHALIA, GERMANY.
- Author
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Eberwein, G., Wilheim, M., Hölzer, J., Gladtke, D., Angerer, J., Kraft, M., Marczynski, B., Behrendt, H., Ring, J., Sugiri, D., and Ranft, U.
- Subjects
- *
CHILDREN'S health , *AIR pollution , *EMISSION exposure , *AIR quality - Abstract
Objective: Evaluating exposure and health of children living in three highly industrialized districts ("hot-spots") in the Ruhr-Area and one rural community in North Rhine-Westphalia. Material and methods: Cross-sectional study comprising 968 preschool children was conducted in 2000. Exposure assessment based on ambient air quality data, small scale dispersion models and human biomonitoring, including measurement of PAH and heavy metals. Markers of early effects were DNA strand breaks measured by comet assay in lymphocytes. Health outcome were assessed by questionnaire, lung function and dermatological testing (RAST radioallergosorbent test, patch, prick). Influence of exposure on biomarkers and health outcome was measured by multiple linear and logistic regression analysis. Results: Children living close to a coke oven plant bad increased levels of PAH metabolites in urine and DNA exposure was increased. Children exposed to elevated Cr/Ni ambient air levels from a steel mill revealed high prevalence of allergic symptoms. Sensitization against Ni was associated with internal Ni exposure and Ni in ambient air was positively associated with the frequency of allergic symptoms. Children from the hot spot areas had increased respiratory tract problems. Positive associations between external and internal exposure were found between benzo[a]pyrene in ambient air and 1-hydroxypyrene in urine and between lead in ambient air and in children's blood. Conclusions: Despite improved air quality during the last decades, living in industrialized districts results to some extend in increased internal contaminant exposure and in effects on health outcome. Ongoing studies are aimed to find out if increased PAH and DNA exposure of children had decreased after the coke oven plant had been shut down and if the striking results on the high prevalence of allergic sensitization can he confirmed by an expanded cross sectional study at other districts with increased Cr/Ni ambient air levels. [ABSTRACT FROM AUTHOR]
- Published
- 2007
39. Benefits of improved air quality on ageing lungs: impacts of genetics and obesity.
- Author
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Hüls A, Sugiri D, Abramson MJ, Hoffmann B, Schwender H, Ickstadt K, Krämer U, and Schikowski T
- Subjects
- Aged, Cohort Studies, Female, Forced Expiratory Volume, Germany, Humans, Middle Aged, Nitrogen Dioxide analysis, Prospective Studies, Vital Capacity, Aging, Air Pollutants adverse effects, Air Pollution, Lung drug effects, Lung physiopathology, Obesity genetics, Obesity physiopathology
- Abstract
Introduction: The beneficial effect of improving air quality on lung function in the elderly remains unclear. We examined associations between decline in air pollutants and lung function, and effect modifications by genetics and body mass index (BMI), in elderly German women., Methods: Data were analysed from the prospective SALIA (Study on the influence of Air pollution on Lung function, Inflammation and Aging) study (n=601). Spirometry was conducted at baseline (1985-1994; age 55 years), in 2007-2010 and in 2012-2013. Air pollution concentrations at home addresses were determined for each time-point using land-use regression models. Global Lung Initiative 2012 z-scores were calculated. Weighted genetic risk scores (GRSs) were determined from lung function-related risk alleles and used to investigate interactions with improved air quality. Multiple linear mixed models were fitted., Results: Air pollution levels decreased substantially during the study period. Reduction of air pollution was associated with an increase in z-scores for forced expiratory volume in 1 s (FEV
1 ) and the FEV1 /forced vital capacity ratio. For a decrease of 10 µg·m-3 in nitrogen dioxide (NO2 ), the z-score for FEV1 increased by 0.14 (95% CI 0.01-0.26). However, with an increasing number of lung function-related risk alleles, the benefit from improved air quality decreased (GRS×NO2 interaction: p=0.029). Interactions with BMI were not significant., Conclusions: Reduction of air pollution is associated with a relative improvement of lung function in elderly women, but also depends on their genetic make-up., Competing Interests: Conflict of interest: D. Hüls has nothing to disclose. Conflict of interest: D. Sugiri has nothing to disclose. Conflict of interest: M.J. Abramson reports grants from Pfizer, grants from Boehringer Ingelheim, assistance with conference attendance and honoraria for consultancy from Sanofi, outside the submitted work. Conflict of interest: B. Hoffmann has nothing to disclose. Conflict of interest: H. Schwender has nothing to disclose. Conflict of interest: K. Ickstadt has nothing to disclose. Conflict of interest: U. Krämer has nothing to disclose. Conflict of interest: T. Schikowski has nothing to disclose., (Copyright ©ERS 2019.)- Published
- 2019
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40. Lentigine Formation in Caucasian Women-Interaction between Particulate Matter and Solar UVR.
