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Objectives: The purpose of study was to report the clinical improvement of late complications of COVID-19 patient complaining of dyspnea treated with Korean medicine pulmonary rehabilitation.Methods: To assess the treatment outcomes, we used the modified medical research council scale (mMRC), 6-minute walk distance (6MWD), peak expiratory flow rate (PEFR), St. George respiratory questionnaire (SGRQ).Results: After treatments, the patient’s clinical symptoms were improved with mMRC, 6MWD, PEFR, and SGRQ.Conclusions: The Korean medicine pulmonary rehabilitation was effective in the treatment of late complications of COVID-19 patient. This study suggested the possibility of Korean Medicine pulmonary rehabilitation program in the clinic for late complications of COVID-19.

In this study, the two-phase pressure drop in a one-sided high-heat-loaded screw tube was analyzed under subcooled flow boiling conditions. When the loaded heat flux is gradually increased under one-sided heating conditions, although the pressure drop changes slightly in the single phase, it starts to increase when loading above the onset of significant void (OSV) heat flux. The effect of system parameters on the two-phase pressure drop in relation to the change of heat transfer mechanism or fluid properties was analyzed according to each variable change. In addition, this study evaluated the prediction performance of existing two-phase pressure drop multiplier correlations developed under subcooled flow boiling conditions. Because most existing correlations are based on a smooth channel with a small diameter, they tend to overpredict the experimental values. The correlation proposed by Ramesh showed the lowest average error rate (31.94%); however, the results were underpredicted for high-heat-flux conditions. To obtain more accurate results, we developed a Python code using an artificial intelligence regression method to proceed with the optimization process based on the experimental values. Using this code, we developed a novel two-phase pressure drop multiplier correlation for a one-side-heated screw tube that can be used in fusion divertors under high-heat-load conditions.

Objectives: This study aimed to review the clinical research of the gut microbiome for respiratory diseases to assist the design of trials for respiratory diseases by regulating the gut microbiome with herbal medicine later. Methods: We searched three international databases (PubMed, CENTRAL and EMBASE) to investigate randomized controlled trials (RCTs) of the gut microbiome for respiratory diseases. The selected trials were analyzed by study design, subject diseases, inclusion/exclusion criteria, sample size, study period, intervention group, control group, outcome measures, and study results. Results: A total of 25 studies were included and published from 1994 to 2021 mostly in Europe and Asia. Subject diseases were many in the order of respiratory tract infection, cystic fibrosis, allergy, and so on. As outcome measures, the gut microbiome in a fecal sample was analyzed by 16S rRNA sequencing analysis method, and symptom assessment tools related each disease were used. Major intervention drugs were probiotics and the results were mostly improved in the composition and diversity of the gut microbiome. Conclusion: Clinical studies of the gut microbiome for respiratory diseases have confirmed various effects and this review provides basic data for a well-designed clinical study for respiratory diseases by regulating the gut microbiome with herbal medicine.

Objectives: This study is aimed to evaluate the protective effects of GGX on lung injury of Chronic Obstructive Lung Disease (COPD) mice model. Materials and Methods: C57BL/6 mice were challenged with lipopolysaccharide (LPS) and cigarette smoke extract (CSE) and then treated with vehicle only (Control group), dexamethasone 3 ㎎/㎏ (Dexa group), gam-gil-tang 200 ㎎/㎏ (GGT group), GGX 100, 200, and 400 ㎎/㎏ (GGX group). After sacrifice, its bronchoalveolar lavage fluid (BALF) or lung tissue was analyzed with cytospin, Enzyme-Linked Immunosorbent Assay (ELISA), real-time polymerase chain reaction (PCR) and hematoxylin & eosin (H&E), and Masson’s trichrome staining. Results: In the COPD model, GGX significantly inhibited the increase of neutrophils, TNF-α, IL-17A, CXCL-1, MIP2 in BALF and TNF-α, IL-1β, IL-10 mRNA expression in lung tissue. It also decreased the severity of histological lung injury. Conclusion: This study suggests the usability of GGX for COPD patients by controlling lung tissue injury.

Our first strategy for rapidly accessing pyrrolidinone cores of salinosporamides involved combined use of memory of chirality and dynamic kinetic resolution principles in aldol reactions of the serine-derived 5-oxazolidinone substrate, which was ultimately unsuccessful with respect to enantioselectivity. This failure led us to the revised strategy. The influence of the stereocenter in 5-oxazolidinone enabled selective installation of the C-2 stereocenter. The intramolecular aldol reaction of the C-2 stereodefined aldol substrate was successful. An unexpected hydrolytic dynamic kinetic resolution was observed in hydrolyses of the bicyclic aldol products. This unprecedented substrate-driven hydrolytic dynamic kinetic resolution was utilized in preparing the pyrrolidinone core with excellent efficiency. Through this strategy, the concise total syntheses of salinosporamides A and B as well as cinnabaramides A, E, and F were achieved with high selectivity.

