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31 results on '"Su, Yung-Shun"'

1. The crude extract obtained from Cinnamomum macrostemon Hayata regulates oxidative stress and mitophagy in keratinocytes.

Author

Su, Yung-Shun, Cheng, Ming-Jen, Kwan, Aij-Lie, Huang, Shu-Ping, Tyan, Yu-Chang, Chai, Chee-Yin, and Huang, Bin

Subjects
*CINNAMOMUM, *CELL survival, *REACTIVE oxygen species, *KERATINOCYTES, *MEMBRANE potential
Abstract

Four ethanol fractionated crude extracts (EFCEs [A-D]) purified from the leaves of Cinnamomum macrostemon Hayata were screened for antioxidative effects and mitochondrial function in HaCaT cells. The higher cell viability indicated that EFCE C was mildly toxic. Under the treatment of 50 ng/mL EFCE C, the hydrogen peroxide (H2O2)-induced cytosolic and mitochondrial reactive oxygen species levels were reduced as well as the H2O2-impaired cell viability, mitochondrial membrane potential (MMP), ATP production, and mitochondrial mass. The conversion of globular mitochondria to tubular mitochondria is coincident with EFCE C-restored mitochondrial function. The mitophagy activator rapamycin showed similar effects to EFCE C in recovering the H2O2-impaired cell viability, MMP, ATP production, mitochondrial mass, and also mitophagic proteins such as PINK1, Parkin, LC3 II, and biogenesis protein PGC-1α. We thereby propose the application of EFCE C in the prevention of oxidative stress in skin cells. [ABSTRACT FROM AUTHOR]

Published
2024
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4. The crude extract obtained from Cinnamomum macrostemonHayata regulates oxidative stress and mitophagy in keratinocytes

Author

Su, Yung-Shun, Cheng, Ming-Jen, Kwan, Aij-Lie, Huang, Shu-Ping, Tyan, Yu-Chang, Chai, Chee-Yin, and Huang, Bin

Abstract

Four ethanol fractionated crude extracts (EFCEs [A-D]) purified from the leaves of Cinnamomum macrostemonHayata were screened for antioxidative effects and mitochondrial function in HaCaT cells. The higher cell viability indicated that EFCE C was mildly toxic. Under the treatment of 50 ng/mL EFCE C, the hydrogen peroxide (H2O2)-induced cytosolic and mitochondrial reactive oxygen species levels were reduced as well as the H2O2-impaired cell viability, mitochondrial membrane potential (MMP), ATP production, and mitochondrial mass. The conversion of globular mitochondria to tubular mitochondria is coincident with EFCE C-restored mitochondrial function. The mitophagy activator rapamycin showed similar effects to EFCE C in recovering the H2O2-impaired cell viability, MMP, ATP production, mitochondrial mass, and also mitophagic proteins such as PINK1, Parkin, LC3 II, and biogenesis protein PGC-1α. We thereby propose the application of EFCE C in the prevention of oxidative stress in skin cells.Graphical AbstractThe ethanol fractionated crude extract C isolated from leaves of Cinnamomum macrostemonHayata showed regulatory effects on antioxidation and mitophagy in keratinocytes.

Published
2024
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24. Strategies for autonomous robot to inspect pavement distresses

Author

Jia-Ruey Chang, Yuan-Hsu Tseng, Cheng-Hao Lee, Shih-Chung Kang, and Su Yung-Shun

Subjects
Engineering, business.industry, Real-time computing, Mobile robot, Remotely operated underwater vehicle, computer.software_genre, Autonomous robot, Maintenance engineering, Field (computer science), Virtual machine, Robot, Motion planning, business, computer, Simulation
Abstract

Distress inspection is an important task in pavement maintenance. Pavement inspection requires tremendous human resources, so many investigators start developing automatic and robotic inspection methods to increase the efficiency and accuracy. However, the systems they developed are applicable for network-level inspection (large areas, long-distance) but too expensive or too big for project-level inspection (small areas, short-distance). Dealing with this problem, some researchers have developed an autonomous vehicle for inspection. In this research, we specific focus on developing strategies for executing the inspection tasks using robots. We developed three strategies. The first strategy is random-walk. The second strategy is random-walk with map recording. The third one adds the vision capacity to the robot. To validate the three strategies, we developed a test field in a virtual environment. This test field includes 5 types of common distress, including an alligator crack, a patching, a breaking hole, a rectangular manhole and a circular manhole. We also developed a virtual robot which can autonomously navigate in the test field. We then implemented the three survey strategies in the robot and compare their performances with traditional longitudinal survey method. The results show that using the first strategy, we can increase frequency for passing the distresses; it means that robot can detect and collect data more times than traditional longitudinal survey. The results of the second strategy show that we can increase the repeatability by using map recording to guide random-walk. The results of third strategy show that the robot can find more distresses in a certain amount of time; it means that we can improve survey efficiency by adding vision capacity to adjust motion path when distresses detected. Comparing these strategies with conventional Longitudinal survey strategy(L strategy), the three proposed strategies have a higher possibility of revisiting distresses, and it means making the results more reliable.

Published
2010
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