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Hüls A, Sugiri D, Fuks K, Krutmann J, and Schikowski T
- Subjects
- Female, Follow-Up Studies, Humans, Lentigo diagnosis, Middle Aged, Risk Factors, Sunlight adverse effects, Time Factors, Environmental Exposure adverse effects, Lentigo etiology, Particulate Matter adverse effects, Ultraviolet Rays adverse effects
- Published
- 2019
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41. Tropospheric ozone and skin aging: Results from two German cohort studies.
- Author
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Fuks KB, Hüls A, Sugiri D, Altug H, Vierkötter A, Abramson MJ, Goebel J, Wagner GG, Demuth I, Krutmann J, and Schikowski T
- Subjects
- Aged, Aged, 80 and over, Air Pollutants analysis, Cohort Studies, Female, Humans, Male, Middle Aged, Nitrogen Dioxide analysis, Ozone analysis, Particulate Matter analysis, Skin Aging radiation effects, Time, Ultraviolet Rays, Air Pollutants toxicity, Ozone toxicity, Skin Aging drug effects
- Abstract
During the last two decades, it has been well established that a short-term exposure to ozone (O
3 ) elicits an oxidative stress response in human and mouse skin, which leads to aberrant transcriptional expression of genes consistent with increased skin aging. Whether a long-term exposure to ambient O3 is associated with any skin aging traits, has remained unclear. We addressed this question in two elderly German cohorts: the SALIA study (806 women aged 66-79 years), and the BASE-II study (1207 men and women aged 60-84 years). Five-year mean residential exposure to O3 was modeled as the number of days with maximum daily 8-h mean O3 concentrations ≥120 μg/m3 per year in the wider neighborhood (5-digit postcode) of a participant's residence. Extrinsic (environmentally induced) skin aging traits - coarse wrinkles and pigment spots (lentigines) on the face - were assessed by means of SCINEXA™, a validated visual score previously shown to be well suited to measure extrinsic facial skin aging in cohort studies. We observed positive associations of O3 exceedances with coarse wrinkles in the face, but not with pigment spots. These associations were present in each cohort as well as in the combined sample of both cohorts. They were independent of chronic ultraviolet radiation exposure as the most obvious confounder, and also of co-pollutants such as particulate matter and nitrogen dioxide. Thus, long-term exposure to elevated concentrations of tropospheric O3 appears to contribute to skin aging., (Copyright © 2019 Elsevier Ltd. All rights reserved.)- Published
- 2019
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42. Residential and school greenspace and academic performance: Evidence from the GINIplus and LISA longitudinal studies of German adolescents.