In this study, the heat transfer characteristics of one-side heated screw tubes were analyzed using subcooled flow boiling experiments. The experiments were performed until the critical heat flux was reached, while the applied heat flux was gradually increased. Subsequently, the boiling curves derived from the experimental results were divided into partial nucleate boiling (PDB) and fully developed nucleate boiling (FDB) regimes. As the flow rate increases, the forced convective heat transfer is enhanced, improving the single-phase heat transfer performance. However, as the FDB region is approached, most of the heat transfer proceeds via nucleate boiling heat transfer, so the heat transfer coefficient curve converges into the same straight line. The same trend was observed when analyzing the effect of the degree of subcooling. However, as the system pressure increased, and the liquid surface tension and latent heat decreased, a faster transition was observed from the single-phase regime to the PDB regime. From evaluating the prediction performance of the existing subcooled flow boiling heat transfer correlations, among the PDB regime; Liu and Winterton correlation, a kind of Chen-type correlation, showed the highest accuracy with mean absolute error (MAE) of 13.62% and root mean square error (RMSE) of 16.13%. However, most of the FDB correlations did not accurately predict the heat transfer performance of the one-side heated screw tube under a high heat flux load of several MW/m2. Therefore, a new screw tube FDB correlation was developed using Python code combined with artificial intelligence technology. The authors believe that the proposed correlation will be useful for not only predicting the heat transfer performance in the FDB region, but also establishing an operating map of the screw tube in the future.

Background. Allergic rhinitis (AR) is a common disease, and conventional medications are often insufficient for treatment. Bojungikgi-tang (BJIGT) is an herbal medicine widely used in traditional medicine and has anti-inflammatory and immunoregulatory effects. We hypothesize that BJIGT would improve nasal symptoms in patients with persistent AR (PAR). Methods. This is a randomized, double-blind, placebo-controlled, phase II trial. A total of 105 patients, identified with perennial allergens, with a history of PAR and a mean total nasal symptom score (TNSS) ≥ 5 during the run-in period will be recruited from Daejeon Korean Medicine Hospital. Participants will be randomly assigned to a high-dose BJIGT group, standard-dose BJIGT group, or control group (placebo) in a 1 : 1 : 1 allocation ratio after a week run-in period. The treatment medication will be taken three times per day for 4 weeks. The primary outcome measure is the mean change in the TNSS before and after medication. The secondary outcome measures include the Korean Allergic Rhinitis-Specific Quality of Life Questionnaire, total IgE and eosinophil count, overall assessment of AR, pattern identification questionnaire for AR, and Sasang constitution. Discussion. The aim of this study is to investigate the efficacy and safety of BJIGT in the treatment of PAR and to determine the suitable dosage of BJIGT. Therefore, we planned a randomized, controlled, phase II trial of two different doses of BJIGT compared with placebo, and the results of this study are expected to provide evidence for the use of BJIGT as a treatment of PAR. Trial Registration. The National Clinical Trial Registry Clinical Research Information Service, CRIS, KCT0006616, https://cris.nih.go.kr/cris/search/detailSearch.do/20706.

Background. Obstructive airway disease is a major health problem and has a great impact on global socioeconomic burden. Despite therapeutic advances in recent decades, there is still a need for effective and safe therapeutic agents for patients with asthma or chronic obstructive pulmonary disease (COPD). Methods. This prospective observational study explored the effects of herbal medicines in patients with asthma and COPD. All participants visited the hospital at least every 4 weeks for 12 weeks to receive their herbal medicines based on their pattern identification and to evaluate safety and efficacy endpoints. We followed the diagnostic criteria used by Korean medicine doctors to prescribe herbal medicines, explored variations in prescribed herbal medicines, and explored a number of clinical features in patients with asthma or COPD. Results. A total of 24 patients were enrolled: 14 were diagnosed with asthma and 10 with COPD and 19 completed the study. After 12 weeks of herbal medicine treatment, herbal medicines significantly improved the modified Clinical Asthma Measurement Scale in Oriental Medicine-V in asthma patients and the modified Medical Research Council Dyspnoea Scale and St. George’s Respiratory Questionnaire in COPD patients. For all patients, modified Medical Research Council Dyspnoea Scale score and interleukin-13 were found to be significantly different after treatment. Additionally, the majority of patients were satisfied with our herbal medicine treatments, and no severe adverse events were reported during the study. Conclusions. Our study provides preliminary clinical data on the safety and efficacy of herbal medicines in patients with asthma and COPD.

