250 results on '"Su Min Chang"'
Search Results
2. Sex differences in machine learning computed tomography-derived fractional flow reserve
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Mahmoud Al Rifai, Ahmed Ibrahim Ahmed, Yushui Han, Jean Michel Saad, Talal Alnabelsi, Faisal Nabi, Su Min Chang, Myra Cocker, Chris Schwemmer, Juan C. Ramirez-Giraldo, William A. Zoghbi, John J. Mahmarian, and Mouaz H. Al-Mallah
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Medicine ,Science - Abstract
Abstract Coronary computed tomography angiography (CCTA) derived machine learning fractional flow reserve (ML-FFRCT) can assess the hemodynamic significance of coronary artery stenoses. We aimed to assess sex differences in the association of ML-FFRCT and incident cardiovascular outcomes. We studied a retrospective cohort of consecutive patients who underwent clinically indicated CCTA and single photon emission computed tomography (SPECT). Obstructive stenosis was defined as ≥ 70% stenosis severity in non-left main vessels or ≥ 50% in the left main coronary. ML-FFRCT was computed using a machine learning algorithm with significant stenosis defined as ML-FFRCT
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- 2022
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3. Prosthetic Aortic Valve Thrombosis
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Payam Pournazari, Su Min Chang, Stephen H Little, Sachin Goel, and Nadeen N Faza
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Prosthetic valve thrombosis is the second leading cause of prosthetic valve deterioration and is being more readily diagnosed with the use of echocardiography and multidetector cardiac CT. Presentation of valve thrombosis can be acute or subacute and any change in clinical status of a patient with a prosthetic valve should raise a suspicion of prosthetic valve thrombosis. Diagnosis entails detailed clinical examination and comprehensive imaging. The choice of therapeutic options includes anticoagulation, fibrinolytic therapy, or valve replacement. Antiplatelet and anticoagulation therapy remain the mainstay of thrombosis prevention in patients with a prosthetic valve and a personalized approach is required to optimize prosthetic valve function and minimize the risk of bleeding.
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- 2022
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4. Mechanical Mitral Valve Thrombosis in a Patient With Prior Nonbacterial Thrombotic Endocarditis
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Kalyan R. Chitturi, DO, Miguel A. Castro, MD, Eric Salazar, MD, Michael Deavers, MD, Su Min Chang, MD, John J. Mahmarian, MD, and Karla M. Kurrelmeyer, MD
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antiphospholipid syndrome ,antithrombotic therapies ,mitral valve disease ,nonbacterial thrombotic endocarditis ,prosthetic valve thrombosis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
A 54-year-old woman with a mechanical mitral valve replacement presented with recurrent admissions for pneumonia and pulmonary edema. Multimodality imaging revealed mobile masses on the prosthesis and discrepant point of care and inpatient international normalized ratio levels owing to antiphospholipid antibody cross-reactivity on the outpatient assay. The prosthetic valve thromboses resolved with therapeutic anticoagulation. (Level of Difficulty: Beginner.)
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- 2020
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5. Outflow cannula alignment in continuous flow left ventricular devices is associated with stroke
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Mahwash Kassi, Tanushree Agrawal, Jiaqiong Xu, Hernan Gerardo Marcos-Abdala, Raquel Araujo-Gutierrez, Thomas Macgillivray, Erik E Suarez, Rayan Yousefzai, Nadia Fida, Ju H Kim, Imad Hussain, Ashrith Guha, Barry Trachtenberg, Arvind Bhimaraj, Su Min Chang, and Jerry Estep
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Biomaterials ,Biomedical Engineering ,Medicine (miscellaneous) ,Bioengineering ,General Medicine - Abstract
We sought to evaluate whether differences in left ventricular assist device (LVAD) canula alignment are associated with stroke. There is a paucity of clinical data on contribution of LVAD canulae alignment to strokes. We conducted a retrospective analysis of patients who underwent LVAD implantation at Houston Methodist hospital from 2011 to 2016 and included those who had undergone cardiac computed tomography (CT) with contrast. LVAD graft alignment using X-ray, echocardiography, and cardiac CT was evaluated. The primary outcome was stroke within 1 year of LVAD implantation. Of the 101 patients that underwent LVAD Implantation and cardiac CT scan during the study period, 78 met inclusion criteria. The primary outcome occurred in 12 (15.4%) patients with a median time to stroke of 77 days (interquartile range: 42–132 days). Of these, 10 patients had an ischemic and two had hemorrhagic strokes. The predominant device type was Heart Mate II (94.8%). Patients with LVAD outflow cannula to aortic angle lesser than 37.5° and those with outflow graft diameter of anastomosis less than 1.5 cm (assessed by cardiac CT) had significantly higher stroke risk ( p
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- 2023
6. Dynamic Imaging of Aortic Pathologies: Review of Clinical Applications and Imaging Protocols
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Peter Osztrogonacz, Marton Berczeli, Ponraj Chinnadurai, Su-Min Chang, Dipan J. Shah, and Alan B. Lumsden
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General Medicine - Published
- 2023
7. Role of Multimodality Imaging in Transcatheter Structural Interventions
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Amr Telmesani, Su Min Chang, Nadeen Faza, Stephen H. Little, and Dipan J. Shah
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General Medicine - Published
- 2023
8. Dynamic Computed Tomography Angiography is More Accurate in Diagnosing Endoleaks than Standard Triphasic Computed Tomography Angiography and Enables Targeted Embolization
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Marton Berczeli, Ponraj Chinnadurai, Peter Osztrogonácz, Eric K. Peden, Charudatta S. Bavare, Péter Sótonyi, Su Min Chang, and Alan B. Lumsden
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Surgery ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
The primary objective was to compare the accuracy of dynamic computed tomography (CT) angiography (d-CTA) with standardized triphasic contrast enhanced CT angiography (t-CTA) in diagnosing endoleak type after endovascular aortic repair (EVAR) using digital subtraction angiography (DSA) as reference standard. The secondary objective was to study the impact of d-CTA on image fusion-guided endoleak embolization.A retrospective review of patients who underwent d-CTA imaging after EVAR between March 2019 and July 2021 was performed. Deidentified images were independently reviewed by two-two blinded readers to document endoleak type and target vessels. An impact of d-CTA-guided embolization was evaluated by a number of planning angiograms, radiation exposure, and accuracy of target vessel overlay.During the study period, 52 patients underwent d-CTA and 19 had all 3 modalities available for analysis. DSA imaging confirmed 4 (21.0%) type-I, 14 (73.7%) type-II, and 1 (5.3%) type-III endoleak. Findings from d-CTA matched with DSA in 19/19 cases (100%), whereas t-CTA matched in 14/19 cases (73.7%). In type-II endoleaks, the number of target vessels identified by d-CTA, t-CTA, and DSA were 23, 17, and 16, respectively. Mean dose-length product from d-CTA and t-CTA was 1,445 ± 551 and 1,612 ± 530 mGy × cm (P = 0.26). Nine patients underwent d-CTA-guided type-II endoleak embolization, using a median of 1 (range: 1-4) planning angiogram before embolization using 21.6 (± 8.7)% of total procedural radiation dose. Target vessel overlay was accurate in 9/9 (100%) cases.Dynamic, time-resolved CTA is more accurate compared to standardized triphasic contrast enhanced CTA in diagnosing endoleak type after EVAR. In type-II endoleak, d-CTA better identified target vessels and enabled safe, targeted embolization.
