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395 results on '"Subbaramaiah, Kotha"'

1. Data from NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non–Small Cell Lung Cancer

Author

Hughes, Duncan, primary, Otani, Taisuke, primary, Yang, Peiying, primary, Newman, Robert A., primary, Yantiss, Rhonda K., primary, Altorki, Nasser K., primary, Port, Jeff L., primary, Yan, Min, primary, Markowitz, Sanford D., primary, Mazumdar, Madhu, primary, Tai, Hsin-Hsiung, primary, Subbaramaiah, Kotha, primary, and Dannenberg, Andrew J., primary

Published
2023
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4. Perspective on this Article from NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non–Small Cell Lung Cancer

Author

Hughes, Duncan, primary, Otani, Taisuke, primary, Yang, Peiying, primary, Newman, Robert A., primary, Yantiss, Rhonda K., primary, Altorki, Nasser K., primary, Port, Jeff L., primary, Yan, Min, primary, Markowitz, Sanford D., primary, Mazumdar, Madhu, primary, Tai, Hsin-Hsiung, primary, Subbaramaiah, Kotha, primary, and Dannenberg, Andrew J., primary

Published
2023
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9. Data from Obesity Is Associated with Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland

Author

Subbaramaiah, Kotha, primary, Howe, Louise R., primary, Bhardwaj, Priya, primary, Du, Baoheng, primary, Gravaghi, Claudia, primary, Yantiss, Rhonda K., primary, Zhou, Xi Kathy, primary, Blaho, Victoria A., primary, Hla, Timothy, primary, Yang, Peiying, primary, Kopelovich, Levy, primary, Hudis, Clifford A., primary, and Dannenberg, Andrew J., primary

Published
2023
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11. Data from Effects of Cigarette Smoke on the Human Oral Mucosal Transcriptome

Author

Boyle, Jay O., primary, Gümüş, Zeynep H., primary, Kacker, Ashutosh, primary, Choksi, Vishal L., primary, Bocker, Jennifer M., primary, Zhou, Xi Kathy, primary, Yantiss, Rhonda K., primary, Hughes, Duncan B., primary, Du, Baoheng, primary, Judson, Benjamin L., primary, Subbaramaiah, Kotha, primary, and Dannenberg, Andrew J., primary

Published
2023
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12. Data from The Effect of HIV and HPV Coinfection on Cervical COX-2 Expression and Systemic Prostaglandin E2 Levels

Author

Fitzgerald, Daniel W., primary, Bezak, Karl, primary, Ocheretina, Oksana, primary, Riviere, Cynthia, primary, Wright, Thomas C., primary, Milne, Ginger L., primary, Zhou, Xi Kathy, primary, Du, Baoheng, primary, Subbaramaiah, Kotha, primary, Byrt, Erin, primary, Goodwin, Matthew L., primary, Rafii, Arash, primary, and Dannenberg, Andrew J., primary

Published
2023
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17. Supplementary Data from Obesity Is Associated with Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland

Author

Subbaramaiah, Kotha, primary, Howe, Louise R., primary, Bhardwaj, Priya, primary, Du, Baoheng, primary, Gravaghi, Claudia, primary, Yantiss, Rhonda K., primary, Zhou, Xi Kathy, primary, Blaho, Victoria A., primary, Hla, Timothy, primary, Yang, Peiying, primary, Kopelovich, Levy, primary, Hudis, Clifford A., primary, and Dannenberg, Andrew J., primary

Published
2023
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22. Commentaries for This Article from The Effect of HIV and HPV Coinfection on Cervical COX-2 Expression and Systemic Prostaglandin E2 Levels

Author

Fitzgerald, Daniel W., primary, Bezak, Karl, primary, Ocheretina, Oksana, primary, Riviere, Cynthia, primary, Wright, Thomas C., primary, Milne, Ginger L., primary, Zhou, Xi Kathy, primary, Du, Baoheng, primary, Subbaramaiah, Kotha, primary, Byrt, Erin, primary, Goodwin, Matthew L., primary, Rafii, Arash, primary, and Dannenberg, Andrew J., primary