Acute bronchitis and acute exacerbations of chronic bronchitis (AECB) have cough and sputum as the main symptoms with a high prevalence and substantial economic burden. Although the demand for bronchitis treatment increases due to causes, such as air pollution, the appropriateness of antibiotic prescriptions and the effects of current symptomatic treatments for bronchitis are unclear. GHX02, which is a combined formulation containing four herbs, and has been clinically used for bronchitis in South Korea. We conducted a phase II, randomized, double-blind, and placebo-controlled, multicenter trial to evaluate its efficacy and safety. Patients with acute bronchitis or AECB were recruited and randomized to receive high-dose GHX02 (1920 mg/day), standard-dose GHX02 (960 mg/day), or placebo for 7 days. The primary outcome measure was the change in Bronchitis Severity Score (BSS) from baseline to Day 7. The secondary outcomes were the frequency of coughing fits, Questionnaire of Clinical Symptoms of Cough and Sputum (QCSCS), Leicester Cough Questionnaire (LCQ), Integrative Medicine Outcome Scale (IMOS), and Integrative Medicine Patient Satisfaction Scale (IMPSS). A total of 117 patients were randomized to parallel groups (38 in the high-dose GHX02, 41 in the standard-dose GHX02 group, and 38 in the placebo group). The mean differences in BSS from baseline to Day 7 in the treatment groups (4.2 ± 2.0 and 4.5 ± 1.8 in the high-dose GHX02 and standard-dose GHX02 groups, respectively) were higher than the placebo group (3.8 ± 2.1), p = 0.028. The mean differences in the frequency of coughing fits from baseline to Day 7 and IMPSS were better in the GHX02 treatment group than in the placebo group (standard-dose GHX02 group vs placebo group, p = 0.036). The QCSCS, LCQ, IMOS, and GHX02 of the treatment groups also showed more improvement than the placebo group, but there were no statistically significant differences between the groups. There were no severe adverse effects during the trial. This study supports that GHX02 is effective and safe for patients with bronchitis and provides the basis for progression to a phase III study.Clinical Trial Registration: [https://cris.nih.go.kr] WHO International Clinical Trials Registry Platform, Clinical Research Information Service [KCT0003665].

The aim of this study was to evaluate the efficacy and safety of CAEC (Canavalia gladiata arctium lappa extract complex) in adults with white blood cells between 3 and 8 × 103 cells/µL by assessing natural killer (NK) cell activity and immune-related biomarkers. Overall, 100 participants (CAEC group = 50, placebo group = 50) were randomised, and administered CAEC or placebo once daily for 8 weeks, with an evaluation visit performed every 4 weeks. NK cell activity, the primary outcome, significantly increased in CAEC when compared with the placebo at effector-to-target (E:T) ratios of 25:1 and 50:1 after 8 weeks. Compared with the placebo group, IL-10 demonstrated significant differences at week 8 in the CAEC group. Our findings demonstrate that CAEC is safe and enhances immune function by stimulating NK cell activity through IL-10 expression. Hence, we anticipate that CAEC can be developed as a functional food for stimulating immunity.

Ethnopharmacological relevance The modified gamgil-tang (GGX) is a mixture of four herbal medicine including Platycodi Radix, Glycyrrhizae Radix, Lonicerae Flos and Mori Radicis Cortex which has been traditionally used to treat lung and airway diseases to relieve symptoms like sore throat, cough, and sputum in Korea. Its major component chlorogenic acid had been reported to have antioxidant, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antiviral, and anti-microbial activity. Aim of the study To identify the inhibitory effect of GGX in a particulate matter (PM) induced lung injury mouse model. Materials and methods We evaluated NO production, the release of TNF-α and IFN-γ in PM-induced MH-S cells, and the number of neutrophils, immune cell subtypes, and the secretion of TNF-α, IL-17, CXCL-1, MIP-2 in the PM-stimulated mouse model to assess the inhibitory effect of GGX against PM. In addition, as exposure to PM increases respiratory symptoms, typically cough and sputum, we attempted to evaluate the antitussive and expectorant activities of GGX. Results Our study provided evidence that GGX has inhibitory effects in PM-induced lung injury by inhibiting the increase in neutrophil and inflammatory mediators, deactivating T cells, and ameliorating lung tissue damage. Notably, GGX reduced PM-induced neutrophilic inflammation by attenuating the number of neutrophils and regulating the secretion of neutrophil-related cytokines and chemokines, such as TNF-α, IL-17, MIP2, and CXCL-1. In addition, GGX demonstrated an antitussive activity by significantly reducing citric acid-induced cough frequency and delaying the latent period and expectorant activities by the increased phenol red secretion compared to the control group. Conclusions GGX is expected to be an effective herbal remedy to prevent PM-induced respiratory disease.