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- 2023
9. Late Transcatheter Aortic Valve Thrombosis Leading to Cardiogenic Shock
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Qasim Al Abri, Lamees I. El Nihum, Tomoya Hinohara, Su Min Chang, Nadeen N. Faza, Sachin S. Goel, Neal S. Kleiman, Moritz C. Wyler von Ballmoos, Marvin D. Atkins, and Michael J. Reardon
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Cardiology and Cardiovascular Medicine - Published
- 2022
10. Temporal trends in the use of cardiac computerized tomography angiography and transesophageal echocardiography for left atrial appendage thrombus detection
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Malek Nayfeh, Ahmed Ibrahim Ahmed, Mahmoud Al Rifai, Fares Alahdab, Sherif F. Nagueh, Mohammed A. Chamsi-Pasha, John J. Mahmarian, Su Min Chang, William A. Zoghbi, and Mouaz H. Al-Mallah
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Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine - Published
- 2023
11. Time-resolved, Cardiac-gated Computed Tomography After Endovascular Ascending Aortic and Arch Repair
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Marton Berczeli, Ponraj Chinnadurai, Juan Carlos Ramirez-Giraldo, Zsolt Garami, Alan B. Lumsden, Marvin D. Atkins, and Su Min Chang
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Pulmonary and Respiratory Medicine ,Blood Vessel Prosthesis Implantation ,Aortic Aneurysm, Thoracic ,Endoleak ,Computed Tomography Angiography ,Endovascular Procedures ,Humans ,Stents ,Surgery ,Cardiology and Cardiovascular Medicine ,Aorta ,Blood Vessel Prosthesis ,Retrospective Studies - Abstract
Better time-resolved imaging of stent grafts in the ascending aorta and arch accounting for cardiac motion is necessary to understand device-related complications and endoleaks. This report describes dynamic time-resolved computed tomographic angiography (d-CTA) and its combination with electrocardiography gating (d-gated CTA) to image stent grafts in the ascending aorta and to characterize endoleaks more clearly.d-CTA involves multiple scans acquired at different time points along the contrast enhancement curve. d-Gated CTA involves concomitant electrocardiography gating in a predefined cardiac phase minimizing motion-induced artifacts.This report illustrates the utility of d-CTA and d-gated CTA in 2 clinical cases. d-CTA demonstrated a type 1A endoleak in a patient with an aortic arch aneurysm treated with total arch debranching and a thoracic stent graft. d-gated CTA demonstrated a type 1A endoleak in a patient with an ascending aortic pseudoaneurysm treated with aortic cuff placement.Dynamic, cardiac-gated CTA enables time-resolved angiographic imaging of the ascending aorta and arch without any cardiac motion-related artifacts. Such advanced imaging techniques help with better characterization of endoleaks after stent graft deployment in the ascending aorta and arch.
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- 2022
12. Prognostic Value of Computed Tomography-Derived Fractional Flow Reserve Comparison With Myocardial Perfusion Imaging
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Talal Alnabelsi, Myra Cocker, Su Min Chang, Ahmed Ibrahim Ahmed, William A. Zoghbi, Faisal Nabi, Juan Carlos Ramirez-Giraldo, Mouaz H. Al-Mallah, John J. Mahmarian, Yushui Han, Mahmoud Al Rifai, Chris Schwemmer, and Neal S. Kleiman
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Male ,medicine.medical_specialty ,Computed Tomography Angiography ,medicine.medical_treatment ,Coronary Artery Disease ,Fractional flow reserve ,Coronary Angiography ,Revascularization ,Myocardial perfusion imaging ,Percutaneous Coronary Intervention ,Predictive Value of Tests ,Internal medicine ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Myocardial infarction ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Myocardial Perfusion Imaging ,Percutaneous coronary intervention ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,Fractional Flow Reserve, Myocardial ,Angiography ,Conventional PCI ,Cardiology ,Female ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business - Abstract
The aim of this study was to compare the incremental prognostic value of coronary computed tomography (CT) angiography (CCTA)-derived machine learning fractional flow reserve CT (ML-FFRct) versus that of ischemia detected on single-photon emission-computed tomography (SPECT) myocardial perfusion imaging (MPI) on incident cardiovascular outcomes.SPECT MPI and ML-FFRct are noninvasive tools that can assess the hemodynamic significance of coronary atherosclerotic disease.We studied a retrospective cohort of consecutive patients who underwent clinically indicated CCTA and SPECT MPI. ML-FFRct was computed using a ML prototype. The primary outcome was all-cause mortality and nonfatal myocardial infarction (D/MI), and the secondary outcome was D/MI and unplanned revascularization, percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) occurring more than 90 days postimaging. Multiple nested multivariate cox regression was used to model a scenario wherein an initial anatomical assessment was followed by a functional assessment.A total of 471 patients (mean age: 64 ± 13 year; 53% males) were included. Comorbidities were prevalent (78% hypertension, 66% diabetes, 81% dyslipidemia). ML-FFRct was 0.8 in at least 1 proximal/midsegment was present in 41.6% of patients, and ischemia on MPI was present in 13.8%. After a median follow-up of 18 months, 7% of patients (n = 33) experienced D/MI. On multivariate Cox proportional analysis, the presence of ischemia on MPI but not ML-FFRct significantly predicted D/MI (HR: 2.3; 95% CI: 1.0-5.0; P = 0.047; or HR: 0.7; 95% CI: 0.3-1.4; P = 0.306 respectively) when added to CCTA obstructive stenosis. Furthermore, the model with SPECT ischemia had higher global chi-square result and significantly improved reclassification. Results were similar using the secondary outcome and on several sensitivity analyses.In a high-risk patient cohort, SPECT MPI but not ML-FFRct adds independent and incremental prognostic information to CCTA-based anatomical assessment and clinical risk factors in predicting incident outcomes.
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- 2022
13. Dynamic, Time-Resolved CT Angiography After EVAR: A Quantitative Approach to Accurately Characterize Aortic Endoleak Type and Identify Inflow Vessels
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Marton Berczeli, Ponraj Chinnadurai, Peter Legeza, Eric K. Peden, Charudatta S. Bavare, Su Min Chang, and Alan B. Lumsden
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Radiology, Nuclear Medicine and imaging ,Surgery ,Cardiology and Cardiovascular Medicine - Abstract
Purpose: Our purpose was to study the accuracy of dynamic computed tomography angiography (d-CTA) in characterizing endoleak type, inflow vessels as compared with digital subtraction angiography (DSA) using qualitative and quantitative analysis. Methods: Between March 2019 and January 2021, all patients who underwent d-CTA imaging after EVAR were retrospectively reviewed. Two blinded independent reviewers qualitatively reviewed d-CTA and DSA images. Quantitative region of interest (ROI) analysis was performed by measuring time-resolved contrast enhancement within the aorta and endoleak lesion(s) in the aneurysm sac. Differences between time-to-peak enhancement (Δ TTP) across different ROIs were quantified. Results: A total of 48 patients underwent d-CTA during the study period, of whom 24 patients had abdominal EVAR and DSA imaging for comparison. Qualitative review of DSA imaging showed type I (n=4), type II (n=16), and type III (n=2) and no endoleak (n=2). In 23 of 24 patients (95.8%), d-CTA findings correlated with DSA findings for endoleak type. One patient had a type III endoleak that was demonstrated only in d-CTA (arising from defect in polymer sealing ring of Ovation stent graft) imaging. In type II endoleak cases, d-CTA identified more inflow vessels than DSA imaging (33 vs 21 vessels, p=0.010). Quantitative analysis showed mean (±SD) Δ TTP values for type I endoleak as 1.8 (±1.8) seconds, type II as 9.6 (±3.5) seconds, and for type III endoleak as 5.6 (±1.3) seconds. Conclusion: Dynamic CTA can accurately characterize aortic endoleak type, inflow vessels as compared with DSA imaging. Quantitative parameters such as Δ TTP enhancement can help better differentiate endoleak types and provide an objective approach to endoleak diagnosis.
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- 2022
14. Role of Multimodality Imaging in Transcatheter Structural Interventions.
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TELMESANI, AMR, SU MIN CHANG, FAZA, NADEEN, LITTLE, STEPHEN H., and SHAH, DIPAN J.
