58 results on '"Su-Jung Yeon"'
Search Results
2. Revolutionizing Renewable Resources: Cutting-Edge Trends and Future Prospects in the Valorization of Oligosaccharides
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Ramachandran Chelliah, Nam Hyeon Kim, SeonJu Park, Younseo Park, Su-Jung Yeon, Kaliyan Barathikannan, Selvakumar Vijayalakshmi, and Deog-Hwan Oh
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agricultural by-products ,prebiotics ,lignocellulosic wastes ,Fermentation industries. Beverages. Alcohol ,TP500-660 - Abstract
Lignocellulosic wastes, primarily from agricultural by-products, are a renewable resource increasingly used in the sustainable production of oligosaccharides, significantly contributing to the growing bioeconomy. This innovative utilization of biological resources aligns with the global shift towards sustainable development, focusing on creating products such as food, feed, and bioenergy from renewable sources. Oligosaccharides, specialized carbohydrates, are synthesized either chemically or more eco-friendly, biologically. Biological synthesis often involves enzymes or whole-cell systems to transform lignocellulosic wastes into these valuable sugars. As functional food supplements, oligosaccharides play a crucial role in human and animal health. They serve as prebiotics, indigestible components that promote the proliferation of beneficial gut microbiota, especially within the colon. This positive impact on gut flora is essential for boosting the immune system and regulating physiological functions. Important prebiotics, including galactooligosaccharides (GOS), xylooligosaccharides (XOS), fructooligosaccharides (FOS), mannan-oligosaccharides (MOS), and isomaltooligosaccharides (IMOS), are produced through methods involving enzymes or the use of whole cells, with agricultural waste as substrates. Recent advancements focus on refining these biological processes for oligosaccharide synthesis using lignocellulosic substrates, emphasizing the principles of a circular bioeconomy, which promotes resource reuse and recycling. This review highlights the potential and challenges in the biological synthesis of oligosaccharides from renewable resources. It underscores the need for innovation in process optimization and commercialization strategies to fully exploit lignocellulosic wastes. This approach not only contributes to sustainable product development, but also opens new avenues for the profitable and environmentally friendly utilization of agricultural residues, marking a significant step forward in the bio-based industry.
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- 2024
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3. Quality characteristic and antioxidant activity of yogurt containing olive leaf hot water extract
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Won-Young Cho, Da-Hee Kim, Ha-Jung Lee, Su-Jung Yeon, and Chi-Ho Lee
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yogurt ,olive leaf ,antioxidant activity ,sensory evaluation ,hplc ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
The objective of this study was to determine the antioxidant and quality characteristics of yogurt containing olive leaf hot water extract (CON: 0, OLY1: 0.1, OLY2: 0.2, and OLY4: 0.4% (w/v)) stored at 4°С for 15 days. After storage, the lactic acid bacteria count showed no significant difference between yogurt samples either in the presence or absence of olive leaf extract (p > 0.05). The total phenolic content, DPPH radical scavenging activity, and reducing power increased upon increasing the content of the olive leaf hot water extract. Oleuropein was found to be the most abundant phenolic compounds present in olive leaf, and the oleuropein content in OLY4, as measured by HPLC, decreased gradually to 1.09, 1.00, and 0.96 g/L upon increasing the storage time; however, this reduction was not significant (p > 0.05). In sensory evaluations, OLY1 gave the highest score among the experimental groups. The results of this study thereby demonstrate that olive leaf hot water extract can be used to improve the antioxidant capacity and sensory characteristics of yogurt.
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- 2020
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4. In vitro antioxidant actions of sulfur-containing amino acids
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Ji-Han Kim, Hyun-Joo Jang, Won-Young Cho, Su-Jung Yeon, and Chi-Ho Lee
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Chemistry ,QD1-999 - Abstract
Sulfur-containing amino acids such as methionine, cysteine, and taurine are present in animals and plants with biological functions. The aim of this study was to determine the antioxidant activities of representative sulfur-containing amino acids using various in vitro antioxidant assays including radical scavenger activities against DPPH·, ABTS·, and superoxide radicals, ferric reducing antioxidant power, hydrogen peroxide scavenging activity, and metal chelating activities. Of the three sulfur-containing amino acids, cysteine had the highest DPPH·, ABTS·, and O2− radical and H2O2 scavenging activities, FRAP, and metal chelating activities except for Fe2+ chelating. However, methionine and taurine failed to show DPPH· or ABTS· radical scavenging activity. Based on the results of the present study, sulfur-containing amino acids with excellent antioxidant abilities might be useful for the food processing industry as antioxidant additives to extend shelf-life of food or food products and offer beneficial pharmacological effect against cell damage caused by oxidative stress. Keywords: Sulfur containing amino acid, Antioxidant, Cysteine, Radical scavenging activity, Oxidative stress
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- 2020
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5. Journal of Food Quality Evaluation of Effect of Extraction Solvent on Selected Properties of Olive Leaf Extract
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Won-Young Cho, Da-Hee Kim, Ha-Jung Lee, Su-Jung Yeon, and Chi-Ho Lee
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Nutrition. Foods and food supply ,TX341-641 - Abstract
The quest for natural preservatives and functional foods with health benefits has seen an increasing demand for natural products having therapeutic value. Herein, we investigated the influence of ethanol, methanol, acetone (50%, 70%, and 90% v/v), and distilled water on selected properties of olive leaf extract and determined the yield, total phenolic content (TPC), antioxidant activity, and antimicrobial activity. Extracts were analyzed for their oleuropein, hydroxytyrosol, and tyrosol contents by high-performance liquid chromatography (HPLC). The highest extraction yield of 20.41% was obtained when using 90 vol% methanol, while the highest total polyphenol contents of 232 and 231 mggallic-acid-equivalent/100 g were obtained for 90 vol% methanol and 90 vol% ethanol, respectively. Antioxidant activity was determined using the α,α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging assay, by determining the ferric reducing antioxidant power (FRAP), and using the Fe2+-chelating activity assay, which provided the highest values when 90 vol% methanol was used (33.84%, 0.75, and 12.91%, respectively). HPLC analysis showed that the highest oleuropein contents corresponded to the extracts obtained using 90 and 70 vol% methanol (26.10 ± 0.20 and 24.92 ± 1.22 g/L, respectively), and the highest antimicrobial activity was observed for 90 vol% methanol and distilled water. Olive leaf extracts using 90 vol% methanol had high levels of polyphenols and were highly antioxidant and antimicrobial. The results of this study facilitate the commercial applications of natural extracts with antioxidant and antibacterial activities and are expected to establish a foundation for further optimization studies.
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- 2020
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6. Effect of Allium hookeri and whey powder in diet of pigs on physicochemical characteristics and oxidative stability of pork
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Ji-Han Kim, Min-Gu Ju, Su-Jung Yeon, Go-Eun Hong, and Chi-Ho Lee
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Allium hookeri ,pork ,whey ,meat quality ,oxidative stability ,Animal culture ,SF1-1100 - Abstract
The objective of this study was to determine the effect of Allium hookeri supplementation with whey powder in pig diet on meat quality, oxidative stability and sensory characteristics of Longissimus dorsi muscle samples. A total of 60 pigs were randomly assigned into the following three groups (four replicate pens per group with five pigs per pen): CON group, basal diet; AH, dietary supplementation with 10 g A. hookeri/kg feed and AHW, dietary supplementation with 5 g A. hookeri/40 g whey powder/kg feed. Proximate composition of muscle sample was not significantly affected by A. hookeri supplementation. On average, the AHW group showed higher pH but less cooking loss than the CON group. However, the AH and AHW groups had lower (p
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- 2018
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7. The Role of Bioactive Peptides in Diabetes and Obesity
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Ramachandran Chelliah, Shuai Wei, Eric Banan-Mwine Daliri, Fazle Elahi, Su-Jung Yeon, Akanksha Tyagi, Shucheng Liu, Inamul Hasan Madar, Ghazala Sultan, and Deog-Hwan Oh
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diabetes ,obesity ,bioactive peptides ,antioxidant ,anti-inflammatory ,antimicrobial ,Chemical technology ,TP1-1185 - Abstract
Bioactive peptides are present in most soy products and eggs and have essential protective functions. Infection is a core feature of innate immunity that affects blood pressure and the glucose level, and ageing can be delayed by killing senescent cells. Food also encrypts bioactive peptides and protein sequences produced through proteolysis or food processing. Unique food protein fragments can improve human health and avoid metabolic diseases, inflammation, hypertension, obesity, and diabetes mellitus. This review focuses on drug targets and fundamental mechanisms of bioactive peptides on metabolic syndromes, namely obesity and type 2 diabetes, to provide new ideas and knowledge on the ability of bioactive peptide to control metabolic syndromes.