- Author
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Markevych I, Feng X, Astell-Burt T, Standl M, Sugiri D, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, and Heinrich J
- Subjects
- Adolescent, Child, Child, Preschool, Cohort Studies, Environment, Female, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Trees, Educational Status, Residence Characteristics, Schools
- Abstract
Background: Few studies have reported the association between greenspace and academic performance at school level. We examined associations between both residential and school greenspace and individual school grades in German adolescents., Methods: German and maths grades from the latest school certificate, residential and school greenspace, and covariates were available for 1351 10 and 15 years old Munich children and 1078 Wesel children from two German birth cohorts - GINIplus and LISA. Residential and school greenspace was assessed by the Normalized Difference Vegetation Index (NDVI), tree cover, and (in Munich only) proportion of agricultural land, forest, and urban green space in 500-m and 1000-m circular buffers. Longitudinal associations between each exposure-outcome pair were assessed by logistic mixed effects models with person and school as random intercepts and adjusted for potential confounders., Results: No associations were observed between any of the greenspace variables and grades in Wesel children. Several statistically significant associations were observed with German and maths grades in Munich children, however associations were inconsistent across sensitivity analyses., Conclusions: There is no evidence of an association of higher greenspace at residence, school or combined with improved academic performance in German adolescents from the GINIplus and LISA longitudinal studies., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2019
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43. Nonatopic eczema in elderly women: Effect of air pollution and genes.
- Author
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Hüls A, Abramson MJ, Sugiri D, Fuks K, Krämer U, Krutmann J, and Schikowski T
- Subjects
- Female, Follow-Up Studies, Humans, Incidence, Middle Aged, Prevalence, Risk Factors, Air Pollution adverse effects, Alleles, Eczema chemically induced, Eczema epidemiology, Eczema genetics, Eczema immunology, Environmental Exposure adverse effects, Gene Frequency
- Abstract
Background: Although many risk factors have been described for atopic eczema in children, little is known about the eczema phenotype in middle-aged or elderly adults., Objective: We sought to examine the association between air pollution, atopy, and eczema in adulthood., Methods: This analysis was based on 834 women from the Study on the influence of Air pollution on Lung Function, Inflammation and Ageing cohort in Germany. Incident symptoms of eczema after age 55 years and prevalent symptoms of eczema 12 months or less before investigation were assessed by means of questionnaire at the second follow-up (2007-2010). Total serum IgE levels were measured at baseline (1985-1994) and in 2007-2010. Exposure to air pollution was assessed by using land-use regression. Adjusted logistic regression models were applied to estimate the association between air pollution and incident and prevalent symptoms of eczema. Weighted genetic risk scores were used to investigate the effect of atopic eczema-related risk alleles on this association., Results: Exposures to oxides of nitrogen (nitrogen dioxide and nitrogen oxides) and particulate matter (fine particulate matter with an aerodynamic diameter of ≤2.5 μm [PM
2.5 ] and particulate matter with an aerodynamic diameter of <10 μm) were significantly associated with increased odds of incident eczema (eg, with PM2.5 per 4.7 μg/m3 ; odds ratio, 1.45; 95% CI, 1.06-1.99). These associations were slightly more pronounced with nonatopic eczema (eg, with PM2.5 ; odds ratio of 1.65 and 95% CI of 1.15-2.34 for participants without hay fever or increased IgE levels). Associations with air pollution were stronger in carriers of fewer risk alleles for atopic eczema., Conclusion: Nonatopic eczema in the elderly is associated with traffic-related air pollutants, and this phenotype differs from genetically driven atopic eczema., (Copyright © 2018 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)- Published
- 2019
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44. Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe.