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Cardiac imaging is the backbone for safe and optimal transcatheter structural interventions. Transthoracic echocardiogram is the initial modality to assess valvular disorders, while transesophageal echocardiogram is best to delineate the mechanism of valvular regurgitation, preprocedural assessment for transcatheter edge-to-edge repair, and for intraprocedural guidance. Cardiac computed tomography is the modality of choice for assessing calcifications, maneuvering multiplaner reconstruction of different cardiac structures, preprocedural planning for various transcatheter valve replacement, and assessing for hypoattenuated leaflet thickening and reduced leaflet motion. Cardiac magnetic resonance imaging is best known for most accurate volumetric assessment of valvular regurgitation and chamber size quantification. Cardiac positron emission tomography is the only modality that could assess active infection through using fluorine 18 fluorodeoxyglucose radiotracer. [ABSTRACT FROM AUTHOR]
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- 2023
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15. Association Between FFRCT and Instantaneous Wave-Free Ratio (iFR) of Intermediate Lesions on Coronary Computed Tomography Angiography
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Mouaz H. Al-Mallah, Su Min Chang, Hasan Rehman, Faisal Nabi, Faheemullah Beg, Mohammed A. Chamsi-Pasha, and John J. Mahmarian
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business.industry ,Coronary computed tomography angiography ,Coronary flow reserve ,General Medicine ,Fractional flow reserve ,030204 cardiovascular system & hematology ,medicine.disease ,Predictive value ,03 medical and health sciences ,Stenosis ,0302 clinical medicine ,Long term outcomes ,Medicine ,Vessel analysis ,030212 general & internal medicine ,Instantaneous wave-free ratio ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine - Abstract
Background New data suggests long term outcomes of coronary revascularization based on instantaneous wave free ratio (iFR) are equivalent to invasive fractional flow reserve (FFR). We aimed to evaluate the correlation between non-invasive FFR derived from cardiac CT (FFR CT) and iFR. Methods Data from 21 patients with 26 vessels, who underwent both FFRCT computation and invasive iFR measurement, were analysed. We evaluated diagnostic performance of FFRCT according to two cut-off values of ≤0.80 and ≤0.70 with iFR ≤0.89 as the reference standard. Results In a per vessel analysis, the average diameter stenosis was 59%, mean FFRCT was 0.81 while mean iFR was 0.90. Using an FFRCT cut-off of 0.80, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy for FFRCT were 86%, 84%, 67%, 94%, and 85% respectively. When the cut-off was lowered to 0.70, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy for FFRCT were 57%, 100%, 100%, 86% and 88% respectively. Conclusion FFRCT correlates well with iFR in this small retrospective study. Larger studies are required to confirm this finding.
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- 2021
16. Dynamic, Time-Resolved Computed Tomography Angiography Technique to Characterize Aortic Endoleak Type, Inflow and Provide Guidance for Targeted Treatment
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Su Min Chang, Ponraj Chinnadurai, A.B. Lumsden, Marton Berczeli, and Charudatta S. Bavare
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medicine.medical_specialty ,Endoleak ,Computed Tomography Angiography ,medicine.medical_treatment ,Inflow ,Aortography ,Endovascular aneurysm repair ,Blood Vessel Prosthesis Implantation ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Image guidance ,Retrospective Studies ,Computed tomography angiography ,Image fusion ,medicine.diagnostic_test ,business.industry ,Endovascular Procedures ,Treatment Outcome ,Surgery ,Imaging technique ,Radiology ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Aortic Aneurysm, Abdominal - Abstract
Purpose: To illustrate dynamic, time-resolved CTA (d-CTA) imaging technique in characterizing aortic endoleak type/inflow using quantitative parameters and its value in providing image guidance for targeted treatment approach. Technique: Dedicated endoleak protocol involved acquiring multiple time-resolved contrast enhanced scans using third-generation CT scanner (Somatom Force®, Siemens Healthineers). Parameters such as scan field of view (FOV), kV, number/timing of scans were customized based on patient’s body-mass-index, timing bolus, and prior imaging findings. D-CTA image datasets were evaluated qualitatively and quantitatively using time-attenuation curves (TAC) analysis after motion correction using a dedicated software ( syngo.via®, Siemens). D-CTA findings from 4 illustrative cases demonstrating type I, type II (inferior mesenteric and lumbar artery inflow), and type III endoleak were illustrated. TAC analysis with time to peak parameter enabled better characterization of endoleak type and inflow. During endoleak intervention, target vessels from d-CTA images were electronically annotated and overlaid on fluoroscopy using 2D−3D image fusion to provide image guidance for targeted treatment. Conclusion: D-CTA imaging with TAC analysis characterizes aortic endoleak type and inflow, in addition to providing image guidance for targeted endoleak treatment. Such dynamic, time-resolved imaging techniques may provide further insights into understanding aortic endoleak that remains an Achilles heel for endovascular aortic aneurysm repair.
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- 2021
17. Outcomes of patients with moderate-to-severe Ischemia excluded from the ischemia trial
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Ahmed Ibrahim Ahmed, Su Min Chang, Mouaz H. Al-Mallah, Alpesh Shah, Yuishi Han, Faisal Nabi, Mohammed A. Chamsi-Pasha, Neal S. Kleiman, William A. Zoghbi, and John J. Mahmarian
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Moderate to severe ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Ischemia ,medicine.disease ,Lower risk ,Coronary revascularization ,Coronary artery disease ,Diabetes mellitus ,Internal medicine ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,Cardiology and Cardiovascular Medicine ,business ,Perfusion ,Emission computed tomography - Abstract
The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial showed no difference in outcomes between medical therapy vs coronary revascularization in the management of patients with stable coronary artery disease. We aimed to determine the percentage of patients with at least moderate ischemia that would have been eligible for enrollment and evaluate the outcomes of those who would not. Consecutive patients who underwent cardiac single-photon emission computed tomography (SPECT) between April 2016 and September 2019 were identified and all-cause mortality was determined. There were a total of 1508 patients (mean age 67 ± 11.6 years, 69.5% males) with any perfusion defect on SPECT. Patients had a high prevalence of cardiac risk factors (73.4% with hypertension and 54.4% with diabetes mellitus.) Nearly half (709, 47%) had moderate-to-severe ischemia but over two-thirds (479/709, 66.3%) had at least one ISCHEMIA trial exclusion criteria. Patients meeting ISCHEMIA enrollment criteria had a significantly lower all-cause mortality than those who would have been excluded (3.91% vs. 11.3%, respectively, P
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- 2021
18. TEMPORAL TRENDS IN THE US OF CARDIAC CT FOR DIAGNOSIS OF LEFT ATRIAL APPENDAGE THROMBUS; THE IMPACT OF COVID-19 PANDEMIC
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Malek Nayfeh, Ahmed Ibrahim Ahmed, Fares Alahdab, Faisal Nabi, Su Min Chang, John J. Mahmarian, Mohammed A. Chamsi-Pasha, Maan Malahfji, Mahmoud Al Rifai, and Mouaz H. Al-Mallah
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Cardiology and Cardiovascular Medicine - Published
- 2023
19. INVASIVE PROCEDURE UTILIZATION AFTER SEVERE CORONARY ARTERY CALCIUM SCORING IN ASYMPTOMATIC PATIENTS
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Abhinaya Muruganandham, Kristian Kragholm, Camila Trujillo, Abhiraj Sinha, Salma Zook, and Su Min Chang
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Cardiology and Cardiovascular Medicine - Published
- 2023
20. Dynamic Imaging of Aortic Pathologies: Review of Clinical Applications and Imaging Protocols.
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OSZTROGONACZ, PETER, BERCZELI, MARTON, CHINNADURAI, PONRAJ, SU-MIN CHANG, SHAH, DIPAN J., and LUMSDEN, ALAN B.