Published
2023
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28. Supplementary Methods, Figures 1-6 from Selective Visualization of Cyclooxygenase-2 in Inflammation and Cancer by Targeted Fluorescent Imaging Agents

Author

Uddin, Md. Jashim, primary, Crews, Brenda C., primary, Blobaum, Anna L., primary, Kingsley, Philip J., primary, Gorden, D. Lee, primary, McIntyre, J. Oliver, primary, Matrisian, Lynn M., primary, Subbaramaiah, Kotha, primary, Dannenberg, Andrew J., primary, Piston, David W., primary, and Marnett, Lawrence J., primary

Published
2023
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38. Retraction: Obesity Is Associated With Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland

Author

Subbaramaiah, Kotha, primary, Howe, Louise R., additional, Bhardwaj, Priya, additional, Du, Baoheng, additional, Gravaghi, Claudia, additional, Yantiss, Rhonda K., additional, Zhou, Xi Kathy, additional, Blaho, Victoria A., additional, Hla, Timothy, additional, Yang, Peiying, additional, Kopelovich, Levy, additional, Hudis, Clifford A., additional, and Dannenberg, Andrew J., additional

Published
2022
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43. Bile acids inhibit [NAD.sup.+]-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes

Author

Miyaki, Akira, Yang, Peiying, Tai, Hsin-Hsiung, Subbaramaiah, Kotha, and Dannenberg, Andrew J.

Subjects
Prostaglandins E -- Research, Prostaglandins E -- Physiological aspects, Bile acids -- Research, Bile acids -- Physiological aspects, Protein kinases -- Research, Protein kinases -- Physiological aspects, Colon cancer -- Research, Colon cancer -- Physiological aspects, Gene expression -- Research, Gene expression -- Physiological aspects, Biological sciences
Abstract

Multiple lines of evidence have suggested a role for both bile acids and prostaglandins (PG) in gastrointestinal carcinogenesis. Levels of [PGE.sub.2] are determined by both synthesis and catabolism. Previously, bile acid-mediated induction of cyclooxygenase-2 (COX-2) was found to stimulate [PGE.sub.2] synthesis. [NAD.sup.+]-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for the catabolism of [PGE.sub.2], has been linked to colorectal carcinogenesis. In this study, we determined whether bile acids altered the expression of 15-PGDH in human colon cancer cell lines. Treatment with unconjugated bile acids (chenodeoxycholate and deoxycholate) suppressed the transcription of 15-PGDH, resulting in reduced amounts of 15-PGDH mRNA, protein, and enzyme activity. Conjugated bile acids were less potent suppressors of 15-PGDH expression than unconjugated bile acids. Treatment with chenodeoxycholate activated protein kinase C (PKC), leading in turn to increased extracellular signal-regulated kinase (ERK) 1/2 activity. Small molecules that inhibited bile acid-mediated activation of PKC and ERK1/2 also blocked the downregulation of 15-PGDH. Bile acids induced early growth response factor-1 (Egr-1) and Snail, a repressive transcription factor that bound to the 15-PGDH promoter. Silencing Egr-1 or Snail blocked chenodeoxycholate-mediated downregulation of 15-PGDH. Together, these data indicate that bile acids activate the signal transduction pathway PKC [right arrow] ERK1/2 [right arrow] Egr-1 [right arrow] Snail and thereby suppress 15-PGDH transcription. Bile acids appear to increase the release of PGs from cells by downregulating catabolism in addition to stimulating synthesis. These results provide new mechanistic insights into the link between bile acids and gastrointestinal carcinogenesis. prostaglandin [E.sub.2]; early growth response factor-l; Snail; mitogen-activated protein kinase

Published
2009

45. Levels of [NAD.sup.+]-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-[alpha]

Author

Otani, Taisuke, Yamaguchi, Kentaro, Scherl, Ellen, Du, Baoheng, Tai, Hsin-Hsiung, Greifer, Melanie, Petrovic, Lydia, Daikoku, Takiko, Dey, Sudhansu K., Subbaramaiah, Kotha, and Dannenberg, Andrew J.

