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3. The Possibility of HyFlex : Innovation and Inclusion in Course Design, Teaching, and Learning

Author

SUGIMORI, Kimikazu

Abstract

オンライン授業への転換に迫られた1 年を経て、オンライン・対面それぞれの利点を活かしたハイブリッド授業の試行錯誤がなされてきた。さらには対面授業再開の模索のなか、より柔軟に（フレキシブルに）学習形態を選ぶことのできる「ハイフレックス」も紹介された。しかし、その実現には「TA やオンライン授業アシスタント、意図的にデザインされた教室環境、そして学生と教員両方から多大な忍耐が必要」であり、その授業設計・学習設計・教室環境設計に必要な工夫は見過ごされたままである。本稿では、ハイフレックス概念を整理し、様々なクラスサイズでの実践事例を加えて、これからの大学教育の再設計を試みたい。, A year of emergency remote instruction prompted a trial-and-error process of hybrid classes that utilize the advantages of both online and face-to-face classes. Furthermore, in the search for the resumption of face-to-face classes, “HyFlex," which allows students to choose a more flexible learning with hybridized format, was introduced. However, the realization of such a system “often requires real-time in-class help (a TA or course assistant to manage the online students), an intentionally designed classroom and a great deal of patience from both the students and faculty," and the necessary innovations in the design of teaching, learning, and the classroom environment have been overlooked. In this paper, the author tries to redesign the future of university education by organizing the HyFlex concept and adding practical examples of various class sizes.

Published
2022

5. Visualization of Non-verbal Expressions in Voice for Hearing Impaired : Ambient Font and Onomatopoeic Subsystem

Author

Nambo, Hidetaka, Seto, Shuichi, Arai, Hiroshi, Sugimori, Kimikazu, Shimomura, Yuko, Kawabe, Hiroyuki, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Miesenberger, Klaus, editor, Karshmer, Arthur, editor, Penaz, Petr, editor, and Zagler, Wolfgang, editor

Published
2012
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11. 遠隔授業がつなぐ大学の学びのリ・デザイン ―デジタル・ペダゴジーへ

Author

Sugimori, Kimikazu

Subjects
アクティブラーニング, 遠隔授業, 大学教育, LMS, デジタル・ペダゴジー
Abstract

金沢大学国際基幹教育院高等教育開発・支援系, 大学教育リ・デザインに向けて、デジタル・ペダゴジーを反映させた今後の授業のあり方について紹介した。・大学教育の遠隔授業化の知見共有、本学対応・LMSを用いた遠隔授業設計概論とパターン・遠隔授業とアクティブラーニング（事例）・緊急遠隔授業の５つの原則・「デジタル・ペダゴジー」（デジタル時代の教育学）へ, 第23回関西大学FDフォーラム「遠隔授業のデザインを考える-人の縁を描く授業-」関西大学教育開発支援センター(主催), 2020年6月13日(開催)

Published
2020

16. Theoretical study of above-threshold dissociation on diatomic molecules by using nonresonant intense laser pulses

Author

Sugimori, Kimikazu, Ito, Tomoya, Takata, Yusuke, Ichitani, Kazuhiro, Nagao, Hidemi, and Nishikawa, Kiyoshi

Subjects
Diatomic molecules -- Structure, Diatomic molecules -- Chemical properties, Diatomic molecules -- Spectra, Dissociation -- Analysis, Laser pulses, Ultrashort -- Analysis, Chemicals, plastics and rubber industries
Abstract

Various studies are conducted to examine the above-threshold dissociation on diatomic molecules by using nonresonant intense laser pulses. Various new methods for controlling the spectrum peaks are also discussed.