- Author
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Forns J, Sunyer J, Garcia-Esteban R, Porta D, Ghassabian A, Giorgis-Allemand L, Gong T, Gehring U, Sørensen M, Standl M, Sugiri D, Almqvist C, Andiarena A, Badaloní C, Beelen R, Berdel D, Cesaroni G, Charles MA, Eriksen KT, Estarlich M, Fernandez MF, Forhan A, Jaddoe VWV, Korek M, Lichtenstein P, Lertxundi A, Lopez-Espinosa MJ, Markevych I, de Nazelle A, Raaschou-Nielsen O, Nieuwenhuijsen M, Pérez-Lobato R, Philippat C, Slama R, Tiesler CMT, Verhulst FC, von Berg A, Vrijkotte T, Nybo Andersen AM, Heude B, Krämer U, Heinrich J, Tiemeier H, Forastiere F, Pershagen G, Brunekreef B, and Guxens M
- Subjects
- Air Pollution analysis, Attention Deficit Disorder with Hyperactivity diagnosis, Attention Deficit Disorder with Hyperactivity epidemiology, Child, Child, Preschool, Europe epidemiology, Female, Humans, Inhalation Exposure analysis, Nitrogen Dioxide adverse effects, Nitrogen Dioxide analysis, Particulate Matter adverse effects, Particulate Matter analysis, Pregnancy, Air Pollution adverse effects, Attention Deficit Disorder with Hyperactivity etiology, Inhalation Exposure adverse effects, Prenatal Exposure Delayed Effects epidemiology
- Abstract
Background: Exposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29,127 mother-child pairs., Methods: Air pollution concentrations (nitrogen dioxide [NO2] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3-10 years of age. We classified children as having ADHD symptoms within the borderline/clinical range and within the clinical range using validated cutoffs. We combined all adjusted area-specific effect estimates using random-effects meta-analysis and multiple imputations and applied inverse probability-weighting methods to correct for loss to follow-up., Results: We classified a total of 2,801 children as having ADHD symptoms within the borderline/clinical range, and 1,590 within the clinical range. Exposure to air pollution during pregnancy was not associated with a higher odds of ADHD symptoms within the borderline/clinical range (e.g., adjusted odds ratio [OR] for ADHD symptoms of 0.95, 95% confidence interval [CI] = 0.89, 1.01 per 10 µg/m increase in NO2 and 0.98, 95% CI = 0.80, 1.19 per 5 µg/m increase in PM2.5). We observed similar associations for ADHD within the clinical range., Conclusions: There was no evidence for an increase in risk of ADHD symptoms with increasing prenatal air pollution levels in children aged 3-10 years. See video abstract at, http://links.lww.com/EDE/B379.
- Published
- 2018
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45. Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry.
- Author
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Lanzinger S, Rosenbauer J, Sugiri D, Schikowski T, Treiber B, Klee D, Rathmann W, and Holl RW
- Subjects
- Adolescent, Air Pollutants adverse effects, Child, Cross-Sectional Studies, Diabetes Mellitus, Type 1 metabolism, Female, Germany, Glycated Hemoglobin analysis, Humans, Male, Multivariate Analysis, Particulate Matter, Registries, Regression Analysis, Air Pollution adverse effects, Diabetes Mellitus, Type 1 blood, Environmental Exposure adverse effects, Ozone adverse effects
- Abstract
Aims/hypothesis: Studies on the association between air pollution and metabolic control in children and adolescents with type 1 diabetes are rare and findings are inconsistent. We examined the relationship between air pollution variables (particulate matter with an aerodynamic diameter <10 μm [PM
10 ], NO2 and accumulated ozone exposure [O3 -AOT]) and metabolic variables (HbA1c and daily insulin dose [U/kg body weight]) in children and adolescents with type 1 diabetes., Methods: We investigated 37,372 individuals with type 1 diabetes aged <21 years, documented between 2009 and 2014 in 344 German centres of the prospective diabetes follow-up registry (Diabetes-Patienten-Verlaufsdokumentation [DPV]). Long-term air pollution exposure (annual and quinquennial means) data were linked to participants via the five-digit postcode areas of residency. Cross-sectional multivariable regression analysis was used to examine the association between air pollution and metabolic control., Results: After comprehensive adjustment, an interquartile range increase in O3 -AOT was associated with a lower HbA1c (-3.7% [95% CI -4.4, -3.0]). The inverse association between O3 -AOT and HbA1c persisted after additional adjustment for degree of urbanisation or additional adjustment for PM10 . Moreover, the inverse association remained stable in further sensitivity analyses. No significant associations between HbA1c and PM10 or NO2 were found. No association was observed between any of the three air pollutants and insulin dose., Conclusions/interpretation: The inverse association between O3 -AOT and HbA1c could not be explained by regional differences in diabetes treatment or by other differences between urban and rural areas. Furthermore, our results remained stable in sensitivity analyses. Further studies on the association between air pollution and HbA1c in children and adolescents with type 1 diabetes are needed to confirm our observed association and to elucidate underlying mechanisms.- Published
- 2018
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46. [Epidemiological studies with environmental relevance in Germany].