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CLINICAL pathology ,DIAGNOSTIC imaging ,AORTA ,MAGNETIC resonance imaging ,CLINICAL medicine - Abstract
The past decade has seen significant advances in dynamic imaging of the aorta. Today's vascular surgeons have the opportunity to choose from a wide array of imaging modalities to evaluate different aortic pathologies. While vascular ultrasound and aortography are considered to be the bread and butter imaging modalities, newer dynamic imaging techniques provide time-resolved information in various aortic pathologies. However, despite growing evidence of their advantages in the literature, they have not been routinely adopted. In order to understand the role of these emerging modalities, one must understand their principles, advantages, and limitations in the context of various clinical scenarios. In this review, we provide an overview of dynamic imaging techniques for aortic pathologies and describe various dynamic computed tomography and magnetic resonance imaging protocols, clinical applications, and potential future directions. [ABSTRACT FROM AUTHOR]
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- 2023
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21. Imaging aortic intramural hematoma with blood pools using time-resolved, dynamic computed tomography angiography
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Marton Berczeli, Su Min Chang, Alan B. Lumsden, and Ponraj Chinnadurai
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Hematoma ,Computed Tomography Angiography ,Angiography ,Aortic Diseases ,Humans ,Surgery ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine - Published
- 2022
22. A stable method for 4D CT-based CFD simulation in the right ventricle of a TGA patient
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Chun Huie Lin, Yushui Han, Maxim A. Olshanskii, Victoria Salamatova, Yuri V. Vassilevski, Alexander Danilov, Alexander Lozovskiy, and Su Min Chang
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Numerical Analysis ,Cfd simulation ,Computer science ,Mechanics ,Blood flow ,01 natural sciences ,Finite element method ,010305 fluids & plasmas ,010101 applied mathematics ,medicine.anatomical_structure ,Ventricle ,Modeling and Simulation ,0103 physical sciences ,Fluid–structure interaction ,medicine ,0101 mathematics ,Numerical stability - Abstract
The paper discusses a stabilization of a finite element method for the equations of fluid motion in a time-dependent domain. After experimental convergence analysis, the method is applied to simulate a blood flow in the right ventricle of a post-surgery patient with the transposition of the great arteries disorder. The flow domain is reconstructed from a sequence of 4D CT images. The corresponding segmentation and triangulation algorithms are also addressed in brief.
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- 2020
23. Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging
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Marton, Berczeli, Ponraj, Chinnadurai, Su Min, Chang, and Alan B, Lumsden
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Treatment Outcome ,Endoleak ,Computed Tomography Angiography ,Endovascular Procedures ,Contrast Media ,Humans ,Aortography ,Aortic Aneurysm, Abdominal ,Retrospective Studies - Abstract
In the United States, more than 80% of all abdominal aortic aneurysms are treated by endovascular aortic aneurysm repair (EVAR). The endovascular approach warrants good early results, but adequate follow-up imaging after EVAR is imperative to maintain long-term positive outcomes. Potential graft-related complications are graft migration, infection, fraction, and endoleaks, with the last one being the most common. The most frequently used imaging after EVAR is computed tomography angiography (CTA) and duplex ultrasound. Dynamic, time-resolved computed tomography angiography (d-CTA) is a reasonably new technique to characterize the endoleaks. Multiple scans are done sequentially around the endograft during acquisition that grants good visualization of the contrast passage and graft-related complications. This high diagnostic accuracy of d-CTA can be implemented into therapy via image fusion and reduce additional radiation and contrast material exposure. This protocol describes the technical aspects of this modality: patient selection, preliminary image review, d-CTA scan acquisition, image processing, qualitative and quantitative endoleak characterization. The steps of integrating dynamic CTA into intra-operative fluoroscopy using 2D-3D fusion-imaging to facilitate targeted embolization are also demonstrated. In conclusion, time-resolved, dynamic CTA is an ideal modality for endoleak characterization with additional quantitative analysis. It can reduce radiation and iodinated contrast material exposure during endoleak treatment by guiding interventions.
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- 2021
24. Time-Resolved, Dynamic Computed Tomography Angiography for Characterization of Aortic Endoleaks and Treatment Guidance via 2D-3D Fusion-Imaging
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Alan B. Lumsden, Su Min Chang, Ponraj Chinnadurai, and Marton Berczeli
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General Immunology and Microbiology ,General Chemical Engineering ,General Neuroscience ,General Biochemistry, Genetics and Molecular Biology - Published
- 2021
25. Mechanical Mitral Valve Thrombosis in a Patient With Prior Nonbacterial Thrombotic Endocarditis
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DO Kalyan R. Chitturi, Su Min Chang, Miguel A. Castro, Eric Salazar, Karla M. Kurrelmeyer, Michael Deavers, and John J. Mahmarian
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0301 basic medicine ,medicine.medical_specialty ,prosthetic valve thrombosis ,030105 genetics & heredity ,MV, mitral valve ,Nonbacterial thrombotic endocarditis ,POC, point of care ,03 medical and health sciences ,0302 clinical medicine ,Mechanical Mitral Valve ,Antiphospholipid syndrome ,PT, prothrombin time ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Prosthetic Valve Thrombosis ,mitral valve disease ,business.industry ,HIT, heparin-induced thrombocytopenia ,APS - Antiphospholipid syndrome ,INR, international normalized ratio ,NBTE, nonbacterial thrombotic endocarditis ,antithrombotic therapies ,TEE, transesophageal echocardiography ,medicine.disease ,Pulmonary edema ,Thrombosis ,Mini-Focus Issue on Valvular Heart Disease ,APS, antiphospholipid syndrome ,Pneumonia ,RC666-701 ,Cardiology ,MHV, mechanical heart valve ,nonbacterial thrombotic endocarditis ,Case Report: Clinical Case ,Cardiology and Cardiovascular Medicine ,business ,antiphospholipid syndrome ,030217 neurology & neurosurgery ,PVT, prosthetic valve thrombosis - Abstract
A 54-year-old woman with a mechanical mitral valve replacement presented with recurrent admissions for pneumonia and pulmonary edema. Multimodality imaging revealed mobile masses on the prosthesis and discrepant point of care and inpatient international normalized ratio levels owing to antiphospholipid antibody cross-reactivity on the outpatient assay. The prosthetic valve thromboses resolved with therapeutic anticoagulation. (Level of Difficulty: Beginner.), Graphical abstract, A 54-year-old woman with a mechanical MVR presented with recurrent admissions for pneumonia and pulmonary edema. Multimodality imaging revealed…
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- 2020
26. Prognostic value of computed tomography derived fractional flow reserve
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Ahmed Ibrahim Ahmed, Faisal Nabi, Yushui Han, M Al Rifai, Mouaz H. Al-Mallah, Talal Alnabelsi, Mohammed A. Chamsi-Pasha, John J. Mahmarian, and Su-Min Chang
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medicine.diagnostic_test ,business.industry ,Medicine ,Applied mathematics ,Computed tomography ,Fractional flow reserve ,Cardiology and Cardiovascular Medicine ,business ,Value (mathematics) - Abstract
Introduction Cardiac computed tomography angiography (CCTA) derived fractional flow reserve (FFRCT) has been shown to add incremental diagnostic value by providing functional severity of coronary lesion in patients with coronary artery disease (CAD). Purpose We aimed to assess the prognostic value of FFRCT in patients with suspected CAD. Methods Consecutive patients who had clinically indicated CCTA and FFRCT determination at a tertiary care cardiology practice were included. FFRCT was determined off-site using computational flow dynamics. Patients were followed for major adverse cardiovascular events (MACE, inclusive of all-cause death, non-fatal myocardial infarction, and late percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) 90-days after imaging test.) Results A total of 667 patients with at least Coronary Artery Disease Reporting & Data System (CAD-RADS) 2 were included. Mean age was 68±10 years, 37% were women, 73% had hypertension, 12% had diabetes and 61% had dyslipidemia. More than half (57%) of the patients had moderate (CAD-RADS 3) stenosis. FFRCT Conclusion Our results suggest that in a real-world cohort of patients with suspected CAD, FFRCT can identify patients at higher risk of incident cardiovascular outcomes. Funding Acknowledgement Type of funding sources: None.