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- 2021
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8. Development of Nanosensors Based Intelligent Packaging Systems: Food Quality and Medicine
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Ramachandran Chelliah, Shuai Wei, Eric Banan-Mwine Daliri, Momna Rubab, Fazle Elahi, Su-Jung Yeon, Kyoung hee Jo, Pianpian Yan, Shucheng Liu, and Deog Hwan Oh
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drug management ,iMedBox ,in-home healthcare station (IHHS) ,wireless sensor network (WSN) ,controlled delamination material (CDM) ,radio frequency identification (RFID) ,Chemistry ,QD1-999 - Abstract
The issue of medication noncompliance has resulted in major risks to public safety and financial loss. The new omnipresent medicine enabled by the Internet of things offers fascinating new possibilities. Additionally, an in-home healthcare station (IHHS), it is necessary to meet the rapidly increasing need for routine nursing and on-site diagnosis and prognosis. This article proposes a universal and preventive strategy to drug management based on intelligent and interactive packaging (I2Pack) and IMedBox. The controlled delamination material (CDM) seals and regulates wireless technologies in novel medicine packaging. As such, wearable biomedical sensors may capture a variety of crucial parameters via wireless communication. On-site treatment and prediction of these critical factors are made possible by high-performance architecture. The user interface is also highlighted to make surgery easier for the elderly, disabled, and patients. Land testing incorporates and validates an approach for prototyping I2Pack and iMedBox. Additionally, sustainability, increased product safety, and quality standards are crucial throughout the life sciences. To achieve these standards, intelligent packaging is also used in the food and pharmaceutical industries. These technologies will continuously monitor the quality of a product and communicate with the user. Data carriers, indications, and sensors are the three most important groups. They are not widely used at the moment, although their potential is well understood. Intelligent packaging should be used in these sectors and the functionality of the systems and the values presented in this analysis.
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- 2021
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9. In Vitro and In Silico Screening and Characterization of Antimicrobial Napin Bioactive Protein in Brassica juncea and Moringa oleifera
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Sangeeta Chandrashekar, Raman Vijayakumar, Ramachandran Chelliah, Eric Banan-Mwine Daliri, Inamul Hasan Madar, Ghazala Sultan, Momna Rubab, Fazle Elahi, Su-Jung Yeon, and Deog-Hwan Oh
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Moringa oleifera ,Brassica juncea ,coagulant protein ,cell aggregation ,growth inhibition ,LCMS ,Organic chemistry ,QD241-441 - Abstract
The study aimed to investigate the antibacterial activity of Mustard (Brassica juncea) and Moringa (Moringa oleifera) leaf extracts and coagulant protein for their potential application in water treatment. Bacterial cell aggregation and growth kinetics studies were employed for thirteen bacterial strains with different concentrations of leaf extracts and coagulant protein. Moringa oleifera leaf extract (MOS) and coagulant protein showed cell aggregation against ten bacterial strains, whereas leaf extract alone showed growth inhibition of five bacterial strains for up to 6 h and five bacterial strains for up to 3 h. Brassica juncea leaf extract (BJS) showed growth inhibition for up to 6 h, and three bacterial strains showed inhibition for up to 3 h. The highest inhibition concentration with 2.5 mg/mL was 19 mm, and furthermore, the minimum inhibitory concentration (MIC) (0.5 mg/mL) and MBC (1.5 mg/mL) were determined to have a higher antibacterial effect for Moringa oleifera purified protein (MOP) and Brassica juncea purified protein (BJP) that could act as an effective antimicrobial agent to replace currently available antibiotics. The result implies that MOP and Brassica juncea purified coagulant (BJP) proteins may perform a wide degree of antibacterial functions against different pathogens.
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- 2021
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10. Untargeted Metabolomics of Korean Fermented Brown Rice Using UHPLC Q-TOF MS/MS Reveal an Abundance of Potential Dietary Antioxidative and Stress-Reducing Compounds
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Akanksha Tyagi, Su-Jung Yeon, Eric Banan-Mwine Daliri, Xiuqin Chen, Ramachandran Chelliah, and Deog-Hwan Oh
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brown rice ,fermentation ,germination ,antioxidants ,stress ,bioactive compounds ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Free radical-induced oxidative stress is the root cause of many diseases, such as diabetes, stress and cardiovascular diseases. The objective of this research was to screen GABA levels, antioxidant activities and bioactive compounds in brown rice. In this study, we first fermented brown rice with different lactic acid bacteria (LABs), and the best LAB was selected based on the levels of GABA in the fermentate. Lactobacillus reuterii generated the highest levels of GABA after fermentation. To ascertain whether germination can improve the GABA levels of brown rice, we compared the levels of GABA in raw brown rice (Raw), germinated brown rice (Germ), fermented brown rice (Ferm) and fermented-germinated brown rice (G+F) to identify the best approach. Then, antioxidant activities were investigated for Raw BR, Germ BR, Ferm BR and G+F BR. Antioxidant activity was calculated using a 2,2-diphenyl-1-picryl hydrazile radical assay, 2,2-azino-bis-(3-ethylene benzothiozoline-6-sulfonic acid) radical assay and ferric-reducing antioxidant power. In Ferm BR, DPPH (114.40 ± 0.66), ABTS (130.52 ± 0.97) and FRAP (111.16 ± 1.83) mg Trolox equivalent 100 g, dry weight (DW), were observed as the highest among all samples. Total phenolic content (97.13 ± 0.59) and total flavonoids contents (79.62 ± 1.33) mg GAE/100 g and catechin equivalent/100 g, DW, were also found to be highest in fermented BR. Furthermore, an untargeted metabolomics approach using ultra-high-performance liquid tandem chromatography quadrupole time of flight mass spectrometry revealed the abundance of bioactive compounds in fermented BR, such as GABA, tryptophan, coumaric acid, L-ascorbic acid, linoleic acid, β-carotenol, eugenol, 6-gingerol, etc., as well as bioactive peptides which could contribute to the health-promoting properties of L. reuterii fermented brown rice.
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- 2021
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11. Flavonoids in Decorticated Sorghum Grains Exert Antioxidant, Antidiabetic and Antiobesity Activities
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Fred Kwame Ofosu, Fazle Elahi, Eric Banan-Mwine Daliri, Su-Jung Yeon, Hun Ju Ham, Joong-Hark Kim, Sang-Ik Han, and Deog-Hwan Oh
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sorghum grains ,decortication ,digestive enzymes inhibitors ,flavonoids ,advanced glycation end products ,functional food ,Organic chemistry ,QD241-441 - Abstract
Eight new genotypes of brown sorghum grain were decorticated and assessed for their antioxidant, antidiabetic and antiobesity activities in vitro. The DPPH and ABTS radical scavenging assays of the soluble fractions were evaluated, followed by digestive enzymes and advanced glycation end-products (AGEs) formation inhibition assays. DSOR 33 and DSOR 11 exhibited the highest DPPH (IC50 = 236.0 ± 1.98 µg/mL and 292.05 ± 2.19 µg/mL, respectively) and ABTS radical scavenging activity (IC50 = 302.50 ± 1.84 µg/mL and 317.05 ± 1.06 µg/mL, respectively). DSOR 17, DSOR 11 and DSOR 33 showed significantly higher inhibitory activity of both α-glucosidase and α-amylase (IC50 = 31.86, 35.10 and 49.40 µg/mL; and 15.87, 22.79 and 37.66 µg/mL, respectively) compared to acarbose (IC50 = 59.34 and 27.73 µg/mL, respectively). Similarly, DSOR 33, DSOR 11 and DSOR 17 showed potent inhibition of both AGEs and lipase with IC50 values of 18.25, 19.03 and 38.70 µg/mL; and 5.01, 5.09 and 4.94 µg/mL, respectively, compared to aminoguanidine (52.30 µg/mL) and orlistat (5.82 µg/mL). Flavonoids were the predominant compounds identified, with flavones being the major subclass in these three extracts. Our findings suggest that decorticated sorghum grains contain substantial amounts of flavonoids and could be promising candidates for the prevention and treatment of diabetes and obesity.
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- 2020
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12. Effect of Yogurt Fermented by Lactobacillus Fermentum TSI and L. Fermentum S2 Derived from a Mongolian Traditional Dairy Product on Rats with High-Fat-Diet-Induced Obesity
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Won-Young Cho, Go-Eun Hong, Ha-Jung Lee, Su-Jung Yeon, Hyun-Dong Paik, Yoshinao Z. Hosaka, and Chi-Ho Lee
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yogurt ,mongolian fermented dairy product ,lactic acid bacteria ,cholesterol ,adiponectin ,adipocyte ,Chemical technology ,TP1-1185 - Abstract
This study aimed to investigate the metabolic effect of yogurt fermented by Lactobacillus fermentum TSI and S2 isolated from a Mongolian traditional dairy product on rats with high-fat-diet-induced obesity. Quality characteristics of yogurt fermented by commercial starter (CON), L. fermentum TSI2 (TSI2 group), L. fermentum S2 (S2 group), and mixed TSI2 and S2 strains at 1:1 (MIX group), were verified. Six-week-old male Sprague-Dawley rats were divided into five groups and administered the following diets: group NOR, normal diet with oral saline administration; group HF, high-fat diet (HD) with oral saline administration; group TSI, HD and L. fermentum TSI-fermented yogurt; group S2, HD and L. fermentum S2-fermented yogurt; and group MIX, HD and MIX-fermented yogurt. After eight weeks, the HD groups displayed significantly increased body weight and fat, serum cholesterol, and abdominal adipose tissue levels. However, serum HDL cholesterol levels were higher, triglyceride levels were lower, and abdominal adipocytes were smaller in the TSI and S2 groups than in the HF group. These results indicate that L. fermentum TSI reduces abdominal fat and improves blood lipid metabolism in HD-induced obese rats.