Published
2007

17. Theoretical study of NMR chemical shift induced by H/D isotope effect

Author

Sugimori, Kimikazu and Kawabe, Hiroyuki

Subjects
Thermal average, Isotope effect, Physics::Atomic and Molecular Clusters, Physics::Chemical Physics, NMR shielding constant, Morse oscillator, Vibrationally averaged property
Abstract

The isotope effect induced by deuterium substituted species is observed in molecular properties, such as geometry, kinetics, and electronic state, of the molecules through nuclear-electron interaction. Theoretical considerations and experimental alignments have been studied by ab initio molecular orbital, density functional theory, and other empirical strategies. The Born-Oppenheimer approximation with nuclear vibrational wavefunction can treat isotope effect because nuclear mass effect account for the average istance of vibrational motion. In this study, we introduce Morse anharmonic oscillator model to calculate average internuclear distance of diatomic molecules having X-H bonding and X-D bonding. Morse parameters are determined by fitting to potential energy surface of molecular orbital and/or density functional calculations, and then the average distance are obtained as the expectation value of the analytical Morse vibrational wavefunction. Nuclear magnetic resonance shielding constants of the H/D isotopomer are calculated again on the average distance by using GIAO with B3LYP and CCSD calculation. © 2010 Wiley Periodicals, Inc., 研究者情報DB

Published
2010

35. An approach to water molecule dynamics associated with motion of catalytic moiety.

Author

Shimahara, Hideto, Sugimori, Kimikazu, Koyimatu, Muhmad, Nagao, Hidemi, Ohkubo, Tadayasu, and Kobayashi, Yuji

Subjects
*WATER, *MOLECULAR dynamics, *CATALYSIS, *ZINC, *SOLVENTS, *METHYL groups, *CRYSTAL structure
Abstract

A water bridge composed of several water molecules between the catalytic moieties, His64 and the zinc-bound solvent, in human carbonic anhydrase II (hCAII) is disrupted when the inhibitor acetazolamide (ACZ) binds to the zinc ion, according to the crystallographic structure of the ACZ-hCAII complex. In this structure, the ACZ methyl group is far (∼10 Å) from the His64. However, this binding causes an 1H NMR chemical shift change (∼1 ppm) in His64 in solution. This suggests two alternative mechanisms: a) the ACZ methyl group may be closer to His64 in the complex in solution, compared to the crystal, or b) the disruption of the water bridge might cause the His64 to move or behave in a different manner. The binding of ACZ to the enzyme in solution was examined by observing the NMR signals of the 13C-labeled ACZ methyl group in the ACZ-hCAII complex. The 13C signals of the free and bound forms were detected. In the bound form, the signal for the acetamide group was pH dependent, whereas the sulfonamide group signal was pH independent. Some 13C-filtered NOE signals were observed, although none of the signals were related to the His64 chemical shift. Based on these observations, we suggest that the position or motion of His64 is associated with disruption of the water bridge in the ACZ-hCAII complex in solution, which could change the 1H chemical shift. [ABSTRACT FROM AUTHOR]

Published
2013
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38. Analysis of water molecules around GTP in Hras-GTP complex and GDP in Hras-GDP complex by molecular dynamics simulations.

Author

Miyakawa, Takeshi, Morikawa, Ryota, Takasu, Masako, Sugimori, Kimikazu, Kawaguchi, Kazutomo, Saito, Hiroaki, and Nagao, Hidemi

Subjects
SOLVENTS, WATER analysis, GUANOSINE triphosphate, MOLECULAR dynamics, HYDROLYSIS, ANGULAR distribution (Nuclear physics)
Abstract

We investigate the structures of the Hras-GTP and the Hras-GDP complexes in water solvents in order to understand the mechanism of GTP hydrolysis in the Hras-GTP complex. We performed MD simulations of these complexes in order to study the positions and the orientations of water molecules around the guanosine nucleotides. Using trajectories we calculated the angular distribution of water molecules around the most distant phosphorus from guanosine in our previous work. It was shown that water molecules are distributed evenly in GTP, although unevenly in GDP. This suggests that the trigger of GTP hydrolysis is possibly the attack of water molecule to γ−phosphate from the appropriate direction. In this paper, in order to investigate the role of water molecules in GTP hydrolysis in detail, we calculate the orientation of water molecules. The distribution of the orientation is different between GTP and GDP. In order to investigate the cause of this difference, we examine the hydrogen bonds between water molecules and oxygen atom of the most distant phosphate from guanosine. We find that these hydrogen bonds are formed. We also find that the oxygen atom of hydrogen bond is determined by the position of the water molecule of hydrogen bond. [ABSTRACT FROM PUBLISHER]

Published
2014
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