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- 2021
27. Outcomes of patients with moderate-to-severe Ischemia excluded from the ischemia trial
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Mouaz H, Al-Mallah, Ahmed Ibrahim, Ahmed, Faisal, Nabi, Su Min, Chang, Neal S, Kleiman, Mohammed A, Chamsi-Pasha, Alpesh, Shah, Yuishi, Han, William A, Zoghbi, and John J, Mahmarian
- Subjects
Male ,Tomography, Emission-Computed, Single-Photon ,Ischemia ,Risk Factors ,Myocardial Ischemia ,Humans ,Female ,Coronary Artery Disease ,Middle Aged ,Aged - Abstract
The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial showed no difference in outcomes between medical therapy vs coronary revascularization in the management of patients with stable coronary artery disease. We aimed to determine the percentage of patients with at least moderate ischemia that would have been eligible for enrollment and evaluate the outcomes of those who would not.Consecutive patients who underwent cardiac single-photon emission computed tomography (SPECT) between April 2016 and September 2019 were identified and all-cause mortality was determined.There were a total of 1508 patients (mean age 67 ± 11.6 years, 69.5% males) with any perfusion defect on SPECT. Patients had a high prevalence of cardiac risk factors (73.4% with hypertension and 54.4% with diabetes mellitus.) Nearly half (709, 47%) had moderate-to-severe ischemia but over two-thirds (479/709, 66.3%) had at least one ISCHEMIA trial exclusion criteria. Patients meeting ISCHEMIA enrollment criteria had a significantly lower all-cause mortality than those who would have been excluded (3.91% vs. 11.3%, respectively, P .001).Our results show that ISCHEMIA selected a relatively small subset of lower risk patients among the larger higher risk group of patients with moderate-to-severe ischemia typical to most cardiology centers.
- Published
- 2021
28. AORTIC VALVE CALCIUM SCORE IN COMPARISON TO DOBUTAMINE STRESS ECHOCARDIOGRAPHY IN THE ASSESSMENT OF SEVERE LOW FLOW LOW GRADIENT AORTIC STENOSIS
- Author
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Ola Abdelkarim, Abhiraj Sinha, Ramez Barsoom, Nadeen Nader Faza, and Su Min Chang
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2022
29. LATE TRANSCATHETER HEART VALVE THROMBOSIS WITH SEVERE AORTIC STENOSIS LEADING TO CARDIOGENIC SHOCK: A HEART TEAM APPROACH
- Author
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Qasim Al Abri, Tomoya Hinohara, Su Min Chang, Nadeen Nader Faza, Moritz C. Wyler von Ballmoos, Sachin S. Goel, Neal S. Kleiman, and Michael J. Reardon
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2022
30. AI-BASED GATED NON-CONTRAST CARDIAC CT MID-DIASTOLIC VOLUME ANALYSES COMPARED TO MULTI-PHASE GATED, CONTRAST CT
- Author
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Ola Abdelkarim, Athira J. Jacob, Salma Zook, Myra Cocker, Prantik Gupta, Juan R. Giraldo, Diana Tran, Max Schoebinger, Chris Schwemmer, Mehmet A. Gulsun, Puneet Sharma, Saikiran Rapaka, and Su Min Chang
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2022
31. AI-BASED CARDIAC CHAMBER ANALYSIS FROM NON-CONTRAST, GATED CARDIAC CT
- Author
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Athira Jacob, Ola Abdelkarim, Salma Zook, Myra Cocker, Prantik Gupta, Juan Ramirez Giraldo, Diana Tran, Max Schoebinger, Chris Schwemmer, Mehmet A. Gulsun, Saikiran Rapaka, Puneet Sharma, and Su Min Chang
- Subjects
Cardiology and Cardiovascular Medicine - Published
- 2022
32. Association Between FFR
- Author
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Faheemullah, Beg, Hasan, Rehman, Mohammed A, Chamsi-Pasha, Faisal, Nabi, Su-Min, Chang, John J, Mahmarian, and Mouaz H, Al-Mallah
- Subjects
Fractional Flow Reserve, Myocardial ,Computed Tomography Angiography ,Predictive Value of Tests ,Coronary Stenosis ,Humans ,Coronary Artery Disease ,Coronary Angiography ,Tomography, X-Ray Computed ,Coronary Vessels ,Severity of Illness Index ,Retrospective Studies - Abstract
New data suggests long term outcomes of coronary revascularization based on instantaneous wave free ratio (iFR) are equivalent to invasive fractional flow reserve (FFR). We aimed to evaluate the correlation between non-invasive FFR derived from cardiac CT (FFRData from 21 patients with 26 vessels, who underwent both FFRIn a per vessel analysis, the average diameter stenosis was 59%, mean FFRFFR
- Published
- 2020
33. Patient-Specific 3-Dimensional Printed Modeling of the Tricuspid Valve for MitraClip Procedure Planning
- Author
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Nadeen N. Faza, Su Min Chang, Kinan Carlos El-Tallawi, Stefano Filippini, Stephen H. Little, Eleonora Avenatti, Ponraj Chinna Durai, and Marija Vukicevic
- Subjects
medicine.medical_specialty ,medicine.anatomical_structure ,Tricuspid valve ,business.industry ,Mitral valve ,MitraClip ,medicine ,Radiology, Nuclear Medicine and imaging ,Patient specific ,Cardiology and Cardiovascular Medicine ,business ,Surgery - Published
- 2020
34. Case of Hemorrhagic Cardiac Tamponade in a Patient with COVID-19 Infection
- Author
-
Omar F. Hadidi, Gholamreza Khoshnevis, Rahul Singh, Miguel A. Chavez, Henry Ellison, Su Min Chang, and Stephanie Fuentes
- Subjects
medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,General Medicine ,medicine.disease ,Hemorrhagic effusion ,Article ,Cardiac Tamponade ,Cardiac tamponade ,Internal medicine ,medicine ,Cardiology ,cardiovascular system ,business ,COVID 19 - Abstract
Highlights • There are protean manifestations of cardiac involvement with COVID 19 • Hemorrhagic pericardial effusion may be the sole cardiac manifestation of COVID 19
- Published
- 2020
35. Cardiac Computed Tomography for Comprehensive Coronary Assessment: Beyond Diagnosis of Anatomic Stenosis
- Author
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John J. Mahmarian, Apurva Patel, Bin Lu, Roosha Parikh, Alpana Senapati, and Su Min Chang
- Subjects
medicine.medical_specialty ,Percutaneous ,Computed Tomography Angiography ,Clinical Decision-Making ,Fractional flow reserve ,Review ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Chest pain ,Coronary Angiography ,Severity of Illness Index ,Coronary artery disease ,03 medical and health sciences ,Coronary artery bypass surgery ,0302 clinical medicine ,Percutaneous Coronary Intervention ,Predictive Value of Tests ,Medicine ,Humans ,030212 general & internal medicine ,Coronary Artery Bypass ,business.industry ,Coronary Stenosis ,Myocardial Perfusion Imaging ,Reproducibility of Results ,General Medicine ,medicine.disease ,Fractional Flow Reserve, Myocardial ,Stenosis ,medicine.anatomical_structure ,Radiology ,medicine.symptom ,business ,Perfusion ,Artery - Abstract
Cardiac computed tomography angiography (CCTA) has evolved into a versatile imaging modality that can depict atherosclerosis burden, determine functional significance of a stenotic lesion, and guide the management and treatment of stable coronary artery disease.1 With newer-generation scanners, diagnostic CCTA can be obtained in the majority of patients with a very acceptable radiation dose. We discuss the ability of CCTA to provide comprehensive assessment of a patient with suspected CAD, including functional techniques of stress-rest myocardial perfusion assessment using a vasodilator and a purely post-processing approach that assesses fractional flow reserve derived by CCTA. In addition, recent data validated the role of CCTA in managing stable patients with chest pain and suspected CAD, serving as a gatekeeper for invasive coronary angiogram as well as optimizing the preprocedural planning of percutaneous coronary revascularization and coronary artery bypass surgery.
