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31 results on '"Sugawa, Hikari"'

9. RAGE activation in macrophages and development of experimental diabetic polyneuropathy

Author

Osonoi, Sho, primary, Mizukami, Hiroki, additional, Takeuchi, Yuki, additional, Sugawa, Hikari, additional, Ogasawara, Saori, additional, Takaku, Shizuka, additional, Sasaki, Takanori, additional, Kudoh, Kazuhiro, additional, Ito, Koichi, additional, Sango, Kazunori, additional, Nagai, Ryoji, additional, Yamamoto, Yasuhiko, additional, Daimon, Makoto, additional, Yamamoto, Hiroshi, additional, and Yagihashi, Soroku, additional

Published
2022
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15. Anti-Diabetic Activity of Soymilk Yogurt and Identification of Inhibitory Compounds on the Formation of Advanced Glycation End-Products

Author

Nakashima, Yuki, primary, Yamamoto, Naoki, additional, Tsukioka, Ryosuke, additional, Sugawa, Hikari, additional, Ohshima, Rina, additional, Aoki, Kaede, additional, Hibi, Tomoyuki, additional, Onuki, Kotone, additional, Fukuchi, Yudai, additional, Yasuda, Shin, additional, Nagai, Ryoji, additional, and Kinoshita, Hideki, additional

Published
2022
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16. Trapa bispinosa Roxb. and lutein ameliorate cataract in type 1 diabetic rats

Author

Kinoshita, Sho, Sugawa, Hikari, Nanri, Tomoaki, Ohno, Rei-ichi, Shirakawa, Jun-ichi, Sato, Hikari, Katsuta, Nana, Sakake, Shiori, and Nagai, Ryoji

Subjects
oxidation, cataract, advanced glycation end products, diabetes mellitus, food and beverages, Original Article, Trapa bispinosa Roxb
Abstract

Trapa bispinosa Roxb. is an annual aquatic grass of the citrus family. Although its hot water extract displays antioxidative activity in vitro, little is known about its biological effectiveness. In the present study, we evaluated the extract’s inhibitory effect on diabetic cataractogenesis and formation of advanced glycation end-product. Lutein, which is beneficial for eye diseases, was administered concurrently. For short-term administration, Trapa bispinosa Roxb. hot water extract and/or lutein were administered to type 1 diabetic rats. Nɛ-(carboxymethyl)lysine and Nɛ-(carboxyethyl)lysine were quantified in serum using mass spectrometry. The long-term administration study was similar to the short-term, except that the dosages were lower. In the short-term study, co-administration of the extract and lutein inhibited Nɛ-(carboxymethyl)lysine and Nɛ-(carboxyethyl)lysine in serum. However, in the long-term study, only lutein inhibited Nɛ-(carboxymethyl)lysine and Nɛ-(carboxyethyl)lysine in serum. These results suggest that lutein exerts its long-term effect regardless of the concentration administered, while the extract exerts its effect when its concentration is increased. Relative to the consumption of the control diet, oral intake of the combination of the extract and lutein significantly inhibited the progression of cataractogenesis in the lens of diabetic rats, even at low doses, and the combination was more effective than individual treatments.

Published
2019

21. Glucoselysine is derived from fructose and accumulates in the eye lens of diabetic rats

Author

Ohno, Rei-ichi, primary, Ichimaru, Kenta, additional, Tanaka, Seitaro, additional, Sugawa, Hikari, additional, Katsuta, Nana, additional, Sakake, Shiori, additional, Tominaga, Yu-ki, additional, Ban, Ikuho, additional, Shirakawa, Jun-ichi, additional, Yamaguchi, Yoshiki, additional, Ito, Emi, additional, Taniguchi, Naoyuki, additional, and Nagai, Ryoji, additional

Published
2019
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25. Salacia chinensis L. extract ameliorates abnormal glucose metabolism and improves the bone strength and accumulation of AGEs in type 1 diabetic rats

Author

Shirakawa, Jun-ichi, primary, Arakawa, Shoutaro, additional, Tagawa, Tomoya, additional, Gotoh, Kentaroh, additional, Oikawa, Norihisa, additional, Ohno, Rei-ichi, additional, Shinagawa, Masatoshi, additional, Hatano, Kota, additional, Sugawa, Hikari, additional, Ichimaru, Kenta, additional, Kinoshita, Sho, additional, Furusawa, Chisato, additional, Yamanaka, Mikihiro, additional, Kobayashi, Masakazu, additional, Masuda, Shuichi, additional, Nagai, Mime, additional, and Nagai, Ryoji, additional

Published
2016
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27. Non-invasive measurement of skin autofluorescence to evaluate diabetic complications

Author

Yamanaka, Mikihiro, primary, Matsumura, Takeshi, additional, Ohno, Rei-ichi, additional, Fujiwara, Yukio, additional, Shinagawa, Masatoshi, additional, Sugawa, Hikari, additional, Hatano, Kota, additional, Shirakawa, Jun-ichi, additional, Kinoshita, Hiroyuki, additional, Ito, Kenji, additional, Sakata, Noriyuki, additional, Araki, Eiichi, additional, and Nagai, Ryoji, additional

Published
2016
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29. In vitroevaluation of the anti-diabetic potential of soymilk yogurt and identification of inhibitory compounds on the formation of advanced glycation end-products

