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1. Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113): a multicentre, randomised, phase 2 trial

Author

Hennes, Elke, Lindig, Udo, Geer, Thomas, Stahl, Michael, Senkal, Metin, Südhoff, Thomas, Egger, Matthias, Kahl, Christoph, Große-Thie, Christina, Reiser, Marcel, Mahlmann, Stefan, Fix, Peter, Schulz, Holger, Maschmeyer, Georg, Blau, Wolfgang, Kunzmann, Volker, Siveke, Jens T, Algül, Hana, Goekkurt, Eray, Siegler, Gabriele, Martens, Uwe, Waldschmidt, Dirk, Pelzer, Uwe, Fuchs, Martin, Kullmann, Frank, Boeck, Stefan, Ettrich, Thomas J, Held, Swantje, Keller, Ralph, Klein, Ingo, Germer, Christoph-Thomas, Stein, Hubert, Friess, Helmut, Bahra, Marcus, Jakobs, Ralf, Hartlapp, Ingo, and Heinemann, Volker

Published
2021
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2. Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era - analysis of the European LeukemiaNet Blast Phase Registry

Author

Brioli, Annamaria, Lomaia, Elza, Fabisch, Christian, Sacha, Tomasz, Klamova, Hana, Morozova, Elena, Golos, Aleksandra, Ernst, Philipp, Olsson-Strömberg, Ulla, Zackova, Daniela, Nicolini, Franck E., Bao, Han, Castagnetti, Fausto, Patkowska, Elzbieta, Mayer, Jiri, Hirschbuehl, Klaus, Podgornik, Helena, Paczkowska, Edyta, Parry, Anne, Ernst, Thomas, Voskanyan, Astghik, Szczepanek, Elzbieta, Saussele, Susanne, Franke, Georg-Nikolaus, Kiani, Alexander, Faber, Edgar, Krause, Stefan, Casado, Luis Felipe, Lewandowski, Krzysztof, Eder, Matthias, Anhut, Peter, Gil, Justyna, Suedhoff, Thomas, Hebart, Holger, Heibl, Sonja, Pfirrmann, Markus, Hochhaus, Andreas, Lauseker, Michael, Brioli, Annamaria, Lomaia, Elza, Fabisch, Christian, Sacha, Tomasz, Klamova, Hana, Morozova, Elena, Golos, Aleksandra, Ernst, Philipp, Olsson-Strömberg, Ulla, Zackova, Daniela, Nicolini, Franck E., Bao, Han, Castagnetti, Fausto, Patkowska, Elzbieta, Mayer, Jiri, Hirschbuehl, Klaus, Podgornik, Helena, Paczkowska, Edyta, Parry, Anne, Ernst, Thomas, Voskanyan, Astghik, Szczepanek, Elzbieta, Saussele, Susanne, Franke, Georg-Nikolaus, Kiani, Alexander, Faber, Edgar, Krause, Stefan, Casado, Luis Felipe, Lewandowski, Krzysztof, Eder, Matthias, Anhut, Peter, Gil, Justyna, Suedhoff, Thomas, Hebart, Holger, Heibl, Sonja, Pfirrmann, Markus, Hochhaus, Andreas, and Lauseker, Michael

Abstract

Blast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the condition and the heterogeneity of the biology and clinical presentation, prospective trials and concise treatment recommendations are lacking. Here we present the analysis of the European LeukemiaNet Blast Phase Registry, an international collection of the clinical presentation, treatment and outcome of blast phases which had been diagnosed in CML patients after 2015. Data reveal the expected heterogeneity of the entity, lacking a clear treatment standard. Outcomes remain dismal, with a median overall survival of 23.8 months (median follow up 27.8 months). Allogeneic stem cell transplantation (alloSCT) increases the rate of deep molecular responses. De novo BP and BP evolving from a previous CML do show slightly different features, suggesting a different biology between the two entities. Data show that outside clinical trials and in a real-world setting treatment of blast phase is individualized according to disease- and patient-related characteristics, with the aim of blast clearance prior to allogeneic stem cell transplantation. AlloSCT should be offered to all patients eligible for this procedure.

