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Selected spatial geometries can either enhance or suppress scattering amplitudes, to produce either extremely sharp resonances or approximate invisibility for a specified angular momentum. A simple model is presented in detail for an impenetrable sphere surrounded by a Riemannian step geometry. [ABSTRACT FROM AUTHOR]

Smriti Subedi,1,2,* Yu Gong,1,2,* Youdong Chen,1,2, Yuling Shi1,21Department of Dermatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China; 2Department of Dermatology, Institute of Psoriasis, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China*These authors contributed equally to this workAbstract: Psoriasis is a chronic immune-mediated skin disease affecting multiple systems, and tumor necrosis factor-α (TNF-α) plays a significant role in the initiation and progression of the disease process. Psoriasis has a high prevalence rate in the Western world, especially in the USA and Australia; in China, although the prevalence rate is much lower, there is still a large number of patients suffering from psoriasis and its comorbidities. As TNF-α is thought to be crucial in the pathogenesis of psoriasis, specific therapy blocking TNF-α may be beneficial in the treatment of this disease. Infliximab, a murine–human monoclonal antibody, is highly efficacious in the treatment of moderate-to-severe psoriasis, with better skin clearance and faster onset of action than topical medications such as methotrexate, narrow-band ultraviolet B, and calcipotriol. Lack of adherence to infliximab therapy is mainly due to loss of response (LOR) over time and adverse events, particularly because infusion reactions are usually encountered. Anti-infliximab antibody is thought to be responsible for the LOR and infusion reactions. However, the mechanism underlying the formation of anti-infliximab antibody and its side effects remains unclear. Further studies identifying patients at risk for LOR will probably help clinicians to select the right patients for anti-TNF-α therapy and to increase the durability of the treatment. This review discusses the efficacy of infliximab as demonstrated by various clinical trials, LOR to infliximab, combatting LOR, as well as the adverse events usually faced during the use of infliximab therapy and the infliximab biosimilar Remsima®,. We hope that we can discover a better way to use infliximab in the therapy of psoriasis from the current research data.Keywords: anti-infliximab antibody, infliximab, psoriasis, TNF-α, treatment

Qian Yu,1,2,* Smriti Subedi,1,2,* Yunlei Tong,1,2 Qing Wei,3 Hui Xu,1,2 Yao Wang,1,2 Yu Gong,1,2 Yuling Shi1,2 1Department of Dermatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China; 2Institute of Psoriasis, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China; 3Department of Pathology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China *These authors contributed equally to this work Abstract: Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence ranging from 0.22% to 12% of all malignancies. Here we report a 64-year-old asymptomatic female patient with Peutz–Jeghers syndrome presenting with multiple scalp metastases as the initial manifestation secondary to lung adenocarcinoma. Subsequent lung computed tomography scan showed large masses involving the left upper lobe associated with extensive mediastinal lymphadenopathy. After treatment with an epidermal growth factor receptor inhibitor gefitinib, the size of the tumor in the lung reduced significantly and the condition of the patient also gradually improved. Our case demonstrated that scalp metastasis could be the first sign of an internal malignancy. Asymptomatic elderly patients presenting with multiple, painless, immobile cutaneous nodules should be considered for further investigations to rule out the underlying primary cause. Metastasis to the skin is often a preterminal event that heralds poor prognosis. Keywords: cancer, metastasis, scalp, lung adenocarcinoma

In this study, wavelet analysis and traditional cross-correlation analysis (TCA) have been employed to explore the temporal characteristics of the Air Quality Index (AQI) (PM2.5) and its relationships with meteorological factors, air temperature, and rainfall in the capital city of Nepal, Kathmandu, during 2017 - 2020. The temporal variation of monthly averaged (AQI) (PM2.5) revealed that the air quality was unhealthy in winter, improved in summer, and subsequently became unhealthy again in autumn and spring. We also noticed that the lowest AQI (PM2.5) was recorded in 2020, which is due to the COVID-19 pandemic lockdown. By analyzing the time-frequency relationship of (AQI) (PM2.5) with air temperature and rainfall, using Cross Wavelet Transform (XWT), we observed the interannual, seasonal, and monthly common periodicity between them. The coherency of XWT is then tested by using Wavelet Transform Coherence (WTC), which showed a negative correlation of AQI (PM2.5) with rainfall and air temperature, while an anomaly was seen among AQI (PM2.5) and temperature as they were positively associated for a few months in 2017, 2018, and 2020. Moreover, the results of cross-correlation and multiresolution analysis (MRA) are consistent with wavelet analysis, indicating the driving effect of air temperature and rainfall on (AQI) (PM2.5). [ABSTRACT FROM AUTHOR]

Despite these interventions, there is no detection of serovar new serovar of dengue and dengue-like illness (Kathmandu Syndrome?) is on the rise in Kathmandu. Dengue is a febrile disease caused by the dengue virus (Flaviviridae Family) transmitted by I Aedes i mosquitoes ( I Aedes aegypti i and I Aedes albopictus i ). [Extracted from the article]