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3. Helicobacter

Author

Suerbaum, S., Suerbaum, Sebastian, editor, Burchard, Gerd-Dieter, editor, Kaufmann, Stefan H.E., editor, and Schulz, Thomas F., editor

Published
2016
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4. Campylobacter

Author

Josenhans, C., Suerbaum, S., Hofreuter, D., Suerbaum, Sebastian, editor, Burchard, Gerd-Dieter, editor, Kaufmann, Stefan H.E., editor, and Schulz, Thomas F., editor

Published
2016
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5. Enterobakterien

Author

Suerbaum, S., Hornef, M., Karch, H., Suerbaum, Sebastian, editor, Burchard, Gerd-Dieter, editor, Kaufmann, Stefan H.E., editor, and Schulz, Thomas F., editor

Published
2016
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9. Helicobacter

Author

Suerbaum, S., Suerbaum, Sebastian, editor, Hahn, Helmut, editor, Burchard, Gerd-Dieter, editor, Kaufmann, Stefan H. E., editor, and Schulz, Thomas F., editor

Published
2012
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10. Campylobacter

Author

Josenhans, C., Suerbaum, S., Hofreuter, D., Suerbaum, Sebastian, editor, Hahn, Helmut, editor, Burchard, Gerd-Dieter, editor, Kaufmann, Stefan H. E., editor, and Schulz, Thomas F., editor

Published
2012
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11. Enterobakterien

Author

Suerbaum, S., Bockemühl, J., Karch, H., Suerbaum, Sebastian, editor, Hahn, Helmut, editor, Burchard, Gerd-Dieter, editor, Kaufmann, Stefan H. E., editor, and Schulz, Thomas F., editor

Published
2012
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13. Campylobacter

Author

Vogt, K., Suerbaum, S., Hahn, H., Miksits, K., Hahn, Helmut, editor, Falke, Dietrich, editor, Kaufmann, Stefan H. E., editor, and Ullmann, Uwe, editor

Published
2005
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14. Helicobacter

Author

Suerbaum, S., Vogt, K., Hahn, Helmut, editor, Falke, Dietrich, editor, Kaufmann, Stefan H. E., editor, and Ullmann, Uwe, editor

Published
2005
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15. Bakterielle Infektionen

Author

Allewelt, M., Autenrieth, LB., Bär, W., Bailly, E., Bauernfeind, A., Engelhart, S., Exner, M., Geiss, H.K., Hadlich, S.-F., Hagedorn, H.-J., Heesemann, J., Hof, H., Kohl, P.K., Krausse, R., Krech, T., Lode, H., Lütticken, R., Mauch, H., Pleischl, S., Reinert, R.R., Riffelmann, M., Rodloff, A., Schaal, K.P., Schmidt, H., Schneider, I., Scholz, H., Stoll, M., Suerbaum, S., Ullmann, U., Wilske, B., Wirsing von König, C.H., Witte, W., Zabel, LT., Adam, D., editor, Doerr, H. W., editor, Link, H., editor, and Lode, H., editor

Published
2004
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17. Spezielle Bakteriologie

Author

Hahn, H., Miksits, K., Gatermann, S., Meyer, Th. F., Bockemühl, J., Vogt, K., Liesenfeld, O., Suerbaum, S., Arvand, M., Mielke, M., Thilo, W., Rodloff, A. C., Kaufmann, S. H. E., Kmety, E., Marre, R., Hahn, Helmut, editor, Falke, Dietrich, editor, Kaufmann, Stefan H. E., editor, and Ullmann, Uwe, editor

Published
2001
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18. Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations

