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3. First-in-human phase I clinical trial of the NY-ESO-1 protein cancer vaccine with NOD2 and TLR9 stimulants in patients with NY-ESO-1-expressing refractory solid tumors

Author

Ishihara, Mikiya, Tono, Yasutaka, Miyahara, Yoshihiro, Muraoka, Daisuke, Harada, Naozumi, Kageyama, Shinichi, Sasaki, Takeshi, Hori, Yasuhide, Soga, Norihito, Uchida, Katsunori, Shiraishi, Taizo, Sato, Eiichi, Kanda, Hideki, Mizuno, Toshiro, Webster, Gill A., Ikeda, Hiroaki, Katayama, Naoyuki, Sugimura, Yoshiki, and Shiku, Hiroshi

Published
2020
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5. Castration-induced stromal remodeling disrupts the reconstituted prostate epithelial structure

Author

Kajiwara, Shinya, Ishii, Kenichiro, Sasaki, Takeshi, Kato, Manabu, Nishikawa, Kohei, Kanda, Hideki, Arima, Kiminobu, Watanabe, Masatoshi, and Sugimura, Yoshiki

Abstract

The normal prostate epithelial structure is maintained by homeostatic interactions with smooth muscle cells. However, structural alterations of the stroma are commonly observed in prostatic proliferative diseases, leading to the abnormalities of prostate epithelial structure. A decrease in the androgen level experimentally induces stromal remodeling, i.e., replacement of smooth muscle cells with fibroblasts or myofibroblasts. In this study, we investigated the effects of castration-induced stromal remodeling and subsequent aberrant activation of epithelial–stromal interactions on the reconstituted human prostate-like epithelial structure. We performed in vivo experiments using the human prostate epithelial cell line BPH-1 and fetal rat urogenital sinus mesenchyme to generate heterotypic tissue recombinants that form human prostate-like epithelial structure (i.e., solid- and canalized-epithelial cords). Host mice were castrated at 12 weeks post transplantation (castration) and implanted with a dihydrotestosterone pellet at 14 days post castration (androgen replacement treatment; ART). In the castration group, the percentages of fibrotic area and disrupted prostate epithelial structure without the basement membrane (BM) increased proportionally in a time-dependent manner, but were suppressed by ART. In the castration group, tenascin-C (TNC)-positive fibroblasts were abundant in the stroma surrounding disrupted prostate epithelial structure without the BM. TGF-β1 secretion from BPH-1 cells was increased by co-culturing with human primary cultured prostate fibroblasts. TNCmRNA expression was increased in fibroblasts co-culturing with BPH-1 cells and was suppressed by treatment with a TGF-β RI kinase inhibitor. Moreover, in the castration group, the percentage of p-Smad2-positive cells was significantly higher in the stroma surrounding disrupted prostate epithelial structure without the BM. Our results demonstrate that castration-induced stromal remodeling disrupted the reconstituted human prostate-like epithelial structure and induced the appearance of TNC-positive fibroblasts accompanied by activation of TGF-β signaling. The alteration of prostate stromal structure may be responsible for loss of the BM and epithelial cell polarity.

Published
2024
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7. The clinical trial on the safety and effectiveness of the photodynamic diagnosis of non-muscle-invasive bladder cancer using fluorescent light-guided cystoscopy after oral administration of 5-aminolevulinic acid (5-ALA)

Author

Inoue, Keiji, Matsuyama, Hideyasu, Fujimoto, Kiyohide, Hirao, Yoshihiko, Watanabe, Hironobu, Ozono, Seiichiro, Oyama, Masafumi, Ueno, Munehisa, Sugimura, Yoshiki, Shiina, Hiroaki, Mimata, Hiromitsu, Azuma, Haruhito, Nagase, Yasushi, Matsubara, Akio, Ito, Yoichi M, and Shuin, Taro

Published
2016
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11. Initial Experience of Photodynamic Diagnosis-Assisted Transurethral Resection of Bladder Tumor (PDD-TURBT)

Author

SUGINO, Yusuke, NISHIKAWA, Kouhei, KATO, Momoko, SASAKI, Takeshi, KATO, Manabu, MASUI, Satoru, YOSHIO, Yuko, KANDA, Hideki, SUGIMURA, Yoshiki, and INOUE, Takahiro