Background: Pulmonary rehabilitation (PR) is a management modality that improves the quality of life of patients with chronic obstructive pulmonary disease (COPD); however, PR is not readily accessible. Therefore, we developed lung-conduction exercises (LCE) that can be performed easily without any limitations. The purpose of this randomized, assessor-blind, multicenter pilot trial was to compare the effects of LCE with PR and standard care (SC) in COPD patients. Methods: Twenty-five participants who met the eligibility criteria were randomly allocated to the SC group (only medication, n = 9), LCE group (medication + LCE, 5 times a week, n = 8), or PR group (medication + PR, 5 times a week, n = 8). The 6-minute walk distance (6WMD), pulmonary function test, modified Medical Research Council dyspnea scale, COPD assessment test (CAT), and St. George Respiratory Questionnaire (SGRQ) survey were carried out before starting the trial and after 4 and 8 weeks to determine motor performance, lung function, and dyspnea. Results: After 8 weeks, the pulmonary function test scores were the same. The 6MWD (PR, 28.3 ± 38.5; LCE, 14.5 ± 53.1; SC, 11.5 ± 20.5; P = .984), modified Medical Research Council dyspnea scale (PR, 0.8 ± 1.0; LCE, 0.8 ± 0.8; SC, 0.3 ± 0.5; P = .772), CAT (PR, 7.3 ± 6.2; LCE, 4.2 ± 5.2; SC, 1.0 ± 2.2; P = .232), and SGRQ scores (PR, 11.5 ± 15.4; LCE, 5.5 ± 13.1; SC, 4.8 ± 5.1; P = .358 [PR vs LCE], P = .795 [PR vs SC]) had improved in order of PR, LCE, and SC group. Although there were no statistically significant differences in the outcome measures between the groups, there were clinically significant improvements in the CAT and SGRQ scores. Conclusions: In this trial, PR showed more improvement in symptoms and quality of life than SC alone. To seek a more precise use of LCE, further full-sized studies with a long duration and additional outcome measures such as psychological assessment tools and cost-effectiveness ratio should be conducted. Trial registration: KCT0004724.

본 연구는 수해폐기물 관리에 대한 청주시 사례조사를 통하여 실제적인 지방정부의 정책대안을 마 련하고자 하였다. 청주시의 사례를 통해 종합적으로 판단해 볼 때 우리나라의 수해폐기물 관리는 평상 시 생활폐기물 체계에서 업무강도를 늘리거나, 그럼에도 불구하고 초과하는 수해폐기물에 대 해서는 위탁 처리하는 수준에 그치고 있었다. 이러한 실태에 따른 문제는 복구지체, 생활계 유해폐기 물 관리 취약성, 재활용 및 재이용 부족으로 나타나고 있었다. 향후 지속적으로 발생할 수 있는 수해 폐기물에 대비하기 위해서는 동⋅면⋅읍 단위의 수해폐기물 관리 세부계획 수립, 유해폐기물의 별 도 관리가 필요하다. 그리고 폐기물 처리에 있어서 가연성 물질은 전량 소각처리가 이루어지고 있었 으며, 자갈과 같은 무기물은 전량 매립처리 되고 있었다. 수해폐기물은 다량으로 많은 양의 폐기물이 발생하는 만큼 처리의 다변화가 필요하며, 이를 위해 가연물과 무기물의 재활용 비율을 늘려나가는 방안이 필요하다고 판단된다.

In this study, the onset of flow instability (OFI) heat flux of a one-side heated swirl tube is experimentally investigated. The OFI heat flux means the minimum heat flux that can cause flow instability by the vapor generated in the flow path. An analysis of the effect of system parameters on the OFI heat flux indicates that as the pressure increases, the bubble size decreases. Therefore, the void fraction decreases and, consequently, the OFI heat flux tends to increase. Similarly, the higher the flow rate and degree of subcooling, the faster the vapor can be removed; thus, the OFI heat flux increases. In addition, the prediction performances of the existing OFI correlations developed under the subcooled flow-boiling condition are evaluated. Therefore, although the Wang correlation indicates the lowest error rate, it yields a high mean absolute error rate of 87.75%. Thus, it is difficult to predict the OFI heat flux of a one-side heated swirl tube using the existing OFI correlations. Therefore, in this study, a new correlation is developed using a Python code created by employing an artificial intelligence regression method. The developed correlation incorporates the impact of one-side heating, swirl tape, mass flow rate, subcooling, and pressure (mean absolute error = 12.17%, root mean square error = 14.99%).