Published
2024
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3. Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD

Author

Schlenk, Richard F., Weber, Daniela, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Salwender, Hans, Schroeder, Thomas, Kindler, Thomas, Lübbert, Michael, Wolf, Dominik, Westermann, Jörg, Kraemer, Doris, Götze, Katharina S., Horst, Heinz-August, Krauter, Jürgen, Girschikofsky, Michael, Ringhoffer, Mark, Südhoff, Thomas, Held, Gerhard, Derigs, Hans-Günter, Schroers, Roland, Greil, Richard, Grießhammer, Martin, Lange, Elisabeth, Burchardt, Alexander, Martens, Uwe, Hertenstein, Bernd, Marretta, Lore, Heuser, Michael, Thol, Felicitas, Gaidzik, Verena I., Herr, Wolfgang, Krzykalla, Julia, Benner, Axel, Döhner, Konstanze, Ganser, Arnold, Paschka, Peter, and Döhner, Hartmut

Published
2019
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6. Dünndarmerkrankungen

Author

Beglinger, Christoph, Daum, Severin, Zeitz, Martin, Schuppan, Detlef, Willert, Jörg, Hollerbach, Stephan, Südhoff, Thomas, Schmiegel, Wolff, and Schölmerich, Jürgen, editor

Published
2007
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7. Dünndarmerkrankungen

Author

Beglinger, Christoph, Schuppan, Detlef, Willert, Jörg, Hollerbach, Stephan, Südhoff, Thomas, Schmiegel, Wolff-H., Schölmerich, Jürgen, editor, Burdach, S., editor, Drexler, H., editor, Hallek, M., editor, Hiddemann, W., editor, Hörl, W.H., editor, Klein, H., editor, Landthaler, M., editor, Lenz, K., editor, Mann, K., editor, Mössner, J., editor, Müller-Ladner, U., editor, Reichen, J., editor, Schmiegel, W., editor, Schröder, J.O., editor, Seeger, W., editor, Stremmel, W., editor, Suttorp, N., editor, Weilemann, L.S., editor, and Wöhrle, J.C., editor

Published
2005
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8. Erkrankungen des Magen-Darm-Traktes

Author

Frieling, Thomas, Petrasch, Stephan, Röscx, T., Malfertheiner, Peter, von Schrenck, Tammo, Allescher, Hans-Dieter, Fischbach, Wolfgang, Rebensburg, Stefan, Neuhaus, Horst, Beglinger, Christoph, Schuppan, Detlef, Willert, Jörg, Hollerbach, Stephan, Südhoff, Thomas, Schmiegel, Wolff-H., Graeven, Ullrich, Graeven, Stephan Hollrich, Holstege, Axel, Pommer, Gerd, Reiser, Markus, Tromm, Andreas, Kruis, Wolfgang, Herrlinger, Klaus, Stange, Eduard F., Bischoff, Stephan C., Schölmerich, Jürgen, editor, Burdach, Stefan, editor, Diehl, Volker, editor, Drexler, Helmut, editor, Hiddemann, Wolfgang, editor, Hörl, Walter H., editor, Klein, Helmfried, editor, Landthaler, Michael, editor, Lenz, Kurt, editor, Mann, Klaus, editor, Mössner, Joachim, editor, Müller-Ladner, Ulf, editor, Reichen, Jürg, editor, Schmiegel, Wolff, editor, Schröder, Johann Oltmann, editor, Seeger, Werner, editor, Stremmel, Wolfgang, editor, Suttorp, Norbert, editor, and Weilemann, L. Sacha, editor

Published
2003
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9. Treatment and Disease Characteristics of Chronic Myeloid Leukemia in Blast Crisis: The European Leukemianet Blast Crisis Registry