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- 2020
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13. In Vitro Studies of Fermented Korean Chung-Yang Hot Pepper Phenolics as Inhibitors of Key Enzymes Relevant to Hypertension and Diabetes
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Su-Jung Yeon, Ji-Han Kim, Won-Young Cho, Soo-Ki Kim, Han Geuk Seo, and Chi-Ho Lee
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pepper ,fermentation ,hyperglycemia ,angiotensin i-converting enzyme (ace) inhibition ,antioxidant ,Chemical technology ,TP1-1185 - Abstract
This study was investigated to evaluate the antioxidant activity, the angiotensin I-converting enzyme (ACE) inhibition effect, and the α-amylase and α-glucosidase inhibition activities of hot pepper water extracts both before and after their fermentation. The fermented pepper water extract (FP) showed significantly higher total phenol content, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical inhibition effect, metal chelating activity and ACE inhibition activity compared to the non-fermented raw pepper water extract (RP) (p < 0.05). Meanwhile, the FP showed lower α-amylase and higher α-glucosidase inhibitory activities, but the RP showed similar levels of α-amylase and α-glucosidase inhibitory activities. Taken together, these results suggested that fermented pepper extract using water should be expected to have potentially inhibitory effects against both hyperglycemia and hypertension.
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- 2019
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14. Evaluation of Lignan Compound Content and Bioactivity of Raw Omija and Sugared Omija in Serum of Sprague Dawley Rat
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Sung-Hyun Hwa, Su-Jung Yeon, Go-Eun Hong, Won-Young Cho, Ha-Jung Lee, Ji-Han Kim, and Chi-Ho Lee
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omija ,Schizandra chinensis ,sugared omija ,byproduct ,renin ,Chemical technology ,TP1-1185 - Abstract
This study evaluated the lignan contents of raw omija (R) and sugared omija (S), byproducts discarded after the use of raw omija, by HPLC and determined their bioactivity by feeding rats R and S for eight weeks. S retained 63% more lignan than R. Body weight gains in the raw omija-fed group (RO) and sugared omija-fed group (SO) decreased significantly compared to that of the control group (CON, p < 0.05). Glucose and aspartate aminotransferase levels in the serum of the experimental groups were lower than those in CON, especially in SO (p < 0.05). The amount of atrial natriuretic peptide in RO decreased significantly compared to that in CON (p < 0.05). The renin activity in RO increased and that in SO decreased compared to the same in CON (p > 0.05). Therefore, it was suggested that sugared omija contains lignan compounds and potentially contributes to bioactivity in that it decreases blood glucose levels and blood pressure.
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- 2019
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15. A review on the application of bioinformatics tools in food microbiome studies.
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Ramachandran Chelliah, Eric Banan-Mwinedaliri, Imran Khan, Shuai Wei, Fazle Elahi, Su-Jung Yeon, Vijayalakshmi Selvakumar, Fred Kwame Ofosu, Momna Rubab, Hum Hun Ju, Harikrishna Reddy Rallabandi, Inamul Hasan Madar, Ghazala Sultan, and Deog Hwan Oh
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- 2022
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16. Impact of Sequencing and Bioinformatics Tools in Food Microbiology
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Ramachandran, Chelliah, primary, Daliri, Eric Banan-Mwine, additional, Fazle, Elahi, additional, Imran, Khan, additional, Shuai, Wei, additional, Su-Jung, Yeon, additional, Kandasamy, Saravanakumar, additional, Madar, Inamul Hasan, additional, Miskeen, Sumaira, additional, Sultan, Ghazala, additional, Arockianathan, Marie, additional, Alagarsamy, Shanmugarathinam, additional, Vasan, Thirumalai, additional, Wang, Myeong-Hyeon, additional, Usha, Antony, additional, Thangadurai, Devarajan, additional, and Deog Hwan, Oh, additional
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- 2021
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17. Application of Next-Generation Sequencing Techniques in Food-Related Microbiome Studies
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Ramachandran, Chelliah, primary, Eric Banan-Mwine, Daliri, additional, Fazle, Elahi, additional, Imran, Khan, additional, Shuai, Wei, additional, Su-Jung, Yeon, additional, Kandasamy, Saravanakumar, additional, Inamul Hasan, Madar, additional, Sumaira, Miskeen, additional, Ghazala, Sultan, additional, Marie, Arockianathan, additional, Shanmugarathinam, Alagarsamy, additional, Thirumalai, Vasan, additional, Myeong-Hyeon, Wang, additional, Usha, Antony, additional, Devarajan, Thangadurai, additional, and Oh, Deog Hwan, additional
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- 2021
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18. Seed-Based Oil in Nanomaterials Synthesis and Their Role in Drug Delivery and Other Applications
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Vijayalakshmi Selvakumar, Ramachandran Chelliah, Kaliyan Barathikannan, Fazle Elahi, Momna Rubab, Simpy Sanyal, Su-Jung Yeon, and Deog-Hwan Oh
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- 2023
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19. Plant-Based Metabolites and Their Uses in Nanomaterials Synthesis: An Overview
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Kaliyan Barathikannan, Ramachandran Chelliah, Vijayalakshmi Selvakumar, Fazle Elahi, Momna Rubab, Simpy Sanyal, Su-Jung Yeon, and Deog-Hwan Oh
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- 2023
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20. Role of Peptides in Antiviral (COVID-19) Therapy
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Jo kyoung Hee, Chae Rin Park, Eric Banan-Mwine Daliri, Fazle Elahi, Akanksha Tyagi, Ramachandran Chelliah, Eun Ji Kim, Deog-Hwan Oh, and Su-Jung Yeon
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chemistry.chemical_classification ,medicine.diagnostic_test ,Drug discovery ,Mechanism (biology) ,business.industry ,Peptidomimetic ,Proteolysis ,Peptide ,Computational biology ,medicine.disease_cause ,Pharmacotherapy ,chemistry ,medicine ,business ,Receptor ,Coronavirus - Abstract
Trends in the developing era to discover and design peptide-based treatments throughout an epidemic infection scenario such as COVID-19 could progress into a more efficient and low-cost therapeutic environment. However, the weakening of proteolysis is one downside of natural peptide drugs. But, peptidomimetics may help resolve this issue. In this review, peptide and peptide-based drug discovery were summarized to target one key entry mechanism of severe coronavirus pulmonary emboli syndrome (SARS-CoV-2), which encompasses the association of the host angiotensin-converting enzyme-2 (ACE2) receptor and viral spike (S) protein. Furthermore, the benefits of proteins, peptides and other possible actions that have been studied for COVID-19 through new peptide-based treatments are discussed in the review. Lastly, an overview of the peptide-based drug therapy environment is comprised of an evolutionary viewpoint, structural properties, operational thresholds, and an explanation of the therapeutic area.
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- 2021
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21. Quality characteristic and antioxidant activity of yogurt containing olive leaf hot water extract
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Ha-Jung Lee, Da-Hee Kim, Won-Young Cho, Su-Jung Yeon, and Chi-Ho Lee
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Antioxidant ,sensory evaluation ,030309 nutrition & dietetics ,General Chemical Engineering ,medicine.medical_treatment ,antioxidant activity ,lcsh:TX341-641 ,hplc ,Industrial and Manufacturing Engineering ,yogurt ,03 medical and health sciences ,0404 agricultural biotechnology ,Olive leaf ,medicine ,Food science ,Quality characteristics ,0303 health sciences ,lcsh:TP368-456 ,Chemistry ,food and beverages ,04 agricultural and veterinary sciences ,General Chemistry ,040401 food science ,olive leaf ,lcsh:Food processing and manufacture ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
The objective of this study was to determine the antioxidant and quality characteristics of yogurt containing olive leaf hot water extract (CON: 0, OLY1: 0.1, OLY2: 0.2, and OLY4: 0.4% (w/v)) stored at 4°С for 15 days. After storage, the lactic acid bacteria count showed no significant difference between yogurt samples either in the presence or absence of olive leaf extract (p > 0.05). The total phenolic content, DPPH radical scavenging activity, and reducing power increased upon increasing the content of the olive leaf hot water extract. Oleuropein was found to be the most abundant phenolic compounds present in olive leaf, and the oleuropein content in OLY4, as measured by HPLC, decreased gradually to 1.09, 1.00, and 0.96 g/L upon increasing the storage time; however, this reduction was not significant (p > 0.05). In sensory evaluations, OLY1 gave the highest score among the experimental groups. The results of this study thereby demonstrate that olive leaf hot water extract can be used to improve the antioxidant capacity and sensory characteristics of yogurt.