An Organic Rankine Cycle (ORC) has a variety of environmental and operating conditions, which result in different efficiency and net work of cycle. In this regard, it is important to determine the optimal operating conditions with the consideration of various operating variables since the outcomes of the low-grade waste heat recovery systems are low as well as highly dependent on the conditions. In this study, the ORC having seawater as a heat source and LNG cold energy as a heat sink is analyzed with cycle parameters as well as the environmental conditions such as seawater temperature. An ORC Economic evaluation Code (OEC) is developed to consider the effects of numerous parameters such as the pump outlet pressure, mass flow rate, pinch point, materials of the heat exchangers, the type of working fluid, cycle configuration, and seawater temperature simultaneously. Based on the analysis, an economic assessment is conducted, so we could find the optimal conditions for the designed ORC systems. Also, it is found that the seawater temperature variation could affect about 23.8% in terms of net work compared to fixed heat source temperature conditions.

In this study, the onset of flow instability (OFI) of the hypervapotron channel was experimentally explored under one-side high heat load conditions. The OFI was detected based on the heat flux (q'') where the standard deviation of the inlet pressure rapidly increased. Moreover, the effect of the system parameters was analyzed, showing that the OFI q'' increased as the inset subcooling and mass flow rate increased. The reason is the high subcooling and flow rate that rapidly condense the vapor, which is the leading cause of OFI. Unfortunately, because most of the OFI correlations in previous studies were developed based on micro-channels, these correlations could not predict the hypervapotron OFI q'' properly under one-side high heat load conditions. Finally, the authors found that the Reynolds number and Jakob number were inversely proportional to the ratio of the OFI heat flux (q''OFI) and saturation heat flux (q''sat). Furthermore, a new correlation was developed using a PYTHON code and an artificial intelligence technique (mean absolute error rate =12.89%, root mean square error rate =14.81%).

In nuclear power plants (NPPs), one of the important yet uncertain phenomena during a station blackout (SBO) accident is the possibility for a counter-current natural circulation flow in the reactor coolant system (RCS) pressure boundary, which could divert the core melt progression and/or the in-vessel fission product (FP) distribution and, in turn, lead to a heatup and eventual creep rupture. From the risk and accident management points of view, one of key concerns is to predict more explicitly whether such a creep rupture can occur in the RCS pressure boundary, and if it indeed can, also predict the most probable time and the most likely location. This paper presents plant-specific analysis results on the potential characteristics of natural circulation-induced creep rupture of the RCS pressure boundary that could potentially take place during an SBO accident of a reference pressurized water reactor (APR1400). MELCOR-CFD (Computational Fluid Dynamics) coupled analysis was performed to determine more precisely the relevant physical parameter that could greatly influence on the behaviour of natural circulation and the ensuing creep rupture. Multiple sensitivity analyses were also carried out to investigate the influence that particular MELCOR modeling schemes and plant conditions have in estimating the RCS creep rupture characteristics. The analysis results and relevant insights were summarized in terms of particular points of interest.

This study was conducted to investigate the effect of chlorine dioxide fumigation as a substitute for sulfur fumigation which has been used as a method to prevent the quality change of persimmon during storage and distribution process. Dried persimmons were treated with chlorine dioxide gas concentration (0, 15 30, and 45 ppm) and time (0, 15, 30, and 45 min) and microbiological changes, texture properties and color of the treated samples were investigated during storage at room temperature. Total aerobic bacteria, yeast and mold numbers after chlorine dioxide gas fumigation were decreased when compared with the control group. The inhibitory effects of total aerobic bacteria, yeast, and mold were observed during storage. The texture properties and color value of dried persimmons were not affected by chlorine dioxide gas fumigation concentration and time. There was no difference in quality between chlorine dioxide gas fumigation treatment group and control group. These results suggested that chlorine dioxide gas fumigation treatment can be utilized as a processing technique to secure microbiological storage stability of dried persimmons.