Author

Thorpe, H. A. (Harry A.), Tourrette, E. (Elise), Yahara, K. (Koji), Vale, F. F. (Filipa F.), Liu, S. (Siqi), Oleastro, M. (Mónica), Alarcon, T. (Teresa), Perets, T.-T. (Tsachi-Tsadok), Latifi-Navid, S. (Saeid), Yamaoka, Y. (Yoshio), Martinez-Gonzalez, B. (Beatriz), Karayiannis, I. (Ioannis), Karamitros, T. (Timokratis), Sgouras, D. N. (Dionyssios N.), Elamin, W. (Wael), Pascoe, B. (Ben), Sheppard, S. K. (Samuel K.), Ronkainen, J. (Jukka), Aro, P. (Pertti), Engstrand, L. (Lars), Agreus, L. (Lars), Suerbaum, S. (Sebastian), Thorell, K. (Kaisa), Falush, D. (Daniel), Thorpe, H. A. (Harry A.), Tourrette, E. (Elise), Yahara, K. (Koji), Vale, F. F. (Filipa F.), Liu, S. (Siqi), Oleastro, M. (Mónica), Alarcon, T. (Teresa), Perets, T.-T. (Tsachi-Tsadok), Latifi-Navid, S. (Saeid), Yamaoka, Y. (Yoshio), Martinez-Gonzalez, B. (Beatriz), Karayiannis, I. (Ioannis), Karamitros, T. (Timokratis), Sgouras, D. N. (Dionyssios N.), Elamin, W. (Wael), Pascoe, B. (Ben), Sheppard, S. K. (Samuel K.), Ronkainen, J. (Jukka), Aro, P. (Pertti), Engstrand, L. (Lars), Agreus, L. (Lars), Suerbaum, S. (Sebastian), Thorell, K. (Kaisa), and Falush, D. (Daniel)

Abstract

Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori from East Asia, which have undergone little admixture, have accumulated many more non-synonymous mutations than African strains. European and Middle Eastern bacteria have elevated African ancestry at the sites of these mutations, implying selection to remove them during admixture. Simulations show that population fitness can be restored after bottlenecks by migration and subsequent admixture of small numbers of bacteria from non-bottlenecked populations. We conclude that recent spread of African DNA has been driven by deleterious mutations accumulated during the original out-of-Africa bottleneck.

Published
2022

20. Spezielle Bakteriologie

Author

Hahn, H., Miksits, K., Gatermann, S., Bockemühl, J., Liesenfeld, O., Vogt, K., Suerbaum, S., Arvand, M., Thilo, W., Rodloff, A. C., Kaufmann, S. H. E., Kmety, E., Marre, R., Hahn, Helmut, editor, Falke, Dietrich, editor, Kaufmann, Stefan H. E., editor, and Ullmann, Uwe, editor

Published
1999
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38. Microbiology

Author

Figura, N., Owen, R. J., Desai, M., Bayeli, P. F., HGregorio, L. Di, Russi, M., Musmanno, R. A., Hawtin, P. R., Sharpstone, D., Hayes, L., Nøorgaard, A., Nielsen, H., Andersen, L. P., Geis, G., Leying, H., Suerbaum, S., Opferkuch, W., Tonokatsu, Y., Hayashi, T., Fukuda, Y., Yamamoto, I., Takami, S., Tamura, T., Shimoyama, T., Lopez-Brea, M., Martin, E., C.Sanz, J., Alonso, M., Alarcon, T., Michetti, P., Porta, N., Racine, L., P.Kraehenbuhl, J., L.Blum, A., Cardeñoso, L., Moran, A. P., Muotiala, A., Pyhälä, L., Kosunen, T. U., Helander, I. M., Roine, R. P., Salmela, K. S., Höök-Nikanne, J., Salaspuro, M., Daw, M. A., Xia, H. X., O’Morain, C., Lelwala-Guruge, J., Ascencio, F., Ljungh, Å., Wadström, T., Ringnér, Martina, Valkonen, Kaija, Paulsson, Marianne, Ljungh, Åsa, Wadström, Torkel, Guldvog, I., Tannaes, T., Bukholm, G., Grav, H., Corinaldesi, R., Tucci, A., Stanghellini, V., Gasperoni, S., Varoli, O., Paparo, G. F., Gaetani, M., Cioffi, G., Barbara, L., Husson, M. O., Legrand, D., Mazurier, J., Caron, C., Leclerc, H., Spik, G., English, L., Keane, C. T., O’Morain, C. A., Fox, J. G., Correa, P., Taylor, N. S., Fatela, N., Melo Cristino, J., Monteiro, L., Ramalho, F., Saragoça, A., Salgado, M.J, Mauch, F., Bode, G., Ditschuneit, H., Malfertheiner, P., Nilius, M., Pugliese, M., Moshkowitz, M., Gorea, A., Santo, M., Berger, S., Gilat, T., Belluzzi, A., Vaira, D., Campieri, M., Boschi, S., Gionchetti, P., Mulè, P., Brignola, C., Rizzello, F., Miglioli, M., Barbara, L., Lamouliatte, H., Brugmann, D., Cayla, R., H. Bernard, P., Mégraud, F., Quinton, A., Bär, W., Wagner, S., Glen-Calvo, E., Koopmann, H., Szentmihalyi, A., Radnai, Z., Molnar, Gy., Bálint, A., and Ihász, M.

