1. Subcortical volumetric abnormalities in bipolar disorder
- Author
-
Paul M. Thompson, Joshua Faskowitz, Jerod M. Rasmussen, Chantal Henry, Michael Bauer, Jorge R. C. Almeida, Oliver Gruber, L. Abramovic, Mary L. Phillips, Mikael Landén, Godfrey D. Pearlson, Amelia Versace, Lars T. Westlye, Anders M. Dale, Martin Ingvar, Andrew M. McIntosh, Christoph Abé, Marco P. Boks, Clare E. Mackay, Ralica Dimitrova, Xavier Caseras, Sophia Frangou, Daniel H. Wolf, Adrian J. Lloyd, Carrie E. Bearden, Ingrid Agartz, Benny Liberg, Allan H. Young, N.E.M. van Haren, Josselin Houenou, Louise Emsell, Nhat Trung Doan, Amy C. Bilderbeck, T.G.M. van Erp, Tomas Hajek, Nelson B. Freimer, Bernd Krämer, Benson Mwangi, Emma Sprooten, Derrek P. Hibar, G. Delvecchio, Natalia Lawrence, Jess E. Sussmann, Thomas Nickson, C J Ekman, Unn K. Haukvik, Colm McDonald, Ole A. Andreassen, Martin Alda, Cathy Scanlon, Roel A. Ophoff, Dara M. Cannon, David C. Glahn, Erlend Bøen, Saskia P. Hagenaars, Heather C. Whalley, Cecilie B. Hartberg, Ulrik Fredrik Malt, C. Bourne, Andrea Pfennig, Guy M. Goodwin, Torbjørn Elvsåshagen, Joanne Kenney, Jair C. Soares, Theodore D. Satterthwaite, Sarah Trost, René S. Kahn, Danai Dima, Cassandra D. Leonardo, and Scott C. Fears
- Subjects
Male ,Bipolar Disorder ,Subcortical volumetric abnormalities ,bipolar disorder ,Hippocampus ,Medical and Health Sciences ,functional neuroanatomy ,Lateral ventricles ,0302 clinical medicine ,Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar Endophenotypes ,2.1 Biological and endogenous factors ,Aetiology ,Psychiatry ,Putamen ,Brain ,Organ Size ,Biological Sciences ,Middle Aged ,Serious Mental Illness ,Magnetic Resonance Imaging ,3. Good health ,Psychiatry and Mental health ,Mental Health ,Globus pallidus ,Schizophrenia ,Brain size ,Cardiology ,lithium treatment ,Original Article ,Female ,metaanalysis ,Adult ,medicine.medical_specialty ,brain ,Thalamus ,BF ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Rare Diseases ,hippocampal volumes ,Clinical Research ,Internal medicine ,medicine ,Journal Article ,Humans ,Bipolar disorder ,Molecular Biology ,Retrospective Studies ,model ,business.industry ,Psychology and Cognitive Sciences ,Neurosciences ,treatment response ,medicine.disease ,R1 ,Brain Disorders ,030227 psychiatry ,schizophrenia ,mood stabilizers ,nervous system ,Case-Control Studies ,gray-matter volume ,business ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=-0.232; P=3.50 × 10(-7)) and thalamus (d=-0.148; P=4.27 × 10(-3)) and enlarged lateral ventricles (d=-0.260; P=3.93 × 10(-5)) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.Molecular Psychiatry advance online publication, 9 February 2016; doi:10.1038/mp.2015.227. ispartof: Molecular Psychiatry vol:21 issue:12 pages:1710-1716 ispartof: location:England status: published
- Published
- 2016
- Full Text
- View/download PDF