A steam generator tube rupture (SGTR) is a type of containment bypass accidents that if core damage is not prevented during this accident progression, has the potential to lead to a significant release of fission products (FPs) to the environment through the faulted steam generator (SG) or other possible paths in the secondary system. This paper presents a best practice modeling approach to more realistically quantify the FP source terms expected during an SGTR accident of a reference pressurized water reactor (PWR) plant, and also investigates the impact of dedicated accident mitigation actions on the results of interest through the established modeling approach. To consider the integral responses of the reactor, SGs, and containment to a severe accident initiated by SGTR, detailed modeling was performed for a broad spectrum of plant safety/mitigation systems and relevant phenomena influencing the evolution of the accident. As the modeling and simulation tools for the SGTR accident analysis, MELCOR 2.2 and MAAP5 were employed to compare the results of interest. The results of the analysis demonstrate that the release of FPs into the environment could be estimated more realistically as a result of the best practice modeling for the SGTR accident and also it could be greatly decreased through dedicated mitigation actions. Relevant insights are summarized in terms of particular points of interest and remaining uncertainty issues for further study.

To investigate biological activities in Aronia melanocarpa various drying methods were employed such as vacuum freeze drying, hot air drying and cold air drying. DPPH radical scavenging activity and ABTS radical scavenging activity of vacuum freeze dried Aronia melanocarpa was higher than hot and cold air dried Aronia melanocarpa. Vacuum freeze drying method showed the greatest contents of total phenol (15.34 g GAE/100 g), flavonoid (3.10 g GE/100 g) and tannin (2.46 g TE/100 g). Total anthocyanin content decreased to 163.52 mg C3G/100 g and 50.15 mg C3G/100 g for hot and cold air drying, respectively. Vacuum freeze-dried method increased the total anthocyanin content (743.09 mg C3G/100 g) when compared with fresh Aronia melanocarpa (163.52 mg C3G/100 g). Total proanthocyanidin content of vacuum freeze dried Aronia melanocarpa has increased to 6.21 g CE/100 g more than eight times compared with fresh Aronia melanocarpa (0.71 g CE/100 g). Chlorogenic acid and neochlorogenic acid content of vacuum freeze dried Aronia melanocarpa were higher than hot air dried and cold air dried Aronia melanocarpa, increasing about three times compared with fresh Aronia melanocarpa. These results suggested that vacuum freeze drying is optimal drying method to enhance biological activities in Aronia melanocarpa.

In order to investigate the utilization of the Omija (Schizandra chinensis Baillon) extract as a natural coagulant for manufacturing soybean curd, the quality characteristics of white (Baktae) and black (Seoritae) soybean curds, coagulated by the Omija extract or MgCl2, were evaluated. Crude protein (6.14±0.30 and 6.25±0.18%, respectively) and crude lipid (10.86±1.74 and 11.29±1.69%, respectively) contents of white and black soybean curds coagulated using the Omija extract were higher than those coagulated using MgCl2. Black soybean curds coagulated using the Omija extract showed higher L, a, and b values than those using MgCl2. The most abundant amino acid in white and black soybean curds coagulated using the Omija extract was arginine (3.74 and 3.71 mg/100 g, dry basis, respectively). The amounts of Ca, K, Mg, and Na were the highest in both soybean curds prepared with the Omija extract. The sensory evaluation (color, flavor, taste, texture, and overall preference) showed that white and black soybean curds coagulated using the Omija extract were more preferred than those produced using MgCl2. The results suggested that using the Omija extract as a natural coagulant agent could improve the quality and sensory characteristics of soybean curds.

An interfacing systems loss of coolant accident (ISLOCA) is a type of containment bypass accident that may lead to a significant release of fission products (FPs) to the environment. This paper presents a best practice modeling approach to more realistically quantify the FP source terms expected during the ISLOCA of a reference pressurized water reactor (PWR) plant and investigates the influence of a dedicated accident mitigation action on the results of interest through the established modeling approach. In addition to this, the key plant features and phenomenological mechanisms that might have a significant influence on the magnitude and timing of FP releases to the environment during an ISLOCA were examined through a couple of sensitivity analyses. To consider the integral responses of the reactor, containment, and auxiliary building to a severe accident initiated by an ISLOCA, detailed modeling was performed for a broad spectrum of relevant phenomena, plant systems, and structures that promote the deposition and retention of FPs along the flow path to the environment. As the modeling and simulation tools for the ISLOCA analysis, MELCOR 2.2 and MAAP5.04 were employed to compare the results of interest. The results of the analysis shows that the present best practice modeling approach proposed here has the potential to significantly decrease the release of FPs into the environment in the event of an ISLOCA. Relevant insights are summarized in terms of particular points of interest and remaining uncertainty issues for further study.