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- 2020
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22. In vitro antioxidant actions of sulfur-containing amino acids
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Chi-Ho Lee, Won-Young Cho, Hyun-Joo Jang, Su-Jung Yeon, and Ji-Han Kim
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chemistry.chemical_classification ,Taurine ,ABTS ,Methionine ,Antioxidant ,DPPH ,General Chemical Engineering ,medicine.medical_treatment ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Scavenger ,0104 chemical sciences ,Amino acid ,lcsh:Chemistry ,chemistry.chemical_compound ,chemistry ,Biochemistry ,lcsh:QD1-999 ,medicine ,0210 nano-technology ,Cysteine - Abstract
Sulfur-containing amino acids such as methionine, cysteine, and taurine are present in animals and plants with biological functions. The aim of this study was to determine the antioxidant activities of representative sulfur-containing amino acids using various in vitro antioxidant assays including radical scavenger activities against DPPH·, ABTS·, and superoxide radicals, ferric reducing antioxidant power, hydrogen peroxide scavenging activity, and metal chelating activities. Of the three sulfur-containing amino acids, cysteine had the highest DPPH·, ABTS·, and O2− radical and H2O2 scavenging activities, FRAP, and metal chelating activities except for Fe2+ chelating. However, methionine and taurine failed to show DPPH· or ABTS· radical scavenging activity. Based on the results of the present study, sulfur-containing amino acids with excellent antioxidant abilities might be useful for the food processing industry as antioxidant additives to extend shelf-life of food or food products and offer beneficial pharmacological effect against cell damage caused by oxidative stress. Keywords: Sulfur containing amino acid, Antioxidant, Cysteine, Radical scavenging activity, Oxidative stress
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- 2020
23. Untargeted metabolomics of fermented onion (Allium cepa L) using UHPLC Q-TOF MS/MS reveals anti-obesity metabolites and in vivo efficacy in Caenorhabditis elegans
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Kaliyan Barathikannan, Ramachandran Chelliah, Su-Jung Yeon, Akanksha Tyagi, Fazle Elahi, Selvakumar Vijayalakshmi, Paul Agastian, Vijayakumar Arockiasami, and Deog Hawn Oh
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Plant Extracts ,General Medicine ,Lipase ,Ascorbic Acid ,Lipids ,Antioxidants ,Analytical Chemistry ,Tandem Mass Spectrometry ,Onions ,Animals ,Quercetin ,Caenorhabditis elegans ,Chromatography, High Pressure Liquid ,Food Science - Abstract
The bioconversion of onion extracts with P. acidilactici MNL5 enhances the metabolites and has a synergistic lipid-reduction impact that is beneficial for anti-obesity studies. The 48 h fermented onion extracts (FOE) demonstrated an enhanced inhibitory activity against pancreatic lipase (89.5 ± 1.25 %) as compared to the raw onion extract (ROE) (33.4 ± 0.86 %). The antioxidant properties of FOE significantly increased compared to the ROE inhibitory effect on DPPH (99.5 ± 2.40 mg vitamin C equiv./mg, DW FOE), and ABTS (104.5 ± 2.32 mg vitamin C equiv./mg, DW FOE). Based on FOE's higher antioxidant activity, UHPLC-Q-TOF-MS/MS demonstrated dramatic changes in the untargeted metabolite profile as compared to ROE. Moreover, C. elegans supplemented with FOE and quercetin exhibited an enhanced lifespan activity, lipid reduction, and decreased triglycerides. FOE can lower cholesterol and enhance quercetin to promote pancreatic lipase activity for synergistic anti-obesity effects.
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- 2022
24. The Role of Bioactive Peptides in Diabetes and Obesity
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Su-Jung Yeon, Akanksha Tyagi, Shuai Wei, Ramachandran Chelliah, Eric Banan-Mwine Daliri, Shucheng Liu, Fazle Elahi, Inamul Hasan Madar, Ghazala Sultan, and Deog-Hwan Oh
- Subjects
Drug ,obesity ,Health (social science) ,antioxidant ,medicine.drug_class ,media_common.quotation_subject ,Proteolysis ,Inflammation ,TP1-1185 ,Plant Science ,Type 2 diabetes ,Review ,Pharmacology ,Biology ,Health Professions (miscellaneous) ,Microbiology ,Anti-inflammatory ,Diabetes mellitus ,medicine ,media_common ,anti-inflammatory ,Innate immune system ,medicine.diagnostic_test ,diabetes ,Chemical technology ,medicine.disease ,Obesity ,antiviral ,antimicrobial ,medicine.symptom ,bioactive peptides ,Food Science - Abstract
Bioactive peptides are present in most soy products and eggs and have essential protective functions. Infection is a core feature of innate immunity that affects blood pressure and the glucose level, and ageing can be delayed by killing senescent cells. Food also encrypts bioactive peptides and protein sequences produced through proteolysis or food processing. Unique food protein fragments can improve human health and avoid metabolic diseases, inflammation, hypertension, obesity, and diabetes mellitus. This review focuses on drug targets and fundamental mechanisms of bioactive peptides on metabolic syndromes, namely obesity and type 2 diabetes, to provide new ideas and knowledge on the ability of bioactive peptide to control metabolic syndromes.
- Published
- 2021
25. Effects of Lotus (Nelumbo nucifera) Leaf on Quality and Antioxidant Activity of Yogurt during Refrigerated Storage
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Su-Jung Yeon, Won-Young Cho, Da-Hee Kim, Chi-Ho Lee, and Sung-Hee Choi
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Antioxidant ,Chemistry ,DPPH ,medicine.medical_treatment ,0402 animal and dairy science ,Cold storage ,Titratable acid ,04 agricultural and veterinary sciences ,040201 dairy & animal science ,03 medical and health sciences ,Ingredient ,chemistry.chemical_compound ,0302 clinical medicine ,Polyphenol ,030221 ophthalmology & optometry ,medicine ,Animal Science and Zoology ,Lotus effect ,Food science ,Food quality ,Food Science - Abstract
The supplementation with natural ingredients that are rich in polyphenols could improve the quality and functionality of yogurt. Lotus leaf (LL) are abundant in phenolic compounds. We aimed to investigate the effects of LL powder on the quality properties, total phenolic content (TPC), and antioxidant activity of yogurt. Yogurt was supplemented with four different concentrations (0%, 0.2%, 0.5%, and 1%) of LL powder and evaluated for 14 d refrigerated storage. During storage, the titratable acidity (TA) of all LL yogurt groups was higher than that of the control (p
- Published
- 2019
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26. In Vitro and In Silico Screening and Characterization of Antimicrobial Napin Bioactive Protein in Brassica juncea and Moringa oleifera
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Ghazala Sultan, Sangeeta Chandrashekar, Ramachandran Chelliah, Eric Banan-Mwine Daliri, Momna Rubab, Su-Jung Yeon, Raman Vijayakumar, Fazle Elahi, Inamul Hasan Madar, and Deog-Hwan Oh
- Subjects
Protein Conformation, alpha-Helical ,molecular-docking ,Brassica ,Pharmaceutical Science ,Peptide ,Analytical Chemistry ,Moringa ,growth inhibition ,chemistry.chemical_compound ,Drug Discovery ,Food science ,coagulant protein ,Moringa oleifera ,chemistry.chemical_classification ,topoisomerase ,0303 health sciences ,biology ,lipoprotein ,food and beverages ,Antimicrobial ,Cell aggregation ,Anti-Bacterial Agents ,Molecular Docking Simulation ,napin ,Chemistry (miscellaneous) ,Molecular Medicine ,Growth inhibition ,Antibacterial activity ,2S Albumins, Plant ,Mustard Plant ,Protein Binding ,Brassica juncea ,Microbial Sensitivity Tests ,Gram-Positive Bacteria ,Article ,Amidohydrolases ,lcsh:QD241-441 ,03 medical and health sciences ,Minimum inhibitory concentration ,lcsh:Organic chemistry ,LCMS ,Gram-Negative Bacteria ,Protein Interaction Domains and Motifs ,Physical and Theoretical Chemistry ,030304 developmental biology ,Binding Sites ,Plant Extracts ,030306 microbiology ,Organic Chemistry ,fungi ,cell aggregation ,biology.organism_classification ,Plant Leaves ,DNA Topoisomerases, Type II ,chemistry ,Protein Conformation, beta-Strand - Abstract
The study aimed to investigate the antibacterial activity of Mustard (Brassica juncea) and Moringa (Moringa oleifera) leaf extracts and coagulant protein for their potential application in water treatment. Bacterial cell aggregation and growth kinetics studies were employed for thirteen bacterial strains with different concentrations of leaf extracts and coagulant protein. Moringa oleifera leaf extract (MOS) and coagulant protein showed cell aggregation against ten bacterial strains, whereas leaf extract alone showed growth inhibition of five bacterial strains for up to 6 h and five bacterial strains for up to 3 h. Brassica juncea leaf extract (BJS) showed growth inhibition for up to 6 h, and three bacterial strains showed inhibition for up to 3 h. The highest inhibition concentration with 2.5 mg/mL was 19 mm, and furthermore, the minimum inhibitory concentration (MIC) (0.5 mg/mL) and MBC (1.5 mg/mL) were determined to have a higher antibacterial effect for <, 3 KDa peptides. Based on LCMS analysis, napin was identified in both MOS and BJS, furthermore, the mode of action of napin peptide was determined on lipoprotein X complex (LpxC) and four-chained structured binding protein of bacterial type II topoisomerase (4PLB). The docking analysis has exhibited moderate to potent inhibition with a range of dock score −912.9 Kcal/mol. Thus, it possesses antibacterial-coagulant potential bioactive peptides present in the Moringa oleifera purified protein (MOP) and Brassica juncea purified protein (BJP) that could act as an effective antimicrobial agent to replace currently available antibiotics. The result implies that MOP and Brassica juncea purified coagulant (BJP) proteins may perform a wide degree of antibacterial functions against different pathogens.