Author

Brioli, Annamaria, Lomaia, Elza, Fabisch, Christian, Sacha, Tomasz, Klamová, Hana, Morozova, Elena, Golos, Aleksandra, Ernst, Philipp, Olsson-Strömberg, Ulla, Mayer, Jiri, Nicolini, Franck E., Bao, Han, Castagnetti, Fausto, Patkowska, Elzbieta, Hirschbühl, Klaus, Paczkowska, Edyta, Parry, Anne, Voskanyan, Astghik, Saussele, Susanne, Franke, Georg-Nikolaus, Kiani, Alexander, Faber, Edgar, Lewandowski, Krzysztof, Krause, Stefan W., Dammann, Elke, Anhut, Peter, Gil, Justyna, Südhoff, Thomas, Heibl, Sonja, Pfirrmann, Markus, Hochhaus, Andreas, and Lauseker, Michael

Published
2022
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10. Prognostic value of pre-infection routine laboratory parameters for COVID-19 mortality in tumor patients: Results of the ADHOK Coronavirus Tumor Registry.

Author

Roesch, Romina, primary, Suedhoff, Thomas, additional, Wendtner, Clemens M., additional, Kullmann, Frank, additional, Kubin, Thomas, additional, Schaich, Markus, additional, Mueller-Naendrup, Clemens U., additional, Augustin, Marinela, additional, Hartmann, Frank, additional, Illerhaus, Gerald, additional, Hebart, Holger Frithjof, additional, Seggewiss-Bernhardt, Ruth, additional, Graeven, Ullrich, additional, Naumann, Ralph, additional, and Kiani, Alexander, additional

Published
2021
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11. Therapy with antifungals decreases the diagnostic performance of PCR for diagnosing invasive aspergillosis in bronchoalveolar lavage samples of patients with haematological malignancies

Author

Reinwald, Mark, Hummel, Margit, Kovalevskaya, Elena, Spiess, Birgit, Heinz, Werner J., Vehreschild, Jörg Janne, Schultheis, Beate, Krause, Stefan W., Claus, Bernd, Suedhoff, Thomas, Schwerdtfeger, Rainer, Reuter, Stefan, Kiehl, Michael G., Hofmann, Wolf-Karsten, and Buchheidt, Dieter

Published
2012
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13. Low-Dose Azacitidine, Pioglitazone and All-Trans Retinoic Acid Versus Standard-Dose Azacitidine in Patients ≥ 60 Years with Acute Myeloid Leukemia Refractory to Standard Induction Chemotherapy (AMLSG 26-16/AML-ViVA): Results of the Safety Run-in Phase I

Author

Heudobler, Daniel, Klobuch, Sebastian, Lüke, Florian, Hahn, Joachim, Grube, Matthias, Kremers, Stephan, Südhoff, Thomas, Westermann, Jörg, Huetter-Kroenke, Marie-Luise, Paschka, Peter, Bouche, Gauthier, Döhner, Hartmut, Herr, Wolfgang, Thomas, Simone, and Reichle, Albrecht

Published
2019
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14. Detection of Aspergillus Species in Blood and Bronchoalveolar Lavage Samples from Immunocompromised Patients by Means of 2-Step Polymerase Chain Reaction: Clinical Results

Author

Buchheidt, Dieter, Baust, Corinna, Skladny, Heyko, Ritter, Joerg, Suedhoff, Thomas, Baldus, Michael, Seifarth, Wolfgang, Leih-Moesch, Christine, and Hehlmann, Ruediger

Subjects
Aspergillosis -- Diagnosis, Blood -- Analysis, Bronchoalveolar lavage -- Analysis, Amphotericin B -- Adverse and side effects, Antifungal agents -- Adverse and side effects, Health, Health care industry
Published
2001

15. Treatment of invasive fungal infections in cancer patients-updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)

Author

Mousset, Sabine, Buchheidt, Dieter, Heinz, Werner, Ruhnke, Markus, Cornely, Oliver A., Egerer, Gerlinde, Krueger, William, Link, Hartmut, Neumann, Silke, Ostermann, Helmut, Panse, Jens, Penack, Olaf, Rieger, Christina, Schmidt-Hieber, Martin, Silling, Gerda, Suedhoff, Thomas, Ullmann, Andrew J., Wolf, Hans-Heinrich, Maschmeyer, Georg, Boehme, Angelika, Mousset, Sabine, Buchheidt, Dieter, Heinz, Werner, Ruhnke, Markus, Cornely, Oliver A., Egerer, Gerlinde, Krueger, William, Link, Hartmut, Neumann, Silke, Ostermann, Helmut, Panse, Jens, Penack, Olaf, Rieger, Christina, Schmidt-Hieber, Martin, Silling, Gerda, Suedhoff, Thomas, Ullmann, Andrew J., Wolf, Hans-Heinrich, Maschmeyer, Georg, and Boehme, Angelika