Background: Chronic obstructive pulmonary disease (COPD) is an irreversible disease characterized by cough, sputum production, and dyspnea, and has a high prevalence and mortality. Pulmonary rehabilitation (PR) is a management that improves the quality of life for COPD patients; however, PR is not readily accessible. Therefore, we developed lung-conduction exercises (LCE) that can be performed without any limitations. LCE consists of breathing, stretching, and tapping to relieve dyspnea in COPD patients. Methods/design: This randomized, assessor-blind, multicenter trial aims to recruit 54 patients with moderate and severe COPD. Subjects will be randomly allocated to a control group (only medication), an LCE group (medication + LCE, 5 times a week), or a PR group (medication + PR, 5 times a week). The 6-minute walk distance, pulmonary function tests (forced expiratory volume at 1 second, forced vital capacity, and forced expiratory volume at 1 second/forced vital capacity), modified Borg scale, modified medical research council dyspnea scale, COPD assessment test, and St. George respiratory questionnaire will be measured before starting the trial and after the 4th and 8th weeks to determine motor performance, lung function, and dyspnea. Conclusion: We aim to demonstrate that LCE is effective in improving symptoms and psychosomatic stability in COPD patients. Therefore, this trial will play an important role in fortifying the foundation of clinical application.

Recent shifts in the water resource management paradigm and information and communication technologies (ICT) call for platform-based integrated operation management technology, which provides the multidimensional approach of two-way communication. To domestically prepare for such paradigm changes, research on the Smart Water Grid, which is intelligent water management that combines water resource management with ICT, remains ongoing. In this paper, we propose a framework for using the components of a variety of program modules to build an intelligent water-management-integrated operation system that is appropriate for the Smart Water Grid. In addition, we suggest a system development environment and integrated operation system implementation plan for using the Core-Platform framework

This study investigated the quality characteristics of fermented wines using a selected strain to obtain basic data on sugar-free tomato wine production. Alcohol content of the tomato and commercial wine was 8.2~12.9%, whereas tomato wine showed a relatively low alcohol content of 8.2%. For total phenol content, Chile wine showed the highest value of 162.89 mg/100 g, followed by persimmon wine at 122.33 mg/100 g. Tomato wine showed a relatively high total phenol content of 96.57 mg/100 g. In all sections, xylose was not detected, although there were differences in free sugars depending on each product. Acetic and citric acid contents were highest in tomato wine, and the six kinds of commercial wine and tomato wine showed acetic acid content of 800.6 mg/100 g and citric acid content of 1,064.4 mg/100 g. The total free amino acid content was 100.63 mg/100 g in tomato wine, which was 2~3 times higher compared to that in commercial wine ().

The antioxidative effect and quality characteristics of different drying methods (hot air drying, far-infrared radiation drying, vacuum freeze drying) from Schizandra Chinensis Baillon were investigated. The moisture contents and water activity(Aw) contents each 4.46% and 0.38 values of the vacuum freeze drying were lower than those of other samples. A significant not difference in pH values occurred in all samples (p fructose>sucrose, and that of the total free sugar contents were vacuum freeze drying (6.33 g/100 g) > far infrared drying (5.01 g/100 g) > hot air drying (3.73 g/100g). Antioxidant acitivy (DPPH radical scavenging, ABTS radical scavenging) and total phenol, total flavonoid, and total tannin content was highest in vaccum freeze drying than other different drying methods except nitrite scavenging ability.

The experimental design method based-on the measured data in the several LF monopole antenna was used in MF monopole antenna design. The design technique is also utilized in MF DGPS antenna design. It is not possible to predict the antenna performance of the MF short-monopole antenna because of simple experimental antenna design. Furthermore, it is difficult to design and analyze the various wired short-monopole antenna. The antenna models for performance analysis of the DGPS antenna with the various wired short-monopole structure are proposed in this paper. Based on the proposed antenna models, also, the antenna performance and design data of the wired short-monopole antennas are presented. To evaluate the validity of the analyzed antenna models, the wired short-monopole antenna for 100 kHz are modeled and analyzed. The antenna performance of the wired short-monopole antenna are compared with those of the previously presented LF antenna performance. Based on the evaluation for proposed antenna analyzing models, the DGPS wired short-monopole antennas are modeled and analyzed.