- Author
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Schneider A, Rückerl R, Standl M, Markevych I, Hoffmann B, Moebus S, Jöckel KH, Weber A, Herr C, Heißenhuber A, Nennstiel-Ratzel U, Heinze S, Schulz C, Kolossa-Gehring M, Niemann H, Gößwald A, Schikowski T, Hüls A, Sugiri D, and Peters A
- Subjects
- Adult, Aged, Child, Environmental Exposure, Epidemiologic Studies, Germany, Humans, Air Pollution, Environmental Health, Environmental Monitoring, Quality of Life
- Abstract
Our environment is a major factor in determining health and well-being throughout life, from conception into old age. This overview illustrates the most important epidemiological studies and health monitoring systems in Germany, which investigate environmental influences in various population subgroups and estimate related health effects. Environmental factors examined in each study are described. The mentioned studies in children and adults build the basis for predictions and preventive measures. The number of the assessed environmental factors, the depth of the examinations as well as the (phenotypical) characterization of the study participants differ. Still, the obtained data build a base for important future research. However, for this, a permanent and Germany-wide assessment of environmental factors is necessary.The proportion of the European population living in urban areas is projected to increase in the future. Therefore, environmental factors such as air pollution, air temperature, and noise, but also social inequality, are likely to have a negative effect on health and quality of life of the population. The challenge of the aging population as well as potential adaptation processes to the diverse environmental stimuli requires multidisciplinary approaches. From an environmental epidemiology view, the collected data from the described studies are of immense value because only with this data can associations between environment and health be investigated and public health-relevant preventive measures be identified.The NAKO health study will be the largest resource of health data and should therefore be included in future activities related to the investigation of environmental health effects in Germany.
- Published
- 2018
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47. The role of air pollution and lung function in cognitive impairment.
- Author
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Hüls A, Vierkötter A, Sugiri D, Abramson MJ, Ranft U, Krämer U, and Schikowski T
- Subjects
- Aged, Aged, 80 and over, Aging, Air Pollution analysis, Cognitive Dysfunction etiology, Cohort Studies, Cross-Sectional Studies, Female, Forced Expiratory Volume, Germany epidemiology, Humans, Lung Diseases etiology, Middle Aged, Nitrogen Dioxide, Particulate Matter analysis, Regression Analysis, Respiratory Function Tests, Vital Capacity, Air Pollutants analysis, Cognitive Dysfunction complications, Environmental Exposure, Lung drug effects, Lung Diseases complications
- Abstract
Air pollution has been associated with impaired lung and cognitive function, especially impairment in visuo-construction performance (VCP). In this article, we evaluate whether the effect of air pollution on VCP is mediated by lung function.We used data from the SALIA cohort (baseline 1985-1994 and follow-up 2007-2010) including 587 women aged 55 years at baseline. Particulate matter (PM) and nitrogen dioxide (NO
2 ) exposures at baseline were estimated via land-use regression models. Lung function was characterised by averages between baseline and follow-up. We used age- and height-controlled Global Lung Initiative (GLI) z-scores of forced expiratory volume in 1 s (FEV1 ), forced vital capacity (FVC) and FEV1 /FVC. VCP was assessed at follow-up with the CERAD-Plus neuropsychological test battery and causal mediation analysis was conducted.An increase of one interquartile range in FEV1 and FVC was positively associated with VCP (β=0.18 (95% CI 0.02-0.34) and β=0.23 (95% CI 0.07-0.39), respectively). The proportion of the association between NO2 on VCP mediated by FEV1 was 6.2% and this was higher in never smokers (7.2%) and non-carriers of the APOE-ε4 allele (11.2%). However, none of the mediations were statistically significant.In conclusion, air pollution associated VCP was partially mediated by lung function. Further studies on the mechanisms underlying this pathway are required to develop new strategies to prevent air pollution induced cognitive impairment., Competing Interests: Conflict of interest: M.J. Abramson has received investigator initiated grants for unrelated research from Pfizer and Boehringer-Ingelheim, and reimbursement for congress attendance from Sanofi., (Copyright ©ERS 2018.)- Published
- 2018
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48. Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study.