Subjects
Inflammatory bowel diseases -- Risk factors, Prostaglandins -- Health aspects, Messenger RNA -- Research, Biological sciences
Abstract

Increased amounts of [PGE.sub.2] have been detected in the inflamed mucosa of patients with inflammatory bowel disease (IBD). This increase has been attributed to enhanced synthesis rather than reduced catabolism of [PGE.sub.2]. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) plays a major role in the catabolism of [PGE.sub.2]. In this study, we investigated whether amounts of 15-PGDH were altered in inflamed mucosa from patients with IBD. Amounts of 15-PGDH protein and mRNA were markedly reduced in inflamed mucosa from patients with Crohn's disease and ulcerative colitis. In situ hybridization demonstrated that 15-PGDH was expressed in normal colonic epithelium but was virtually absent in inflamed colonic mucosa from IBD patients. Because of the importance of TNF-[alpha] in IBD, we also determined the effects of TNF-[alpha] on the expression of 15-PGDH in vitro. Treatment with TNF-[alpha] suppressed the transcription of 15-PGDH in human colonocytes, resulting in reduced amounts of 15-PGDH mRNA and protein and enzyme activity. In contrast, TNF-[alpha] induced two enzymes (cyclooxygenase-2 and microsomal prostaglandin E synthase-1) that contribute to increased synthesis of [PGE.sub.2]. Overexpressing 15-PGDH blocked the increase in [PGE.sub.2] production mediated by TNF-[alpha]. Taken together, these results suggest that reduced expression of 15-PGDH contributes to the elevated levels of [PGE.sub.2] found in inflamed mucosa of IBD patients. The decrease in amounts of 15-PGDH in inflamed mucosa can be explained at least, in part, by TNF-[alpha]-mediated suppression of 15-PGDH transcription. prostaglandin [E.sub.2]; inflammatory bowel disease; tumor necrosis factor-[alpha]; cyclooxygenase

Published
2006

46. Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk

Author

Terry, Mary Beth, Gammon, Marilie D., Fang Fang Zhang, Tawfik, Heba, Teitelbaum, Susan L, Britton, Julie A, Subbaramaiah, Kotha, and Dannenberg, Andrew J.

Subjects
Nonsteroidal anti-inflammatory drugs -- Dosage and administration, Nonsteroidal anti-inflammatory drugs -- Research, Aspirin -- Dosage and administration, Aspirin -- Research, Breast cancer -- Care and treatment, Breast cancer -- Research
Abstract

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are effective chemopreventive agents for breast cancer. The reduction in the incidence of breast cancer with aspirin use was seen among those with hormone receptor-positive tumors.

Published
2004

47. The overexpression of cyclo-oxygenase-2 in chronic periodontitis

Author

Zhang, Fan, Engebretson, Steven P., Cavanaugh, Paul F., Jr., Subbaramaiah, Kotha, and Dannenberg, Andrew J.

Subjects
Health
Abstract

People with periodontal disease may have greater than normal amounts of cyclo-oxygenase-2 (COX-2) in the fluid in space between their gums and teeth. This confirms that gingivitis is an inflammation of the gums. These patients could be treated with COX-2 inhibitors.

Published
2003

48. Cyclooxygenase 2: a molecular target for cancer prevention and treatment

Author

Subbaramaiah, Kotha and Dannenberg, Andrew J.

Subjects
COX-2 inhibitors -- Research, Cancer -- Research, Biological sciences, Chemistry, Pharmaceuticals and cosmetics industries
Abstract

Cyclooxygenase 2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in several human cancers. Here, the potential utility of selective COX-2 inhibitors in the prevention and treatment of cancer is considered. The mechanisms by which COX-2 levels increase in cancers, key data that indicate a causal link between increased COX-2 activity and tumorigenesis, and possible mechanisms of action of COX-2 are discussed. In a proof-of-principle clinical trial, treatment with the selective COX-2 inhibitor celecoxib reduced the number of colorectal polyps in patients with familial adenomatous polyposis. Selective COX-2 inhibitors appear to be sufficiently safe to permit large-scale clinical testing and numerous clinical trials are currently under way to determine whether selective inhibitors of COX-2 are effective in the prevention and treatment of cancer.

Published
2003

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