경북대학교 식품외식산업학과 We investigated the quality characteristics of the Korean and American blueberry. There was a similarity between the general composition and sugar content of the Korean and American values. The pH values showed a low of 3.46 in American blueberries to a high of 4.49 in Korean blueberries. The L (lightness), a (redness), and b (yellowness) value scores of the American blueberry were higher than the Korean blueberry. The levels of total phenol content and DPPH radical scavenging abilities were 205 mg%, 93.48% in the Korean blueberry and 182 mg%, 84.32% in the American blueberry, respectively. The free sugar levels showed fructose 2,514 mg%, glucose 2,315 mg%, and sucrose 69 mg% in the Korean blueberry, while the free sugar levels of the American blueberry showed fructose 2,106 mg%, glucose 1,825 mg%. The contents of organic acid were lactic acid and tartaric acid in the Korean blueberry, while the organic acid in the American blueberry contained tartaric acid, succinic acid, oxalic acid, and lactic acid. The Korean blueberry has 12 kinds of free amino acids, while the American blueberry has 9 kinds of free amino acids. Furthermore, the Korean blueberry contains 390 mg% of total amino acids, which was higher than 32% in the American blueberry with 295 mg% of total amino acids. The fatty acid contents of the American blueberry (2,897 mg%) was higher than that of the Korean blueberry (2,783 mg%) as well as in the oleic acid, linoleic acid, and palmitic acid. The mineral contents of all the samples were P>K>Ca>Mg, respectively. Given the above results, the Korean blueberry bioactive chemicals or properties were thought to be somewhat higher than the American blueberry. Key words blueberry, quality characteristics, total phenol, DPPH radical scavenging

Recently, persulfate (PS) has been applied to the oxidation of organic contaminants in wastewater, groundwater, and soil. However, PS requires activation by UV light, heat, transition metal, or pH control to be useful. In particular, transition metals are able to rapidly activate PS to sulfate radical. However, it is difficult to control the concentration of transition metal solution in an environmental setting. In this study, the potential of an electrochemical reaction using an iron anode to activate PS was investigated with phenol as a model contaminant. Based on Faraday’s law, Fe(II) generated by the electrochemical reaction was regularly supplied to the solution to activate PS to sulfate radical. The activation of PS was influenced by current intensity; however, excess Fe(II) decreased the oxidation rate of phenol because anodic oxidation-generated Fe(II) also scavenged sulfate radical. However, the electrochemical reaction using the iron anode could be readily controlled to supply an optimal amount of Fe(II) for activation of PS. Therefore, it is expected that this electrochemical process using an iron anode could be useful for the effective removal of phenol.

The quality of brown rice vinegar that was produced via static culture (A) was compared with the quality of three types of domestic commercial brown rice vinegar (B, C, and D) and of three types of Japanese brown rice vinegar (E, F, and G). The results showed titratable acidity levels of 6.39%, 4.52-6.32%, and 4.51-4.89% in the static-cultured brown rice vinegar, the domestic commercial brown rice vinegars, and the Japanese brown rice vinegars, respectively. The pH levels were 3.28, 2.58-2.97, and 3.03-3.27 in the static-culture brown rice vinegar, the domestic commercial brown rice vinegars, and the Japanese brown rice vinegars, respectively, which show similar values of the static-culture brown rice vinegar and the Japanese brown rice vinegars. The total nitrogen (TN) values of the static-culture brown rice vinegar, the domestic commercial brown rice vinegars, and the Japanese brown rice vinegars were 0.24, 0.03-0.16, and 0.12-0.17, respectively, with the highest value for the static-culture brown rice vinegar, substantial differences among the domestic commercial brown rice vinegars, and similar contents among the Japanese brown rice vinegars. For free sugar, glucose was either detected only in a small quantity or not detected at all in the static-culture brown rice vinegar and the Japanese brown rice vinegars, which showed perfect fermentation. The glucose and maltose contents were higher in the domestic commercial brown rice vinegars. The organic acid content of the static-culture brown rice vinegar was similar to that of the Japanese brown rice vinegars. Therefore, the total acidity content, TN value, sensory property, and quality of the static-culture brown rice vinegar (A) were superior to those of the domestic and Japanese brown rice vinegars.

The effects of different nuruk contents and fermentation methods (AV, vinegar fermented in an agitated culture; SV, vinegar fermented in a static culture) on organic acids and volatile compounds in brown rice vinegars were investigated. In the SV, the contents of acetic, oxalic, tartaric, and malic acids increased with hipher contents of nuruk. Acetic, tartaric, and malic acid contents were higher in the SV than those in the AV. Volatile compounds that can affect vinegar quality, including acetic acid, isoamyl acetate, phenethyl acetate, and phenethyl alcohol were present at high concentrations in the AV. With the increase in nuruk contents in the AV, acetic acid content decreased and isoamyl acetate and phenethyl acetate content increased. No significant differences in sensory scores were observed regarding the amount of nuruk and the type of fermentation. However, electronic-nose analysis showed its potential to effectively differentiate different samples.