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- 2021
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27. Current Advances in Therapeutic Peptides: Past and Future Trends
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Su-Jung Yeon, Akanksha Tyagi, Ramachandran Chelliah, Eric Banan-Mwine Daliri, Fazle Elahi, and Deog-Hwan Oh
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Clinical Practice ,business.industry ,Medicine ,Current (fluid) ,business ,Data science - Abstract
The treatment of peptides has played an important role in clinical practice since the discovery of insulin therapy in the 1920s. Over 60 peptide drugs are approved in the United States (US and other regional mar-kets, and peptides continue to undergo drug discovery steadily. Peptide research and development has lev-eraged a wider range of structures known from other plant sources, via pharmacology and medicinal molecular biology, beyond its conventional focus on individual endogenous peptides. We build a comprehensive database of peptides that have met scientific studies with more than 150 constantly evolving peptides. Here we provide a simple overview of the peptide-based drug therapy environment, comprising evolutionary points of view, structural properties, operational thresholds, and explanation of the therapeutic area.
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- 2021
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28. Effect of dietary processed sulfur supplementation on water-soluble flavor precursors, free amino acids, and taste characteristics of pork during refrigerated storage
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Ji-Han Kim, Hyun-Jin Lee, Min-Gu Ju, Chi-Ho Lee, and Su-Jung Yeon
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Taste ,Nutrition and Dietetics ,Glycogen ,Electronic tongue ,0402 animal and dairy science ,chemistry.chemical_element ,04 agricultural and veterinary sciences ,Umami ,Free amino ,040401 food science ,040201 dairy & animal science ,Sulfur ,chemistry.chemical_compound ,0404 agricultural biotechnology ,Water soluble ,chemistry ,Food science ,Agronomy and Crop Science ,Flavor ,Food Science ,Biotechnology - Abstract
A total of 60 three-way crossbred (Landrace, Duroc, and Yorkshire) pigs were divided into two groups (processed sulfur-fed pigs (SFPs) and nonprocessed sulfur-fed pigs, (NSFPs)) and used to determine the effect of supplementation with 3 g kg-1 processed sulfur on water-soluble precursors, free amino acids, and taste of meat using an electronic tongue, during refrigerated storage.; Results: Glycogen and glucose levels of SFP were significantly higher than in NSFPs. Glycogen levels decreased and glucose levels increased during storage (P < 0.001). The pH and moisture content of SFPs were higher than in NSFPs. Inosine of SFPs was higher than in NSFPs (P < 0.05). Hence, umami and richness tastes of SFPs were higher than in NSFPs and increased during storage. The total free amino acid content of both groups was not different, although it increased during storage (P < 0.001). The umami taste of water-soluble precursors was improved in meat derived from SFPs during refrigeration.; Conclusion: The storage time and dietary supplementation with processed sulfur increased the taste components of meat. Application of an electronic tongue system can be used to distinguish the taste characteristics of different types of pork, based on differential supplementation and aging. © 2018 Society of Chemical Industry.; © 2018 Society of Chemical Industry.
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- 2018
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29. Effect of Allium hookeri and whey powder in diet of pigs on physicochemical characteristics and oxidative stability of pork
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Min-Gu Ju, Chi-Ho Lee, Go-Eun Hong, Su-Jung Yeon, and Ji-Han Kim
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0301 basic medicine ,pork ,whey ,Oxidative phosphorylation ,oxidative stability ,meat quality ,03 medical and health sciences ,Lipid oxidation ,Dietary supplementation ,Food science ,lcsh:SF1-1100 ,chemistry.chemical_classification ,Allium hookeri ,030109 nutrition & dietetics ,biology ,Longissimus dorsi muscle ,0402 animal and dairy science ,Fatty acid ,food and beverages ,04 agricultural and veterinary sciences ,Proximate composition ,biology.organism_classification ,040201 dairy & animal science ,chemistry ,Animal Science and Zoology ,lcsh:Animal culture - Abstract
The objective of this study was to determine the effect of Allium hookeri supplementation with whey powder in pig diet on meat quality, oxidative stability and sensory characteristics of Longissimus dorsi muscle samples. A total of 60 pigs were randomly assigned into the following three groups (four replicate pens per group with five pigs per pen): CON group, basal diet; AH, dietary supplementation with 10 g A. hookeri/kg feed and AHW, dietary supplementation with 5 g A. hookeri/40 g whey powder/kg feed. Proximate composition of muscle sample was not significantly affected by A. hookeri supplementation. On average, the AHW group showed higher pH but less cooking loss than the CON group. However, the AH and AHW groups had lower (p
- Published
- 2018
30. Evaluation of Lignan Compound Content and Bioactivity of Raw Omija and Sugared Omija in Serum of Sprague Dawley Rat
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Ha-Jung Lee, Chi-Ho Lee, Su-Jung Yeon, Go-Eun Hong, Won-Young Cho, Sung-Hyun Hwa, and Ji-Han Kim
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0106 biological sciences ,Health (social science) ,sugared omija ,030309 nutrition & dietetics ,Plant Science ,lcsh:Chemical technology ,Body weight ,01 natural sciences ,Health Professions (miscellaneous) ,Microbiology ,High-performance liquid chromatography ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,010608 biotechnology ,lcsh:TP1-1185 ,Schizandra chinensis ,Food science ,Lignan ,0303 health sciences ,Chemistry ,omija ,byproduct ,Sprague dawley ,renin ,Food Science - Abstract
This study evaluated the lignan contents of raw omija (R) and sugared omija (S), byproducts discarded after the use of raw omija, by HPLC and determined their bioactivity by feeding rats R and S for eight weeks. S retained 63% more lignan than R. Body weight gains in the raw omija-fed group (RO) and sugared omija-fed group (SO) decreased significantly compared to that of the control group (CON, p <, 0.05). Glucose and aspartate aminotransferase levels in the serum of the experimental groups were lower than those in CON, especially in SO (p <, 0.05). The amount of atrial natriuretic peptide in RO decreased significantly compared to that in CON (p <, 0.05). The renin activity in RO increased and that in SO decreased compared to the same in CON (p >, 0.05). Therefore, it was suggested that sugared omija contains lignan compounds and potentially contributes to bioactivity in that it decreases blood glucose levels and blood pressure.
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- 2019
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31. Effects of Lotus (
- Author
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Da-Hee, Kim, Won-Young, Cho, Su-Jung, Yeon, Sung-Hee, Choi, and Chi-Ho, Lee
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yogurt ,antioxidant activity ,phenolic compounds ,Article ,lotus leaf - Abstract
The supplementation with natural ingredients that are rich in polyphenols could improve the quality and functionality of yogurt. Lotus leaf (LL) are abundant in phenolic compounds. We aimed to investigate the effects of LL powder on the quality properties, total phenolic content (TPC), and antioxidant activity of yogurt. Yogurt was supplemented with four different concentrations (0%, 0.2%, 0.5%, and 1%) of LL powder and evaluated for 14 d refrigerated storage. During storage, the titratable acidity (TA) of all LL yogurt groups was higher than that of the control (p
- Published
- 2019
32. Untargeted Metabolomics of Korean Fermented Brown Rice Using UHPLC Q-TOF MS/MS Reveal an Abundance of Potential Dietary Antioxidative and Stress-Reducing Compounds
- Author
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Su-Jung Yeon, Xiuqin Chen, Ramachandran Chelliah, Deog-Hwan Oh, Eric Banan-Mwine Daliri, and Akanksha Tyagi
- Subjects
0301 basic medicine ,Antioxidant ,Physiology ,DPPH ,medicine.medical_treatment ,Linoleic acid ,Clinical Biochemistry ,RM1-950 ,Coumaric acid ,Biochemistry ,Article ,functional food ,stress ,03 medical and health sciences ,chemistry.chemical_compound ,0404 agricultural biotechnology ,medicine ,Food science ,fermentation ,Molecular Biology ,bioactive compounds ,ABTS ,Chemistry ,food and beverages ,Catechin ,04 agricultural and veterinary sciences ,Cell Biology ,brown rice ,040401 food science ,untargeted metabolomics ,antioxidants ,030104 developmental biology ,germination ,Brown rice ,Therapeutics. Pharmacology ,Trolox ,health benefits - Abstract
Free radical-induced oxidative stress is the root cause of many diseases, such as diabetes, stress and cardiovascular diseases. The objective of this research was to screen GABA levels, antioxidant activities and bioactive compounds in brown rice. In this study, we first fermented brown rice with different lactic acid bacteria (LABs), and the best LAB was selected based on the levels of GABA in the fermentate. Lactobacillus reuterii generated the highest levels of GABA after fermentation. To ascertain whether germination can improve the GABA levels of brown rice, we compared the levels of GABA in raw brown rice (Raw), germinated brown rice (Germ), fermented brown rice (Ferm) and fermented-germinated brown rice (G+F) to identify the best approach. Then, antioxidant activities were investigated for Raw BR, Germ BR, Ferm BR and G+F BR. Antioxidant activity was calculated using a 2,2-diphenyl-1-picryl hydrazile radical assay, 2,2-azino-bis-(3-ethylene benzothiozoline-6-sulfonic acid) radical assay and ferric-reducing antioxidant power. In Ferm BR, DPPH (114.40 ± 0.66), ABTS (130.52 ± 0.97) and FRAP (111.16 ± 1.83) mg Trolox equivalent 100g, dry weight (DW), were observed as the highest among all samples. Total phenolic content (97.13 ± 0.59) and total flavonoids contents (79.62 ± 1.33) mg GAE/100 g and catechin equivalent/100 g, DW, were also found to be highest in fermented BR. Furthermore, an untargeted metabolomics approach using ultra-high-performance liquid tandem chromatography quadrupole time of flight mass spectrometry revealed the abundance of bioactive compounds in fermented BR, such as GABA, tryptophan, coumaric acid, L-ascorbic acid, linoleic acid, β-carotenol, eugenol, 6-gingerol, etc., as well as bioactive peptides which could contribute to the health-promoting properties of L. reuterii fermented brown rice.
