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160 results on '"Sugawara, Hiroko"'

6. Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region

Author

Ikegame, Tempei, Hidaka, Yosuke, Nakachi, Yutaka, Murata, Yui, Watanabe, Risa, Sugawara, Hiroko, Asai, Tatsuro, Kiyota, Emi, Saito, Takeo, Ikeda, Masashi, Sasaki, Tsukasa, Hashimoto, Mamoru, Ishikawa, Tomohisa, Takebayashi, Minoru, Iwata, Nakao, Kakiuchi, Chihiro, Kato, Tadafumi, Kasai, Kiyoto, Bundo, Miki, and Iwamoto, Kazuya

Published
2021
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7. Quantification of cytosine modifications in the aged mouse brain.

Author

Sugawara, Hiroko, Date, Akitoshi, Fuke, Satoshi, Nakachi, Yutaka, Kato, Tadafumi, Narita, Minoru, Bundo, Miki, and Iwamoto, Kazuya

Subjects
*CYTOSINE, *GENETIC regulation, *BASAL ganglia, *NEUROBEHAVIORAL disorders, *FRONTAL lobe, *METHYLCYTOSINE, *HEART
Abstract

Quantifying cytosine modifications in various brain regions provides important insights into the gene expression regulation and pathophysiology of neuropsychiatric disorders. In this study, we quantified 5‐methylcytosine (5‐mC), 5‐hydroxymethylation (5‐hmC), and 5‐formylcytosine (5‐fC) levels in five brain regions (the frontal lobe, cerebral cortical region without frontal lobe, hippocampus, basal ganglia, and the cerebellum) and the heart at three developmental periods (12, 48, and 101 weeks). We observed significant regional variations in cytosine modification. Notably, regional variations were generally maintained throughout development, suggesting that epigenetic regulation is unique to each brain region and remains relatively stable with age. The 5‐mC and 5‐hmC levels were positively correlated, although the extent of the correlations seemed to differ in different brain regions. On the contrary, 5‐fC levels did not correlate with 5‐mC or 5‐hmC levels. Additionally, we observed an age‐dependent decrease in 5‐fC levels in the basal ganglia, suggesting a unique epigenetic regulation mechanism. Further high‐resolution studies using animal models of neuropsychiatric disorders as well as postmortem brain evaluation are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Effects of Exercise on Functional Recovery in Patients with Bipolar Depression: A Study Protocol for a Randomized Controlled Trial

Author

Hamada, Fumito, primary, Hori, Hikaru, additional, Iida, Hitoshi, additional, Yokoyama, Hiroyuki, additional, Sugawara, Hiroko, additional, Hatanaka, Akito, additional, Gotoh, Leo, additional, Ogata, Muneaki, additional, Kumagai, Hiroki, additional, Yano, Rika, additional, Tomiyama, Yuko, additional, Yoshida, Tetsuya, additional, Yamaguchi, Yoshimi, additional, Asada, Ryo, additional, Masuda, Masato, additional, Okamoto, Yuta, additional, and Kawasaki, Hiroaki, additional

Published
2023
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11. Prospective clinical intervention study of aripiprazole and risperidone in the management of postoperative delirium in elderly patients after cardiovascular surgery

Author

Sugawara, Hiroko, primary, Koyama, Asuka, additional, Maruyama, Takashi, additional, Koda, Yumiko, additional, Fukunaga, Hiroe, additional, Ishikawa, Tomohisa, additional, Takebayashi, Minoru, additional, Okamoto, Ken, additional, Fukui, Toshihiro, additional, and Hashimoto, Mamoru, additional

Published
2022
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20. Knockdown of LIM15/DMC1 in the mushroom Coprinus cinereus by double-stranded RNA-mediated gene silencing

Author

Namekawa, Satoshi H., Iwabata, Kazuki, Sugawara, Hiroko, Hamada, Fumika N., Koshiyama, Akiyo, Chiku, Hiroyuki, Kamada, Takashi, and Sakaguchi, Kengo

Subjects
Basidiomycota -- Genetic aspects, Basidiomycota -- Research, Gene silencing -- Research, Genetic research, Biological sciences
Abstract

The basidiomycete Coprinus cinereus has many advantages as a model organism for studying sexual development and meiosis, but it has been difficult to investigate using reverse-genetics methods, such as gene disruption by homologous recombination. Here, gene repression by dsRNA-mediated gene silencing was tried as an alternative method for reverse-genetics studies. It was shown that transformation of the LIM15/DMC1 dsRNA expression construct (LIM15dsRNA) resulted in genomic insertion of LIM15dsRNA and paucity of the LIM15/DMC1 transcript. First, LIM15dsRNA was transformed into the homothallic strain AmutBmut to generate a homozygote in which both nuclei had a copy of LIM15dsRNA. The LIM15/DMC1-repressed strain showed abnormal homologous chromosome synapsis during meiosis. Basidiospore production was reduced to 16 % by the induction of dsRNA. However, approximately 60 % of basidiospores were viable. Next, a heterozygote was generated in which one nucleus had a copy of LIM15dsRNA. The phenotype was similar to that of the homozygote. These results are not only the first demonstration of dsRNA-mediated gene silencing in a member of the homobasidiomycete fungi, to which 90 % of mushroom species belong, but also the first successful use of a reverse-genetics approach in C. cinereus research.