Subjects
PDD, Bladder cancer, 494.9, 5-ALA, NMIBC, TURBT
Abstract

Photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-ALA) is expected to be useful in preventing oversight of non-muscle-invasive bladder cancer (NMIBC) and in reducing the intravesical recurrence rate after transurethral resection of bladder tumor (TURBT). We report our initial experience with28 cases of PDD-assisted TURBT (122 samples) performed at our hospital from February 2018 to April 2019. The median age of the patients was 74.5 years, and 18 of the 28 were primary cases. Each patient underwent TURBT with oral administration of 5-ALA 20 mg/kg 3 hours before endoscopic examination. The sensitivity was 89.8% when both white light and blue light were used, which was superior to the sensitivity of 67.8% when using only white light (p＜0.01, McNemar’s test). Among the first several cases, we experienced high false positivity, which suggested that some experience may be required to discriminate tumors from inflammatory lesions. In fact, the specificity and the positive likelihood ratio improved with experience. No grade 2 or higher adverse events were observed among our cases. The median follow-up period was 738 days, and 9 of 28 patients (32. 1%) had recurrence within the follow-up period. In conclusion, our initial experience with PDD-assisted TURBT demonstrated its excellent diagnostic sensitivity and safety, as previously reported.

Published
2021

15. Neoajuvant Chemotherapy with Gemcitabine and Cisplatin Plus S-1 for Primary Female Urethral Adenocarcinoma

Author

Nishikawa, Taketomo, Sugino, Yusuke, Owa, Shunsuke, Kitano, Goshi, Sasaki, Takeshi, Kato, Manabu, Masui, Satoru, Nishikawa, Kohei, Yoshio, Yuko, Kanda, Hideki, Arima, Kiminobu, Sugimura, Yoshiki, and Uchida, Katsunori

Subjects
Female urethral tumor, 494.9, Adenocarcinoma, GC/S-1, Neoadjuvant chemotherapy, Multimodal therapy
Abstract

A 67-year-old female presented for evaluation of a left inguinal mass. Contrast-enhanced computed tomography revealed a tumor surrounding the urethra. Magnetic resonance imaging showed that the tumor had invaded the bladder neck on the anterior aspect of the urethra. The serum carbohydrate antigen 19-9 level was elevated. The clinical diagnosis was a primary adenocarcinoma of the female urethra (cT4N2M0). The initial treatment consisted of gemcitabine plus cisplatin (GC) and oral fluoropyrimidine (S-1). A total cysto-urethrectomy with anterior vaginal wall resection, pelvic and inguinal lymphadenectomy, and urinary diversion with ileal conduit formation were performed. The final diagnosis was urethral adenocarcinoma (ypT4ypN2, stage IV). Twelve months post-operatively, there was no evidence of recurrence or distant metastases.

Published
2020

20. PROSTATE-SPECIFIC ANTIGEN DENSITY IS THE MOST APPROPRIATE FACTOR FOR DETECTING UNFAVORABLE PATHOLOGY AFTER RADICAL PROSTATECTOMY IN MEN ELIGIBLE FOR ACTIVE SURVEILLANCE FROM MUTLI-INSTITUTIONAL STUDY: MP57-08

Author

Inoue, Takahiro, Mizuno, Kei, Kinoshita, Hidefumi, Yano, Toshifumi, Kawanishi, Hiroaki, Kanda, Hideki, Terada, Naoki, Kamba, Tomomi, Okumura, Kazuhiro, Kawakita, Mutsushi, Ogura, Keiji, Sugimura, Yoshiki, Matsuda, Tadashi, and Ogawa, Osamu

Published
2016
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23. A case of adenocarcinoma of the rete testis with durable response to cisplatin‐based chemotherapy

Author

Owa, Shunsuke, primary, Sasaki, Takeshi, additional, Uchida, Katsunori, additional, Watanabe, Susumu, additional, Kato, Momoko, additional, Sugino, Yusuke, additional, Kato, Manabu, additional, Masui, Satoru, additional, Nishikawa, Kouhei, additional, Yoshio, Yuko, additional, Kanda, Hideki, additional, Sugimura, Yoshiki, additional, and Inoue, Takahiro, additional