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- 2021
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33. Changes of Physicochemical and Sensory Properties of Fermented Sausage from Sulfur-fed Pork
- Author
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Hyun-Joo Jang, Go-En Hong, Woojoon Park, Su-Jung Yeon, Han Geuk Seo, Min-Gu Ju, Chi-Ho Lee, and Ji-Han Kim
- Subjects
Taste ,Water activity ,Thiobarbituric acid ,0402 animal and dairy science ,chemistry.chemical_element ,processed sulfur-fed pigs ,04 agricultural and veterinary sciences ,Umami ,umami ,040401 food science ,040201 dairy & animal science ,Sulfur ,Article ,chemistry.chemical_compound ,free amino acid ,0404 agricultural biotechnology ,lipid oxidation ,chemistry ,Lipid oxidation ,Saturated fatty acid ,Animal Science and Zoology ,Fermentation ,Food science ,Food Science - Abstract
This study was performed to evaluate the quality of fermented sausages manufactured with processed sulfur-fed pigs. The fermented sausages were divided into two groups; one was manufactured with non sulfur-fed pigs (NP), the other one was made with processed sulfur-fed pigs (SP). No differences were found in moisture and fat contents (p>0.05) between NP and SP, but the protein and ash contents of SP were significantly higher than those of NP (p
- Published
- 2016
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34. Effects of Whey Powder Supplementation on Dry-Aged Meat Quality
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Chi-Ho Lee, Go Eun Hong, Ji Han Kim, Su-Jung Yeon, and Woojoon Park
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0301 basic medicine ,Whey protein ,030109 nutrition & dietetics ,0402 animal and dairy science ,whey powder ,food and beverages ,chemistry.chemical_element ,04 agricultural and veterinary sciences ,Protein degradation ,Calcium ,Mineral composition ,Loin ,040201 dairy & animal science ,Article ,meat quality ,03 medical and health sciences ,Dietary treatment ,Lipid oxidation ,chemistry ,ripening process ,Weaning ,Animal Science and Zoology ,dry-aged meat ,Food science ,Food Science - Abstract
The objective of this study was to determine the effect of dietary supplementation with whey powder (WP, 1g/kg feed) from weaning to slaughter (150 d) on dry-aged loin quality of pigs. Fifty-eight pigs were randomly divided into two dietary treatment groups (seven replications of four pigs per treatments). Basal diet with 0.1% whey powder was supplied to the WP group. Basal diet was used for the control group (CON). Diet whey protein did not appear to influence the moisture or protein contents. However, ash and fat contents were significantly (p
- Published
- 2016
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35. Production of sesaminol and antioxidative activity of fermented sesame with Lactobacillus plantarum P8, Lactobacillus acidophilus ATCC 4356, Streptococcus thermophilus S10
- Author
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Jin-Ju Bae, Go-Eun Hong, Chi-Ho Lee, Woojoon Park, and Su-Jung Yeon
- Subjects
0301 basic medicine ,Streptococcus thermophilus ,030109 nutrition & dietetics ,biology ,DPPH ,food and beverages ,04 agricultural and veterinary sciences ,biology.organism_classification ,040401 food science ,Applied Microbiology and Biotechnology ,Lactic acid ,Microbiology ,carbohydrates (lipids) ,03 medical and health sciences ,chemistry.chemical_compound ,0404 agricultural biotechnology ,Aglycone ,Lactobacillus acidophilus ,chemistry ,Fermentation ,Food science ,Bacteria ,Lactobacillus plantarum ,Food Science ,Biotechnology - Abstract
This study was carried out to select the most competent bacterial cultures that could convert sesaminol glycosides to aglycone by β-glucosidase produced by lactic acid bacteria such as Lactobacillus acidophilus, Lactobacillus plantarum (LP), and Streptococcus thermophilus in sesame fermented at 37°C for 24 h. The pH of fermented sesame was decreased compared to non-fermented controls. The pH of LP was lower than that of the other two during fermentation. Fermented sesame had higher antioxidant activity compared to non-fermented controls during the entire fermentation time. Total phenol content, DPPH free radical scavenging assay, reducing power assay of sesame fermented by LP was the highest compared to the others. In addition, sesame fermented by LP had more bioconversion of sesaminol glycoside to aglycone compared to the others. Therefore, LP was the best bacterial culture of the three strains studied for producing functional fermented sesame for good health.
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- 2016
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36. Food-Derived Opioid Peptides in Human Health: A Review
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Fred Kwami Ofosu, Eric Banan-Mwine Daliri, Akanksha Tyagi, Deog-Hwan Oh, and Su-Jung Yeon
- Subjects
0301 basic medicine ,Drug ,Nausea ,media_common.quotation_subject ,Review ,Anxiety ,human health ,Bioinformatics ,Catalysis ,lcsh:Chemistry ,Inorganic Chemistry ,stress ,03 medical and health sciences ,0302 clinical medicine ,Monoaminergic ,endogenous and exogenous opioid peptides ,medicine ,Humans ,Physical and Theoretical Chemistry ,Medical prescription ,Opioid peptide ,lcsh:QH301-705.5 ,Molecular Biology ,Stress Disorders, Traumatic, Acute ,Spectroscopy ,Depression (differential diagnoses) ,media_common ,Depression ,business.industry ,Organic Chemistry ,General Medicine ,Computer Science Applications ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,Opioid Peptides ,Opioid ,Western World ,medicine.symptom ,business ,Delivery of Health Care ,bioactive peptides ,030217 neurology & neurosurgery ,medicine.drug - Abstract
World Health Organization data suggest that stress, depression, and anxiety have a noticeable prevalence and are becoming some of the most common causes of disability in the Western world. Stress-related disorders are considered to be a challenge for the healthcare system with their great economic and social impact. The knowledge on these conditions is not very clear among many people, as a high proportion of patients do not respond to the currently available medications for targeting the monoaminergic system. In addition, the use of clinical drugs is also associated with various side effects such as vomiting, dizziness, sedation, nausea, constipation, and many more, which prevents their effective use. Therefore, opioid peptides derived from food sources are becoming one of the safe and natural alternatives because of their production from natural sources such as animals and plant proteins. The requirement for screening and considering dietary proteins as a source of bioactive peptides is highlighted to understand their potential roles in stress-related disorders as a part of a diet or as a drug complementing therapeutic prescription. In this review, we discussed current knowledge on opioid endogenous and exogenous peptides concentrating on their production, purification, and related studies. To fully understand their potential in stress-related conditions, either as a drug or as a therapeutic part of a diet prescription, the need to screen more dietary proteins as a source of novel opioid peptides is emphasized.
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- 2020
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37. Erratum: Effect of dietary processed sulfur supplementation on water‐soluble flavor precursors, free amino acids, and taste characteristics of pork during refrigerated storage
- Author
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Ji‐Han Kim, Min‐Gu Ju, Hyun‐Jin Lee, Su‐Jung Yeon, and Chi‐Ho Lee
- Subjects
Nutrition and Dietetics ,Agronomy and Crop Science ,Food Science ,Biotechnology - Published
- 2020
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38. Flavonoids in Decorticated Sorghum Grains Exert Antioxidant, Antidiabetic and Antiobesity Activities
- Author
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Su-Jung Yeon, Hun Ju Ham, Eric Banan-Mwine Daliri, Sang-Ik Han, Deog-Hwan Oh, Fazle Elahi, Fred Kwame Ofosu, and Joong-Hark Kim
- Subjects
Antioxidant ,030309 nutrition & dietetics ,DPPH ,medicine.medical_treatment ,Pharmaceutical Science ,sorghum grains ,Antioxidants ,Analytical Chemistry ,functional food ,chemistry.chemical_compound ,Tandem Mass Spectrometry ,Drug Discovery ,decortication ,Food science ,Chromatography, High Pressure Liquid ,Acarbose ,chemistry.chemical_classification ,Whole Grains ,0303 health sciences ,ABTS ,biology ,advanced glycation end products ,04 agricultural and veterinary sciences ,040401 food science ,Chemistry (miscellaneous) ,Molecular Medicine ,digestive enzymes inhibitors ,medicine.drug ,Flavones ,Article ,lcsh:QD241-441 ,Inhibitory Concentration 50 ,03 medical and health sciences ,0404 agricultural biotechnology ,lcsh:Organic chemistry ,Phenols ,medicine ,Hypoglycemic Agents ,Glycoside Hydrolase Inhibitors ,Physical and Theoretical Chemistry ,Lipase ,IC50 ,Sorghum ,Flavonoids ,Plant Extracts ,Organic Chemistry ,Enzyme ,chemistry ,biology.protein ,alpha-Amylases ,Tannins - Abstract
Eight new genotypes of brown sorghum grain were decorticated and assessed for their antioxidant, antidiabetic and antiobesity activities in vitro. The DPPH and ABTS radical scavenging assays of the soluble fractions were evaluated, followed by digestive enzymes and advanced glycation end-products (AGEs) formation inhibition assays. DSOR 33 and DSOR 11 exhibited the highest DPPH (IC50 = 236.0 ±, 1.98 µ, g/mL and 292.05 ±, 2.19 µ, g/mL, respectively) and ABTS radical scavenging activity (IC50 = 302.50 ±, 1.84 µ, g/mL and 317.05 ±, 1.06 µ, g/mL, respectively). DSOR 17, DSOR 11 and DSOR 33 showed significantly higher inhibitory activity of both &alpha, glucosidase and &alpha, amylase (IC50 = 31.86, 35.10 and 49.40 µ, g/mL, and 15.87, 22.79 and 37.66 µ, g/mL, respectively) compared to acarbose (IC50 = 59.34 and 27.73 µ, g/mL, respectively). Similarly, DSOR 33, DSOR 11 and DSOR 17 showed potent inhibition of both AGEs and lipase with IC50 values of 18.25, 19.03 and 38.70 µ, and 5.01, 5.09 and 4.94 µ, g/mL, respectively, compared to aminoguanidine (52.30 µ, g/mL) and orlistat (5.82 µ, g/mL). Flavonoids were the predominant compounds identified, with flavones being the major subclass in these three extracts. Our findings suggest that decorticated sorghum grains contain substantial amounts of flavonoids and could be promising candidates for the prevention and treatment of diabetes and obesity.