Published
1992
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40. BaiCD gene abundance is negatively correlated with Clostridium difficile infection

Author

Solbach, P., Woltemate, S., Chhatwal, P., Tacconelli, E., Buhl, M., Gerhard, M., Vehreschild, M., Jazmati, N., Rupp, J., Manns, M. P., Bachmann, O., Suerbaum, S., Solbach, P., Woltemate, S., Chhatwal, P., Tacconelli, E., Buhl, M., Gerhard, M., Vehreschild, M., Jazmati, N., Rupp, J., Manns, M. P., Bachmann, O., and Suerbaum, S.

Published
2018

42. Management of helicobacter pylori infection-the Maastricht V/Florence consensus report

Author

Malfertheiner, P., Mégraud, F., O'Morain, C. (C.), Gisbert, J.P. (Javier), Kuipers, E.J. (Ernst), Axon, A.T., Bazzoli, F. (Franco), Gasbarrini, A., Atherton, J., Graham, D.Y. (David Y.), Hunt, R., Moayyedi, P. (Paul), Rokkas, T., Rugge, M. (Massimo), Selgrad, M., Suerbaum, S., Sugano, K. (Kentaro), El-Omar, E., Malfertheiner, P., Mégraud, F., O'Morain, C. (C.), Gisbert, J.P. (Javier), Kuipers, E.J. (Ernst), Axon, A.T., Bazzoli, F. (Franco), Gasbarrini, A., Atherton, J., Graham, D.Y. (David Y.), Hunt, R., Moayyedi, P. (Paul), Rokkas, T., Rugge, M. (Massimo), Selgrad, M., Suerbaum, S., Sugano, K. (Kentaro), and El-Omar, E.

Abstract

Important progress has been made in the management of Helicobacter pylori infection and in this fifth edition of the Maastricht Consensus Report, key aspects related to the clinical role of H. Pylori were re-evaluated in 2015. In the Maastricht V/Florence Consensus Conference, 43 experts from 24 countries examined new data related to H. pylori in five subdivided workshops: (1) Indications/ Associations, (2) Diagnosis, (3) Treatment, (4) Prevention/Public Health, (5) H. pylori and the Gastric Microbiota. The results of the individual workshops were presented to a final consensus voting that included all participants. Recommendations are provided on the basis of the best available evidence and relevance to the management of H. pylori infection in the various clinical scenarios.

Published
2017
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46. Microevolution of Helicobacter pylori during prolonged infection of single hosts and within families

Author

Morelli, G., Didelot, X., Kusecek, B., Schwarz, S., Bahlawane, C., Falush, D., Suerbaum, S., and Achtman, M.