- Published
- 2020
36. Cardiac Computed Tomography for Structural Heart Disease Assessment and Therapeutic Planning: Focus on Prosthetic Valve Dysfunction
- Author
-
Nadeen N. Faza, Alpana Senapati, John J. Mahmarian, and Su Min Chang
- Subjects
Reoperation ,medicine.medical_specialty ,Cardiac computed tomography ,Heart disease ,Prosthetic Valve Dysfunction ,Review ,030204 cardiovascular system & hematology ,Surgical planning ,Multimodal Imaging ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Predictive Value of Tests ,Risk Factors ,Multidetector computed tomography ,Multidetector Computed Tomography ,Prevalence ,Medicine ,Humans ,030212 general & internal medicine ,Heart Valve Prosthesis Implantation ,business.industry ,Incidence ,General Medicine ,medicine.disease ,Heart Valves ,Prosthesis Failure ,Treatment Outcome ,Heart Valve Prosthesis ,cardiovascular system ,Radiology ,business - Abstract
Of the 100,000-plus valve surgeries performed each year in the United States, up to 6% of those develop complications from prosthetic valve dysfunction. Prosthetic valve dysfunction (PVD) can be life threatening and often challenging to diagnose. In this review, we discuss the prevalence and incidence of PVD, explore its different etiologies, and assess the role of multimodality imaging with an emphasis on cardiac multidetector computed tomography (MDCT) for evaluating patients with PVD. We also investigate the utility of MDCT in preprocedural planning for transcatheter devices and redo surgical planning and discuss management strategies for patients with PVD.
- Published
- 2020
37. Prognostic Performance of Prospective versus Retrospective Electrocardiographic Gating in Coronary Computed Tomographic Angiography
- Author
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Pradnya Velankar, Kongkiat Chaikriangkrai, Belqis Elferjani, Sama Alchalabi, Ninad Dewal, Sayf Khaleel Bala, and Su Min Chang
- Subjects
Male ,medicine.medical_specialty ,Multivariate analysis ,Computed Tomography Angiography ,Population ,Coronary Artery Disease ,Gating ,030204 cardiovascular system & hematology ,Coronary Angiography ,Radiation Dosage ,Risk Assessment ,030218 nuclear medicine & medical imaging ,Coronary artery disease ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Multidetector Computed Tomography ,Humans ,Medicine ,cardiovascular diseases ,Clinical Investigation ,Prospective Studies ,education ,Retrospective Studies ,education.field_of_study ,Prospective gating ,business.industry ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,Computed tomographic angiography ,Predictive value of tests ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Coronary computed tomographic angiography (CCTA) with prospective electrocardiographic gating reduces radiation exposure, but its prognostic power for predicting cardiovascular risk in patients with suspected CAD has not been fully validated. To determine whether prospective gating performs as well as retrospective gating in this population, we compared these scan modes in patients undergoing 64-slice CCTA. From January 2009 through September 2011, 1,407 patients underwent CCTA; of these, 915 (mean age, 57.8 ± 13.5 yr; 54% male) had suspected coronary artery disease at the time of CCTA and were included in the study. Prospective gating was used in 195 (21%) and retrospective gating in 720 (79%). The mean follow-up duration was 2.4 ± 0.9 years. Overall, 390 patients (42.6%) had normal results on CCTA, 382 (41.7%) had nonobstructive coronary artery disease, and 143 (15.6%) had obstructive disease. Major adverse cardiac events occurred in 32 patients (3.5%): 11 cardiac deaths, 15 late revascularizations, and 6 nonfatal myocardial infarctions. Total event occurrences were similar in both groups (retrospective, 3.8%; prospective, 2.6%; P=0.42), as were the occurrences of each type of event. On adjusted multivariate analysis, nonobstructive (P=0.015) and obstructive (P The prognostic value of CCTA with prospective electrocardiographic gating compares favorably with that of retrospective gating, and it involves significantly less radiation exposure.
- Published
- 2018
38. Dynamic, Time-resolved CT Angiography Characterizes Aortic Endoleak Type, Inflow With out Additional Radiation Exposure and Provides Image Guidance for Targeted Treatment Approach
- Author
-
Su Min Chang, Márton Berczeli, Ponraj Chinnadurai, Peter Legeza, and Alan B. Lumsden
- Subjects
Radiation exposure ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Angiography ,medicine ,Surgery ,Radiology ,Inflow ,Cardiology and Cardiovascular Medicine ,business ,Image guidance - Published
- 2021
39. Fluorescent Determination of Copper(II) in Industrial Wastewater Using Thiol-Capped Cadmium Sulfide–Zinc Sulfide Quantum Dots as the Probe
- Author
-
Zhao Jun Chang, Su-Min Chang, and Shu Kang Hsu
- Subjects
chemistry.chemical_classification ,010401 analytical chemistry ,Biochemistry (medical) ,Clinical Biochemistry ,Inorganic chemistry ,chemistry.chemical_element ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Biochemistry ,Fluorescence ,Copper ,Zinc sulfide ,Cadmium sulfide ,0104 chemical sciences ,Analytical Chemistry ,Industrial wastewater treatment ,chemistry.chemical_compound ,chemistry ,Quantum dot ,Electrochemistry ,Thiol ,0210 nano-technology ,Effluent ,Spectroscopy - Abstract
In situ detection of Cu2+ ions in the effluent from thin-film transistor-liquid crystal display (TFT-LCD) manufacturing facility has been successfully achieved using thiol-capped CdS/ZnS quantum do...
- Published
- 2017
40. Added Prognostic Value Of Plaque Burden To Computed Tomography Angiography And Myocardial Perfusion Imaging
- Author
-
Ahmed Ibrahim Ahmed, Khurram Nasir, Mohammed A. Chamsi-Pasha, Yushui Han, Faisal Nabi, Miguel Cainzos-Achirica, Mouaz H. Al-Mallah, Mahmoud Al Rifai, John J. Mahmarian, Su Min Chang, and Talal Alnabelsi
- Subjects
Male ,medicine.medical_specialty ,Computed Tomography Angiography ,medicine.medical_treatment ,Coronary Artery Disease ,Single-photon emission computed tomography ,Coronary Angiography ,Coronary artery disease ,Myocardial perfusion imaging ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Myocardial infarction ,Aged ,Computed tomography angiography ,medicine.diagnostic_test ,business.industry ,Myocardial Perfusion Imaging ,Percutaneous coronary intervention ,Middle Aged ,medicine.disease ,Prognosis ,Stenosis ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Value (mathematics) ,Mace - Abstract
Purpose: Cardiac computed tomographic angiography (CCTA) - derived measures of coronary artery disease (CAD) burden such as segment involvement score (SIS), which quantifies the number of segments with plaque, have been shown to independently predict incident cardiovascular events. We aimed to compare the added prognostic value of plaque burden to CCTA anatomic assessment and single photon emission computed tomography (SPECT) physiologic assessment in a high-risk cohort undergoing both tests.Methods: Consecutive patients who underwent clinically indicated CCTA and SPECT myocardial imaging for suspected CAD at a tertiary care cardiology practice were included. Stenosis severity and SIS were determined from CCTA, and presence of ischemia was determined from SPECT. Patients were followed for major adverse cardiovascular events (MACE, inclusive of all-cause death, non-fatal myocardial infarction, and percutaneous coronary intervention or coronary artery bypass grafting 90-days after imaging test.)Results: A total of 956 patients were included. Mean age was 61.1 ± 14.2 years, 54% were men, 89% had hypertension, 81% had diabetes, 84% had dyslipidemia and 56% had recorded chest pain. Obstructive stenosis (left main ≥ 50%, all other coronary segments ≥ 70%) and ischemia were observed in similar number of patients (14%). After a median follow-up of 31 months, 102 patients (11%, 29.2 events per 1000 person-year) experienced a MACE. In multivariable Cox regression models, SIS significantly predicted outcomes and improved risk discrimination in models with CCTA obstructive stenosis (HR 1.15 95% CI 1.09 - 1.21 p= Conclusion: Our results suggest that in high-risk patients with suspected CAD, plaque burden adds incremental prognostic value over established measures in predicting incident cardiovascular outcomes.