- Published
- 2020
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39. Effect of Dietary Processed Sulfur Supplementation on Water-holding Capacity, Color, and Lipid Profiles of Pork
- Author
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Go-Eun Hong, Woojoon Park, Fengqi Yang, Ji-Han Kim, Su-Jung Yeon, and Chi-Ho Lee
- Subjects
chemistry.chemical_classification ,Triglyceride ,Cholesterol ,pork ,cholesterol ,food and beverages ,Myristic acid ,chemistry.chemical_element ,fatty acids ,Sulfur ,Article ,chemistry.chemical_compound ,Nutrient ,chemistry ,processed sulfur ,Animal Science and Zoology ,Heptadecanoic acid ,triglyceride ,Stearic acid ,Food science ,Food Science ,Polyunsaturated fatty acid - Abstract
This study was performed to investigate the effect of dietary processed sulfur supplementation on water-holding capacity, color, and lipid profiles of pork according to the level of dietary processed sulfur (0%, CON; 0.3%, S). The pigs were slaughtered at an average final weight of 120 kg, and the longissimus dorsi muscles were collected from the carcasses. As results, pork processed with sulfur had significantly higher moisture and ash contents compared to those of CON but lower crude fat, pH, expressible drip, lower redness and yellowness, and greater lightness. Pork processed with sulfur showed significantly lower total lipid content, triglycerides, and atherosclerosis index but significantly higher high-density lipoprotein cholesterol. Feeding processed sulfur significantly lowered myristic acid, heptadecanoic acid, and stearic acid contents, whereas monounsaturated fatty acids and oleic acids were significantly higher compared to those in the CON. Higher amounts of polyunsaturated fatty acids and n-6 fatty acids were observed in the pork processed with sulfur than that of the CON. Therefore, supplementing pigs with dietary sulfur improved nutrient and meat quality.
- Published
- 2015
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40. Effect of Dietary Processed Sulfur Supplementation on Texture Quality, Color and Mineral Status of Dry-cured Ham
- Author
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Chi-Ho Lee, Woojoon Park, Su-Jung Yeon, Min-Gu Ju, Go-Eun Hong, and Ji-Han Kim
- Subjects
Lightness ,antioxidant ,Antioxidant ,Chemistry ,medicine.medical_treatment ,chemistry.chemical_element ,Sulfur ,Article ,meat quality ,Pigment ,dry cured ham ,visual_art ,medicine ,visual_art.visual_art_medium ,Weaning ,Animal Science and Zoology ,Food science ,Texture (crystalline) ,sulfur-fed pigs ,texture ,Dry cured ,Food Science - Abstract
This study was performed to investigate the chemical composition, mineral status, oxidative stability, and texture attributes of dry-cured ham from pigs fed processed sulfur (S, 1 g/kg feed), and from those fed a basal diet (CON), during the period from weaning to slaughter (174 d). Total collagen content and soluble collagen of the S group was significantly higher than that of the control group (p
- Published
- 2015
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41. Effects of Yogurt Containing Fermented Pepper Juice on the Body Fat and Cholesterol Level in High Fat and High Cholesterol Diet Fed Rat
- Author
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Go-Eun Hong, Su-Jung Yeon, Chi-Ho Lee, Woo Joon Park, Soo-Ki Kim, and Chang-Kyu Kim
- Subjects
Chemistry ,Cholesterol ,Body weight ,fermented pepper juice ,Liver weight ,Article ,yogurt ,chemistry.chemical_compound ,Hepatic lipid ,Pepper ,High cholesterol diet ,High fat ,Bacillus licheniformis ,lipids (amino acids, peptides, and proteins) ,high fat and high cholesterol diet ,Animal Science and Zoology ,Fermentation ,Food science ,body fat accumulation ,Food Science - Abstract
This experiment investigated whether yogurt containing fermented pepper juice (FPJY) affects cholesterol level in high fat and high cholesterol diet (HFCD) fed rat. Twenty five Sprague-Dawley male rats of 7 wk were divided into 5 groups, and fed following diets for 9 wk; CON (control diet), HFCD (HFCD), PY (HFCD supplemented with 2% of plain yogurt), LFY (HFCD supplemented with 2% of FPJY), and HFY (HFCD supplemented with 5% of FPJY). In the LFY group, hepatic total lipid level decreased significantly compared to the HFCD group (p0.05). In HFY group, body weight and hepatic total lipid level significantly decreased over the HFCD group (p0.05). Liver weight decreased as FPJY content was increased. Results suggested FPJY would inhibit organ hypertrophy and accumulation of body fat, hepatic lipid, and cholesterol in HFCD fed rat.
- Published
- 2015
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42. Fermentation of hot pepper juice by Bacillus licheniformis to reduce pungency
- Author
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Soo-Ki Kim, Mi-Sang Yu, Su-Jung Yeon, Jeong-Mee Kim, Sang-Buem Cho, and Chi-Ho Lee
- Subjects
Pungency ,biology ,fungi ,Organic Chemistry ,food and beverages ,biology.organism_classification ,General Biochemistry, Genetics and Molecular Biology ,Dihydrocapsaicin ,chemistry.chemical_compound ,chemistry ,Polyphenol ,Capsaicin ,Pepper ,lipids (amino acids, peptides, and proteins) ,Fermentation ,Food science ,Bacillus licheniformis ,Sugar - Abstract
Capsaicin, an active component of hot pepper, has considerable health benefits; however, the pungency of hot pepper has limited its usage. This study aimed to reduce the pungency of hot pepper by fermentation to enhance its application in the food industry. Hot pepper juice was fermented by Bacillus licheniformis SK1230, which was previously isolated as a capsaicin-degrading bacterium. B. licheniformis SK1230 was inoculated into the juice of red or green pepper, and the mixture was then fermented for 19 days to determine the degradation level of capsaicinoids. It was observed that with a gradual increase in pH, the growth of B. licheniformis SK1230 increased to 1.0 × 109 CFU/mL after day 1, and its viability persisted until the end of fermentation. The sugar content of green pepper drastically reduced at day 1 and that of red pepper reduced at day 5. The total polyphenol content of the medium containing red pepper was about 2-fold higher than that of the medium containing green pepper. The antioxidant activity of the medium containing red pepper was also higher than that of the medium containing green pepper; however, the activity gradually decreased during the course of the fermentation period. The capsaicinoid content of both types of peppers radically decreased at day 5. Thus, we suggest that a fermentation period of 5 days would be optimal for the degradation of capsaicin with minimal loss of antioxidant activity and would provide higher polyphenol content.
- Published
- 2015
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43. Antioxidant Activity and Quality Characteristics of Yogurt Added Green Olive Powder during Storage
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Won-Young, Cho, Su-Jung, Yeon, Go-Eun, Hong, Ji-Han, Kim, Chuluunbat, Tsend-Ayush, and Chi-Ho, Lee
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yogurt ,sensory evaluation ,dairy ,antioxidant activity ,green olive powder ,Article - Abstract
The objective of this study was to determine the antioxidant and quality characteristics of yogurt added green olive powder stored at 4°С for 15 d. The following four groups were used in this study: Control group (GY0), Yogurt added with 1% green olive (GY1), with 3% green olive (GY3), and with 5% green olive (GY5). The more time of titratable acidity went by, the more it increased. Except GY0, viscosity tended to decrease in other groups (p>0.05), and the more time of syneresis went by, the more it increased, but GY3 of them showed the lowest syneresis. Lactic acid bacteria showed no significant with GY0 until 5 d, but after that, GY1, GY3 and GY5 showed lower than GY0. Yogurt added green olive showed darker color than GY0 (low L* and high a*). The antioxidant activity of GY5 was found to be the highest among the four groups at day 1 of storage. Total phenolic content, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and reducing power of GY5 was found to be the highest among the four groups at day 1 of storage which were 6.96 mg GAE/kg, 47.53%, and 0.57, respectively. In the sensory evaluation sweet and overall of GY3 indicated the highest score among the four groups. Results of this study demonstrated that green olive powder might be used to improve the antioxidant capacity and sensory characteristics of yogurt.