- Author
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Tischer C, Dadvand P, Basagana X, Fuertes E, Bergström A, Gruzieva O, Melen E, Berdel D, Heinrich J, Koletzko S, Markevych I, Standl M, Sugiri D, Cirugeda L, Estarlich M, Fernández-Somoano A, Ferrero A, Ibarlueza J, Lertxundi A, Tardón A, Sunyer J, and Anto JM
- Subjects
- Child, Germany epidemiology, Humans, Respiratory Sounds, Spain epidemiology, Sweden epidemiology, Environmental Exposure, Environmental Pollutants adverse effects, Rhinitis, Allergic epidemiology
- Abstract
Objective: We integratively assessed the effect of different indoor and outdoor environmental exposures early in life on respiratory and allergic health conditions among children from (sub-) urban areas., Methods: This study included children participating in four ongoing European birth cohorts located in three different geographical regions: INMA (Spain), LISAplus (Germany), GINIplus (Germany) and BAMSE (Sweden). Wheezing, bronchitis, asthma and allergic rhinitis throughout childhood were assessed using parental-completed questionnaires. We designed "environmental scores" corresponding to different indoor, green- and grey-related exposures (main analysis, a-priori-approach). Cohort-specific associations between these environmental scores and the respiratory health outcomes were assessed using random-effects meta-analyses. In addition, a factor analysis was performed based on the same exposure information used to develop the environmental scores (confirmatory analysis, data-driven-approach)., Results: A higher early exposure to the indoor environmental score increased the risk for wheezing and bronchitis within the first year of life (combined adjusted odds ratio: 1.20 [95% confidence interval: 1.13-1.27] and 1.28 [1.18-1.39], respectively). In contrast, there was an inverse association with allergic rhinitis between 6 and 8 years (0.85 [0.79-0.92]). There were no statistically significant associations for the outdoor related environmental scores in relation to any of the health outcomes tested. The factor analysis conducted confirmed these trends., Conclusion: Although a higher exposure to indoor related exposure through occupants was associated with an increased risk for wheezing and bronchitis within the 1st year, it might serve as a preventive mechanism against later childhood allergic respiratory outcomes in urbanized environments through enhanced shared contact with microbial agents., (Copyright © 2017 Elsevier Inc. All rights reserved.)
- Published
- 2018
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49. Associations of long-term exposure to air pollution and road traffic noise with cognitive function-An analysis of effect measure modification.
