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Diabetes is one of the chronic medical condition with high prevalence rates. Long standing diabetes is associated with impaired cognitive functioning. Yoga is known to improve the cognitive functions in normal and chronic diseased individuals. Mind sound resonance technique (MSRT) is one of the mindfulness based yogic relaxation technique, know to enhance cognitive functions. The objective comprised to study the immediate effect of MSRT practice on cognitive function in patient with type 2 diabetes.Forty three (18 male) type 2 diabetes patientswith an age range between 30 to 65 (mean age ± SD = 56.83 ± 12.54) with minimum history of diabetes since last 5 years, were enrolled in this study. All the subjects underwent training of 15 sessions of MSRT practice in 6 days. 7th day subjects were administered DLST before and immediately after the MSRT intervention. Data was found normally distributed by Shapiro-Wilcox test. The paired sample t test was used to see the pre-post changes.There was significant improvement in total score (p = 0.001; +24.99) and net score (p = 0.001; +25.47) along with a nonsignificant decrease in wrong attempts (p- 0.855) of DLST.Present pilot study indicates that MSRT may have a potential role in enhancing psychomotor performance in patients suffering from diabetes, immediately after the practice. These findings need confirmation from studies with a larger sample size and randomized controlled design, which will be implicated in the future. Key words: Mind sound resonance technique; psychomotor performance; diabetes, mindfulness, cognitive function