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- 2017
44. Effect of dietary processed sulfur supplementation on water-soluble flavor precursors, free amino acids, and taste characteristics of pork during refrigerated storage
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Ji-Han, Kim, Min-Gu, Ju, Hyun-Jin, Lee, Su-Jung, Yeon, and Chi-Ho, Lee
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Flavoring Agents ,Meat ,Swine ,Taste ,Dietary Supplements ,Animals ,Humans ,Amino Acids ,Animal Feed ,Sulfur - Abstract
A total of 60 three-way crossbred (Landrace, Duroc, and Yorkshire) pigs were divided into two groups (processed sulfur-fed pigs (SFPs) and nonprocessed sulfur-fed pigs, (NSFPs)) and used to determine the effect of supplementation with 3 g kgGlycogen and glucose levels of SFP were significantly higher than in NSFPs. Glycogen levels decreased and glucose levels increased during storage (P0.001). The pH and moisture content of SFPs were higher than in NSFPs. Inosine of SFPs was higher than in NSFPs (P0.05). Hence, umami and richness tastes of SFPs were higher than in NSFPs and increased during storage. The total free amino acid content of both groups was not different, although it increased during storage (P0.001). The umami taste of water-soluble precursors was improved in meat derived from SFPs during refrigeration.The storage time and dietary supplementation with processed sulfur increased the taste components of meat. Application of an electronic tongue system can be used to distinguish the taste characteristics of different types of pork, based on differential supplementation and aging. © 2018 Society of Chemical Industry.
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- 2017
45. In Vitro Studies of Fermented Korean Chung-Yang Hot Pepper Phenolics as Inhibitors of Key Enzymes Relevant to Hypertension and Diabetes
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Soo-Ki Kim, Won-Young Cho, Ji-Han Kim, Su-Jung Yeon, Chi-Ho Lee, and Han Geuk Seo
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0106 biological sciences ,Metal chelating activity ,antioxidant ,Health (social science) ,Antioxidant ,DPPH ,medicine.medical_treatment ,Plant Science ,lcsh:Chemical technology ,01 natural sciences ,Health Professions (miscellaneous) ,Microbiology ,Article ,angiotensin I-converting enzyme (ACE) inhibition ,chemistry.chemical_compound ,pepper ,0404 agricultural biotechnology ,010608 biotechnology ,Renin–angiotensin system ,Pepper ,medicine ,lcsh:TP1-1185 ,Food science ,fermentation ,chemistry.chemical_classification ,food and beverages ,04 agricultural and veterinary sciences ,040401 food science ,In vitro ,Enzyme ,chemistry ,Fermentation ,hyperglycemia ,Food Science - Abstract
This study was investigated to evaluate the antioxidant activity, the angiotensin I-converting enzyme (ACE) inhibition effect, and the &alpha, amylase and &alpha, glucosidase inhibition activities of hot pepper water extracts both before and after their fermentation. The fermented pepper water extract (FP) showed significantly higher total phenol content, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical inhibition effect, metal chelating activity and ACE inhibition activity compared to the non-fermented raw pepper water extract (RP) (p <, 0.05). Meanwhile, the FP showed lower &alpha, amylase and higher &alpha, glucosidase inhibitory activities, but the RP showed similar levels of &alpha, glucosidase inhibitory activities. Taken together, these results suggested that fermented pepper extract using water should be expected to have potentially inhibitory effects against both hyperglycemia and hypertension.
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- 2019
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46. Effects of Fermented Pepper Powder on Body Fat Accumulation in Mice Fed a High-Fat Diet
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Jong Moon Kim, Si-Kyung Lee, Chi-Ho Lee, Soo-Ki Kim, and Su-Jung Yeon
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Male ,Bacillus ,Diet, High-Fat ,Applied Microbiology and Biotechnology ,Biochemistry ,Analytical Chemistry ,Mice ,chemistry.chemical_compound ,Fat accumulation ,Pepper ,Animals ,Obesity ,Food science ,Bacillus licheniformis ,Molecular Biology ,Mice, Inbred ICR ,biology ,Chemistry ,Body Weight ,fungi ,Organic Chemistry ,food and beverages ,Lipid metabolism ,General Medicine ,Lipid Metabolism ,biology.organism_classification ,Dietary Fats ,Adipose Tissue ,Liver ,Fat diet ,Capsaicin ,Dietary Supplements ,Fermentation ,lipids (amino acids, peptides, and proteins) ,Powders ,Capsicum ,Biotechnology - Abstract
We investigated the effects of non-pungent pepper powder fermented by Bacillus licheniformis SK1230 on the fat accumulation in mice. Four weeks of feeding a high-fat diet with fermented pepper powder resulted in a significantly decreased hepatic total-lipid level and increased serum HDL-cholesterol, and tended to lower the fat weight. These results suggest that fermented pepper powder inhibited fat accumulation and improved lipid metabolism in mice fed the high-fat diet.
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- 2013
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47. Enhancing quality characteristics of salami sausages formulated with whole buckwheat flour during storage
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Ji-Han Kim, Min-Gu Ju, Han Geuk Seo, Su-Jung Yeon, Go-Eun Hong, Woojoon Park, and Chi-Ho Lee
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Water activity ,0402 animal and dairy science ,04 agricultural and veterinary sciences ,040401 food science ,040201 dairy & animal science ,Lactic acid ,chemistry.chemical_compound ,0404 agricultural biotechnology ,Plate count ,chemistry ,Lipid oxidation ,Original Article ,Food science ,Quality characteristics ,Food Science - Abstract
This study was performed to investigate the quality characteristics of salami sausages added with different levels of whole buckwheat flour (BWF) during storage. Samples included the control (Con), addition of 1% BWF (T1), 3% BWF (T2), and 5% BWF (T3). Water activity (aw) and pH decreased with increased level of BWF. Salami sausage samples containing 5% BWF demonstrated significantly lower 2-thiobarbituric acid (TBA) values than the control. Changes in TBA values between day 0 and 21 for T2 and T3 were less than that for control. Total plate count (TPC) of all groups significantly decreased, whereas lactic acid bacteria significantly increased after 21 days. TPC of samples added with BWF was significantly lower during storage. Inclusion of BWF seemed to be an effective means of retarding lipid oxidation and enhancing storability of salami sausages.
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- 2016
48. Physical and Sensory Properties of Ice Cream Containing Fermented Pepper Powder
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Go-Eun Hong, Chi-Ho Lee, Han-Geuk Seo, Woojoon Park, Su-Jung Yeon, Ji-Han Kim, and Soo-Ki Kim
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Pungency ,Chemistry ,digestive, oral, and skin physiology ,fungi ,food and beverages ,unpungent pepper ,04 agricultural and veterinary sciences ,functional dessert ,040401 food science ,Sensory analysis ,Article ,fermented pepper ,sensory analysis ,0404 agricultural biotechnology ,Functional food ,Ice cream ,Pepper ,ice cream ,Animal Science and Zoology ,Fermentation ,lipids (amino acids, peptides, and proteins) ,Food science ,Food Science - Abstract
This study was conducted to investigate the physical and sensory properties of ice cream containing fermented pepper powder. Three ice cream formulas were manufactured: 1, control; 2, supplemented with 0.1% fermented pepper powder; and 3, supplemented with 0.2% fermented pepper powder. Formulas 2 and 3 had significantly higher viscosity and lower overrun than formula 1 (p
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- 2016
49. Production of sesaminol and antioxidative activity of fermented sesame with
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Jin-Ju, Bae, Su-Jung, Yeon, Woo-Joon, Park, Go-Eun, Hong, and Chi-Ho, Lee
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carbohydrates (lipids) ,food and beverages ,Article - Abstract
This study was carried out to select the most competent bacterial cultures that could convert sesaminol glycosides to aglycone by β-glucosidase produced by lactic acid bacteria such as Lactobacillus acidophilus, Lactobacillus plantarum (LP), and Streptococcus thermophilus in sesame fermented at 37°C for 24 h. The pH of fermented sesame was decreased compared to non-fermented controls. The pH of LP was lower than that of the other two during fermentation. Fermented sesame had higher antioxidant activity compared to non-fermented controls during the entire fermentation time. Total phenol content, DPPH free radical scavenging assay, reducing power assay of sesame fermented by LP was the highest compared to the others. In addition, sesame fermented by LP had more bioconversion of sesaminol glycoside to aglycone compared to the others. Therefore, LP was the best bacterial culture of the three strains studied for producing functional fermented sesame for good health.
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- 2015
50. Physicochemical and textural properties of pork patties as affected by buckwheat and fermented buckwheat
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Min-Gu Ju, Woojoon Park, Chi-Ho Lee, Ji-Han Kim, Su-Jung Yeon, and Go-Eun Hong
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Antioxidant ,Chemistry ,Fat content ,medicine.medical_treatment ,0402 animal and dairy science ,food and beverages ,04 agricultural and veterinary sciences ,Proximate ,040401 food science ,040201 dairy & animal science ,Tenderness ,0404 agricultural biotechnology ,Lipid oxidation ,Texture profile analysis ,Reduced fat ,medicine ,Fermentation ,Original Article ,Food science ,medicine.symptom ,Food Science - Abstract
This study was investigated to assess the effects of buckwheat (BW) and fermented buckwheat (FBW) on the proximate compositions, pH change, cooking quality, lipid oxidation, textural properties, and sensory characteristics of pork patties. Pork patties treated with BW and FBW were divided into six groups; Con, non-treated patties; T0, reduced fat patties; T1 and T2, addition of 1 and 3 % BW; FT1 and FT2, addition of 1 and 3 % FBW. FBW showed significantly higher antioxidant activity and total phenolic contents than BW (P
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- 2015
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