Subjects
Recombination, Genetic, Microbiology/Microbial Evolution and Genomics, Evolutionary Biology/Evolutionary and Comparative Genetics, Helicobacter pylori, lcsh:QH426-470, Bayes Theorem, Computational Biology/Comparative Sequence Analysis, Middle Aged, Genetics and Genomics/Microbial Evolution and Genomics, Computational Biology/Evolutionary Modeling, QR, Helicobacter Infections, Infectious Diseases/Bacterial Infections, Evolution, Molecular, Kinetics, lcsh:Genetics, Evolutionary Biology/Microbial Evolution and Genomics, Genetics and Genomics/Population Genetics, Mutation, Humans, Gastroenterology and Hepatology/Stomach and Duodenum, Family, Computational Biology/Population Genetics, Research Article
Abstract

Our understanding of basic evolutionary processes in bacteria is still very limited. For example, multiple recent dating estimates are based on a universal inter-species molecular clock rate, but that rate was calibrated using estimates of geological dates that are no longer accepted. We therefore estimated the short-term rates of mutation and recombination in Helicobacter pylori by sequencing an average of 39,300 bp in 78 gene fragments from 97 isolates. These isolates included 34 pairs of sequential samples, which were sampled at intervals of 0.25 to 10.2 years. They also included single isolates from 29 individuals (average age: 45 years) from 10 families. The accumulation of sequence diversity increased with time of separation in a clock-like manner in the sequential isolates. We used Approximate Bayesian Computation to estimate the rates of mutation, recombination, mean length of recombination tracts, and average diversity in those tracts. The estimates indicate that the short-term mutation rate is 1.4×10−6 (serial isolates) to 4.5×10−6 (family isolates) per nucleotide per year and that three times as many substitutions are introduced by recombination as by mutation. The long-term mutation rate over millennia is 5–17-fold lower, partly due to the removal of non-synonymous mutations due to purifying selection. Comparisons with the recent literature show that short-term mutation rates vary dramatically in different bacterial species and can span a range of several orders of magnitude., Author Summary Mutation rates in bacteria have generally been considered to be much slower than in viruses. This is partly because estimates of long-term mutation rates for the evolution of distinct species have been inappropriately used for dating divergence within species. Furthermore, the most commonly used long-term mutation rate is based on geological dates that are no longer accepted. In addition, only few short-term mutation rates have been calculated within bacterial species, and these differ with the species by several orders of magnitude. Here, we provide robust estimates for short-term mutation and recombination rates within Helicobacter pylori, a bacterium that commonly infects the human gastric mucosa, based on serial isolates from long-term infections and on differences between isolates from multiple family members. These short-term mutation rates are 5–17-fold faster than long-term mutation rates in H. pylori that have been calibrated by parallel ancient migrations of humans. Short-term mutation rates in bacteria, including those for H. pylori, can be quite fast, partially overlapping with those for viruses. Future calculations of ages of bacterial species will need to account for dramatic differences in mutation rate between species and for dramatic differences between short- and long-term mutation rates.

Published
2016

50. Determining the Whole Genome Sequence of Helicobacter hepaticus ATCC 51449

Author

Suerbaum, S., Josenhans, C., Frosch, M., Bell, M., Braig, K., Brandt, P., Chevreux, B., Diectrich, G., Drescher, B., Droege, M., Fartmann, B., Fischer, H.P., Ge, Z., Holland, R., Mann, W., Nyakatura, G., Pfannes, O., Schauer, D., Weber, Joseph, and Fox, J.G.

Subjects
Helicobacter infections -- Genetic aspects -- Analysis, Comorbidity -- Analysis -- Genetic aspects, Liver cancer -- Causes of -- Genetic aspects -- Analysis, Chronic active hepatitis -- Genetic aspects -- Analysis, Health, Analysis, Genetic aspects, Causes of
Abstract

S. Suerbaum [1] C. Josenhans [1] M. Frosch [1] M. Bell [2] K. Braig [3] P. Brandt [2] B. Chevreux [2] G. Diectrich [1] B. Drescher [2] M. Droege [2] [...]

Published
2001

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