Author

Nakashima, Yuki, Yamamoto, Naoki, Tsukioka, Ryosuke, Sugawa, Hikari, Ohshima, Rina, Aoki, Kaede, Hibi, Tomoyuki, Onuki, Kotone, Fukuchi, Yudai, Yasuda, Shin, Nagai, Ryoji, and Kinoshita, Hideki

Abstract

In this study, we aimed to identify starter strains of lactic acid bacteria (LAB) to produce soymilk yogurt that can decrease the risk of diabetes mellitus (DM) and its complications. The inhibition assays of the dipeptidyl peptidase IV (DPP- IV) and advanced glycation end products (AGEs) formation were conducted using 70% ethanol (EtOH) extraction of freeze-dried soymilk yogurt. Soymilk yogurt produced using Weissella confusaTOKAI 2 showed the highest inhibition rate in the α-amylase inhibition assay, while soymilk yogurt produced using Lactiplantibacillus plantarumTOKAI 17 showed the highest inhibition rates in the α-glucosidase and DPP-Ⅳ inhibition assays, respectively. Soymilk yogurt produced using Streptococcus macedonicusTOKAI 4 showed the highest inhibitory activities in Nω-(carboxymethyl) arginine (CMA) and Nε-(carboxymethyl) lysine (CML) formation, respectively. Furthermore, soymilk yogurt prepared using Lb. plantarumTOKAI 17 and Lactiplantibacillus pentosusTOKAI 35 exhibited higher proportions of aglycone isoflavones than soymilk and showed a higher fluorescent AGEs inhibitory activity than that of soymilk (p < 0.05). Interestingly, the inhibition assay assessing fluorescent AGEs formation using isoflavones indicated that aglycone-type isoflavones, such as genistein and daidzein, had higher inhibitory activities than that of glycosides (p < 0.05). These results indicate that soymilk yogurt produced using Lb. plantarumTOKAI 17 and Lb. pentosusTOKAI 35 had inhibitory effects on α-glucosidase, DPP-Ⅳ, and AGEs formation in vitro, and that aglycone isoflavones might inhibit the formation of fluorescent AGEs.

Published
2022
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30. Protein Modification with Ribose Generates N δ -(5-11 hydro-5-methyl-4-imidazolone-2-yl)-ornithine.

Author

Ban, Ikuho, Sugawa, Hikari, and Nagai, Ryoji

Subjects
*RIBOSE, *ADVANCED glycation end-products, *TIME-of-flight mass spectrometry, *AMADORI compounds, *RECEPTOR for advanced glycation end products (RAGE), *PROTEINS, *GLYOXALASE, *ADP-ribosylation
Abstract

Advanced glycation end products (AGEs) are associated with diabetes and its complications. AGEs are formed by the non-enzymatic reactions of proteins and reducing sugars, such as glucose and ribose. Ribose is widely used in glycation research as it generates AGEs more rapidly than glucose. This study analyzed the AGE structures generated from ribose-modified protein by liquid chromatography–quadrupole time-of-flight mass spectrometry. Among these AGEs, Nδ-(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine (MG-H1) was the most abundant in ribose-glycated bovine serum albumin (ribated-BSA) among others, such as Nε-(carboxymethyl) lysine, Nε-(carboxyethyl) lysine, and Nω-(carboxymethyl) arginine. Surprisingly, MG-H1 was produced by ribated-BSA in a time-dependent manner, whereas methylglyoxal levels (MG) were under the detectable level. In addition, Trapa bispinosa Roxb. hot water extract (TBE) possesses several anti-oxidative compounds, such as ellagic acid, and has been reported to inhibit the formation of MG-H1 in vivo. Thus, we evaluated the inhibitory effects of TBE on MG-H1 formation using ribose- or MG-modified proteins. TBE inhibited MG-H1 formation in gelatin incubated with ribose and ribated-BSA, but not in MG-modified gelatin. Furthermore, MG-H1 formation was inhibited by diethylenetriaminepentaacetic acid. These results demonstrated that ribose reacts with proteins to generate Amadori compounds and form MG-H1 via oxidation. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Soymilk yogurt fermented using Pediococcus pentosaceus TOKAI 759 m improves mice gut microbiota and reduces pro-inflammatory cytokine production.

Author

Nakashima Y, Onuki K, Hibi T, Ohno RI, Sugawa H, Tominaga Y, Yasuda S, and Kinoshita H

Abstract

This study aimed to determine the anti-inflammatory activities and bioactive compounds of soymilk yogurt prepared using Lactiplantibacillus plantarum TOKAI 17 or Pediococcus pentosaceus TOKAI 759 m. Mice were divided into five groups: normal diet (ND), soymilk (SM), soymilk yogurt using L. plantarum TOKAI 17 (SY 17) or P. pentosaceus TOKAI 759 m (SY 759 m), and 0.5 × 109 cells of each starter strain (BC 17 or BC759m). In the SY 759 m group, the serum pro-inflammatory cytokine levels and the cytotoxicity of natural killer cells were attenuated compared to the ND group. In the cecum microbiota, the abundances of butyrate-producing bacteria increased in the SY 759 m and BC 17 groups. Furthermore, SY 759 m metabolites contained high levels of aglycone isoflavone, adenine and showed a significant decrease in CCL-2 and IL-6 production in LPS-induced macrophage. In conclusion, soymilk yogurt produced using P. pentosaceus TOKAI 759 m modulates the gut microbiota and can potentially prevent pro-inflammatory cytokine production., (© The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry.)

Published
2024
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