Published
2021
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38. Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation

Author

Ishii, Kenichiro, Imanaka-Yoshida, Kyoko, Yoshida, Toshimichi, and Sugimura, Yoshiki

Subjects
Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ydbio.2008.09.029 Byline: Kenichiro Ishii (a), Kyoko Imanaka-Yoshida (b), Toshimichi Yoshida (b), Yoshiki Sugimura (a) Keywords: Tenascin-C; Knockout mouse; Prostate; Epithelial-stromal interactions; Epithelial cell differentiation; Epithelial cell cluster; Binucleated cell; Androgen receptor; Tissue recombination; Urogenital sinus mesenchyme Abstract: Deregulation of epithelial-stromal interactions is considered to play a critical role in the initiation and promotion of benign prostatic hyperplasia (BPH) and prostate carcinoma (PCa). Expression of tenascin-C (TN-C), an extracellular matrix (ECM) glycoprotein, is reportedly higher in BPH and PCa as compared with normal prostate. Remodeling of the ECM alters the homeostatic balance between epithelium and stroma, resulting in physiological changes in cellular functions. To investigate the role of TN-C in prostatic development and differentiation, we evaluated the morphological phenotype of TN-C knockout (KO) mouse prostate (ventral: VP, dorsolateral: DLP, and anterior: AP) and examined tissue recombinants composed of adult mouse DLP epithelium and fetal TN-C KO urogenital sinus mesenchyme (UGM). Histological analysis showed epithelial cell clusters protruding into the ductal lumens in TN-C KO AP and DLP. Interestingly, binucleated cells appeared in epithelium of TN-C KO DLP at 8 weeks. Simultaneously, androgen receptor (AR)-positive cells were decreased in TN-C KO epithelia. Similar to the TN-C KO phenotype, protruded epithelial clusters, binucleated cells, and AR-negative nuclei were induced in DLP epithelium by recombining with TN-C KO UGM. Our results suggest that stromal TN-C might be involved in maintaining epithelial cytodifferentiation, morphogenesis, and androgen receptor expression of normal prostate glands in adult mice. Author Affiliation: (a) Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan (b) Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Japan Article History: Received 23 July 2008; Revised 18 September 2008; Accepted 19 September 2008

Published
2008

48. Abstract 3983: Direct contact of heterogeneous fibroblasts with cancer cells regulates the invasive phenotype of prostate cancer cells

Author

Ishii, Kenichiro, primary, Nakagawa, Yasuhisa, additional, Shirai, Taku, additional, Ichishi, Masako, additional, Fujiwara, Masaya, additional, Kato, Daisuke, additional, Matsuda, Chise, additional, Hirokawa, Yoshifumi, additional, Sugimura, Yoshiki, additional, Inagaki, Masaki, additional, and Watanabe, Masatoshi, additional

Published
2020
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49. A Kidney Transplant Recipient with Recurrent Henoch-Schönlein Purpura Nephritis Successfully Treated with Steroid Pulse Therapy and Epipharyngeal Abrasive Therapy

Author

Fujimoto, Mika, primary, Katayama, Kan, additional, Nishikawa, Kouhei, additional, Mizoguchi, Shoko, additional, Oda, Keiko, additional, Hirabayashi, Yosuke, additional, Suzuki, Yasuo, additional, Haruki, Ayumi, additional, Ito, Takayasu, additional, Murata, Tomohiro, additional, Ishikawa, Eiji, additional, Sugimura, Yoshiki, additional, and Ito, Masaaki, additional

Published
2020
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50. LEIOMYOSARCOMA ARISING FROM THE RENAL VEIN

Author

Sekito, Sho, primary, Nishikawa, Kohei, additional, Kageyama, Takumi, additional, Higashi, Shinichirou, additional, Miki, Manabu, additional, Kato, Manabu, additional, Masui, Satoru, additional, Yoshio, Yuko, additional, Hasegawa, Yoshihiro, additional, Kanda, Hideki, additional, Arima, Kiminobu, additional, and Sugimura, Yoshiki, additional

Published
2019
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