8 results on '"Sudewi Mukaromah Khoirunnisa"'
Search Results
2. The clinical effectiveness of one-dose vaccination with an HPV vaccine: A meta-analysis of 902,368 vaccinated women.
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Didik Setiawan, Nunuk Aries Nurulita, Sudewi Mukaromah Khoirunnisa, and Maarten J Postma
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Medicine ,Science - Abstract
BackgroundThe comprehensive effectiveness of the HPV vaccine has been widely acknowledged. However, challenges such as dosing adherence and limited budgets have led to delays in HPV vaccination implementation in many countries. A potential solution to these issues could lie in a one-dose vaccination with an HPV vaccine, as indicated by promising outcomes in multiple studies.MethodsIn this systematic review and meta-analysis, we examine the comparative effectiveness of the one-dose vaccination with an HPV vaccine against two- and three-dose regimens. Our investigation focuses on clinical efficacy, encompassing the prevention of HPV16, HPV18, and hrHPV infections, HSIL or ASC-H incidence, and CIN2/3 incidence.ResultsOur analysis suggests that a single-dose HPV vaccine may offer effectiveness on par with two- or three-dose schedules. This conclusion is drawn from its capacity to confer immunogenic protection for at least 8 years of follow-up, coupled with its ability to mitigate infections and pre-cancerous occurrences.ConclusionWhile our findings underscore the potential of the one-dose vaccination with an HPV vaccine, further research and prolonged study durations are necessary to establish robust evidence supporting this recommendation. As such, continued investigation will be critical for informing vaccination strategies.
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- 2024
- Full Text
- View/download PDF
3. Health-related quality of life in Her2-positive early breast cancer woman using trastuzumab: A systematic review and meta-analysis
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Sudewi Mukaromah Khoirunnisa, Fithria Dyah Ayu Suryanegara, Didik Setiawan, and Maarten Jacobus Postma
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trastuzumab ,breast cancer ,meta-analysis ,health-related quality of life ,Her2-positive breast cancer ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: Despite the benefits of trastuzumab in many trials, evidence of its impact on health-related quality of life (HRQoL) in early treatment has not been summarized. This study explored the effects of trastuzumab treatment on HRQoL, including pooled meta-analysis, in an effort to provide an integrated assessment of HRQoL for Her2-positive early breast cancer patients.Methods: A comprehensive literature review to February 2023 using three databases, focusing on treatment using trastuzumab during the early stage, was performed. The mean changes from baseline during and after treatment were extracted from the included randomized control trials (RCTs) papers and total HRQoL scores were obtained from cross-sectional studies included. Mean difference (MD) and 95% confidence intervals were assessed by a random effect or fixed effect model based on heterogeneity (I2).Results: A total of ten studies were identified and reviewed, consisting of seven RCTs and three cross-sectional studies. The pooled analysis of the mean change from baseline during treatment resulted in an MD of 1.92 (95% CI = 1.59 to 2.25, p < 0.05, I2 = 0%), favoring the trastuzumab group. A non-significant result of the mean change from baseline after treatment appeared in the analysis of 12-month follow-up. In the cross-sectional studies, pooled analyses of HRQoL showed that trastuzumab meaningfully demonstrated an improved HRQoL profile (MD = 9.29, 95% CI = 1.31 to 17.27, p = 0.02, I2 = 0%).Conclusion: Trastuzumab as a targeted therapy resulted in a favorable effect on HRQoL in the early stages of Her2-positive breast cancer. The findings of significant improvements in patients’ HRQoL and less clinically meaningful deterioration in side effects of trastuzumab-containing regimen during treatment were supported by prolonged survival.