Abstract

The Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) here presents its updated recommendations for the treatment of documented fungal infections. Invasive fungal infections are a main cause of morbidity and mortality in cancer patients undergoing intensive chemotherapy regimens. In recent years, new antifungal agents have been licensed, and agents already approved have been studied in new indications. The choice of the most appropriate antifungal treatment depends on the fungal species suspected or identified, the patient's risk factors (e.g., length and depth of neutropenia), and the expected side effects. This guideline reviews the clinical studies that served as a basis for the following recommendations. All recommendations including the levels of evidence are summarized in tables to give the reader rapid access to the information.

Published
2014

16. Positron Emission Tomography (PET) Guided Therapy of Aggressive Lymphomas - Interim PET-Based Outcome Prediction and Treatment Changes in Patients with B Cell Lymphomas Participating in the PETAL Trial

Author

Duehrsen, Ulrich, Müller, Stefan P, Rekowski, Jan, Hertenstein, Bernd, Franzius, Christiane, Mesters, Rolf, Weckesser, Matthias, Kroschinsky, Frank, Kotzerke, Jörg, Franzke, Anke, Bengel, Frank M, La Rosée, Paul, Freesmeyer, Martin, Hoeffkes, Heinz-Gert, Hertel, Andreas, Behringer, Dirk, Prange-Krex, Gabriele, Griesshammer, Martin, Holzinger, Jens, Wilop, Stefan, Krohn, Thomas, Raghavachar, Aruna, Maschmeyer, Georg, Brink, Ingo, Schroers, Roland, Gaska, Tobias, Dang, Tu-Anh, Giagounidis, Aristoteles, Dienst, Ariane, Hautzel, Hubertus, Naumann, Ralph, Klein, Alfred, Hahn, Dennis, Pöpperl, Gabriele, Grube, Matthias, Marienhagen, Jörg, Schwarzer, Andreas, Kurch, Lars, Höhler, Thomas, Steiniger, Heike, Nückel, Holger, Südhoff, Thomas, Römer, Wolfgang, Brinkmann, Marcus, Ose, Claudia, Hoelzer, Dieter, Dürig, Jan, Jöckel, Karl-Heinz, Klapper, Wolfram, and Hüttmann, Andreas

Published
2016
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17. Impact of Age and Midostaurin-Dose on Response and Outcome in Acute Myeloid Leukemia with FLT3-ITD: Interim-Analyses of the AMLSG 16-10 Trial

Author

Schlenk, Richard F., Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Thol, Felicitas, Kündgen, Andrea, Kindler, Thomas, Salwender, Hans-Juergen, Lübbert, Michael, Brossart, Peter, Westermann, Jörg, Kraemer, Doris, Goetze, Katharina, Horst, Heinz-August, Krauter, Jürgen, Girschikofsky, Michael, Ringhoffer, Mark, Südhoff, Thomas, Held, Gerhard, Kirchner, Hartmut H., Schmiegel, Wolff, Greil, Richard, Griesshammer, Martin, Lange, Elisabeth, Martens, Uwe, Hertenstein, Bernd, de Wit, Maike, Koller, Elisabeth, Petzer, Andreas L., Hesse, Tanja, Runde, Volker, Reimer, Peter, Schultheis, Beate S., Kirchen, Heinz, Griesinger, Frank, Hebart, Holger, Heil, Gerhard, Kremers, Stephan, Nachbaur, David, Basara, Nadezda, Schwänen, Carsten, Schöndube, Daniel, Greiner, Jochen, Münnich, Anja, Weber, Daniela, Gaidzik, Verena I., Teleanu, Maria-Veronica, Paschka, Peter, Theis, Frauke, Benner, Axel, Heuser, Michael, Döhner, Konstanze, Ganser, Arnold, and Döhner, Hartmut

Published
2016
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18. Cetuximab and chemotherapy in the treatment of patients with initially “nonresectable” colorectal (CRC) liver metastases: Long-term follow-up of the CELIM trial.