- Published
- 2021
41. PROGNOSTIC VALUE OF COMPUTED TOMOGRAPHY DERIVED FRACTIONAL FLOW RESERVE COMPARISON WITH MYOCARDIAL PERFUSION IMAGING
- Author
-
William A. Zoghbi, Talal Alnabelsi, Ahmed Ibrahim Ahmed, Mouaz H. Al-Mallah, Myra S Cocker, Su Min Chang, Faisal Nabi, Chris Schwemmer, Yushui Han, and John J. Mahmarian
- Subjects
Myocardial perfusion imaging ,medicine.diagnostic_test ,business.industry ,Medicine ,Computed tomography ,Fractional flow reserve ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Value (mathematics) - Published
- 2021
42. COMPARATIVE PROGNOSTIC VALUE OF AN INITIAL COMPUTED TOMOGRAPHY ANGIOGRAPHY VS MYOCARDIAL PERFUSION IMAGING APPROACH IN PATIENTS WITH CORONARY ARTERY DISEASE
- Author
-
Ahmed Ibrahim Ahmed, Talal Alnabelsi, Su Min Chang, Yushui Han, Faisal Nabi, Mouaz H. Al-Mallah, John J. Mahmarian, and Hassaan Arshad
- Subjects
Coronary artery disease ,medicine.medical_specialty ,Myocardial perfusion imaging ,medicine.diagnostic_test ,business.industry ,medicine ,In patient ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Value (mathematics) ,Computed tomography angiography - Published
- 2021
43. Fabrication of hydrothermally reduced graphene oxide/chitosan composite membranes with a lamellar structure on methanol dehydration
- Author
-
Rumwald Leo G. Lecaros, Kueir-Rarn Lee, Chien Chieh Hu, Su-Min Chang, Quan Fu An, Juin-Yih Lai, Wei-Song Hung, and Yan Li Ji
- Subjects
Materials science ,Graphene ,Inorganic chemistry ,Oxide ,Ionic bonding ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Hydrothermal circulation ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,Membrane ,chemistry ,law ,General Materials Science ,Lamellar structure ,Carboxylate ,Pervaporation ,0210 nano-technology - Abstract
Reduced graphene oxide (rGO) has been prepared through hydrothermal reduction, an environmentally safe reduction of graphene oxide (GO). rGO is used to fabricate a highly compatible and orderly stacked lamellar structure of composite membranes with chitosan (CS). This method also facilitates a continuous large-scale fabrication of membranes. Conventionally, GO and CS are the preferred compounds for this type of fabrication because of their hydrophilic nature. Nevertheless, when they are mixed together, the occurrence of ionic complexation (−COO− H3+ N−R) between the negatively charged carboxylate ions of GO and the positively charged protonated amines of CS create extreme membrane aggregation. Hydrothermal reduction is useful for preventing undesired ionic complexation from mixing rGO and CS because it can remove most carboxylate ions from GO. Consequently, the hydrophilic CS molecular chain is inserted in between the rGO laminates, improving the dispersion and enabling the rGO/CS to stack-up and self-assemble into a lamellar structure. Furthermore, excellent methanol dehydration can be observed through pervaporation, which is attributed to the selective water channels formed in the rGO laminates.
- Published
- 2017
44. Coronary artery calcium score as a predictor for incident stroke: Systematic review and meta-analysis
- Author
-
Su Min Chang, Faisal Nabi, Kongkiat Chaikriangkrai, Aref A. Bin Abdulhak, Gardar Sigurdsson, Ghanshyam Palamaner Subash Shantha, Hye Yeon Jhun, and John J. Mahmarian
- Subjects
medicine.medical_specialty ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Severity of Illness Index ,Asymptomatic ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Vascular Calcification ,Stroke ,business.industry ,Coronary artery calcium score ,Incidence ,Incidence (epidemiology) ,nutritional and metabolic diseases ,medicine.disease ,Observational Studies as Topic ,Relative risk ,Coronary artery calcification ,Meta-analysis ,Cardiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Coronary artery calcium score (CACS) is a well-established test for risk stratifying asymptomatic patients for overall cardiovascular or coronary events. However; the prognostic value for incident stroke remains controversial. The objective of this study was to investigate the predictive value of CACS obtained by non-contrast electrocardiogram-gated computed tomography for incident stroke. Methods We searched PubMed, EMBASE, Cochrane databases for prospective longitudinal studies of CACS which reported the incidence of stroke. Incidence of stroke was compared in patients with and without coronary calcification. Results Three studies evaluated 13,262 asymptomatic patients (mean age=60years, 50% men) without apparent cardiovascular diseases. During a follow-up of 7.2years (median 5years, range 4.4–9.5years, 95,434patient-years), the overall pooled incidence of stroke was 0.26%/year. The pooled risk ratio of CACS>0 for incident stroke was 2.95 (95% CI: 2.18–4.01, p 2 =0%). The pooled incidence rate of stroke categorized by CACS was 0.12%/year for CACS 0, 0.26%/year for CACS 1–99, 0.41%/year for CACS 100–399 and 0.70%/year for CACS ≥400. Conclusions In asymptomatic patients without apparent cardiovascular diseases, the incidence of stroke was overall low. The presence and severity of coronary artery calcification were associated with incident stroke over mid-long term follow-up.
- Published
- 2017
45. Formation of Cu2O/Titanate/Titania Heterojunctions from Hydrothermally Induced Dual Phase Transitions
- Author
-
Ruey-an Doong, Hsin Mu Tsai, Su-Min Chang, and Manchal Chaudhary
- Subjects
Phase transition ,Materials science ,Charge separation ,Nanotechnology ,Heterojunction ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Titanate ,Hydrothermal circulation ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Ion ,General Energy ,Adsorption ,Chemical engineering ,Photocatalysis ,Physical and Theoretical Chemistry ,0210 nano-technology - Abstract
A microwave-assisted hydrothermal method has been developed as an efficient approach to readily induce phase transition of titanate assemblies in conjunction with decoration of Cu2O clusters on the surface. The influence of Cu2+ ions on the hydrothermally induced structural evolution was examined, and the roles of heterojunctions in the resulting composites in charge separation for improved photocatalytic activity were clarified. Hierarchical titanate assemblies with high adsorption capacity for Cu2+ ions (95.7 mg/g) were prepared from a low alkaline condition. Microwave-assisted hydrothermal treatment was then used to transform the adsorbents into Cu2O/titanate/titania photocatalysts in 20 min via inducing titanate-to-titania and Cu2+-to-Cu2O dual transitions. While tubular architecture was maintained in the composites, the Cu2O clusters highly dispersed on the surface. Adsorbed Cu2+ ions have been found to retard the titanate-to-titania transformation locally, thus leading to Cu2O/titanate/titania heter...