- Author
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Tzivian L, Jokisch M, Winkler A, Weimar C, Hennig F, Sugiri D, Soppa VJ, Dragano N, Erbel R, Jöckel KH, Moebus S, and Hoffmann B
- Subjects
- Aged, Air Pollutants adverse effects, Air Pollutants analysis, Air Pollution analysis, Environmental Exposure analysis, Female, Housing, Humans, Linear Models, Male, Middle Aged, Nitrogen Oxides adverse effects, Nitrogen Oxides analysis, Particulate Matter adverse effects, Particulate Matter analysis, Prospective Studies, Air Pollution adverse effects, Cognition, Environmental Exposure adverse effects, Noise, Transportation adverse effects
- Abstract
Background: Adverse effects of traffic-related air pollution (AP) and noise on cognitive functions have been proposed, but little is known about their interactions and the combined effect of co-exposure., Methods: Cognitive assessment was completed by 4086 participants of the population-based Heinz Nixdorf Recall cohort study using five neuropsychological subtests and an additively calculated global cognitive score (GCS). We assessed long-term residential concentrations for size-fractioned particulate matter (PM) and nitrogen oxides with land use regression. Road traffic noise (weighted 24-h (L
DEN ) and night-time (LNIGHT ) means) was assessed according to the EU directive 2002/49/EC. Linear regression models adjusted for individual-level characteristics were calculated to estimate effect modification of associations between AP and noise with cognitive function. We used multiplicative interaction terms and categories of single or double high exposure, dichotomizing the potential effect modifier at the median (AP) or at an a priori defined threshold (road traffic noise)., Results: In fully adjusted models, high noise exposure increased the association of AP with cognitive function. For example, for an interquartile range increase of PM2.5 (IQR 1.43), association s with GCS were: estimate (β)=-0.16 [95% confidence interval: -0.33; 0.01] and β=-0.48 [-0.72; -0.23] for low and high LDEN , respectively. The association of noise with GCS was restricted to highly AP-exposed participants. We observed stronger negative associations in those participants with double exposure compared to the addition of effect estimates of each single exposure., Conclusions: Our study suggests that AP and road traffic noise might act synergistically on cognitive function in adults., (Copyright © 2017 Elsevier Ltd. All rights reserved.)- Published
- 2017
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50. Traffic-related air pollution and hyperactivity/inattention, dyslexia and dyscalculia in adolescents of the German GINIplus and LISAplus birth cohorts.
- Author
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Fuertes E, Standl M, Forns J, Berdel D, Garcia-Aymerich J, Markevych I, Schulte-Koerne G, Sugiri D, Schikowski T, Tiesler CM, and Heinrich J
- Subjects
- Adolescent, Attention Deficit Disorder with Hyperactivity epidemiology, Child, Dyscalculia epidemiology, Dyslexia epidemiology, Female, Germany epidemiology, Humans, Male, Motor Vehicles, Nervous System Diseases, Nitrogen Dioxide toxicity, Air Pollutants toxicity, Attention Deficit Disorder with Hyperactivity chemically induced, Dyscalculia chemically induced, Dyslexia chemically induced, Particulate Matter toxicity, Vehicle Emissions toxicity
- Abstract
Background: Few studies have examined the link between air pollution exposure and behavioural problems and learning disorders during late childhood and adolescence., Objectives: To determine whether traffic-related air pollution exposure is associated with hyperactivity/inattention, dyslexia and dyscalculia up to age 15years using the German GINIplus and LISAplus birth cohorts (recruitment 1995-1999)., Methods: Hyperactivity/inattention was assessed using the German parent-completed (10years) and self-completed (15years) Strengths and Difficulties Questionnaire. Responses were categorized into normal versus borderline/abnormal. Parent-reported dyslexia and dyscalculia (yes/no) at age 10 and 15years were defined using parent-completed questionnaires. Individual-level annual average estimates of nitrogen dioxide (NO
2 ), particulate matter (PM)10 mass, PM2.5 mass and PM2.5 absorbance concentrations were assigned to each participant's birth, 10year and 15year home address. Longitudinal associations between the air pollutants and the neurodevelopmental outcomes were assessed using generalized estimation equations, separately for both study areas, and combined in a random-effects meta-analysis. Odds ratios and 95% confidence intervals are given per interquartile range increase in pollutant concentration., Results: The prevalence of abnormal/borderline hyperactivity/inattention scores and parental-reported dyslexia and dyscalculia at 15years of age was 12.9%, 10.5% and 3.4%, respectively, in the combined population (N=4745). In the meta- analysis, hyperactivity/inattention was associated with PM2.5 mass estimated to the 10 and 15year addresses (1.12 [1.01, 1.23] and 1.11 [1.01, 1.22]) and PM2.5 absorbance estimated to the 10 and 15year addresses (1.14 [1.05, 1.25] and 1.13 [1.04, 1.23], respectively)., Conclusions: We report associations suggesting a potential link between air pollution exposure and hyperactivity/inattention scores, although these findings require replication., (Copyright © 2016 Elsevier Ltd. All rights reserved.)- Published
- 2016
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