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- 2023
- Full Text
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4. PENETAPAN KADAR ALKALI BEBAS PADA SABUN CUCI KRIM YANG DIJUAL DI MINI MARKET SECARA ASIDIMETRI
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Puput Kusuma Dipaningrum, Ade Maria Ulfa, and Sudewi Mukaromah Khoirunnisa
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Laundry soap cream is one PKRT (Household Health) which is used to clean equipment and to wash clothes. The main constituent component of fat and soap is alkaline, where if there is excess base does not react with the excess fat there will be alkali-free. If in the soap containing alkali-free high, it can cause skin irritations such as rough skin, flushed, sometimes there are small spots of water and cause itching. Limit allowed in the free alkali soap cream by the Indonesian National Standard 06-2048-1990 ie a maximum of 0.1%. This study aims to determine the levels of free alkaline detergent contained in the cream is sold in the mini market of Bandar Lampung. The method used is acidimetry, where the principle is the determination of free alkaline by neutralizing acids and bases. In this study HCl titrant used is a strong base that is titrated by using a strong acid, an indicator used is phenolpthalien with stretch pH 8.2 to 9.6 and endpoint occurring from pink to white. From the results obtained with the sample five different brands the average level of alkali-free for sample A: 3.06% B: 2.86%, C: 1.08%, D: 0.40%, E: 1.11 %. Based on the research results obtained showed that the alkali-free in all samples of soap cream does not meet the requirements of the maximum levels of Indonesian National Standard 06-2048-1990 ie 0.1%.
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- 2022
5. Identifikasi Deksametason dalam Jamu Pegal Linu Sediaan Serbuk yang Beredar di Pasar-pasar Kota Bandar Lampung secara Kromatografi Lapis Tipis
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Sudewi Mukaromah Khoirunnisa
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education.field_of_study ,Traditional medicine ,Stationary phase ,Population ,education ,Reference standards ,Mathematics - Abstract
A total of 26.6% of the population in Lampung Province consume traditional medicine, one of which is Jamu Pegal Linu. However, a large public interest in herbal products is often misused by herbal manufacturers that it is possible to add BKO (Medicinal Chemicals), such as dexamethasone.The purpose of this study is to identify the presence or absence of dexamethasone in the preparation of Jamu Pegal Linu. The samples are taken from the store and depot herbs contained in the Markets of Bandar Lampung, acquired three different brands. The method used is Thin Layer Chromatography using dikloretan motion: diethyl ether: methanol: water (77:15: 8: 1,2) as a mobile phase which are non-polar, and silica gel GF 254nm as a stationary phase. The result showed that the detection of three samples of Jamu Pegal Linu contained staining purple and the difference of Rf sample with reference standard on the first repetition is 0.46, 0.44, 0.47, and on the second repetition is 0.45, 0.45 and 0.48, which are ≥ 0.05. It can be concluded that the sample of Jamu Pegal Linu in Bandar Lampung 0% containing dexamethasone.
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- 2017
6. Optimasi Formula Mikroemulsi Berbahan Dasar Crude Palm Oil (CPO) Sebagai Antioksidan Potensial Pada Kulit
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Fina Khaerunnisa Frima, Sudewi Mukaromah Khoirunnisa, Erga Syafitri, and Nur Adliani
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Minyak Kelapa Sawit (Crude Palm Oil/CPO) merupakan salah satu tanaman khas Sumatera yang berpotensi sebagai sediaan antioksidan. Bentuk sediaan mikroemulsi dipilih karena dapat meningkatkan penetrasi CPO ke dalam kulit. Oleh karena itu, pada penelitian ini akan dibentuk sediaan mikroemulsi mengandung CPO dan diuji aktivitas antioksidannya. Mikroemulsi CPO diformulasikan menggunakan metode Phase Titration Method dengan CPO sebagai fase minyak, tween 80 sebagai surfaktan, PEG 400 sebagai kosurfaktan dan aquadest sebagai fase air. Formula optimum dari penelitian ini mengandung 5% (b/b) CPO, 20% (b/b) tween 80, 10% (b/b) PEG 400, dan 65% (b/b) air. Hasil evaluasi formula menunjukkan bahwa formula ini memiliki ukuran globul sebesar 288,87 ± 20,94 nm, zeta potensial sebesar -0,36 mV, bobot jenis 1,024 ± 6,15x10-5 g/mL dan pH berada pada rentang 4,5-6,5. Dari evaluasi stabilitas didapat bahwa sediaan stabil dalam penyimpanan selama 28 hari di suhu ruang (25oC), stabil terhadap perubahan suhu ekstrim dan terhadap agitasi. Sediaan mikroemulsi CPO ini memiliki nilai IC50 sebesar 10,5 µg/mL yang menunjukkan aktivitas antioksidan yang kuat. Dari hasil tersebut dapat disimpulkan bahwa sediaan mikroemulsi CPO memiliki karakterisasi fisik dan kestabilan yang baik dan dapat dikembangkan lebih lanjut sebagai sediaan antioksidan pada kulit.