- Published
- 2016
46. P276Reducing radioisotope dose in regadenoson SPECT MPI: comparison of half-dose scans using a novel solid-state-detector dedicated cardiac camera to full dose scans acquired on standard camera
- Author
-
John J. Mahmarian, Aaron K. Jung, Su-Min Chang, and Faisal Nabi
- Subjects
medicine.diagnostic_test ,business.industry ,Spect mpi ,medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Solid state detector ,Single-photon emission computed tomography ,Cardiology and Cardiovascular Medicine ,business ,Nuclear medicine ,Regadenoson ,medicine.drug - Published
- 2019
47. Utility of Cardiac Computed Tomography in Patients with Left Ventricular Assist Devices
- Author
-
Juan Carlos Ramírez Giraldo, Sardar Muhammad Alamzaib, Bashar Hannawi, Mahwash Kassi, and Su Min Chang
- Subjects
medicine.medical_specialty ,Histology ,genetic structures ,Cardiac computed tomography ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Applied Microbiology and Biotechnology ,Surgical planning ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,In patient ,Functional evaluation ,medicine.diagnostic_test ,business.industry ,Interventional radiology ,Cell Biology ,equipment and supplies ,Cannula ,medicine.anatomical_structure ,Ventricle ,Ventricular assist device ,Cardiology ,business - Abstract
The number of left ventricular assist device implants has increased significantly in the last decade. Left ventricular assist device (LVAD) optimization, trouble-shooting complications, and surgical planning require a multi-modality imaging approach. Echocardiography remains the imaging modality of choice, particularly for physiological evaluation but accurate anatomical evaluation of the entirety of the LVAD is often challenging if not impossible. Cardiac computed tomography (CCT) offers additional information that is valuable in taking care of these complex patients. The purpose of this review is to understand the nuances of LVAD imaging and areas where CCT can aid LVAD evaluation and management. CCT has a well-established role in trouble-shooting complications particularly inflow and outflow cannula-related anatomic complications from suction and kinking. Even though the literature is scarce, there is evolving data to suggest that adverse inflow and outflow cannula positions may result in unfavorable outcomes. There is more interest in novel mechanisms of device implantation and planning for which data set from CCT is ideal. Functional evaluation of the right ventricle with CCT is becoming more sophisticated and maybe particularly useful in this patient population. Development in CCT technology has helped minimize safety concerns and improved image quality with reduction in LVAD-related artifacts. CCT is an important adjunct modality to echocardiography for patients with LVAD. Information obtained from CCT may help our understanding of LVAD and in turn help reduce and managed LVAD-related complications.
- Published
- 2018
48. Accuracy of Dynamic Computed Tomography Angiography in Characterizing Endoleaks and Guiding Treatment in Patients After Endovascular Aortic Repair
- Author
-
Su Min Chang, Ponraj Chinnadurai, Alan B. Lumsden, and Peter Legeza
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine ,Surgery ,In patient ,Radiology ,Cardiology and Cardiovascular Medicine ,Aortic repair ,business ,Computed tomography angiography - Published
- 2020
49. Clinical Utility of Multidetector Computed Tomography in Redo Valve Procedures
- Author
-
Kongkiat Chaikriangkrai, Faisal Nabi, Dimitrios Maragiannis, Stephen H. Little, John J. Mahmarian, Tatiana Belousova, and Su-Min Chang
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Retrospective cohort study ,Regurgitation (circulation) ,030204 cardiovascular system & hematology ,medicine.disease ,030218 nuclear medicine & medical imaging ,Cardiac surgery ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Angiography ,cardiovascular system ,Etiology ,medicine ,Surgery ,cardiovascular diseases ,Intraoperative Period ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
BACKGROUND Transesophageal echocardiography (TEE) is recommended for diagnosis in patients suspected of prosthetic valve dysfunction, but could be limited in its ability to identify the etiology of these dysfunctions and to assess extracardiac structures. Our objective is to examine the usefulness of multidetector computed tomography (MDCT) in establishing the etiology of the dysfunctions and its clinical utility in preoperative assessment in these patients. METHODS Twenty-two prosthetic heart valves from 20 consecutive patients who had a preoperative MDCT and underwent redo prosthetic valve procedures from December 2008 to February 2013 were examined retrospectively. Results from MDCT and TEE were compared to intraoperative findings. Extravalvular MDCT findings including coronary artery/bypass graft, high-risk features for reoperative cardiac surgery, and extracardiac findings were also assessed. RESULTS MDCT correctly identified 15 valve regurgitation and seven valve obstructions compared to intraoperative findings. Both TEE and MDCT were able to correctly identify the etiologies in 93% (14/15) of regurgitant valves. However, MDCT was better able to identify the etiology of obstructive valves than TEE (86% [6/7] vs. 43% [3/7]) compared to intraoperative findings. In patients who had preoperative invasive angiography, MDCT correctly identified two patients with significant coronary artery disease (CAD) and ruled out 11 without significant CAD. Furthermore, MDCT detected five high-risk features for postoperative complications and eight clinically relevant extracardiac findings. CONCLUSIONS MDCT displayed comparable or better diagnostic performance than TEE for identifying the type of dysfunction and its etiology, as well as providing additional coronary and other extravalvular evaluations useful for preoperative planning.
- Published
- 2016
50. Optimizing Evaluation of Patients with Low-to-Intermediate-Risk Acute Chest Pain: A Randomized Study Comparing Stress Myocardial Perfusion Tomography Incorporating Stress-Only Imaging Versus Cardiac CT
- Author
-
Mahwash Kassi, Kamil Muhyieddeen, John J. Mahmarian, Nelda P. Wray, Carol M. Ashton, Beverly A. Shirkey, Jiaqiong Xu, Su Min Chang, Faisal Nabi, and Leif E. Peterson
- Subjects
Male ,Chest Pain ,medicine.medical_specialty ,Acute coronary syndrome ,Longevity ,030204 cardiovascular system & hematology ,Chest pain ,Risk Assessment ,Magnetic resonance angiography ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Myocardial perfusion imaging ,0302 clinical medicine ,medicine ,Clinical endpoint ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Acute Coronary Syndrome ,Prospective cohort study ,Aged ,Tomography, Emission-Computed, Single-Photon ,medicine.diagnostic_test ,business.industry ,Myocardial Perfusion Imaging ,Reproducibility of Results ,Heart ,Middle Aged ,medicine.disease ,Death, Sudden, Cardiac ,Angiography ,Exercise Test ,Female ,Radiology ,medicine.symptom ,Nuclear medicine ,business ,Perfusion ,Magnetic Resonance Angiography ,Follow-Up Studies - Abstract
The purpose of this study was to determine whether stress myocardial perfusion (SPECT) optimized with stress-only (SO) imaging is comparable to cardiac CT angiography (CTA) for evaluating patients with acute chest pain (ACP).This was a prospective randomized observational study in 598 ACP patients who underwent CTA versus SPECT. The primary endpoint was length of hospital stay, and secondary endpoints were test feasibility, time to diagnosis, diagnostic accuracy, radiation exposure, and overall cost. Median follow-up was 6.5 mo, with a 3.8% cardiac event rate defined as death or an acute coronary syndrome.Of 2,994 patients screened, 1,703 (56.9%) were not candidates for CTA because of prior cardiac disease (41%) or imaging contraindications (16%). Time to diagnosis (8.1 ± 8.5 vs. 9.4 ± 7.4 h) and length of hospital stay (19.7 ± 27.8 vs. 23.5 ± 34.4 h) were significantly shorter with CTA than with SPECT (P = 0.002). However, time to diagnosis (7.0 ± 6.2 vs. 6.8 ± 5.9 h, P = 0.20), length of stay (15.5 ± 17.2 vs. 16.7 ± 15.3 h, P = 0.36), and hospital costs ($4,242 ± $3,871 vs. $4,364 ± 1781, P = 0.86) were comparable with CTA versus SO SPECT, respectively. SO was also superior to conventional SPECT regarding all of the above metrics and significantly reduced radiation exposure (5.5 ± 4.4 vs. 12.5 ± 2.7 mSv, P0.0001).Stress SPECT when optimized with SO imaging is similar to CTA in time to diagnosis, length of hospital stay, and cost, with improved prognostic accuracy and less radiation exposure. Our results emphasize the importance of SO imaging, particularly in low-intermediate-risk emergency room patients who are a population likely to have a normal test result.
- Published
- 2015
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