Author

Folprecht, Gunnar, primary, Gruenberger, Thomas, additional, Bechstein, Wolf, additional, Raab, Hans-Rudolf, additional, Weitz, Juergen, additional, Lordick, Florian, additional, Hartmann, Joerg Thomas, additional, Lang, Hauke, additional, Trarbach, Tanja, additional, Stoehlmacher-Williams, Jan, additional, Liersch, Torsten, additional, Ockert, Detlev, additional, Jaeger, Dirk, additional, Steger, Ulrich, additional, Suedhoff, Thomas, additional, and Kohne, Claus-Henning, additional

Published
2013
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20. Midostaurin in Combination with Intensive Induction and As Single Agent Maintenance Therapy after Consolidation Therapy with Allogeneic Hematopoietic Stem Cell Transplantation or High-Dose Cytarabine (NCT01477606)

Author

Schlenk, Richard, Döhner, Konstanze, Salih, Helmut, Kündgen, Andrea, Fiedler, Walter, Salwender, Hans-Juergen, Westermann, Joerg, Götze, Katharina S., Horst, Heinz-August, Wulf, Gerald, Lübbert, Michael, Kraemer, Doris, Kindler, Thomas, Ringhoffer, Mark, Brossart, Peter, Held, Gerhard, Greil, Richard, Südhoff, Thomas, Münnich, Anja, Weber, Daniela, Gaidzik, Verena I., Teleanu, Maria-Veronica, Paschka, Peter, Theis, Frauke, Heuser, Michael, Thol, Felicitas, Benner, Axel, Ganser, Arnold, and Döhner, Hartmut

Published
2015
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23. Detection ofAspergillusSpecies in Blood and Bronchoalveolar Lavage Samples from Immunocompromised Patients by Means of 2‐Step Polymerase Chain Reaction: Clinical Results

Author

Buchheidt, Dieter, primary, Baust, Corinna, additional, Skladny, Heyko, additional, Ritter, Joerg, additional, Suedhoff, Thomas, additional, Baldus, Michael, additional, Seifarth, Wolfgang, additional, Leib‐Moesch, Christine, additional, and Hehlmann, Ruediger, additional

Published
2001
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24. C-reactive Protein in Patients with Metastatic Clear Cell Renal Carcinoma: An Important Biomarker for Tumor-associated Inflammation.

Author

Reichle A, Grassinger J, Bross K, Wilke J, Suedhoff T, Walter B, Wieland WF, Berand A, and Andreesen R

Abstract

Two consecutive multi-center phase II trials were designed to prove the hypothesis, whether therapeutic modeling of tumor-associated inflammatory processes could result in improved tumor response.Therapy in both trials consisted of low-dose capecitabine 1g/m2 twice daily p.o. for 14 days, every 3 weeks, day 1+, and rofecoxib 25 mg daily p.o., day 1+ (from 11/04 etoricoxib 60 mg daily instead) plus pioglitazone 60 mg daily p.o., day 1+. In study II low-dose IFN-alpha 4.5 MU sc. three times a week, week 1+, was added until disease progression.Eighteen, and 33 patients, respectively, with clear cell renal carcinoma and progressive disease were enrolled. Objective response (48%) was exclusively observed in study II (PR 35%, CR 13%), and paralleled by a strong CRP response after 4 weeks on treatment, p = 0.0005, in all 29 pts (100%) with elevated CRP levels. Median progression-free survival could be more than doubled from a median of 4.7 months (95% CI, 1.0 to 10.4) to 11.5 months (6.8 to 16.2) in study II, p = 0.00001. Median overall survival of population II was 26 months.Efficacious negative regulation of tumor-associated inflammation by transcription modulators may result in a steep increase of tumor response and survival.

Published
2007

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