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Objectives: We have developed autologous concentrated bone marrow grafting as the joint-preserving procedure for osteonecrosis of the femoral head (ONFH). The purpose of this study was to evaluate the mid-term results of autologous concentrated bone marrow grafting for steroid-associated femoral head[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2017)

Bulk and surface chemical states were both investigated for electrochemically delithiated LixFePO4 using {7}Li and {31}P MAS NMR spectroscopy. The quantitative lithium extraction/insertion from LiFePO4 and the reversible two-phase reaction behavior between LiFePO4 and FePO4 were confirmed on electrochemical operation. The {7}Li and {31}P NMR spectra of the fully charged LixFePO4 evidenced a single Li-poor phase Li0.05FePO4 instead of a biphasic mixture of 0.05LiFePO4 and 0.95FePO4. Simultaneous growth of LixPOyFz was also shown as a surface film component on the charged electrodes, which dynamically increased and decreased in intensity during charging and discharging reactions, respectively. The electrode surface was further characterized with XPS to discuss the surface film formation during electrochemical cycles. Combined chemical state analyzes by NMR and XPS spectroscopies suggested that the degradation of LiPF6 salt occurred from the initial redox cycles, but that of solvent occurred after multiple cycling. The deposition of carbonaceous species would be related to a small capacity fading observed after the multiple charge-discharge cycles.

Information about interleukin-3 (IL-3) effects in vivo is limited compared with the in vitro effects. We found that a repetitive injection of a low dose of recombinant IL-3 induced protection against intestinal worms of Strongyloides ratti in C57BL/6 mice. When mice were injected i.p. with different doses of recombinant IL-3 twice a day from day -5 to day -1 and infected orally with larvae recovered from the head of infected rats on day 0, worm recovery from the small intestine was markedly reduced by a total of 10(4) U IL-3 or more on day 2 post-infection. The number of intestinal mucosal mast cells (MMC) was increased by the protective dose of IL-3. The IL-3 treatment, however, was ineffective in protecting mice against tissue migrating larvae, as assessed by recovery from the head. The protective effect of IL-3 on intestinal worms was observed within 6 hr post oral infection, suggesting little concern with antigen-specific immune responses. The effective dose of IL-3 treatment increased the number of MMC progenitors five times in the spleen and the mesenteric lymph nodes. An MMC-specific protease, MMCP-1, was secreted 200 times more than in controls in the intestinal lumen by the IL-3 treatment. The IL-3 treatment induced no protection or mastocytosis in mast cell-deficient W/Wv mice. These results suggest that the IL-3-induced intestinal protection against S. ratti is mediated by MMC.