Published
2005

23. Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia

Author

Ikegame, Tempei, primary, Bundo, Miki, additional, Okada, Naohiro, additional, Murata, Yui, additional, Koike, Shinsuke, additional, Sugawara, Hiroko, additional, Saito, Takeo, additional, Ikeda, Masashi, additional, Owada, Keiho, additional, Fukunaga, Masaki, additional, Yamashita, Fumio, additional, Koshiyama, Daisuke, additional, Natsubori, Tatsunobu, additional, Iwashiro, Norichika, additional, Asai, Tatsuro, additional, Yoshikawa, Akane, additional, Nishimura, Fumichika, additional, Kawamura, Yoshiya, additional, Ishigooka, Jun, additional, Kakiuchi, Chihiro, additional, Sasaki, Tsukasa, additional, Abe, Osamu, additional, Hashimoto, Ryota, additional, Iwata, Nakao, additional, Yamasue, Hidenori, additional, Kato, Tadafumi, additional, Kasai, Kiyoto, additional, and Iwamoto, Kazuya, additional

Published
2020
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25. DNA topoisomerase II interacts with Lim15/Dmc1 in meiosis

Author

Iwabata, Kazuki, Koshiyama, Akiyo, Yamaguchi, Taiki, Sugawara, Hiroko, Hamada, Fumika N., Namekawa, Satoshi H., Ishii, Satomi, Ishizaki, Takashi, Chiku, Hiroyuki, Nara, Takayuki, and Sakaguchi, Kengo

Published
2005

26. Association between anxious distress in a major depressive episode and bipolarity

Author

Sugawara,Hiroko, Tsutsumi,Takahiro, Inada,Ken, Ishigooka,Jun, Hashimoto,Mamoru, Takebayashi,Minoru, Nishimura,Katsuji, Sugawara,Hiroko, Tsutsumi,Takahiro, Inada,Ken, Ishigooka,Jun, Hashimoto,Mamoru, Takebayashi,Minoru, and Nishimura,Katsuji

Abstract

Hiroko Sugawara,1 Takahiro Tsutsumi,2 Ken Inada,2 Jun Ishigooka,2 Mamoru Hashimoto,1 Minoru Takebayashi,1,3 Katsuji Nishimura2 1Department of Neuropsychiatry, Faculty of Life Science, Kumamoto University, Kumamoto, Japan; 2Department of Psychiatry, Tokyo Women’s Medical University Hospital, Tokyo, Japan; 3Division of Psychiatry and Neuroscience, Institute for Clinical Research, National Hospital Organization Kure Medical Center, Hiroshima, Japan Purpose: Mixed features in a major depressive episode (MDE) predict bipolar disorder (BD). The mixed features specifier included in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) could be restrictive because it excludes the symptoms common to both mania/hypomania and depression, including psychomotor agitation. On the other hand, an anxious distress (ANXD) specifier has also been introduced in the DSM-5, and psychomotor agitation has been defined as a severity of ANXD. In this study, we retrospectively investigated the association between presence of ANXD in an MDE and bipolarity. Patients and methods: The subjects were patients admitted with an MDE to the Department of Psychiatry at Tokyo Women’s Medical University Hospital from December 2014 to March 2016. Eligible patients were older than 20 years of age and met the DSM-5 criteria for major depressive disorder or BD. All data were extracted from medical records. The subjects were grouped according to whether they did or did not have ANXD. The demographics and clinical features of these groups were compared. Severity of illness was evaluated according to the Hamilton Rating Scale for Depression (HRSD) score on admission. Results: ANXD was present in 31 and absent in 33 of 64 patients with MDE. The HRSD score was significantly higher in the group with ANXD than in the group without ANXD (P=0.0041). Mixed features (P=0.0050) and suicide attempts (P=0.0206) were significantly more common in the group with ANXD than in the g

Published
2019

29. DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder

Author

Sugawara, Hiroko, primary, Murata, Yui, additional, Ikegame, Tempei, additional, Sawamura, Rie, additional, Shimanaga, Shota, additional, Takeoka, Yusuke, additional, Saito, Takeo, additional, Ikeda, Masashi, additional, Yoshikawa, Akane, additional, Nishimura, Fumichika, additional, Kawamura, Yoshiya, additional, Kakiuchi, Chihiro, additional, Sasaki, Tsukasa, additional, Iwata, Nakao, additional, Hashimoto, Mamoru, additional, Kasai, Kiyoto, additional, Kato, Tadafumi, additional, Bundo, Miki, additional, and Iwamoto, Kazuya, additional