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- 2020
7. Quality of Life of Patient with Hypertension in Primary Health Care in Bandar Lampung
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Sudewi Mukaromah Khoirunnisa and Atika Dalili Akhmad
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Univariate analysis ,Multivariate analysis ,SF-36 ,Cross-sectional study ,business.industry ,Pharmaceutical Science ,Pharmacy ,Bivariate analysis ,Confidence interval ,Quality of life ,Medicine ,Marital status ,Pharmacology (medical) ,business ,Demography - Abstract
The high prevalence of hypertension in Indonesia, encourages studies related to how the quality of life of patients with hypertension. The purpose of this study was to measure quality of life, identify and explain factors related to the quality of life of patients with hypertension. The study design was descriptive correlation using a cross sectional study approach. The study subjects were all outpatient hypertensive patients several health centers in Bandar Lampung. The instrument used in this study was the Indonesian SF-36. The data collected included the patient's demographic characteristics including gender, age, education, occupation, and marital status, and the fields related to the health history of the study subjects included the duration of hypertension, complications, and the number of antihypertensive drugs consumed. Data were analyzed using bivariate analysis to see the relationship between two variables with the level of significance used was 5% (α = 0.05) with the value of the confidence interval set was 95%. Multivariate analysis was conducted to study the relationship of several independent variables with one or several dependent variables. The results of univariate analysis showed that age, marital status, duration of illness, complications, and the number of drugs consumed had an effect on the quality of life of hypertensive patients (p
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- 2020
8. The Rheumatoid Arthritis Quality of Life (RAQoL) for Indonesia: Translation and Pilot Test
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Sudewi Mukaromah Khoirunnisa and Perwitasari D.A
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medicine.medical_specialty ,business.industry ,Healthy subjects ,Validity ,medicine.disease ,language.human_language ,Test (assessment) ,Indonesian ,Quality of life ,Rheumatoid arthritis ,medicine ,language ,Physical therapy ,Pilot test ,Completion time ,business - Abstract
— The primary objective of this research were to produce and evaluate the official Indonesian language version of the Rheumatoid Arthritis Quality of Life instrument (RAQoL). The UK RAQoL was translated into Indonesian by a forward-backward translation. A separate lay panel was conducted to consider the appropriateness and comprehensibility of the items in Indonesian. The translated version of the RAQoL was pilot tested to determine whether the questionnaire RAQoL could be well understood and well accepted. Pilot test was conducted by interviews with 20 subjects, which 10 healthy Indonesia people and 10 rheumatoid arthritis patients who were recruited from X hospital in Yogyakarta, Indonesia. Items on the two response format questionnaire used in pilot study were scored one for a ‘yes’ response and zero for a ‘no’ response. The individual total item scores with a high score indicating poor QoL. Few difficulties arose in the translation process and the new language version was well received by the lay panel and field-test participants. Statistical analysis was conducted to determine the difference of completion time between healthy subjects and RA patients, and the total score of the questionnaire answers between healthy subjects and patients. The average total score of responses to questionnaire on the healthy subject and patients by T test was significantly different (p < 0.05). The official Indonesian RAQoL was well received by RA patients. The psychometric quality of the translated questionnaire means that it is suitable for validity and reliability of the questionnaire towards patients with RA.Keywords—Rheumatoid Arthritis, questionnaire, RAQoL, translation, pilot test
- Published
- 2017
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