Published
2018
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31. Identifying predictive clinical characteristics of the treatment efficacy of mirtazapine monotherapy for major depressive disorder

Author

Tsutsumi,Takahiro, Sugawara,Hiroko, Ito,Ryoko, Asano,Mizuho, Shimizu,Satoru, Ishigooka,Jun, Nishimura,Katsuji, Tsutsumi,Takahiro, Sugawara,Hiroko, Ito,Ryoko, Asano,Mizuho, Shimizu,Satoru, Ishigooka,Jun, and Nishimura,Katsuji

Abstract

Takahiro Tsutsumi,1 Hiroko Sugawara,1,2 Ryoko Ito,1 Mizuho Asano,1 Satoru Shimizu,3 Jun Ishigooka,1 Katsuji Nishimura1 1Department of Psychiatry, 2Support Center for Women Health Care Professionals and Research, 3Department of Research, Medical Research Institute, Tokyo Women’s Medical University, Tokyo, Japan Background: Mirtazapine, which is classified as a noradrenergic and specific serotonergic antidepressant, is widely prescribed for the treatment of major depressive disorder. The potential predictive factors of the efficacy of mirtazapine and the tolerability based on the incidence of oversedation and jitteriness/anxiety syndrome were evaluated. Patients and methods: Patients with major depressive disorder were retrospectively investigated. Study subjects comprised 68 patients with depression who received mirtazapine as an initial antidepressant at the Department of Psychiatry of the Tokyo Women’s Medical University Hospital from September 2009 to March 2013. The efficacy of mirtazapine monotherapy was evaluated based on the Clinical Global Impression Improvement score. Clinical characteristics were compared between remission and nonremission groups to determine the factors predicting the efficacy. Moreover, discontinuation rates due to adverse effects, including oversedation and jitteriness/anxiety syndrome, were examined, and the effects of confounding factors were evaluated. Results: The remission rate of mirtazapine monotherapy was 36.8% among the 68 enrolled subjects. The mean final doses in the remission and nonremission groups were 27.6±13.5 mg and 26.0±14.1 mg, respectively, and there was no significant difference between them. Multiple logistic analyses revealed that the absence of guilt (odds ratio [OR] =0.15; 95% CI [1.66–37.24], P=0.006) and the presence of psychomotor retardation (OR =4.30; 95% CI [1.30–16.60], P=0.016) were significantly related to the efficacy of mir

Published
2016

32. A retrospective study of predictive factors for effective aripiprazole augmentation of antidepressant therapy in treatment-resistant depression

Author

Sugawara,Hiroko, Sakamoto,Kaoru, Harada,Tsuyoto, Shimizu,Satoru, Ishigooka,Jun, Sugawara,Hiroko, Sakamoto,Kaoru, Harada,Tsuyoto, Shimizu,Satoru, and Ishigooka,Jun

Abstract

Hiroko Sugawara,1,2 Kaoru Sakamoto,1 Tsuyoto Harada,3 Satoru Shimizu,4 Jun Ishigooka1 1Department of Psychiatry, Tokyo Women’s Medical University, 2Support Center for Women Health Care Professionals and Researchers, Tokyo Women’s Medical University, Shinjuku-ku, 3Department of Psychiatry, Tokyo Women’s Medical University Medical Center East, Arakawa-ku, 4Department of Research, Medical Research Institute, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan Background: Several studies have evaluated the efficacy and tolerability of aripiprazole for augmentation of antidepressant therapy for treatment-resistant depression (TRD). Here, we investigated the efficacy of aripiprazole augmentation for TRD including both major depressive disorder and bipolar disorder and the clinical predictors of treatment efficacy in a Japanese population.  Methods: Eighty-five depressed Japanese patients who underwent aripiprazole augmentation therapy after failing to respond satisfactorily to antidepressant monotherapy were included in the study. Treatment responses were evaluated based on Clinical Global Impression Improvement scores assessed 8 weeks after initiation of aripiprazole administration. We compared demographic and diagnostic variables, psychiatric medication variables, and clinical variables between remission and nonremission groups.  Results: The aripiprazole augmentation remission rate was 36.5%. Multiple logistic regression analysis indicated that aripiprazole augmentation was significantly more effective for bipolar depression than for major depressive disorder, and both absence of comorbid anxiety disorders and current episode duration >3 months were significantly associated with the efficacy of aripiprazole augmentation.  Conclusion: Polarity of depression, comorbidity of anxiety disorders, and current episode duration may predict the efficacy of aripiprazole augmentation for TRD includin

Published
2016

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